House vacation rentals in Downtown San Diego

Find and book unique houses on Airbnb

Top-rated house rentals in Downtown San Diego

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern kitchen features sleek wooden cabinets and white countertops, with a central island that provides additional seating. Stainless steel appliances are present, and a wall of glass allows natural light to fill the space. Cookware hangs elegantly above the island.
Home in Hillcrest
4.95 out of 5 average rating, 356 reviews

Walk to Balboa Park and Hillcrest from an Immaculate Home

Take a stroll through the park, then unwind with a leisurely dinner under the festoon lights. Classic crown molding, hardwood floors, and pared-back tones of gray and taupe create an air of calm at this elegant haven spread out over 1500 square feet. You will find the space charming & spacious with over 1500 sq. feet. This single level property is the lower level of a historic duplex. Hardwood floors, crown molding, gas fireplace and laundry room. Street parking is usually readily available. This A+ location of Banker's Hill is NOT impacted by air plane noise. Enjoy the entire lower level duplex and use of the back yard with patio set for dining. Please note the upper tenant may also want to use this space so this area could be shared. We would love to greet you but are also fine with allowing you to access with a code on the front door. We live nearby and are happy to make suggestions for dining or things to do. Located near numerous restaurants, and Balboa Park, Hillcrest, the zoo, Downtown, Little Italy, and the Convention Center are all within 10 minutes. Be at the beach in less than 15 minutes. The bus line runs up First Ave for easy access to Downtown and Uptown. Near trolley and train station. We are within 10 minutes to the San Diego International Airport and a quick Uber ride to Downtown, Little Italy. Walk to the heart of Hillcrest, Balboa Park and the Zoo. Be at the beach in less then 15 minutes. Central location near the I-5, I-163 & I-8. Because of the hardwood floors, you will hear the footsteps above. The kitchen is well stocked if your a cook and we have an area where you can set up your laptop. wireless available and 3 smart TV's for your enjoyment. Small market less than 1 block away.

Top guest favorite
A charming Spanish bungalow is framed by vibrant greenery and colorful flowers. A small staircase leads to the main entrance, which features a decorative security screen door. The exterior showcases white stucco walls, accentuated by terracotta details and surrounded by lush tropical plants.
Home in Bankers Hill - Park West
4.96 out of 5 average rating, 496 reviews

Admire Harbor Views from the Porch at a City Gem

Unwind in a cozy colorful casita in this light-filled 1920s Spanish bungalow decorated with Mexican folklorico. Take a walk into Little Italy for dinner. Or to a show at the Old Globe.What’s best, is how close you are to so much, all without needing a car. A very small single car garage is provided, think compact car. Street parking is free but challenging at times. The house is located directly below the incoming flight path. You are encouraged to read the reviews regarding this.Ideal for four.

Superhost
An outdoor seating area is furnished with comfortable wicker sofas and a coffee table. A large shade canopy protects the space, while colorful flowers and plants enhance the surroundings. A barbecue grill is positioned nearby, facilitating outdoor cooking.
Home in San Diego
4.84 out of 5 average rating, 396 reviews

Spacious 2bd/1bath House Near Downtown

Recently renovated 2bd/1bath house with outdoor area. Close to downtown, Gaslamp Quarter, 32nd Street Navy Base, and the convention center! The house shares the property with another house. The living room has a smart TV with HBO, Netflix, Hulu, and YouTube TV (w/Redzone). Nicely landscaped front yard and patio with lounge furniture, outdoor grill, and one gated off street parking spot. Have a group larger than 6? Book both houses on the property! https://www.airbnb.com/rooms/962337467912227108

Guest favorite
An inviting outdoor space is featured, illuminated by string lights against a night sky. Comfortable seating areas are present, including a large daybed with a canopy and hammocks. Lush trees provide a natural backdrop, enhancing the relaxing atmosphere of the yard.
Home in San Diego
4.91 out of 5 average rating, 257 reviews

Brunch House 3bd/2 Amazing Baths. Private yard.

