Vacation rentals in Jackson County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Jackson County

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Farm stay in Frohna

4.98 out of 5 average rating, 103 reviews

The Weber Farm - Enjoy a beautiful 100 acre farm!

Enjoy a 125+ year old country home with large yard and beautiful shade trees located on a 100-acre farm in the rolling hills of SE Missouri. The house is very clean and spacious with 4 large bedrooms, comfortable beds, beautiful hardwood floors and a large living room. We have hand-made quilts and antique furniture throughout. The kitchen is fully furnished. Relax on our 40’ front porch with swing, by the fire pit or in a hammock. A perfect place for you to recharge from stress & busy schedules!

May 2 – 9

ﺩ.ﺇ515 per night
Guest favorite

Home in Carbondale

5.0 out of 5 average rating, 503 reviews

Charming 3 bedroom bungalow in Downtown Carbondale

Originally built in 1920, this cute bungalow house has been totally renovated and modernized. You'll enjoy 3 furnished bedrooms, 1 bathroom, covered porch, and back with lighted pergola and firepit. The location is exceptional - just two blocks North of the Carbondale downtown "strip," and EASILY walkable to all the downtown businesses, Memorial Hospital of Carbondale (0.4 miles), restaurants, pubs, Amtrak station (0.5 miles), and SIU (about 1.2 miles). Officially Permitted Airbnb VRU 23-03

Feb 4 – 11

ﺩ.ﺇ396 per night
Guest favorite

Home in Murphysboro

4.89 out of 5 average rating, 83 reviews

Home Away From Home

Enjoy our cozy 2 bedroom home, the sofa bed lets larger families enjoy their stay too. For 6 adults it may be a bit tight but we have had 7 guests in the past. A well equipped kitchen has the laundry. Fully stocked fridge for breakfast. There’s a covered patio and carport. House is in a quiet residential area only a short drive to restaurants, antique & specialty shops. Beautiful hiking trails, lakes, orchards, SIU Campus, ShawneeWine Trail, Microbreweries & many other sights await your visit.

Jul 15 – 22

ﺩ.ﺇ359 per night

Popular amenities for Jackson County vacation rentals

Other great vacation rentals in Jackson County

Guest favorite

Home in Murphysboro

5.0 out of 5 average rating, 54 reviews

Embers of Murphysboro

Feb 18 – 25

ﺩ.ﺇ1,297 per night
Guest favorite

Home in Murphysboro

4.9 out of 5 average rating, 20 reviews

Kinkaid Getaway Lodge

Feb 1 – 8

ﺩ.ﺇ602 per night
Superhost

Home in Altenburg

4.81 out of 5 average rating, 21 reviews

Historic House in the heart of Altenburg

Jul 22 – 29

ﺩ.ﺇ377 per night
Guest favorite

Home in Ava

4.93 out of 5 average rating, 67 reviews

JGB’s Farm and Getaway

Jan 19 – 26

ﺩ.ﺇ545 per night
Superhost

Apartment in Murphysboro

4.94 out of 5 average rating, 33 reviews

The Pink Lady on Walnut, Downtown Murphysboro

Sep 22 – 29

ﺩ.ﺇ433 per night
Guest favorite

Guesthouse in Steeleville

5.0 out of 5 average rating, 12 reviews

RockCastle Retreat

Feb 8 – 15

ﺩ.ﺇ503 per night
Guest favorite

Apartment in Murphysboro

4.96 out of 5 average rating, 26 reviews

2br Private Guest Suite In Town on 4 Acre Estate

Jan 5 – 12

ﺩ.ﺇ405 per night
Guest favorite

Cabin in Carbondale

5.0 out of 5 average rating, 12 reviews

Hot Tub | Cabin in 35 Acre Forest | SIUC < 10 min.

Jan 9 – 16

ﺩ.ﺇ758 per night
Guest favorite

Home in Carbondale

4.99 out of 5 average rating, 71 reviews

Mulberry Hill Farm

Aug 24 – 31

ﺩ.ﺇ467 per night
Guest favorite

Cabin in Makanda

4.98 out of 5 average rating, 62 reviews

Sanctuary Cabin- Hot Tub & Woods

Oct 4 – 11

ﺩ.ﺇ701 per night
Guest favorite

Home in Murphysboro

5.0 out of 5 average rating, 18 reviews

Labrador Lakehouse For Your Family And Friends!

Nov 11 – 18

ﺩ.ﺇ3,223 per night
Guest favorite

Apartment in Carbondale

4.86 out of 5 average rating, 14 reviews

Regal Rustic Retreat

Nov 9 – 16

ﺩ.ﺇ234 per night

Destinations to explore