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Vacation rentals in Murphysboro

Book unique vacation rentals, houses, and more on Airbnb

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Popular amenities for Murphysboro vacation rentals

Stay near Murphysboro's top sights

17th Street Barbecue30 locals recommend
Big Muddy Brewing13 locals recommend
Cummares8 locals recommend
Brews Brothers Taproom6 locals recommend
Cindy B's Cafe3 locals recommend
Molly's Pint Brewpub3 locals recommend

Other great vacation rentals in Murphysboro

Top guest favorite
Home in Jackson
4.94 out of 5 average rating, 177 reviews

*County Club 439*

ThomasRating, 5 stars1 week ago
This house is a favorite of my family. We chose to stay here again because of the avaible space and the area to entertain my large family. Krista is a great host and does a great job at promptly responding to any question I have. I cannot wait to use this property again.
Condo in Creal Springs
4.71 out of 5 average rating, 17 reviews

Fish~Boat~Beach~Relax @ The Blue Heron

JustineRating, 5 stars5 months ago
we stayed here to look at houses in the area. the house was awesome, beautiful views of the lake. host was very responsive and even gave us suggestions for our house hunt. very flexible on our check out time. I would highly recommend!!
Guest favorite
Home in Carterville
4.93 out of 5 average rating, 45 reviews

Experience Carterville Charm near Southern IL Univ

DeniseRating, 5 stars2 months ago
We enjoyed our stay here. The house was exactly as described and in a quiet neighborhood. The house was also very clean, from the bedrooms and living room to the kitchen, which had all of the utensils, pot and pans you'd need for cooking. We also unexpectedly needed to stay an extra night and Lori quickly responded and made it happen seamlessly for us.
Top guest favorite
Home in Benton
4.94 out of 5 average rating, 84 reviews

Backroad Breeze

NicoleRating, 5 starstoday
We loved staying here for our wedding. Andrew accommodated our wedding party since we were getting married in the area. We were amazed at how gorgeous, clean and homey the property felt. The communication with Andrew was top tier. We will be recommending this to all of our friends and might even be back for a weekend away❤️
Top guest favorite
Home in Alto Pass
4.97 out of 5 average rating, 65 reviews

Rhine Hilltop Inn

Elizabeth AnneRating, 5 starstoday
What a lovely spot!! The house was spotless and so cute. The beds were SO comfortable! And the view was great. Close to so many spots! Cheryl was always quick to respond, and so so nice. Cannot wait to stay here again!
Guest favorite
Cabin in Goreville
4.93 out of 5 average rating, 80 reviews

Secluded “Treehouse Feel” Cabin | Cozy & Private

BillieRating, 5 starstoday
I loved it, it was so peaceful! Lots of places to hike. Very cozy and clean.
Cottage in Makanda
5 out of 5 average rating, 3 reviews

West End Cottage (2 Bedroom) - Makanda Inn & Cottages

MelissaRating, 5 stars45 months ago
Loved the Makanda cabin. Perfect location to enjoy nature, hiking, and the wine trail!
Top guest favorite
Cottage in Ava
4.94 out of 5 average rating, 105 reviews

Crazy Joe's Cabin #1

DominiqueRating, 5 stars4 weeks ago
This little cabin is so nicely finished. Every bit of it was well thought out. It is cozy and it has everything you could need, including a front porch. Its location is relatively close to so many things to do in the area. There are great hikes and beautiful national forest all around the area. I think it's the perfect place for 1-2 people to stay.

Quick stats about vacation rentals in Murphysboro

  • Total rentals

    30 properties

  • Nightly prices starting at

    ﺩ.ﺇ110 before taxes and fees

  • Total number of reviews

    1.1K reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Murphysboro?

    Yes! Work meets play with ease at over 10 vacation rentals in Murphysboro featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • How much does it cost to stay in house rentals in Murphysboro?

    Experience the best of Murphysboro with our house rentals, starting at about $30 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Murphysboro?

    Four-legged friends are welcome in Murphysboro. Choose from more than 10 vacation rentals for guests traveling with pets.

  • Do house rentals in Murphysboro have wifi?

    Absolutely! We offer over 10 house rentals with wifi in Murphysboro. Enjoy a tailored experience with all the comforts you desire.

Destinations to explore

  1. Airbnb
  2. United States
  3. Illinois
  4. Jackson County
  5. Murphysboro