
House vacation rentals in Downtown San Diego
Find and book unique houses on Airbnb
Top-rated house rentals in Downtown San Diego
Guests agree: these houses are highly rated for location, cleanliness, and more.

Walk to Balboa Park and Hillcrest from an Immaculate Home
Take a stroll through the park, then unwind with a leisurely dinner under the festoon lights. Classic crown molding, hardwood floors, and pared-back tones of gray and taupe create an air of calm at this elegant haven spread out over 1500 square feet. You will find the space charming & spacious with over 1500 sq. feet. This single level property is the lower level of a historic duplex. Hardwood floors, crown molding, gas fireplace and laundry room. Street parking is usually readily available. This A+ location of Banker's Hill is NOT impacted by air plane noise. Enjoy the entire lower level duplex and use of the back yard with patio set for dining. Please note the upper tenant may also want to use this space so this area could be shared. We would love to greet you but are also fine with allowing you to access with a code on the front door. We live nearby and are happy to make suggestions for dining or things to do. Located near numerous restaurants, and Balboa Park, Hillcrest, the zoo, Downtown, Little Italy, and the Convention Center are all within 10 minutes. Be at the beach in less than 15 minutes. The bus line runs up First Ave for easy access to Downtown and Uptown. Near trolley and train station. We are within 10 minutes to the San Diego International Airport and a quick Uber ride to Downtown, Little Italy. Walk to the heart of Hillcrest, Balboa Park and the Zoo. Be at the beach in less then 15 minutes. Central location near the I-5, I-163 & I-8. Because of the hardwood floors, you will hear the footsteps above. The kitchen is well stocked if your a cook and we have an area where you can set up your laptop. wireless available and 3 smart TV's for your enjoyment. Small market less than 1 block away.

Admire Harbor Views from the Porch at a City Gem
Unwind in a cozy colorful casita in this light-filled 1920s Spanish bungalow decorated with Mexican folklorico. Take a walk into Little Italy for dinner. Or to a show at the Old Globe.What’s best, is how close you are to so much, all without needing a car. A very small single car garage is provided, think compact car. Street parking is free but challenging at times. The house is located directly below the incoming flight path. You are encouraged to read the reviews regarding this.Ideal for four.

Brunch House 3bd/2 Amazing Baths. Private yard.
Centrally located farmhouse with gated yard in vibrant urban neighborhood with Latin roots. Quick Uber to many SD tourist attractions: Chicano Park- 1.2 mi Balboa Park- 1.8 Gaslamp- 1.9 Petco Park Stadium- 1.9 Convention Center- 1.9 Seaport Village- 1.9 San Diego Zoo- 2.5 Little Italy- 3.8 Coronado Island- 3.9 Airport- 4.2 Old Town- 5.6 Ocean Beach- 7.9 Seaworld- 8.3 Mission Beach - 8.9 Pacific Beach- 9.9 La Jolla Beach- 13.8 Cabrillo National Park- 10.7 Close and convenient to EVERYTHING.

NEW Luxury 3BR HOUSE❤️of DT Walk Petco w/Garage AC
Located in the heart of Downtown San Diego, this unique house has been completely remodeled and re-imagined to make your stay unforgettable. Designed with the eye toward comfort and entertainment. 7 min walk Petco Park/14 min walk to Convention Center/6 min to Zoo/9 min Airport/12 min to SeaWorld/9 min to Coronado *Stunning bathrooms w/ dual showers, tub, smart glass *Full Kitchen, AC Central *SONOS Sound System, 4K TVs every room *Walk to coffee, yoga & gyms, dining, entertainment, shopping!

EpicViews | 3-Stories with Rooftop | Cortez Hill
📍 Unbeatable Central Location! Welcome to Casa Cortez Hill! This charming 3-story home features 3 bedrooms, 2 baths, and a private 4th-story rooftop deck with firepit. At 1,510 sq ft, it comfortably sleeps up to 8 guests. Centrally located—walk to Little Italy, Gaslamp, and Petco Park. Just few miles from the airport and minutes to the beach. Enjoy San Diego’s best dining, nightlife, and coastal vibes. Casa Cortez Hill is your home base for all things San Diego. We can't wait to host you!

