Apartment vacation rentals in Saint Charles

Find and book unique apartments on Airbnb

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Popular amenities for Saint Charles apartment rentals

Weekly apartment rentals

Top guest favorite
Apartment in University City
5 out of 5 average rating, 9 reviews

Apartment in University City

EmilyRating, 5 stars3 months ago
Landon's place was so convenient for my friend's wedding in the area! The neighborhood was so quiet, and the place was perfect for a quick weekend away.
Superhost
Apartment in Belleville
4.76 out of 5 average rating, 123 reviews

Eskimo Inn Studio Apartment

LauraRating, 5 stars4 weeks ago
I’ve stayed here before, would stay again. It’s a great location for me to visit family and the spaces have everything I need. Thanks again!
Superhost
Apartment in Lafayette Square
4.76 out of 5 average rating, 25 reviews

Oversized 1 Bd 1 Bath Long Stays Lafayette Square

AlexisRating, 5 stars6 months ago
The place was great! Clean and neat. Much bigger than it looks in the pics. Would definitely book again!!
Superhost
Apartment in Benton Park Historic
4.85 out of 5 average rating, 150 reviews

Relax into Contemporary Loft-Style Living on Antique Row

FrancesRating, 5 stars3 weeks ago
Impeccably clean loft-style space in a cute and walkable neighborhood. Hosts were VERY quick and helpful to respond when one issue (not their fault) came up. Would stay here again!
Guest favorite
Apartment in Richmond Heights
4.91 out of 5 average rating, 47 reviews

Cozy Duplex I Centrally Located

KodiRating, 5 starstoday
We had such an enjoyable stay! The location was great and the home was beautiful and cozy. We felt right at home. The only issue we had were the upstairs neighbors early in the morning but that was no fault of this host. We look forward to visiting again!!
Superhost
Apartment in Central West End
4.82 out of 5 average rating, 100 reviews

Vagabond King Suite- CWE w/ Fitness Center (315)

TaraRating, 5 stars3 months ago
very nice place to stay. close to many restaurants, stores, and local attractions. Just minutes away from downtown stadiums and attractions. Ikea is just around the block! Very clean and very secure getting in the parking lot and building. Very quick response from the team
Superhost
Apartment in Central West End
4.73 out of 5 average rating, 11 reviews

Cozy CWE Apartment - Free Garage Parking

DrewRating, 5 stars6 months ago
I had a fantastic stay at John’s place in St. Louis! The location was perfect—close to all the main attractions, great restaurants, and public transport. The apartment itself was clean, modern, and well-equipped with everything I needed for a comfortable stay. The bed was cozy, and the kitchen had all the essentials for making meals at home. John was very responsive and made sure I had everything I needed. I highly recommend this place to anyone visiting St. Louis, and I’ll definitely stay here again when I’m back in town!
Guest favorite
Apartment in Central West End
4.9 out of 5 average rating, 88 reviews

1 BR Loft Near Central West End, Walk to BJC

DylanRating, 5 stars2 weeks ago
Greg was awesome and responsive with his instructions to get in. Even though his instructions were clear on how to get in, I got lost and confused and he was immediately messaging me how to get in. AWESOME AND COOL PLACE

Private apartment rentals

Top guest favorite
Apartment in St. Louis
4.98 out of 5 average rating, 388 reviews

Large, Woodsy, Warm and Inviting | Cozy 2BR Apt

FeliciaRating, 5 stars1 week ago
The home was in the perfect location for our trip. I felt very safe and actually took a 3 mile walk around the neighborhood. The beds and pillows and comforters were sooooo comfortable and everything was just as pictured and described. Very clean with a well stocked kitchen . We will definitely return.
Guest favorite
Apartment in Soulard
4.95 out of 5 average rating, 57 reviews

*SAFE Soulard 1bd1bth APT / 5 mins frm Dwntwn STL*

LisaRating, 5 stars1 month ago
Logan’s place was a gem in Soulard! It was easy to find, very clean and close to a lot of local spots. I would stay here again in the future.
Guest favorite
Apartment in Pevely
4.87 out of 5 average rating, 92 reviews

Upstairs 2 bedroom Private Apt Off I- 55 in Pevely

RegeniceRating, 5 stars7 months ago
I liked the home it was great for me and my siblings and goddaughter🩷🫶🏽
Top guest favorite
Apartment in Shaw Historic District
5 out of 5 average rating, 126 reviews

Gorgeous Flat by TG Park: Favorite in Shaw!

BonnieRating, 5 stars5 days ago
We had an excellent week-long stay in this well furnished apartment situated in a beautiful neighborhood. It was super clean, has modern appliances and a well-functioning (and quiet!) AC system. But I especially liked all the little things that make a huge difference: extra towels, plenty of hangers in the large closet, lots of drawer space in the bedroom, nightstands on both sides of the bed with lamps and USB outlets, a great hairdryer with separate controls for heat and fan, a sunny laundry room with laundry supplies, a bottle of wine…I could go on and on. I will definitely book this place again.
Top guest favorite
Apartment in St. Louis
5 out of 5 average rating, 61 reviews

Modern Apartment near The Hill; Bright,Quiet,Cozy!

