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Vacation rentals in Santa Cruz Island

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz Island

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Apartment in Puerto Ayora
4.96 out of 5 average rating, 85 reviews

Bright and cozy 2 bedroom home away from home

Kick back and relax in this calm, stylish space. A bright and comfortable two-bedroom apartment in the heart of the Galapagos, Santa Cruz Island. Surrounded by vegetation, it is situated only four blocks from the main street, five minutes walk from the main dock, and at the entrance of Tortuga Bay. AMAZING terrace with outside dining areas. Perfect for couples or a small group of friends. It offers working spaces, a kitchen, a washing machine, all you need to have your own home in the Galapagos.

Top guest favorite
The sitting area features a modern gray sofa adorned with decorative pillows and is complemented by a wooden coffee table. Artwork hangs on the walls, and large glass doors provide ample natural light and views of a private balcony and the surrounding greenery.
Apartment in Puerto Ayora
4.91 out of 5 average rating, 210 reviews

Planet House Apt2 Sunny 1 BR flat. Great location

This is a beautiful legally registered property, with great views and wonderful fresh ocean breeze. Our apartment is located two blocks away from Charles Darwin Avenue. Guests can enjoy a leisurely walk to main attractions like the Charles Darwin Research Station and beach, great restaurants, cafés, shops, dive shops, tour operators and more. Great option for guests seeking flexibility, comfort and good value. The bedroom has AC, however the living area only benefits from a nice sea breeze.

Top guest favorite
Cabin in Santa Cruz
4.96 out of 5 average rating, 209 reviews

Casa Vikingo • A Unique, Secluded Highland Cabin

Perched high in the Galápagos Highlands, Casa Vikingo is a private cabin designed for those seeking nature, architecture, and complete tranquility. Surrounded by endemic forest and resting on a lava rock foundation built from materials found on site, the cabin is immersed in one of the most unique landscapes in the archipelago. Wake up to views of the Pacific and drifting cloud formations, soak in the private plunge tub, and experience a side of the Galápagos that few visitors ever see.

Guest favorite
Home in Puerto Ayora
5 out of 5 average rating, 48 reviews

Villa Náutica | Private Jacuzzi | Design

Perfect for couples, families or friends looking to relax in style in the Galápagos Villa Náutica is an elegant loft villa with a private Jacuzzi, spacious areas and a unique nautical design inspired by my Swiss and Galapagos roots. Located in a quiet residential neighborhood, it allows you to enjoy tranquility just a 12-minute walk from downtown Puerto Ayora. It combines comfort, authenticity, and the ideal atmosphere for discovering the islands and returning to rest in a cozy retreat.

Guest favorite
Home in Puerto Ayora
5 out of 5 average rating, 7 reviews

Samana Stay

Samana Stay is a spacious two-level family home in a quiet walkable neighbourhood, with beaches and the Charles Darwin Research Station nearby. Designed for comfort and long stays, it offers generous living areas, air-conditioned downstairs bedrooms, reliable Wi-Fi, and a fully equipped kitchen. The open living and dining space opens to a private garden with cut lava-rock pathways, creating a calm outdoor retreat and complete “entire home” privacy, ideal for families and eco-travellers.

Guest favorite
A welcoming living area features sleek furniture and a natural wood floor that reflects light. Two modern chairs are positioned around a minimalistic coffee table on a round woven rug. Large double doors open to a balcony, offering scenic views of the surroundings.
Apartment in Puerto Ayora
4.84 out of 5 average rating, 176 reviews

Oceanview Suite: Nest House

Welcome to our one-of-a-kind, bird’s nest-inspired suite in Puerto Ayora, Galapagos. Enjoy: ๏ Ocean views from your private balcony ๏ Cozy hanging bed for ultimate relaxation ๏ Artistic tree staircase ๏ Fully-equipped kitchen ๏ High-speed Wi-Fi (120 Mbps) and workspace ๏ Ventilated living space The bathroom is located just below the suite, offering added privacy. Stroll to nearby cafes, bakeries, and restaurants. Let us help you discover the best of the islands!

Top guest favorite
The bright bedroom features two spacious beds with patterned bedding. Wooden beams add character to the ceiling while light fixtures create a warm ambiance. A large window allows natural light to fill the room, and a piece of art depicting a tree adorns one wall.
Bungalow in Puerto Ayora
4.9 out of 5 average rating, 307 reviews

Bright Garden Bungalow in a quiet neighborhood.

