Family-friendly vacation rentals in Downtown San Diego

Find and book unique family-friendly homes on Airbnb

Top-rated family-friendly rentals in Downtown San Diego

Guests agree: these family-friendly homes are highly rated for location, cleanliness, and more.

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Superhost

A welcoming living area features a comfortable black sofa adorned with decorative pillows, complemented by a wooden coffee table and a potted plant. A cozy tan chair sits nearby, while a wooden ladder leads to the loft above. A door reveals an ensuite bathroom in the background.

Guest suite in Golden Hill

4.9 out of 5 average rating, 317 reviews

Studio + Loft! Near Gaslamp, Balboa & Starbucks!

Come enjoy San Diego in this bright and private studio w/ a loft and private entrance. Located in Golden Hill and walkable to several coffee shops, restaurants, bars, etc. Just one mile from downtown, San Diego Zoo, the charming neighborhood of South Park (also full of unique local spots), Balboa Park & more. The room is under 300 square feet plus a loft, kitchenette and has a private patio. It shares a wall to the main house but provides complete privacy as you come and go. It’s a true gem!

Top guest favorite

A welcoming porch is framed by lush greenery, creating a tranquil entrance. The area features a white railing that provides a sense of openness, while bright sunlight filters through, illuminating a spacious seating arrangement and a table set for relaxation and enjoyment.

Guest suite in Oak Park

4.99 out of 5 average rating, 485 reviews

Super clean & private studio retreat.

We call our place Casita Pacifica (Peaceful Little House) as this suite is a mellow and relaxing retreat, yet in a San Diego suburb only 10-20 minutes from everything. Sadly, we no longer host peacocks, but our space is decorated in memory of their majestic energy. Our standards are high when we travel, so we created a suite that we'd love to stay in ourselves: stocked with goodies, things to do, recommendations, privacy, comfort & above all - cleanliness. WE FOLLOW CDC CLEANING GUIDELINES.

Top guest favorite

A private garden is illuminated at night, featuring various seating areas surrounded by lush greenery and colorful plants. Lanterns provide soft light, casting a warm glow on the outdoor space. A patterned rug and dark wooden furniture complete the serene atmosphere, inviting relaxation.

Guesthouse in Sherman Heights

4.96 out of 5 average rating, 533 reviews

Romantic Private Garden Studio Near Downtown

A magical private garden surrounds a tiny studio (240 sq ft) with kitchenette in historic residential district, 10 blocks to East Village and Petco BallPark, near Gaslamp Quarter, and one mile to Convention Center and downtown. Easy access to freeways, very close to Balboa Park, San Diego Zoo, and Coronado Island. Airport and train station less than 15 min. We offer a safe, sweet, and contemplative getaway near the city, with WiFi but no TV. One pet OK only with prior approval. 420 friendly.

Superhost

The living room features a spacious sectional sofa with orange and gray accent pillows. A modern coffee table sits in the center, complemented by a sleek television on a wooden stand. Natural light filters through large windows draped with sheer curtains, enhancing the airy atmosphere.

Townhouse in Little Italy

4.82 out of 5 average rating, 757 reviews

BEST LOCATION in all of Little Italy & downtown!

Location, location, location! Can't get any closer to the bustling Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. One of the only houses in all of downtown! This modern luxury home is just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & San Diego Zoo! All the frills: ++ Prime location! 98/100 Walker Score rating ++ High-speed internet, Netflix & smart TV ++ A/C ++ Super Host 5-star service

Top guest favorite

The exterior of the suite features a two-story blue structure with large windows and a modern garage door. A small deck with planters is visible on the right, enhancing the outdoor space. The clear sky above complements the welcoming atmosphere.

Loft in South Park

4.95 out of 5 average rating, 292 reviews

A 'Suite' Garage Loft in the Heart of South Park

If you're looking for a 'small-time neighborhood feel' in the midst of a diverse and dynamic city, this is it! Our 'Suite Garage' is located in the eclectic, walkable, and historic neighborhood of South Park, just east of Balboa Park, and 3 miles from downtown San Diego. You're surrounded by a wide variety of local restaurants and shops in our little 'hood' and we aren't far from North Park, Hillcrest, Coronado, the beaches, Mission Bay, the San Diego Zoo, Sea World and other popular spots.

Guest favorite

A spacious living area features a large, brown sofa adorned with colorful cushions and a patterned throw. A retro leather armchair is placed beside a low coffee table. Natural light pours in through large windows, illuminating a decorative area rug with intricate designs.

Loft in Little Italy

4.95 out of 5 average rating, 685 reviews

Room A at The Dutra Inn - Little Italy

“There’s a strange and wonderful energy on top of The Dutra. I imagine the ghosts of pirates past making their way up from San Diego Bay, and cosmic cowboys riding in from the Tijuana night. Room A is a meeting place. It’s actually where we first met. When you look up from the street below, you can see the rows of whiskey bottles.* You might even spot Pappy Van Winkle himself winking down at you. But from Room A, you can see so much more—rooftops, skyrises, and ships.

