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Guesthouse vacation rentals in Panama Canal

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Panama Canal

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite
Guesthouse in El Valle de Antón
4.93 out of 5 average rating, 104 reviews

The Retreat in El Valle - Garden House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favorite
A charming apartment building is nestled among lush greenery and tall trees. The exterior features a welcoming porch with railings and is surrounded by tropical plants, creating a serene environment. Natural sunlight filters through the leaves, highlighting the vibrant foliage.
Guesthouse in Gamboa
4.94 out of 5 average rating, 86 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Superhost
The bungalow is nestled among lush greenery, with tall trees and vibrant plants surrounding its entrance. A private parking space is visible in front, and the structure features a light-colored exterior with a welcoming porch. The clear blue sky adds to the serene atmosphere.
Guesthouse in Panama City
4.76 out of 5 average rating, 92 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park.  A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the  privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Guest favorite
The indoor/outdoor kitchen area features colorful wall murals and is equipped with a refrigerator, stove, and dining table with chairs. A vibrant hammock hangs in the space, inviting relaxation amid the bright décor and natural light.
Guesthouse in Near La India Dormida Tourist Trailhead, Unnamed Road Casa 30, El Valle de Antón, Coclé Province, Panama
4.92 out of 5 average rating, 84 reviews

Private 1 BR cottage near India Dormida hiking

This private fully equipped 1 bedroom casita has been a high rated Super Host Airbnb favorite for years. Relax into the hammocks in this peaceful residential setting where birds and butterflies abound. The kitchen/dining area opens to a wonderful private garden and gives you a fantastic view of India Dormida mountain and nearby hiking trail. A short (~20 minute) walk to the town with shops, restaurants and daily Farmers Market featuring fresh fruits/vegetables & local crafts

Guest favorite
A stone guesthouse with a traditional thatched roof is surrounded by lush greenery. Banana plants and palm trees are visible in the foreground, while a small outdoor seating area with chairs is featured in front of the house, providing a welcoming ambiance.
Guesthouse in Santa Rosa
5 out of 5 average rating, 10 reviews

Chagres River Lodge

You stay in our guest house on the River Chagres, in the village Santa Rosa. it is a stone house with a beautiful Panama rancho over it, so the house stays nice and cool. In our garden you have large trees with many birds such as parrots. We have a sloth in the tree. In the morning you can hear the monkeys on the other side and you can explore the area with the canoe. Or take a dip in the river to cool off. A boat to Gamboa or the Panama Canal is a 20 minute boat ride.

Top guest favorite
Guesthouse in Panamá
4.77 out of 5 average rating, 260 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Superhost
Guesthouse in Ancon
5 out of 5 average rating, 3 reviews

Ancon Garden Studio - Panama City | Fast WiFi

Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.

Guest favorite
A well-lit bedroom features a spacious bed dressed in a light quilt. Two bedside tables with lamps sit on either side. Blue decorative pillows add a pop of color against the neutral walls, while an air conditioning unit and a vibrant artwork piece enhance the atmosphere.
Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City
5 out of 5 average rating, 30 reviews

Apartment in a safe residential area

You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.

Guest favorite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Panamá
4.85 out of 5 average rating, 127 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Top guest favorite
Guesthouse in El Valle de Antón
4.92 out of 5 average rating, 53 reviews

Flor del Aire Cabin

Welcome to our Flor del Aire cabin. A private and cozy retreat, for up to 3 people. The cabin is surrounded by a large garden where you can enjoy the local biodiversity. We have a well-equipped kitchen and shower with hot water. *Private parking. *Wi-Fi-free space, an ideal opportunity to disconnect. For those who need Wi-Fi there is an excellent coffee shop just a few meters away. *We are pet friendly.

Guest favorite
Guesthouse in Rufina Alfaro
4.88 out of 5 average rating, 259 reviews

Boho Studio - Private Terrace 9 km from airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

Superhost
A modern kitchen features a long countertop adorned with a potted plant displaying vibrant flowers. Sleek cabinetry and a stainless steel refrigerator are visible in the background. A cozy sitting area includes a red sofa with checkered cushions, illuminated by natural light filtering through sheer curtains.
Guesthouse in Panama City
4.83 out of 5 average rating, 201 reviews

Entire house near Tocumen Airport

The guest house is located 3.6 km from Tocumen International Airport, located in Panama City, which is only 6 minutes by car and 14 minutes by bus. In this area you can easily access the bus service that covers all routes and the Panama metro.

Popular amenities for Panama Canal guesthouse rentals