Sunshine filled, bright garden suite, next to the entrance to the Galapagos National Park and the Charles Darwin Station, and a few blocks away from some of the best restaurants, art galleries and bars in town. Located on the far end of one of Puerto Ayora's main streets, accessible to the road but removed enough to be isolated from the urban noise. An AC cools the suite when needed in the warmer months, and it’s screened windows are the alternative as well .

Top guest favorite
Apartment in Puerto Ayora
4.98 out of 5 average rating, 53 reviews

New and centrally-located apartment with a great location.

Enjoy this brand new apartment, with brand new furniture and equipment. Its central location allows you to access the main attractions just a few minutes away on foot. It has a bedroom, a living room with a comfortable sofa bed, laundry and patio. In addition, we advise you with recommendations on places to visit, taxi transportation and the best restaurants in the area. Ideal for couples, families with children or groups of friends looking for comfort.

Top guest favorite
Apartment in Puerto Ayora
5 out of 5 average rating, 58 reviews

Bright Loft/Suite by Encantadas

Modern and bright loft, fully equipped with everything you may need. It's air conditioned, has free wifi, a hot shower, hotel amenities, and more, all just a few minutes from the main pier. Your studio has a small terrace, and on the second floor, there's a perfect desk for remote working. With over 11 years in the Airbnb industry, we understand our guests' needs. Explore the Galapagos and relax in your own private studio.

Top guest favorite
Home in Puerto Ayora
4.89 out of 5 average rating, 155 reviews

El Galapagueño House

Come! Enjoy the simplicity of this magical, quiet, centrally-located, and private place with your partner, family, or friends! An ideal place to rest after visiting the most extraordinary tourist sites of the Galapagos Islands!!! 🏡🐢🏞️🏝️☀️🐚 We look forward to seeing you! 15 minutes' walk to the pier 100 meters from the entrance to Tortuga Bay Beach 20 meters from the tennis court

Guest favorite
An open living area is presented, featuring a comfortable seating arrangement with a couch and two armchairs. A dining table is situated nearby, complemented by a fully equipped kitchen in the background. Natural light filters through large windows, enhancing the spacious environment.
Home in Puerto Ayora
4.88 out of 5 average rating, 235 reviews

Casita Muyuyo - Galapagos Islands!

This bright, fully licensed two-bedroom Airbnb is perfect for families or friends seeking a safe, private, and comfortable stay. Located in a walled garden complex near town and just steps from the entrance to the Tortuga Bay trail, it's a peaceful retreat after a day of exploring the Galapagos. Please note this is a fully legal airbnb, with a license from the Ministry of Tourism

Guest favorite
The open kitchen area features modern cabinetry and a compact dining table with three chairs. A refrigerator and a gas stove are included. Natural light fills the space through a large window, complemented by decorative plants and minimalist decor.
Apartment in Puerto Ayora
4.89 out of 5 average rating, 54 reviews

Modern apartment in downtown Puerto Ayora

Welcome to this spacious apartment, perfect for up to three people. Located in a central area, just 6 minutes from the boardwalk, close to restaurants, shops, pharmacies and main attractions, allowing you to explore the island with ease. The apartment has a queen bed and a sofa bed, ideal for couples, friends or travelers looking for comfort and a strategic location.

Popular amenities for Santa Cruz Island vacation rentals

Frequently Asked Questions

  • Where is Santa Cruz Island located?

    Santa Cruz Island sits in the heart of the Galápagos Province, Ecuador, surrounded by the Pacific Ocean. It is part of the Galápagos Archipelago, known for distinct wildlife and protected natural habitats.

  • When is the best time to visit Santa Cruz Island?

    The climate on Santa Cruz Island is often comfortable year-round, with dry and warm conditions frequently suggested for outdoor activities. Many travelers appreciate the wildlife viewing opportunities available during alternating wet and dry seasons.

  • What are some things to do near Santa Cruz Island?

    Explore locally guided wildlife excursions, visit the Charles Darwin Research Station, and wander through traditional markets in nearby Puerto Ayora. Activities such as snorkeling, hiking, and bird spotting are frequently suggested for travelers.

  • How is the weather near Santa Cruz Island?

    Santa Cruz Island typically has mild tropical conditions, with warm temperatures and occasional rainfall distributed throughout the year. Visitors often experience comfortable days and cooler evenings, so packing for variable weather is suggested.

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  2. Ecuador
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  4. Santa Cruz Island