
Hotel vacation rentals in Santa Cruz Island
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Santa Cruz Island
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santa Cruz Island hotel rentals
Family-friendly hotel rentals

Galapagos Homes
Very clean and quiet space. It’s actually in Bellevista, about 5 miles north of Puerto Ayora.

Galapagos Spacious two bedroom with balcony
We had a lovely time at Torre Mar. Donna was great at communicating everything we'd need to know before the trip, and helping coordinate taxis and laundry service for us during our stay. We found the apartment comfortable and spacious. The AC worked great, and it had the best WiFi connection that we had our entire week on both Santa Cruz and Isabela. I loved how convenient it was to walk to the downtown Puerto Aroya, literally a 5 minute walk to the pier. We had excellent meals in Puerto Aroya, including crepes, two good meals at the Santa Cruz Brewing company which has delicious beer, a delicious lunch at Hotel Solymar right on the water, where we could see blue footed boobies diving right below us, and a delicious dinner at Bahia Grill. I would love to stay here again someday!

The Galapagos Pearl Hotel- Room #11
Great location. Good price. I would stay again. Only detractor was that the missed a couple spots when leaning the bathroom. Nothing major. Very nice and welcoming staff

Hostal Costa del Pacifico - Double Room
Our stay was amazing! Super close to all amenities. Hot water in the shower whenever we needed it. The WiFi was great! Free drinking water provided, tv and fridge in room which was really handy plus a balcony which we used for drying our clothes. The only think was our room had a window at the very top which let into the hallway and was covered by black card but we could literally EVERYTHING from out in the hall. We’re heavy sleepers so it didn’t bother us but just a heads up for light sleepers ☺️

Family Twin Room
Beautiful hotel with a lovely rooftop view of Puerto Ayora. We were welcomed by lovely staff and they gave us lemonade as we were settling into our room. The pool was a nice touch. The hotel is a little farther from town, but only a 20-25 minute walk, if you don't mind a walk.

Gloria-Galapagos Inn_Triple
Great value place in a very central location. I stayed here multiple times.

Enchanted Lodge
The lodge is an excellent stay. The hosts were lovely and very accommodating. The food is great when the chef is available. We chose to stay here so as to not be in the busy town, it’s lovely and tranquil, if that is what you’re looking for, it’s a perfect stay. It is 20 minutes and $10/$15 taxi into town though so take this into account.

Hostal del Pacifico - Double Room
my stay was perfect, all staff, friendly and attentive. The spacious room. Go, unbeatable value for money. If I come back, I will stay there, no doubt
Hotel rentals with a pool

Hotel Coloma Galapagos: Triple Room
Such a great place to stay! Central and cute!

Nice family room in Puerto Ayora
Very good for your stay in Santa Cruz

Oferta de temporada
Excellent service , Johnny behaved super well and gave us a quality service

Hostal España - Double Room
Nice place, close to everything. Friendly and helpful staff at all times. A place I will return to for sure.

Linda Triple Room in Galapagos
We felt very comfortable in the Hostal, we had hot and cold water to serve us, we found the place where it was located very strategic since there were many places of food and to walk..

Nice Double Room in Santa Cruz
good place

Family room with balcony in Santa Cruz
Amazing place, close to most of the main attractions in Galapagos. I will book again once I come back to the island!!

Nice affordable room in Santa Cruz 2
Excellent host, she guided me in everything to make my stay the best possible. The accommodation is next to everything you need on foot, it is comfortable and clean, I totally recommend it.
Hotel rentals with a patio

Private Room* Petrel
Alan's place was very nice. Everything was clean and well maintained. Great aircon, TV, nice outdoor areas with tables and seating, free cold drinking water, comfy bed, good hot shower and private. It was good value for the island, and the location was good for us, just over 5 minutes walking to the main street, and it is in a quiet area. Highly recommend this place!

Santa Cruz Accommodation - DOUBLE ROOM
Super good, good people, the service

Cabin I El Edén
We loved our stay at El Eden’s. It was within walking distance of El Chato Ranch and so relaxing! The owner was so sweet and helpful the entire visit. This was definitely one of our favorite stays!

GALAPAGOS DOVE #5
Very comfortable, quiet and the person in charge very friendly and helpful

Beautiful double room.
Carliza was very helpful with bus info as well as providing laundry services. Great place for the price. Close to excellent restaurants and the dock.

Amazing views

Single room in GPS

Hotel Galapagos Santa Cruz.
Destinations to explore
- Tomas de Berlanga (Santo Tomas) Vacation rentals
- Playa de Oro Vacation rentals
- San Cristobal Vacation rentals
- Puerto Baquerizo Moreno Vacation rentals
- Isabela Island Vacation rentals
- Puerto Villamil Vacation rentals
- Puerto Ayora Vacation rentals
- San Cristóbal Island Vacation rentals
- Baltra Island Vacation rentals
- El cascajo Vacation rentals
- Rentals with a fireplace Santa Cruz Island
- Pet-friendly rentals Santa Cruz Island
- Kid-friendly rentals Santa Cruz Island
- Private suite rentals Santa Cruz Island
- Hostel rentals Santa Cruz Island
- House rentals Santa Cruz Island
- Rentals with pools Santa Cruz Island
- Bed and breakfasts Santa Cruz Island
- Smoking-friendly rentals Santa Cruz Island
- Apartment rentals Santa Cruz Island
- Rentals with a patio Santa Cruz Island
- Rentals with outdoor seating Santa Cruz Island
- Rentals with beach access Santa Cruz Island
- Waterfront rentals Santa Cruz Island
- Rentals with a washer and dryer Santa Cruz Island
- Rentals with a fire pit Santa Cruz Island
- Serviced apartment rentals Santa Cruz Island
- Hotel rentals Galápagos Islands
- Hotel rentals Ecuador
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom