Vacation rentals in Downtown San Diego

Home in Bankers Hill - Park West

A charming Spanish bungalow is framed by vibrant greenery and colorful flowers. A small staircase leads to the main entrance, which features a decorative security screen door. The exterior showcases white stucco walls, accentuated by terracotta details and surrounded by lush tropical plants.

Admire Harbor Views from the Porch at a City Gem

Unwind in a cozy colorful casita in this light-filled 1920s Spanish bungalow decorated with Mexican folklorico. Take a walk into Little Italy for dinner. Or to a show at the Old Globe.What’s best, is how close you are to so much, all without needing a car. A very small single car garage is provided, think compact car. Street parking is free but challenging at times. The house is located directly below the incoming flight path. You are encouraged to read the reviews regarding this.Ideal for four.

4.96 out of 5 average rating, 511 reviews

Superhost

A spacious living area features large windows allowing ample natural light. A 85-inch 4K TV is mounted on the wall above a sleek entertainment unit. Comfortable seating includes a plush gray sofa and decorative pillows, with a coffee table at the center of the room.

Home in Downtown San Diego

NEW Luxury 3BR HOUSEof DT Walk Petco w/Garage AC

Located in the heart of Downtown San Diego, this unique house has been completely remodeled and re-imagined to make your stay unforgettable. Designed with the eye toward comfort and entertainment. 7 min walk Petco Park/14 min walk to Convention Center/6 min to Zoo/9 min Airport/12 min to SeaWorld/9 min to Coronado *Stunning bathrooms w/ dual showers, tub, smart glass *Full Kitchen, AC Central *SONOS Sound System, 4K TVs every room *Walk to coffee, yoga & gyms, dining, entertainment, shopping!

4.91 out of 5 average rating, 211 reviews

4.96 out of 5 average rating, 27 reviews

Top Floor Views of Ocean, Bay, City & Petco Park

Experience San Diego from a stunning 32-story penthouse directly across the street from Petco Park, with the Convention Center just steps away. Enjoy floor-to-ceiling views of the ballpark, bay, ocean, and downtown skyline, plus easy walking access to the Gaslamp Quarter, Seaport Village, and the waterfront. With rooftop lounges, resort-style pools, a fitness center, and exceptional amenities, this is the perfect home base for a weekend getaway, business trip, Padres game, or special occasion.

A spacious living area is furnished with a floral-patterned love seat and two armchairs. Custom-built shelves house a collection of books, while a coffee table sits on a patterned rug. Bright yellow walls enhance the natural light streaming through the shuttered windows.

4.96 out of 5 average rating, 381 reviews

Trendy Studio, Natural Light - Heart of Downtown

Large studio with comfortable queen sized Murphy Bed, a love seat, private entrance and private bath. Located in Cortez Hill - walk to the nicest neighborhoods in downtown like Little Italy, Gaslamp, East Village, and the Embarcadero. There is no full kitchen, but there is a small refrigerator, small microwave, and a pot for heating water. This is an ideal space for solo travelers, couples, events at the Convention Center, Padres Games, great eateries, and the best of Downtown San Diego.

Home in Downtown San Diego

Modern Surf Themed Home - Heart of Gaslamp

Step into a modern surf-themed retreat in the vibrant heart of San Diego's Gaslamp Quarter. Perfectly blending laid-back coastal vibes with sleek, urban style, this one-of-a-kind home is designed to be your getaway oasis in the middle of all the action. 7 actual beds no air mattresses or sofa-beds. This is the only 4-bedroom 4-bath for rent in all downtown San Diego. It is close to Convention Center, Petco Park, and Nightlife. This is not a party house. Person booking home must be over 25.

4.97 out of 5 average rating, 157 reviews

Apartment in Little Italy

An expansive outdoor patio is showcased, featuring a comfortable sectional sofa with soft cushions and a stylish coffee table. Bi-folding doors connect to a modern kitchen area adorned with sleek cabinetry. The distant view reveals the San Diego coastline under a clear blue sky.

Calm Luxury Penthouse Getaway With Panoramic Views

Welcome to the most relaxing and luxurious penthouse condo in Little Italy! Featuring 2 expansive balconies with sweeping views, my condo sleeps 4-6 comfortably and is situated right in the heart of San Diego's most desirable neighborhood, Little Italy. Enjoy an area that is rich in exquisite cuisine, boutiques, patio cafés, exciting bars and local breweries. Area amenities nearby feature the famous San Diego Zoo, beautiful Balboa Park, Waterfront Park, the Convention Center and much more!

4.94 out of 5 average rating, 254 reviews

4.89 out of 5 average rating, 108 reviews

Artifact Inn - Historic Deluxe Studio in Downtown

The Artifact Inn professionally managed by NOVIQ. Unwind with ease in this chic Gaslamp studio offering a queen bed, air mattress, Smart TV, and free WiFi. Cook meals in the full kitchen, refresh with in-unit laundry, and enjoy climate control with central AC. With thoughtful touches and professional cleaning, this stylish retreat provides both comfort and security. Perfectly situated near Petco Park and top attractions, it’s ideal for those seeking a central and vibrant San Diego escape.