Centrally located farmhouse with gated yard in vibrant urban neighborhood with Latin roots. Quick Uber to many SD tourist attractions: Chicano Park- 1.2 mi Balboa Park- 1.8 Gaslamp- 1.9 Petco Park Stadium- 1.9 Convention Center- 1.9 Seaport Village- 1.9 San Diego Zoo- 2.5 Little Italy- 3.8 Coronado Island- 3.9 Airport- 4.2 Old Town- 5.6 Ocean Beach- 7.9 Seaworld- 8.3 Mission Beach - 8.9 Pacific Beach- 9.9 La Jolla Beach- 13.8 Cabrillo National Park- 10.7 Close and convenient to EVERYTHING.

Guest favorite
A spacious living area features large windows allowing ample natural light. A 85-inch 4K TV is mounted on the wall above a sleek entertainment unit. Comfortable seating includes a plush gray sofa and decorative pillows, with a coffee table at the center of the room.
Home in Downtown San Diego
4.92 out of 5 average rating, 201 reviews

NEW Luxury 3BR HOUSE❤️of DT Walk Petco w/Garage AC

Located in the heart of Downtown San Diego, this unique house has been completely remodeled and re-imagined to make your stay unforgettable. Designed with the eye toward comfort and entertainment. 7 min walk Petco Park/14 min walk to Convention Center/6 min to Zoo/9 min Airport/12 min to SeaWorld/9 min to Coronado *Stunning bathrooms w/ dual showers, tub, smart glass *Full Kitchen, AC Central *SONOS Sound System, 4K TVs every room *Walk to coffee, yoga & gyms, dining, entertainment, shopping!

Top guest favorite
The exterior of the three-story home is showcased, featuring a warm-colored facade with red doors and decorative balconies. A spacious rooftop deck offers seating and striking views of the surrounding San Diego skyline. The interior layout reveals an open floor plan with comfortable furnishings and natural light.
Home in Downtown San Diego
4.99 out of 5 average rating, 134 reviews

EpicViews | 3-Stories with Rooftop | Cortez Hill

📍 Unbeatable Central Location! Welcome to Casa Cortez Hill! This charming 3-story home features 3 bedrooms, 2 baths, and a private 4th-story rooftop deck with firepit. At 1,510 sq ft, it comfortably sleeps up to 8 guests. Centrally located—walk to Little Italy, Gaslamp, and Petco Park. Just few miles from the airport and minutes to the beach. Enjoy San Diego’s best dining, nightlife, and coastal vibes. Casa Cortez Hill is your home base for all things San Diego. We can't wait to host you!

Top guest favorite
A spacious living area is characterized by high ceilings with exposed beams and large windows allowing natural light. A comfortable gray sofa, adorned with colorful cushions, is paired with a bright yellow accent chair. A modern coffee table and entertainment unit complete the inviting space.
Home in Little Italy
4.9 out of 5 average rating, 748 reviews

#1 LOCATION - Rare Luxury Home in Downtown

***THE BEST RATED RENTAL IN DOWNTOWN SAN DIEGO*** Location doesn't get better than this! Right in the heart of the lively Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. Just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & Zoo! All the frills: + Prime location! 98/100 Walker Score rating + Private parking + Private Sundeck & Backyard Stay at this modern luxury home for your next trip!

Superhost
Home in Barrio Logan
4.92 out of 5 average rating, 184 reviews

Convention Center | Petco Park | Free Parking

Amazing Vibe | Create Memories with this Gem in Barrio Logan next to Downtown, Coronado & the Beaches of SD. Sleeps 6 comfortably with 3 bedrooms. Full Kitchen, 2 Baths, TV, WorkSpace, Board Games, Laundry, & Grill + seating area. Uber drive to the nightlife downtown gaslamp, Petco Park, Convention Center, Airport, Zoo, Trendy Restaurants & less than 10 mins to the Beaches. Loc is close to Everything! Unsuitable for children 2-12 Unsuitable for infants No baby gear at the property

Superhost
The living room showcases a spacious sectional couch with a chaise, paired with a sleek armchair. Natural light is welcomed through large windows, highlighting the warm hardwood flooring. Decorative elements include a coffee table and a soft rug, enhancing the inviting ambiance.
Home in Mission Hills
4.86 out of 5 average rating, 356 reviews

Modern House In The Hills | Killer Location!

