House vacation rentals in Madison County

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Top-rated house rentals in Madison County

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Top guest favorite

Home in Granite City

4.96 out of 5 average rating, 196 reviews

Cozy 2-bedroom home minutes from ST. Louis, MO

Welcome to the Sheridan House. This cozy 2-bedroom home is located in a quiet neighborhood. It sets on a corner lot with a large back yard and a parkway across the street. Spend relaxing evenings on the patio, grilling your dinner. Or challenge your partner to a game of ping pong in the basement rec room. Centrally located, you can spend your days exploring attractions in Saint Louis, Mo, Alton and Edwardsville, IL. Just minutes from World Wide Technology Raceway, Busch Stadium, & the Arch.

Top guest favorite

Home in Edwardsville

4.98 out of 5 average rating, 65 reviews

Historic Leclaire Cottage on the Park

Be part of the Leclaire National Historic District by calling this timeless, updated 1927 bungalow home for two nights, two weeks or longer! This is a neighborhood full of friends of all ages who stop to chat in the twilight. Set your phone down, relax on the porch and let Leclaire take you to a simpler time. Inside, find two separate living rooms w/smart TVs. 2 Qn BDRMS downstairs, 2 twin beds upstairs. Full kitchen&bath stocked with essentials. Complimentary EV charging at NO Nelson campus.

Top guest favorite

Home in Alton

4.99 out of 5 average rating, 145 reviews

Home Away from Home! Historic with Modern Comforts

You'll love this charming 1,750 sq ft home on 1/3 acre in a prestigious & quiet historic Alton-Godfrey neighborhood. High-end comfy beds, nice bath towels, newly painted with hardwood floors and Totally remodeled Kitchen. Central A/C & Heat, abundant natural lighting & outdoor patio living. High-speed wireless internet & local TV channels on the Big Screen HDTV. Impeccably clean & maintained for your ultimate comfort & enjoyment! (NO Parties, Gatherings or Events). PLEASE READ HOUSE RULES!

Superhost

Home in Black Jack

5 out of 5 average rating, 7 reviews

'Hidden Paradise' on 5 Acres w/ Hot Tub & Deck!

Treat yourself to a countryside getaway at this 5-bedroom, 3.5-bathroom vacation rental! This lovely Florissant home features classic architecture and a recently updated interior that will make you feel like royalty. Invite the whole family to relax poolside, or hang back and sip drinks on the wooden deck while you enjoy the beautiful surrounding landscaping. Don’t forget to leave time for a day trip into the city to take the kids to the Saint Louis Zoo and check out the famous Gateway Arch!

Guest favorite

Home in Roxana

4.91 out of 5 average rating, 152 reviews

The House Next Door

This home offers the best of both worlds. The quiet, small-town charm with the quick access to big city amenities. Located 30 short minutes away from downtown St. Louis if you are coming for a vacation. Also located on a quiet street in a small town close to local parks, library, and ice cream shops. Local Attractions SIUE- 15 minute drive World Wide Technology Raceway- 20 minute drive Downtown St. Louis- 30 minutes drive St. Louis zoo- 35 minutes drive Six Flags St. Louis- 1 hour drive

Superhost

Home in Florissant

4.9 out of 5 average rating, 39 reviews

Recently Renovated Townhome

Unique 12ft ceiling 2br 1.5 bath townhome located in Florissant. Perfect for small families, couples, and single adults. Minutes from major highways (67(Lindbergh)/270/ 170/ 70), Hospitals (Christian NE & NW, DePaul), 50 plus food selections within 6 miles, and numerous grocery stores, shopping, and hardware stores. Traveling medical professionals and out-of-town families visiting loved ones in the hospital will appreciate how close the townhome is to the facilities. Secure your dates now!

Guest favorite

Home in Edwardsville

4.96 out of 5 average rating, 115 reviews

The Kansas Street Guest House

Enjoy all that Downtown Edwardsville has to offer while staying at a local, luxury accommodation within walking distance to all the action. Less than 0.2 miles from the Courthouse, cafes, bars, breweries and restaurants! Whether you are traveling for business or pleasure, the Kansas Street Guest House can connect you to one of the most charming small towns in the Midwest. We can help you create an incredibly memorable stay, one in which you can eat, drink, and LIVE like a local.

Top guest favorite

Home in Alton

4.85 out of 5 average rating, 102 reviews

Backyard Seclusion Cottage

Private cottage 2 bedroom home. Built in 1860 Very secluded backyard with porch and patio. Located3 blocks from Great River Road ,bike and walking path and scenic views.Walking distance to downtown Alton, many restaurants, bars, bakery, shops, library. Grafton Is just up river road tourist enjoy water park, zip line, lots of places to eat n relax. Would welcome longer term stays , as …traveling nurses, or business travelers Send me an inquiry for rates n details. Thanks

Top guest favorite

Home in Godfrey

4.94 out of 5 average rating, 137 reviews

Aunt M's Place

The whole group will enjoy easy access to everything from this centrally-located home. There's plenty to see and do in the Riverbend area of Illinois. This home's proximity to the roads along the Mississippi, as well as the short drive to the Clark bridge or Amtrak station, make for easy access to everything the St. Louis area has to offer. The area is a major stopover for many migratory birds and boasts a number of sites for observing the birds during their travels.

Superhost

Home in St. Louis

4.74 out of 5 average rating, 23 reviews

Home Near STL Safari Zoo

Relax with the whole family at this peaceful place to stay. Centrally located in St. Louis county 20 mins away from the St. Louis Zoo and Science Center and just minutes away from the NEW St.Louis Safari Zoo which will be opening in 2025! Home is filled with everything you will need to enjoy your stay rather you’re visiting for business or for pleasure. Make sure to relax in the hot tub on the fully screened in patio to unwind after your day of exploring St. Louis!

Guest favorite

Home in Edwardsville

4.93 out of 5 average rating, 139 reviews

Brick B&B - 3Bed 2Full Bath! Downtown Edwardsville

Welcome to the Brick B&B! Proudly located in Downtown Edwardsville, IL. This newly renovated house is located in a quite neighborhood, only 28 min drive from Downtown St. Louis. Enjoy a short walk or a quick drive to many local coffee shops, boutiques, spas, restaurants, and bars. Other local activities include: City Park only a 3 min walk, an entrance to the Madison County Transit bike path is a quick 6 min walk, & 10 min drive to SIUe campus. Permit # 031602

Guest favorite

Home in Alton

4.94 out of 5 average rating, 77 reviews

Elm Street Escape- Easy Access to Alton & STL

Escape the daily madness and retreat to this perfectly remodeled historic home - situated in the middle of Upper Alton. A truly unique property, this fully updated 1920s colonial home stands out against its surroundings in a way that is both impressive and welcoming. While the 1 Acre oversized lot establishes some separation from the outside world, the central location with easy access to shopping,local colleges, and downtown STL is ideal.