House vacation rentals in Florence

Find and book unique houses on Airbnb

Quick stats about house rentals in Florence

  • Total vacation rentals

    Explore 80 vacation rentals in Florence

  • Nightly prices starting at

    Florence vacation rentals start at ﺩ.ﺇ 110 per night before taxes and fees

  • Verified guest reviews

    Over 2,450 verified reviews to help you choose

  • Family-friendly vacation rentals

    60 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Rentals with dedicated workspaces

    50 properties have a dedicated workspace

  • Wi-Fi availability

    80 of Florence vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Florence rentals

  • 4.9 Average rating

    Florence stays are highly rated by guests—averaging 4.9 out of 5!

Top-rated house rentals in Florence

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Superhost
The charming facade of Kuker Cottage is framed by lush greenery and trees, featuring a covered porch with colorful seating. Large windows are positioned symmetrically, and the brick columns add character to the entrance, inviting guests to relax in a tranquil outdoor space.
Home in Florence
4.86 out of 5 average rating, 617 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Top guest favorite
Home in Pawleys Island
4.94 out of 5 average rating, 186 reviews

Unique New Remodel Close to Beach and Golf

Fully remodeled, the little cabin on the marsh is a 1 BR house with a loft. Inside is almost all wood. The house sits on the marsh water of the Waccamaw river. The neighborhood is a dirt road with a mix of mobile homes and houses. The neighbors are great and have lived on the street for decades. The house is surrounded by live oaks, nature and tidal marsh water in the backyard. Litchfield and Pawleys Island beaches are 5 minutes away. World class golf, restaurants, and grocery stores are near.

Guest favorite
A charming single-story brick home is shown with a welcoming entrance featuring a circular window and black door. The front yard is landscaped with grass and bushes, while large trees provide shade in the background. A concrete pathway leads to the front steps.
Home in Sumter
4.89 out of 5 average rating, 237 reviews

Bungalow on Bobs

This charming 3 bedroom, 2 bathroom brick home features an updated kitchen with granite countertops and stainless steel appliances. The great backyard space is fully-fenced, with a large deck, charcoal grill, and fire pit. The spacious master bedroom has a private bathroom and a large walk-in closet. The master bedroom and living room both have Smart TVs. Log in to your own streaming accounts, or enjoy the complimentary Hulu account. The split floor plan allows for easy separation of guests.

Top guest favorite
A single-story home is shown with a welcoming front porch and bright red door. The exterior is accented by black shutters and a white facade, surrounded by a grassy lawn with small trees. A clear blue sky with soft clouds is visible in the background.
Home in Hartsville
4.98 out of 5 average rating, 182 reviews

Manchester Place

Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Top guest favorite
The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.
Home in Georgetown
4.98 out of 5 average rating, 184 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Superhost
A bright living area features a light-colored sectional sofa arranged around a circular coffee table. Natural light enters through the windows, enhancing the warm ambiance. A simple desk with a chair is positioned nearby, complementing the overall spaciousness of the room.
Home in Florence
4.92 out of 5 average rating, 116 reviews

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

Top guest favorite
A spacious living area features an oversized orange sectional sofa, complemented by a wooden coffee table. A modern kitchen is visible in the background, equipped with stainless steel appliances and white cabinetry. Natural light filters through sheer curtains, creating an inviting atmosphere.
Home in Sumter
4.99 out of 5 average rating, 122 reviews

3 bd, 2ba, near ShawAFB, Game Rm

Welcome to our newly renovated 3 Bed, 2 Bath, home in Sumter. Our modern decor home has the following: - Master bdrm with King bed/ ensuite bath - Queen beds other rooms - Full equipped kitchen, coffee station - 65", 55", 43" TVs in rooms - Game Room, w/ pool table, table tennis, arcade games - Work area, wifi, 32" monitor, printer, adj height desk - Private backyard, BBQ grill ,gazebo, fire table, games. - Centrally located near Shaw AFB, Tuomey Hospital, food, parks and more

Guest favorite
The exterior of the home features a welcoming porch area with two chairs and a small table. Green hanging plants adorn the front windows, and a softly colored door adds to the charm of the white siding. The grassy lawn complements the overall inviting appearance.
Home in Conway
4.95 out of 5 average rating, 109 reviews

Boho-chic whole house Downtown Conway

This adorable boho-chic home is ready to host you and your family! You will be walking distance to downtown Conway where you can enjoy amazing restaurants, shops, the Theatre of the Republic and the River Walk! Only 17 miles to Myrtle Beach and 5 miles to Coastal Carolina University. You will have access to the whole home including an open living area with a queen sofa bed, fully stocked kitchen, three bedrooms, two full baths and a laundry room. We cannot wait to have you!

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 129 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Top guest favorite
A bright living area features a cozy seating arrangement with two plush armchairs and a sectional sofa. A modern coffee table sits in the center, while a large wall-mounted television is positioned above an elegant fireplace. Natural light filters through large windows adorned with light curtains.
Home in Rembert
4.98 out of 5 average rating, 278 reviews

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Built in March 2022 single story home is full of amenities. High speed internet 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/ desk/ and futon (can sleep 1 person). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Top guest favorite
A comfortable living area features a dark gray sofa complemented by two accent pillows. A coffee table is positioned in front of the seating, and two standing lamps provide soft lighting. A simple wall art above the sofa adds a touch of elegance to the space.
Home in Florence
4.99 out of 5 average rating, 138 reviews

Renovated 2 BR/2 B Townhouse Cozy & Clean

Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

Guest favorite
A spacious living room features a gray sofa adorned with blue and neutral accent pillows. A round tufted ottoman sits at the center, surrounded by natural light streaming through two large windows, flanked by light curtains. Two lamps provide soft illumination on side tables.
Home in Florence
4.93 out of 5 average rating, 104 reviews

Historic Charm near Downtown | Clean and Quiet

Experience southern hospitality in this historic charmer perfect for professionals. •Quaint, quiet downtown neighborhood walkable to restaurants •Fast wifi, laundry room, large fenced backyard w/ fire pit, off-street parking •Fully loaded kitchen, 2 Roku TV's, queen sleeper sofa, relaxing front porch •3 min to FMU Performing Arts Center, 5 min to McLeod Hospital, 10 min to FMU & MUSC Medical Center. • Perfect for short or long stays!

Popular amenities for Florence house rentals

When is the best time to visit Florence?

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