
Hotel vacation rentals in Downtown
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Top-rated hotel rentals in Downtown
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Downtown hotel rentals
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Downtown San Diego Stay Near Gaslamp Quarter

Stylish South Bay Home

2 Pet-friendly Rooms—Minutes to Mission Bay Beach

Perched right on the sand in Pacific Beach

Cozy Twin Room w/ Ensuite Bath, Desk & A/C in SD

Pet-friendly Hotel with Free Breakfast and Pool!

Stay Near Top Attractions | Balcony & Pet-Friendly
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

1-Bedroom Hotel Suite - 1 bed

Iconic Resort in San Diego

Soothing neutrals & killer coastline location

Playful escape near games & concerts at Petco Park

Comic-Con 2026 in San Diego @ Marriott Pulse Suite

Idyllic beachside escape with outdoor pool

1 bedroom Suite in downtown San Diego.
Hotel rentals with a patio

Coronado Beach Resort

Modern King Room | Luxe Stay in Little Italy

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm

2 bd/2 bth Resort Style Hotel

Nice Property, stay right in SD!
Quick stats about hotel rentals in Downtown
Total rentals
290 properties
Nightly prices starting at
ﺩ.ﺇ73 before taxes and fees
Total number of reviews
4.6K reviews
Family-friendly rentals
90 properties are a good fit for families
Pet-friendly rentals
150 properties allow pets
Rentals with a pool
120 properties have a pool
Destinations to explore
- Fitness-friendly rentals Downtown San Diego
- Townhouse rentals Downtown San Diego
- Smoking-friendly rentals Downtown San Diego
- Rentals with a fire pit Downtown San Diego
- Serviced apartment rentals Downtown San Diego
- Boutique hotel rentals Downtown San Diego
- Rentals with a sauna Downtown San Diego
- Rentals with outdoor seating Downtown San Diego
- Family-friendly rentals Downtown San Diego
- Waterfront rentals Downtown San Diego
- Rentals with beach access Downtown San Diego
- Rentals with pools Downtown San Diego
- Rentals with a beach view Downtown San Diego
- Rentals with a washer and dryer Downtown San Diego
- Rentals with a patio Downtown San Diego
- Rentals with a fireplace Downtown San Diego
- Apartment rentals Downtown San Diego
- Loft rentals Downtown San Diego
- Rentals with a home theater Downtown San Diego
- House rentals Downtown San Diego
- Rentals with a hot tub Downtown San Diego
- Condo rentals Downtown San Diego
- Rentals with breakfast Downtown San Diego
- Rentals with an EV charger Downtown San Diego
- Hostel rentals Downtown San Diego
- Pet-friendly rentals Downtown San Diego
- Hotel rentals San Diego
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- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Tijuana Beach
- Pacific Beach
- SeaWorld San Diego
- University of California San Diego
- LEGOLAND California
- Coronado Beach
- San Diego Zoo Safari Park
- Balboa Park
- La Misión Beach
- Oceanside Harbor
- Coronado Shores Beach
- Belmont Park
- Liberty Station
- Black's Beach
- Moonlight Beach
- Sesame Place San Diego
- Law Street Beach
- Torrey Pines Golf Course
- Mission Beach
- Santa Monica Beach
- USS Midway Museum