Guest favorite

A cozy kitchen and dining area features wooden cabinetry and dark counter surfaces. A round wooden table is accompanied by four chairs, set with placemats. Natural light enters through a window, highlighting a hanging light fixture with a stained glass design.

Apartment in Little Italy

4.86 out of 5 average rating, 386 reviews

Entire 2bd - Most Convenient Location of San Diego

Professionally cleaned apartment located in Beautiful Bankers Hill - prestigious neighborhood up the hill from Little Italy, perfectly situated in the epicenter of San Diego! Our spacious 2br/1ba is within such short reach of Little Italy, Balboa Park, Downtown, Waterfront Park, Harbor, Airport, etc! Your private apartment comes equipped with high end appliances, finishes, and breath taking views of the city skyline and San Diego Harbor surrounding the property.

Top guest favorite

The exterior of the guest house features two large glass doors framed by greenery, providing a view of the lush, well-maintained lawn. The surrounding area includes a patio space with seating, enhancing the outdoor appeal. Bright sunlight illuminates the scene.

Guesthouse in Kensington

4.96 out of 5 average rating, 286 reviews

Your Kensington Bungalow

Large Guest House in historic Kensington. Our neighborhood is lined with palm trees giving you a true Southern California vibe. Your Guest House is just a 5 minute walk to our town center. Just off the freeway, 20 minutes door to door to the airport, 10 downtown, 15 to Gaslamp and convention center. Uber is perfect for this location, no need to rent a car. 25MPH keeps the cars slow and the walkability high! Off Street Parking...

Top guest favorite

A sunset is captured over the ocean, with shades of orange, pink, and yellow in the sky. Silhouettes of palm trees frame the scene, while the distant pier is visible along the coastline. The tranquil atmosphere reflects a peaceful end to the day.

Guest suite in Ocean Beach

4.94 out of 5 average rating, 707 reviews

Place to Stay with Private Entrance near Beach

The room has a private entrance. It's ideally located in a residential area of Ocean Beach. 5 blocks to the beach, OB pier, and 2 blocks to village life, shops & restaurants. It has a queen bed, a small private bathroom with a shower, a fridge, TV, Wifi, microwave, etc. Guests will love the location and privacy! Beach chairs, towels, umbrellas, etc. are available for your enjoyment. Enjoy the great ocean view from the backyard.

Guest favorite

A serene outdoor wellness space features a wooden privacy fence surrounding a relaxing jacuzzi. Lush greenery and potted plants add a natural touch. The pathway is lined with rectangular stones leading to the jacuzzi, inviting a peaceful ambiance.

Guesthouse in Golden Hill

4.9 out of 5 average rating, 861 reviews

Casita–Hot Tub/Sauna/eBikes/Cold Plunge+Beach Gear

See more of our space and vibe by searching “The Birds & The Trees Vacations” online. California dreaming in our vintage citrus-themed casita! This sweet little guest suite has everything you need: full kitchen, cozy bed, and thoughtful extras. Relax in the outdoor wellness oasis (infrared sauna, jacuzzi, fire pit), and take advantage of access to electric scooters and our new fully stocked Ultimate Beach Kit for Summer 2025!

Top guest favorite

A well-appointed sitting area features patterned seating and decorative tables set on a vibrant area rug. A door opens to an outdoor patio with a small dining table and chairs, allowing for seamless indoor-outdoor access. Walls are adorned with various framed artwork.

Guesthouse in Hillcrest

4.98 out of 5 average rating, 166 reviews

Hidden Casita with Private Deck & Patio

Charming Hidden Gem Studio in the Heart of Hillcrest Discover this hidden gem – a cozy, French-inspired studio casita with elegant furnishings and a private, furnished patio. Enjoy a fully equipped kitchen, a spacious open living and sleeping area, and an attached deck overlooking the tranquil canyon. Perfect for a peaceful retreat just steps from the vibrant Hillcrest scene.

Top guest favorite

A spacious bedroom features a king bed with neutral bedding and decorative pillows. French doors provide natural light and open to a balcony overlooking lush greenery. A modern ceiling fan and soft lighting complement the hardwood floor and simple decor, creating a comfortable and inviting space.

Guesthouse in Greater North Park

4.97 out of 5 average rating, 186 reviews

New Guest House - North Park

One bedroom detached guest house with central air in one of the most desirable locations in North Park / South Park. Extremely walkable and safe location near numerous restaurants, breweries and cafes. Family friendly, we provide a pack n' play and highchair upon request. NO SMOKING OR VAPING ON PROPERTY