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Vacation rentals in Los Santos Province

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Top-rated vacation rentals in Los Santos Province

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A private pool is framed by a stone patio, surrounded by lush greenery and tropical plants. A shaded area features outdoor seating and a grill, while the enclosed space provides a sense of tranquility. The home is visible in the background, set against a clear blue sky.
Home in Pedasí
4.92 out of 5 average rating, 181 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Guest favorite
A beachfront house features a thatched roof and is elevated on stilts, surrounded by lush greenery and palm trees. The structure showcases a spacious porch with wooden railings, offering a shaded area for relaxation and enjoying the natural landscape.
Home in Cambutal
5 out of 5 average rating, 16 reviews

Beachfront Gem w/ Ocean Views & Prime Surf Access

Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

Superhost
Home in Playa Venao
5 out of 5 average rating, 4 reviews

Jungle Tiny House w/ Oceanview – Playa Venao

Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Guest favorite
A shaded patio area features comfortable seating arrangements with dark wicker chairs and a matching table. An oceanfront saltwater pool is visible with loungers arranged beside it. Lush palm trees sway gently in the background against a clear blue sky.
Villa in Cambutal
4.88 out of 5 average rating, 8 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Superhost
A two-story wooden house features a rustic design with a red-tiled roof. The spacious covered porch includes several hammocks and wooden rocking chairs. Green grass surrounds the property, enhancing the natural setting. Large windows provide ample light and views of the landscape.
Cottage in Las Tablas
4.74 out of 5 average rating, 112 reviews

Enjoy the countryside at Playa El Jobo, Las Tablas

Playa El Jobo, a magical place, special to connect with nature and rest. It is facing the sea at 9 meters high, allowing you to receive the cool sea breeze. The property has a PB wooden house and a high one. In PB you find the kitchen, two full bathrooms, two outdoor showers and a roofed space to be with hammocks. Upstairs there is a large balcony with hammocks, two bedrooms, a living area and two bathrooms. There is good lighting, natural ventilation and a/c

Guest favorite
The exterior of Casa Serena showcases a spacious two-story structure with a warm, inviting facade featuring wooden accents. A wooden deck surrounds a private pool, and comfortable lounge chairs are positioned beside it. Umbrellas provide shade, while lush greenery complements the peaceful setting.
Home in Playa Los Destiladeros
5 out of 5 average rating, 12 reviews

Pedasí, Los Destiladeros Beach / Casa Serena

❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of ​​beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Guest favorite
The modern house is surrounded by lush greenery, featuring a spacious wooden deck with lounge chairs and a private pool. Sliding glass doors enhance the connection with nature, while a covered terrace provides shaded seating areas for relaxation.
Home in Playa Venao
4.9 out of 5 average rating, 59 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Guest favorite
A spacious room features vaulted ceilings and large windows offering views of the ocean and palm trees. Natural light floods the space, highlighting the inviting king-size bed, with soft linens neatly arranged. Double doors lead to a private deck, seamlessly connecting indoors and outdoors.
Tiny home in Hacia Playa, Cambutal
5 out of 5 average rating, 22 reviews

Oceanfront Luxury A-Frame Casita

Welcome to Cove, our modern little ocean front Aframe. Set in our tropical garden directly in front of the Pacific. One bedroom with king size bed ( or two twins upon request) Private tropical courtyard with outdoor rain shower and fully equipped kitchen. Private deck with direct access to the beach. Five steps to the sand and surf up front. Wake up and fall asleep to the sounds and sights of the waves kissing the shore.

Top guest favorite
The two-story house is framed by lush greenery, featuring large glass doors that open to a spacious patio. Comfortable seating areas are provided, accompanied by tropical plants. Warm outdoor lighting hangs above, enhancing the inviting ambiance, while views of the sea are visible through the glass.
Home in Cambutal
5 out of 5 average rating, 23 reviews

Beach side stay at Casa Blanca

This beautiful two bedroom, double-storey house sits in one of the best locations around, nestled amongst the trees and overlooking a stunning swimming bay in the tropical paradise of Cambutal. Perfectly situated, you will have the warm Pacific Ocean literally on your doorstep, as well as easy access to the highlights of a beach holiday - surfing, swimming, sunsets and more.

Guest favorite
A spacious sleeping area features a large bed with a white comforter, flanked by two woven pendant lights. Natural wood accents are present in the furniture, including a slatted wooden ceiling and a wall-mounted television, with large windows allowing ample natural light.
Cabin in Playa Venao
4.93 out of 5 average rating, 42 reviews

Dos Mares Venao Village - Cabin

Desconecta de tu rutina y disfruta de la naturaleza. Nuestras Cabañas son amplias, cómodas, con mucho estilo y de alta calidad. La cama king invita a descansar. Además tenemos doble lavado, televisión, ducha y baño separado y una terraza amplia. En nuestro bar puedes disfrutar de los mejores desayunos. Si deseas también te lo llevamos directo a tu cabaña - como lo deseas!

Guest favorite
The villa is nestled within a lush tropical garden, featuring a private pool with clear, inviting water. Lounge chairs are positioned beside the pool, surrounded by greenery. Large windows illuminate the house, which offers views of the serene outdoor environment.
Villa in Pedasí District
4.86 out of 5 average rating, 179 reviews

Charming beach villa Pedasi, Panama

Villa in the Destiladeros Beach Pedasi (3min walk), private garden and private pool only for the guests of the villa. Very quiet place, secure. For people who are looking for a hidden place, far from the crowd but with all the commodities around (markets in Pedasi village 10min driving, several beaches , little restaurants...). Just to enjoy nature with all the comfort.

Guest favorite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.94 out of 5 average rating, 18 reviews

Little home near to the beach -Las Tablas

10 min drive- Las Tablas Get away from it all when you stay under the stars. A room very close to the sea, with an open kitchen that will allow you to disconnect and enjoy the view and nature in Las Tablas. You can plan to visit nearby beaches or take a walk through Pedasí, 30 minutes from Las Tablas.

Popular amenities for Los Santos Province vacation rentals