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Vacation rentals in Rio Grande

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Rio Grande

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Tiny home in El Copé, La Pintada
4.96 out of 5 average rating, 26 reviews

Serena Lodge & Camping - El Copé

Escape to Serena Lodge, a cozy mountain cabin tucked among pine trees in El Copé, Panama. Wake up to birdsong, stunning valley views, and total privacy—just minutes from waterfalls (Las Yayas, Tigrero, Santa Maria, El Harino river, Rio Grande, Chorro Grande) and the Omar Torrijos National Park. Perfect for couples, families, friends, remote workers and nature lovers seeking fresh air, and a true disconnect in the mountains. 🌧️ Rainy Season (May–November) ☀️ Summer Season (December–March) por

Guest favorite
A modern house features a prominent roof and large glass walls surrounded by lush greenery. The structure is set within a hillside landscape, with plants and stones leading to the entrance. Evening light enhances the natural beauty of the surroundings.
Home in El Valle
4.92 out of 5 average rating, 65 reviews

Entre Montañas 1 - Anton Valley

Discover the ultimate retreat in Anton Valley, where breathtaking views meet modern comforts. Relax by the fire pit under starry skies, marvel at the colorful aquarium, and soak in panoramic mountain scenery. This home is designed for unforgettable moments, offering cozy spaces, outdoor lounging areas, is a perfect stay. Whether you’re here to explore or unwind, this is your ideal escape. We are a conservative family that wants their home to be a pleasant experience for other families.

Guest favorite
An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.
Tiny home in Coclé
4.94 out of 5 average rating, 139 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Beautiful cabin with two bedrooms and two bathrooms, panoramic view located about 50 minutes from Penonome, Province of Cocle, in the Omar Torrijos Herrera National Park Area, temperatures between 22 and 25 degrees Celsius on the banks of the tourist Chorro de las Yayas in the community of Barrigon del Cope, district of La Pintada. A pleasant atmosphere surrounded by fruit trees and beautiful waterfalls. Ideal for enjoying nature and relaxing. It has high-speed satellite internet.

Guest favorite
A thatched-roof ranch overlooks a swimming pool area, surrounded by vibrant flowering plants. The ranch provides shaded seating, while a hot tub is positioned next to the pool, enhancing the outdoor space's relaxation opportunities.
Villa in Rio Grande
4.94 out of 5 average rating, 84 reviews

Cheerful 3 bedroom countryside Villa with pool.

Forget your worries in this spacious and serene space. This 2 hectares villa includes an 185 square meters house, with 3 air conditioned bedrooms. In addition it includes a swimming pool and 40 square meter ranch. Bedrooms have in total 9 beds, accomodating 12 people. There are 3. 5 bathrooms, internet and hot water. Total perimeter of land is fenced, including an electric gate at the entrance. The price includes the presence of an employee who will support you during your stay.

Top guest favorite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonomé
4.98 out of 5 average rating, 136 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María
4.82 out of 5 average rating, 327 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Superhost
Home in Altos del María
4.76 out of 5 average rating, 157 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Guest favorite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guesthouse in Panamá Oeste
4.84 out of 5 average rating, 153 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Top guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 193 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite
Home in Cañaveral
5.0 out of 5 average rating, 15 reviews

Peaceful Garden Home |3BR| Fast WiFi|Near Penonomé

We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.

Superhost
A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.
Tiny home in Penonomé
4.84 out of 5 average rating, 76 reviews

Fenced and Pet-Friendly Cottage in Penonomé

Cozy private cottage, fully fenced — perfect for relaxing, remote work, or traveling with your pet. Enjoy the garden surrounded by greenery, rest in the covered hammocks, or do some birdwatching. Equipped kitchen, air conditioning, high-speed WiFi, and secure on-site parking. Just minutes from the Interamerican Highway, with easy access to cafés, shops, and more. Ideal for a peaceful getaway or productive stay.

Guest favorite
A welcoming porch area is furnished with comfortable seating and vibrant hammocks, surrounded by lush greenery and flowering plants. The structure is set against a backdrop of a clear blue sky, with sunlit grass creating an inviting outdoor space.
Home in El Valle de Antón
4.91 out of 5 average rating, 77 reviews

La Florecita - Country house in Valle de Antón

Cozy getaway in the heart of the Anton Valley Enjoy an unforgettable stay in our warm and cozy house, ideal for families and groups of friends. Located in the center of the Anton Valley, you'll be minutes away from markets, restaurants, and major natural attractions. Our house combines comfort and charm, with spacious spaces perfect for relaxing and enjoying the cool mountain climate.

Popular amenities for Rio Grande vacation rentals

  1. Airbnb
  2. Panama
  3. Coclé Province
  4. Rio Grande