Historic Golden Hill Post Office - 3 BR w fire pit
There isn't a more unique experience than staying at an old Post Office! The 3 br 2 bath unit was renovated in 2021 with high-end finishes, designer furniture & 2 WFH workspaces. The interior is flooded with natural light from skylights throughout with access to a large private patio with BBQ, fire pit, and dining table. Ideally located within the trendiest neighborhood in San Diego. Walk to an abundance of cafes, restaurants, bars, shops, & parks. Check it out at postofficelofts . com

#1 LOCATION - Rare Luxury Home in Downtown
***THE BEST RATED RENTAL IN DOWNTOWN SAN DIEGO*** Location doesn't get better than this! Right in the heart of the lively Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. Just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & Zoo! All the frills: + Prime location! 98/100 Walker Score rating + Private parking + Private Sundeck & Backyard Stay at this modern luxury home for your next trip!

Modern House In The Hills | Killer Location!
Enjoy a stylish experience at this centrally-located, spacious 2 bedroom top floor retreat in lower Mission Hills, just 2 minutes north of Little Italy. Perched in one of the most prestigious & historic neighborhoods in San Diego. Be close to downtown, only 10 minutes to Mission Beach and centrally located for all the city has to offer. This is the perfect launching point to exploring San Diego, and coming home to this beautifully appointed home in this location is second to none.

Little Italy 2BR Loft Near Waterfront & Convention
Discover the heart of San Diego from our spacious loft in Little Italy, the culinary gem of downtown. Perfectly situated for both business and leisure travelers, you're steps away from the waterfront, convention center, and vibrant city life. Embrace the urban experience with convenience at your doorstep, including eclectic bars and restaurants. We provide a white noise machine and earplugs, though the lower floor offers a quieter retreat. Experience the best of city living!

Downtown View - 2 Story House Next to Little Italy
Two story house with 2 living rooms; 3 blocks to Little Italy restaurants, bars, & shops. Near Balboa Park, San Diego Zoo, Gaslamp, Waterfront Park & the Harbor. Museums, restaurants, theaters & nature are all nearby. Located in historic Bankers Hill, next to Interstate 5, near the airport and city center. With 2 living rooms, my house is perfect for travelers needing separate space. One parking spot is available. Extra large vehicles will have to park on the street.

🌟BEST LOCATION🌟 4BR/2BA - WALK to Little Italy 🇮🇹
Updated craftsman style home in THE BEST location! This beautiful house is close to almost everything San Diego has to offer. Only about a mile or two away from Balboa Park, the Zoo, Old Town, The Gaslamp Quarter, The Embarcadero, Hillcrest and just minutes from the airport. WALK to Little Italy in 10 minutes! Beautiful huge backyard with plenty of room to entertain. GREAT for families, or larger groups!! Sleeps 8 comfortably!

Grand Victorian Manor • Luxury Downtown Stay
Welcome to The Jade Manor, a 126 year old Victorian reborn as a dreamy San Diego escape. Set inside a gated, Parisian inspired tropical oasis, this home blends historic charm with modern luxury. Sun soaked spaces, elegant details, and celebration ready vibes make it perfect for bachelorette weekends, birthdays, and unforgettable group stays, while still feeling refined, private, and welcoming for all travelers.
Popular amenities for Downtown San Diego house rentals
House rentals with a pool

Modern Central SD Home w/ Pool & Spa Near Beach

Casa De Colores

Lionhead - Private Boutique Home

Bright and spacious home with views, pool & spa.

Heated Pool + Hot Tub | Games | 10 min to Beach

Designer Luxury Rental With Pool

1 bedroom, 1 bath /Hillcrest/San Diego Zoo/Balboa

Oasis with ocean views/Pool/Hot tub! Sleeps 10!
Weekly house rentals

Beautiful Quiet 2 bedroom Vacation House With A/C

Peaceful Jungle Retreat In The Heart of San Diego

Elegant 2 bedroom + loft in Hillcrest.

