Villa vacation rentals in Los Santos Province

Find and book unique villas on Airbnb

Top-rated villa rentals in Los Santos Province

Guests agree: these villas are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Superhost

Villa in Las Escobas del Venado

5 out of 5 average rating, 9 reviews

Villa Tortugas 16, Playa Venao / Beachfront Club

Enjoy a spectacular Villa, just a short 3-minute walk to the beach in the most exclusive gated community, with security guards, surveillance & parking. There are 2 bedrooms, each with a private bathroom and an extra bathroom for guests, full kitchen, living room, and a beautiful terrace to rest with friends and family. The house has a 65" Samsung Smart TV / Appe TV, 130MB Wi-Fi internet in each room, & air conditioning. Our facilities at the oceanfront clubhouse & restaurant are exquisite.

Guest favorite

Villa in Playa Venao

4.96 out of 5 average rating, 45 reviews

Villa Verde - Luxury&Cozy Villa 1BR #26 BlueVenao

Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows

Superhost

Villa in Pedasí

4.79 out of 5 average rating, 29 reviews

Drones Pedasi Ranch - Beach Pool Folk Fest Fishing

FAMILY or couples will Relax at this peaceful on the beach complete Ranch. Restaurant near by or drive (5) min to Pedasi's Town Center or Children can be kept close, a bunk-bed is near the King Size bed, with TV and Disney channel in the spacious Main room . Two other bedrooms with two Double-Bed each. All rooms with Bathroom and closet. Separate Kitchen & Dinning room with a relaxing view of the Ocean and wilderness. Ask us about tours to Isla Iguana, fishing trip or Horse back-riding.

Villa in Cambutal

5 out of 5 average rating, 4 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Villa in Las Escobas del Venado

5 out of 5 average rating, 4 reviews

Villa Atlantis - Blue Venao 3BR

Villa Atlantis is a modern beach house in the most luxarious resort in Playa Venao - 'Blue'. Only 2 minute walking distance from the beach and an exclusive beach club where you will have access to a stunning beachfront infinity pool, delicious restarunt, and a spacious relaxation area. The Blue community is a relaxed, central and secure gated community where you will always be just a few minutes walking distance from the best restaurant, surfing spots, parties and of course - the beach!

Guest favorite

Villa in PA

4.85 out of 5 average rating, 13 reviews

Casa Colibrí, Pedasí

Immerse yourself in this beautiful custom built villa, within walking distances to one of Pedasi’s best beaches. The villa has many things to offer you from a fully equipped kitchen, private pool, bbq area, along with WIFi. The villa offers a tropical retreat with an ocean view, a covered patio with chairs and table to sit while you enjoy a glass of wine and listen to the sound of the waves crashing. In the evenings sit and relax by the fire pit and listen to the water feature and ocean.

Guest favorite

Villa in Playa Venao

4.92 out of 5 average rating, 37 reviews

Villa La Piragua : 3BR Surfside Retreat : 5-7G

Welcome to Villa La Piragua, an enchanting sanctuary in Blue Playa Venao. Let yourself go in this tropical paradise with pristine beaches. This beautiful villa offers 3 comfortable bedrooms and 3 well appointed baths. Two bedrooms have dreamy queen beds, while the third features a bunk bed with a pullout and an additional twin bed. All bedrooms have smart TV's and WiFi. Enjoy a serene spacious atmosphere in the living area, kitchen, and terrace, ensuring a memorable family getaway.

Guest favorite

Villa in Playa Venao

4.91 out of 5 average rating, 22 reviews

Villa Mejor Ubicada en Blue | Con Piscina Privada

Vivienda en Playa Venao; con todo lo necesario para pasar unas excelentes vacaciones con familiares o amigos. 7 personas incluyendo bebés y niños. Se pueden adicionar personas con costo extra. La vivienda es parte de un proyecto privado con garita de seguridad y estacionamiento gratuito. Disfruta de Playa Venao, con sus magníficas olas, disfrutar de un tour a Isla Iguana, hacer yoga, comer delicioso, disfrutar de la vida nocturna y de la naturaleza... todo en este paraíso tropical.

Superhost

Villa in Cambutal

4.56 out of 5 average rating, 25 reviews

Pacific Escape

Pacific Escape looks out over an expanse of pacific ocean and protected reef. The 2 bedroom, 2 full-bath home has panoramic views of the ocean, mountains, and reef. Yet, it is close to the beach, restaurants and dining, and family-friendly activities. You’ll love the expansive oceanside porch, high ceilings, the ocean views from bedrooms and living room, and the ambiance. The villa is great for couples and families (with kids) because it sits at the top of a private gated road.

Villa in Playa Venao

4.69 out of 5 average rating, 13 reviews

Lovely Bohemian Style 3BR Villa 35 at Playa Venao

Set your clock to beach time! Welcome to Villa-35! This charming casita is located in Blue Venao on the Azuero Peninsula, a unique beachfront community and tropical paradise, with miles of amazing beaches. A quick walk and you are on to seek different adventures! Our fabulous and sun filled Villa has 3 bed/3bath, two with a comfy Queen bed, and the third w/2 twin beds. Living, Kitchen and Terrace are fully equipped for you to relax — Fully equipped for your tropical getaway.

Villa in Las Escobas del Venado

4.96 out of 5 average rating, 25 reviews

Casa Vida, Breathtaking Oceanview Villa

This modern and spacious villa is the perfect vacation home. Tall ceilings, amazing views, huge entertainment/kitchen area, beautiful garden, big pool and lots of space to spread out. Bring your group for a yoga retreat, surf camp, or family get away. Rental includes concierge service to assist in arranging activities, transportation, deliveries, services, whatever you need. Tired of cramped or crowded rentals? Casa Vida will relax and amaze you.

Villa in Pedasi

4.75 out of 5 average rating, 4 reviews

spacias villa peaceful environment

Discover our charming 2-bedroom, 2.5-bathroom villa in Pedasi, perfect for a relaxing getaway or long-term stay. Accommodating up to 4 guests, this cozy retreat is ideal for couples or families. Conveniently located just 10 minutes from Pedasi's town center, you’ll have easy access to local bakeries, restaurants, and grocery stores. Whether you're planning a vacation or an extended stay, this villa offers comfort and convenience in a serene setting.