4.93 out of 5 average rating, 408 reviews

An exterior view of a bungalow showcases a unique architectural style with smooth, rounded walls. Soft lighting highlights the inviting entrance, surrounded by potted plants. The paved pathway leads to a wooden fence, adding to the property's privacy, all under a clear evening sky.

Bungalow in Little Italy

Gorgeous 2Bd Corner Bungalow in Little Italy

Little Italy Bungalows are located in the heart of San Diego’s most popular restaurant and entertainment district, Little Italy. Just one block from India Street, Farmer’s Market, and minutes from downtown, Balboa Park, airport, and harbor & beaches. This is a delightful neighborhood, steeped in local history and culture, and popular for dining and exploring. Little Italy Bungalows is perfect for couples, families, business travelers, convention-goers, single travelers and adventurers.

Guesthouse in Mission Hills

A spacious living area features a large sectional sofa adorned with decorative pillows, complemented by a wooden coffee table. A vibrant wall art piece with colorful surfboards is displayed above the couch, while natural light fills the room through expansive windows.

Beautiful Historic Home and Gardens Near Downtown!

Location, Location, Location...Welcome to Union Street Gardens. We are dedicated to providing a peaceful, serene atmosphere in which our guests can relax after a long day of exploring beautiful, sunny San Diego. This unique historic craftsman bungalow is just minutes from downtown, Balboa Park, the Zoo, beaches, and includes a Chef's kitchen, outdoor deck, gardens, fire pit and spa! Perfect for a family of 4 or two couples. Sorry no parties or large groups and no external guests please.

4.97 out of 5 average rating, 299 reviews

4.9 out of 5 average rating, 761 reviews

A spacious living area is characterized by high ceilings with exposed beams and large windows allowing natural light. A comfortable gray sofa, adorned with colorful cushions, is paired with a bright yellow accent chair. A modern coffee table and entertainment unit complete the inviting space.

Home in Little Italy

#1 LOCATION - Rare Luxury Home in Downtown

***THE BEST RATED RENTAL IN DOWNTOWN SAN DIEGO*** Location doesn't get better than this! Right in the heart of the lively Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. Just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & Zoo! All the frills: + Prime location! 98/100 Walker Score rating + Private parking + Private Sundeck & Backyard Stay at this modern luxury home for your next trip!

Loft in Downtown San Diego

Downtown San Diego Loft | Best Walkable Location

Stay steps from Petco Park in a thoughtfully designed two-story loft in the heart of downtown San Diego. Designed by award-winning architect Jonathan Segal, this modern space features high ceilings, a calm open layout, and a private balcony with city views. Enjoy a queen bed upstairs and a sofa bed in the living room, plus a full kitchen, washer/dryer, and easy self check-in. A more spacious, private, and relaxed alternative to typical downtown hotel stays.

4.94 out of 5 average rating, 515 reviews

4.94 out of 5 average rating, 535 reviews

A spacious lounge area features a modern green sofa and two stylish chairs arranged around a low coffee table. Large windows allow natural light to fill the space, complemented by an earthy area rug. The industrial-style decor highlights the room's character.

Loft in Little Italy

Room D at The Dutra Inn - Little Italy

“This is the room that all the locals book. I couldn’t figure out why, so one day I decided to ask a guest. ‘I’ve walked past here a million times, and I just had to see what was behind these doors,’ he replied, as if it were obvious.” Our 20 ft., 100-year-old naval train station doors do seem like have a story to tell. Salvaged and repurposed here in our only street-level loft, they bring in the light and life of downtown San Diego. IG: @the.dutra

Popular amenities for Downtown San Diego vacation rentals

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Air conditioning

Other great vacation rentals in Downtown San Diego

4.97 out of 5 average rating, 99 reviews

A green sofa is positioned against a wall adorned with an eclectic gallery of framed artworks, including abstract designs, floral patterns, and clock. Textures vary with a plush, white throw pillow placed at the center, providing a cozy accent against the diverse art pieces.

Condo in Little Italy

Little Italy King Suite

Home in Downtown San Diego

Walk to Gaslamp & Petco • Rooftop Spa & Game Room

4.98 out of 5 average rating, 45 reviews

4.96 out of 5 average rating, 70 reviews

Home in Little Italy

4BR/5BD - Free Parking - Walk to Nightlife!

4.95 out of 5 average rating, 60 reviews

Stunning Views & 1 min to Petco Park 1BD Apartment

Superhost

Home in Golden Hill

5BD, 3BA Modern Luxury Home w/yard in center of SD

4.96 out of 5 average rating, 23 reviews

Superhost

An open living area is displayed with a cozy sofa featuring yellow accent pillows, paired with a wooden coffee table. Modern artwork adorns the wall. A kitchen with stainless steel appliances is visible in the background, along with dining seating arranged near large windows.

Condo in Downtown San Diego

Contemporary & Chic Downtown 2Story Condo- 1bd/2ba

4.93 out of 5 average rating, 40 reviews

Condo in Downtown San Diego

An inviting living area is characterized by ultra-high ceilings and industrial concrete walls. A plush sofa is arranged around a black circular coffee table, while a large Smart TV is mounted on the wall. Elegant pendant lights hang from above, and a wall clock is prominently displayed.

Hip Industrial Loft in San Diego

4.89 out of 5 average rating, 47 reviews