Sunset View home 2 min walk to beach parking

Convention Center | Petco Park | Free Parking

New Luxury 3BR/3.5BA Point Loma Coastal One Story

The California

NEW❤️Special Deals/HotTub/Firepit/private yard/BBQ
Private house rentals

Designer unit w/FirePit- Petco Park, Zoo, Downtown

Stylish Suite Near Downtown & Convention Center

1stResorts.com WATERVIEW FAMILY VILLA HOT TUB YARD

Walk to Balboa Park and Little Italy for Dinner!

Panoramic Bay Views | Private Deck Bankers Hill

Coastal Chic Retreat in Bankers Hill

Walk to Little Italy Sleeps 8, Backyard + Parking

Little Italy Studio: Private Patio Cozy Getaway
When is the best time to visit Downtown San Diego?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | ﺩ.ﺇ 738 | ﺩ.ﺇ 790 | ﺩ.ﺇ 859 | ﺩ.ﺇ 753 | ﺩ.ﺇ 830 | ﺩ.ﺇ 881 | ﺩ.ﺇ 1,025 | ﺩ.ﺇ 889 | ﺩ.ﺇ 804 | ﺩ.ﺇ 790 | ﺩ.ﺇ 786 | ﺩ.ﺇ 870 |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in Downtown San Diego

Total vacation rentals
Explore 140 vacation rentals in Downtown San Diego

Nightly prices starting at
Downtown San Diego vacation rentals start at ﺩ.ﺇ 220 per night before taxes and fees

Verified guest reviews
Over 14,210 verified reviews to help you choose

Family-friendly vacation rentals
100 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 50 rentals that welcome pets

Rentals with dedicated workspaces
80 properties have a dedicated workspace

Wi-Fi availability
140 of Downtown San Diego vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Downtown San Diego rentals

4.8 Average rating
Downtown San Diego stays are highly rated by guests—averaging 4.8 out of 5!
Destinations to explore
- Rentals with a hot tub Downtown San Diego
- Fitness-friendly rentals Downtown San Diego
- Townhouse rentals Downtown San Diego
- Serviced apartment rentals Downtown San Diego
- Rentals with a fire pit Downtown San Diego
- Rentals with breakfast Downtown San Diego
- Rentals with an EV charger Downtown San Diego
- Hotel rooms Downtown San Diego
- Rentals with outdoor seating Downtown San Diego
- Rentals with a sauna Downtown San Diego
- Condo rentals Downtown San Diego
- Family-friendly rentals Downtown San Diego
- Pet-friendly rentals Downtown San Diego
- Waterfront rentals Downtown San Diego
- Smoking-friendly rentals Downtown San Diego
- Rentals with beach access Downtown San Diego
- Rentals with a home theater Downtown San Diego
- Apartment rentals Downtown San Diego
- Loft rentals Downtown San Diego
- Rentals with pools Downtown San Diego
- Hostel rentals Downtown San Diego
- Resort rentals Downtown San Diego
- Rentals with a washer and dryer Downtown San Diego
- Boutique hotels Downtown San Diego
- Rentals with a patio Downtown San Diego
- Rentals with a fireplace Downtown San Diego
- House rentals San Diego
- House rentals San Diego County
- House rentals California
- House rentals United States
- Rosarito Beach
- San Diego Convention Center E Ent
- SeaWorld San Diego
- Petco Park
- University of California-San Diego
- Oceanside City Beach
- San Diego Zoo Safari Park
- Ocean Front Walk
- Pacific Beach
- San Diego Zoo
- Coronado Beach
- Torrey Pines State Beach
- Tijuana Beach
- Balboa Park
- San Diego State University
- LEGOLAND California
- Mission Beach
- La Misión Beach
- Moonlight State Beach
- Liberty Station
- Oceanside Harbor
- Sesame Place San Diego
- Belmont Park
- Black's Beach