KarlieRating, 5 stars2 weeks ago
I stayed here as an extended stay of around 2.5 months and I would easily recommend this airbnb to anyone: Peggy went above and beyond to not only make it feel like home, but also made sure that there were no everyday needs to worry about. Extremely responsive and proactive with communication. The place was clean, cozy, with great wifi, and with laundry/cleaning supplies/cooking basics included as if it were my own home. The kitchen is a little dated, but never stopped me from doing what I needed. The location is gorgeous and near parks (and a 10 min drive for the hospital, where I worked) and I never had any issues with parking. Very safe as well! The place itself is cute and cozy and the temperature control works very well. Plenty of storage space as well. Honestly I could say many good things as they come to me, but in the end I just truly recommend this place!
Guest favorite
Apartment in Columbia
4.97 out of 5 average rating, 118 reviews

Charming Apartment in Historical Small Town by STL

HankRating, 5 stars1 month ago
Enjoyed my stay. It's on a quiet street and within walking distance to many good restaurants. The hosts answered questions quickly. Worth staying.
Guest favorite
Apartment in Grafton
4.95 out of 5 average rating, 74 reviews

River Town Dreams. one bedroom downstairs unit

PaulRating, 5 starstoday
Our second stay at this perfect property. Host is absolute perfection. We were able to relax on the front porch overlooking Main Street shops and shoppers. Even saw some friends from back home strolling across the street. New Fountain Hill restaurant was excellent, pet friendly, great view and quit reasonably priced. We will return again.
Guest favorite
Apartment in Benton Park Historic
4.81 out of 5 average rating, 16 reviews

Spacious Home Away from Home

MelissaRating, 5 stars2 weeks ago
This was exactly what my daughter was looking for! Perfect say for her 19th birthday. She loves old buildings downtown and this was perfect! Such a perfect location too!

Family-friendly apartment rentals

Guest favorite
Apartment in Arnold
4.83 out of 5 average rating, 105 reviews

Stewart Acres-Big City Close w/ Big Country Charm!

LaurenRating, 5 stars3 months ago
I really appreciated staying at Floyd's place. It was cute and comfortable. The only surprise was the layout - the second bedroom was only accessible via the first bedroom. It was very hard to find a place with a bedroom that had 2 single beds and this definitely fit the bill. But Floyd was very accommodating and responsive when we needed the heat turned up he did it right away. I would definitely stay here again.
Superhost
Apartment in Central West End
4.75 out of 5 average rating, 183 reviews

Luxury 2BD/2BH in Historic CWE/2W

LaurenRating, 5 stars2 weeks ago
Nice and clean place located an a quiet, historical neighborhood. We enjoyed walking around the area to different coffee shops in the morning and grabbing a bottle of wine from the shop just around the corner in the evening. Perfect location for exploring St. Louis!
Guest favorite
Apartment in Shaw Historic District
4.82 out of 5 average rating, 586 reviews

Great Deal in Botanical Garden Area

CoreyRating, 5 stars1 month ago
My family of 6 had a wonderful time staying at this house in Saint Louis. Standouts were: safe neighborhood, fairly quiet at night, close to parks. A few small touches were not quite right, and the interior has seen some aging, but these are not enough to lower my 5 star rating. This is a safe, functional, and budget-friendly home. Chris was very prompt in the questions I had, and he cares about his guests.
Guest favorite
Apartment in Soulard
4.93 out of 5 average rating, 801 reviews

Soulard Base Hit!

AmeeraRating, 5 stars1 week ago
Great host amazing place don’t hesitate to book you will love your stay.
Guest favorite
Apartment in St. Louis
4.95 out of 5 average rating, 411 reviews

The Grove-Near Forest Park, Downtown, Cortex, BJC

JoshRating, 5 stars1 week ago
Fun area of the city, quiet street with no thru traffic. They had snacks, soaps & shampoos, which was very friendly. Place felt extremely spacious for its size with nice high ceilings. Great tech & timely communication made our stay very easy. Can’t stress how nice of an area this little street is. Hard to find in St. Louis… this felt like a hidden gem.
Top guest favorite
Apartment in St. Louis
4.88 out of 5 average rating, 449 reviews

Dutchtown Gem LLC: 4 mi so.of Arch

CathyRating, 5 stars2 weeks ago
Diana’s place was awesome. Has character and was very quiet. Diana was very welcoming and met us at the door when we arrived. She was very friendly and made us feel at home. For the accommodation the place is very charming and quaint. Diana handed us some bread for toast and she had the refrigerator stocked with eggs, milk, orange juice, and butter. The bed was comfortable and the whole place is very clean. There was information on St. Louis and list of things to do. We found it very easy to get around with many different types of restaurants nearby. We will definitely book at the GEM again when we back in the area.
Guest favorite
Apartment in St. Louis
4.93 out of 5 average rating, 777 reviews

Spacious & Centrally Located Apt (Sleeps 8)

Mark & JulieRating, 5 stars6 days ago
We loved Joe’s place and the location was perfect. Joe and his family have thought of everything down to phone chargers:) Love it and hopefully we will be booking again soon.
Guest favorite
Apartment in Soulard
4.93 out of 5 average rating, 109 reviews

The Rustic Roost Awesome Soulard 2 bedroom

ThomasRating, 5 stars2 weeks ago
Nice location.

Quick stats about apartment rentals in Saint Charles

  • Total rentals

    30 properties

  • Nightly prices starting at

    ﺩ.ﺇ73 before taxes and fees

  • Total number of reviews

    2.7K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

Destinations to explore