Enjoy a stylish experience at this centrally-located, spacious 2 bedroom top floor retreat in lower Mission Hills, just 2 minutes north of Little Italy. Perched in one of the most prestigious & historic neighborhoods in San Diego. Be close to downtown, only 10 minutes to Mission Beach and centrally located for all the city has to offer. This is the perfect launching point to exploring San Diego, and coming home to this beautifully appointed home in this location is second to none.

Guest favorite
A bright living area features large floor-to-ceiling windows allowing ample natural light. A light wood coffee table is situated in front of a comfortable sofa adorned with decorative pillows. A large television stands on a modern console, with a potted plant adding a touch of greenery.
Home in Little Italy
4.84 out of 5 average rating, 218 reviews

Little Italy 2BR Loft Near Waterfront & Convention

Discover the heart of San Diego from our spacious loft in Little Italy, the culinary gem of downtown. Perfectly situated for both business and leisure travelers, you're steps away from the waterfront, convention center, and vibrant city life. Embrace the urban experience with convenience at your doorstep, including eclectic bars and restaurants. We provide a white noise machine and earplugs, though the lower floor offers a quieter retreat. Experience the best of city living!

Superhost
Home in Bankers Hill - Park West
4.84 out of 5 average rating, 411 reviews

San Diego House: City Views, BBQ & Free Parking!

Experience the best of San Diego living in our conveniently located Victorian home in the prestigious Banker’s Hill neighborhood. 🏡 The home boasts breathtaking views of the San Diego Bay and downtown skyline 🌊✨ from its private balconies, classic charm with original moldings, high ceilings, and hardwood floors, plus modern amenities like a fully equipped kitchen and dining area. 🍴 The location couldn’t be more perfect — steps to Balboa Park, Little Italy, and Downtown!

Guest favorite
The entrance features a charming arched porch with a tiled roof and elegant railings. Two outdoor sconces flank the front door, which is framed by well-maintained landscaping with palm plants. Sunlight casts gentle shadows across the steps leading up to the door.
Home in South Park
4.88 out of 5 average rating, 155 reviews

South Park Spanish Stunner Renovated & Central

Charming Spanish, newly renovated home and close to everything! Come stay in this brand new place with space for the whole gang! Arched windows and vaulted ceilings make it a beautiful light and bright space. Chef's kitchen ready for you to make big family meals. Great outdoor space to sit back and relax and enjoy the perfect SoCal weather. Central location to get anywhere within minutes while still being in a fun walkable neighborhood!

Popular amenities for Downtown San Diego house rentals

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Avg. priceﺩ.ﺇ 738ﺩ.ﺇ 790ﺩ.ﺇ 859ﺩ.ﺇ 753ﺩ.ﺇ 830ﺩ.ﺇ 881ﺩ.ﺇ 1,025ﺩ.ﺇ 889ﺩ.ﺇ 804ﺩ.ﺇ 790ﺩ.ﺇ 786ﺩ.ﺇ 870
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Quick stats about house rentals in Downtown San Diego

  • Total vacation rentals

    Explore 140 vacation rentals in Downtown San Diego

  • Nightly prices starting at

    Downtown San Diego vacation rentals start at ﺩ.ﺇ 220 per night before taxes and fees

  • Verified guest reviews

    Over 14,210 verified reviews to help you choose

  • Family-friendly vacation rentals

    100 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 50 rentals that welcome pets

  • Rentals with dedicated workspaces

    80 properties have a dedicated workspace

  • Wi-Fi availability

    140 of Downtown San Diego vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Downtown San Diego rentals

  • 4.8 Average rating

    Downtown San Diego stays are highly rated by guests—averaging 4.8 out of 5!

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