
House vacation rentals in Florence
Find and book unique houses on Airbnb
Top-rated house rentals in Florence
Guests agree: these houses are highly rated for location, cleanliness, and more.

Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Renovated 2 BR/2 B Townhouse Cozy & Clean
Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

magical 1840s farm house getaway
Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Unique New Remodel Close to Beach and Golf
Fully remodeled, the little cabin on the marsh is a 1 BR house with a loft. Inside is almost all wood. The house sits on the marsh water of the Waccamaw river. The neighborhood is a dirt road with a mix of mobile homes and houses. The neighbors are great and have lived on the street for decades. The house is surrounded by live oaks, nature and tidal marsh water in the backyard. Litchfield and Pawleys Island beaches are 5 minutes away. World class golf, restaurants, and grocery stores are near.

Manchester Place
Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Pear Tree Farm-pets welcome! Stables/paddocks too!
Relax with the family at this peaceful place with GORGEOUS sunsets. When we say family, we mean pets & horses as well! We have 12 stables, 7 paddocks. Fenced yard & in ground pool. 5 fireplaces & heart pine floors. 3 living/family rooms. Once owned by the DuPont family (yes that DuPont family), the main part of the home is 96 yrs old and has many charming details. The 4 car garage was also the site of building race cars for the DuPonts. Pear Tree Farm offers the best in country quaintness.

Black River Refuge on the Water
The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Charming Home in Florence, SC
Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

The Parkside Retreat
Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

3 bd, 2ba, near ShawAFB, Game Rm
Welcome to our newly renovated 3 Bed, 2 Bath, home in Sumter. Our modern decor home has the following: - Master bdrm with King bed/ ensuite bath - Queen beds other rooms - Full equipped kitchen, coffee station - 65", 55", 43" TVs in rooms - Game Room, w/ pool table, table tennis, arcade games - Work area, wifi, 32" monitor, printer, adj height desk - Private backyard, BBQ grill ,gazebo, fire table, games. - Centrally located near Shaw AFB, Tuomey Hospital, food, parks and more

New Home! Only 15 min to Shaw/Sumter. Dog friendly
Built in March 2022 single story home is full of amenities. High speed internet Upgraded cable 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/printer, desk/ and futon (can sleep 1 person). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Historic Charm near Downtown | Clean and Quiet
Experience southern hospitality in this historic charmer perfect for professionals. •Quaint, quiet downtown neighborhood walkable to restaurants •Fast wifi, laundry room, large fenced backyard w/ fire pit, off-street parking •Fully loaded kitchen, 2 Roku TV's, queen sleeper sofa, relaxing front porch •3 min to FMU Performing Arts Center, 5 min to McLeod Hospital, 10 min to FMU & MUSC Medical Center. • Perfect for short or long stays!
Popular amenities for Florence house rentals
House rentals with a pool

Sunset Serenity Pool/Swim Spa

Wyboo Retreat at Lake Marion W/Pool

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Southern Comfort

Beach Resort Vibes|Pools|Golf Cart|Splash Pad

Luxury Villa in Caribbean-Style Beach Resort

Berkeley - Private In-Ground Pool, Beach Pass Incl

Pawleys - Prvt Pool Hot Tub Fenced Dogs OK 5 BR
Weekly house rentals

Collins Quarters

Farm Cottage in Laurinburg

Private Country Escape

Charming home in Florence, South Carolina

Completely remodeled 3 bedroom upgraded home

Go With the Flo

Florence 3Br Ranch

* NEW * Cozy and Clean 3B/2Bath
Private house rentals

Quiet country stay; close to I95

Spacious 3 bd Home with Office, GameRoom & Balcony

Crystal Place Near MUSC and Mcleod Hospital

The Happy Sac 2

Spacious, Historic Home for 12 - Near Myrtle Beach

Farmhouse

Cozy 3 Bedroom Home! Located NEAR MUSC-Florence

Huddle House Farm
When is the best time to visit Florence?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | ﺩ.ﺇ422 | ﺩ.ﺇ404 | ﺩ.ﺇ422 | ﺩ.ﺇ422 | ﺩ.ﺇ452 | ﺩ.ﺇ422 | ﺩ.ﺇ422 | ﺩ.ﺇ404 | ﺩ.ﺇ422 | ﺩ.ﺇ404 | ﺩ.ﺇ408 | ﺩ.ﺇ422 |
| Avg. temp | 9°C | 11°C | 14°C | 18°C | 22°C | 25°C | 27°C | 26°C | 24°C | 19°C | 14°C | 11°C |
Quick stats about house rentals in Florence

Total vacation rentals
Explore 80 vacation rentals in Florence

Nightly prices starting at
Florence vacation rentals start at ﺩ.ﺇ110 per night before taxes and fees

Verified guest reviews
Over 2,450 verified reviews to help you choose

Family-friendly vacation rentals
60 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 30 rentals that welcome pets

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wi-Fi availability
80 of Florence vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Florence rentals

4.9 Average rating
Florence stays are highly rated by guests—averaging 4.9 out of 5!
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