Vacation rentals in De Soto

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Top-rated vacation rentals in De Soto

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Guest favorite

Home in Bloomsdale

4.9 out of 5 average rating, 193 reviews

Hop off the highway, Relax!

Relax with the whole family at this peaceful place to stay. We are located only 4 miles off of highway 55! There are two bedrooms and two COMFY couches if you have more than 4 staying the night! This is located on a secluded road with two other homes occupied nearby by with quite, but very friendly, residents. This home is 25 minutes away from the historical town of Ste Genevieve, take a look! The host is will be able to assist you almost immediately, whether it be over the app or in person!

Guest favorite

The bathroom features a simple layout with a white sink and wooden cabinetry. A wooden toilet seat complements the rustic charm. Soft towels sit neatly on a lace-covered shelf, while a shower curtain partially conceals the bathtub. Warm lighting enhances the welcoming atmosphere.

Cabin in Bourbon

4.92 out of 5 average rating, 439 reviews

Log Cabin at Meramec Farm

A warm, pine honeymoon cabin surrounded by pastoral Ozark countryside. The Meramec River flows through this seventh generation family farm. Cozy interior includes a kitchenette, dining area, and double bed on main level. All your cooking intensils are provided with coffee, tea, and paper products. DVDs and books available await you up the spiral staircase in the loft. Full bed on main level and two singles bed upstairs. Expansive view from your front porch of the highest bluffs on the Meramec.

Guest favorite

Two baby goats rest comfortably together on a bed of straw. Their fur is a mixture of light brown and white, with one goat displaying distinct white markings on its face. The background consists of wooden barn walls, creating a rustic atmosphere.

Cabin in Bonne Terre

4.86 out of 5 average rating, 104 reviews

Hand Built Log Cabin

This cabin was completed in 1940 by previous owner's grandmother with only the help of her horses. The wood was cut from the property. Originally it had no electric or plumbing, we updated it more in 2021 keeping as much original as possible. Rustic cabin has 2 bedrooms, 1 bathroom with walk-in shower only, washer and dryer, full eat in kitchen and living room. On site you can relax watching horses, mini horses, goats, chickens & ducks as well as wild life. You can feed and pet the 🐐 goats.

Top guest favorite

A newly remodeled house is surrounded by a lush green landscape, featuring vibrant flowers in bloom. The structure has a sloped roof and a welcoming porch, blending harmoniously with the natural environment. Tall trees provide a serene backdrop, enhancing the peaceful setting.

Home in Cadet

4.99 out of 5 average rating, 153 reviews

2BR House with Hot Tub near Washington State Park!

This newly remodeled 2 bedroom house is an ideal choice for guests looking to explore the beauty of Bonne Terre, attend weddings and local events, or visit Fyre Lake Winery, which is only a mile away. You'll find two comfortable bedrooms - one with a king-size bed and the other with a full-size bed - providing a peaceful retreat after a day of adventure. Additionally, Bonne Terre Mines are conveniently located just 16 minutes away, making it a perfect spot to stay while exploring the area.

Top guest favorite

Farm stay in Bloomsdale

4.95 out of 5 average rating, 149 reviews

FUNKS INN-no extra guest fees or cleaning fee

This house was built in 1870, it is a stone structure and was used as a family farm home. It has been remodeled for its use today. It is historically correct, which includes antiques of the time. Post Civil War era, furniture including the beds of this period. Another interesting aspect, is that the floors are all original. Mattresses, blankets pillows, bedding and towels are all new. The wine cellar that we have added, made on location. I always leave some out for guests. No fee.

Guest favorite

A framed stained glass window is showcased on a feature wall, illustrating intricate patterns in hues of amber, red, and blue. The warm wooden frame complements the rustic design, while dark cabinetry is positioned nearby, contributing to the overall charm of the interior.

Home in Dittmer

4.96 out of 5 average rating, 497 reviews

Honeymoon Suite at Camp Skullbone In The Woods

Experience a romantic, quiet, and cozy chalet designed for two! This charming retreat features vintage décor and all the modern amenities you need for a comfortable stay. Unwind indoors by kicking back and watching a movie, surfing the web, curling up with a good book or a friendly board game, or sharing a drink with that special someone. In the evening, relax on the cozy deck under the stars, basking in the warm glow of the gas fire pit or unwinding in the inviting private hot tub!

Superhost

A window view showcases a peaceful landscape filled with trees and open fields. Sunlight gently illuminates the scene, with soft curtains framing the window. A wooden shelf is positioned below the glass, adding a natural touch to the interior.

Farm stay in Hillsboro

4.92 out of 5 average rating, 176 reviews

Shagbark Hickory Cottage (Hot tub & Sauna)

Take it easy at this unique and tranquil getaway. Enjoy a detox in our handcrafted sauna, or take a soak in the hot tub under the stars! Full kitchen, bathR w/claw foot, & screened in porch. It’s very private, with land to explore. Take a stroll to the pond or creek where you will see a little piece of history, or possibly enjoy a visit from our sweet cows. Close to La Chance winery, Desoto town, Big River access points, valley view glades, & Washington state park.

Guest favorite

The secluded treehouse is elevated among trees, featuring a wooden exterior with a pitched roof. A set of stairs leading to the entrance is visible. Surrounding foliage creates a natural and serene environment, while sunlight filters through the leaves.

Treehouse in Dittmer

4.81 out of 5 average rating, 139 reviews

The Den at Dittmer Hollow

Newly Updated** Enjoy the lovely setting of this romantic spot in nature, with a semi-primitive, modern cozy secluded treehouse in the woods! Explore 10 acres or wind down on the deck before relaxing in the *NEW* hot tub. The cabin inside has a very minimalistic design featuring on the first floor an electric fireplace, air conditioner, table, refrigerator, leather futon couch, kitchenette with a hand crank water pump sink, axe throwing and porta-potty bathroom.

Guest favorite

Tiny home in Pacific

4.9 out of 5 average rating, 628 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- toys, books, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Top guest favorite

A charming rock cottage is nestled among tall trees, surrounded by lush green grass. The structure features a stone chimney and a red roof, with a covered porch framed by greenery. Sunlight creates a dappled pattern on the ground, enhancing the serene outdoor setting.

Cottage in De Soto

4.97 out of 5 average rating, 118 reviews

Rock House Retreat

Unplug and enjoy a slower pace of life at this picturesque rock cottage. The 1920’s former hunting lodge was built from stone sourced from the property, and is as charming as ever. Enjoy an early morning stroll on one of the many hiking trails, or just relax on the porch while sipping coffee. There are many great hiking opportunities within a short drive, however, once you get settled in you may not find a reason to leave.

Top guest favorite

Home in Bonne Terre

4.96 out of 5 average rating, 449 reviews

The Silo

Beautiful farm Silo with original exterior TOTALLY NEW boho, industrial, farmhouse, luxury, chic interior design style! Perfect for ANYONE!! The Silo is located on 5 private acres with a double decker deck overlooking the water! This house makes the ultimate escape! SO many close off property activities as well!

Guest favorite

A mounted black bear is positioned on a wooden ledge, showcasing natural decor elements like logs and birch branches. The high ceiling is complemented by wooden beams, and soft lighting enhances the inviting environment.

Home in Ste. Genevieve

4.97 out of 5 average rating, 115 reviews

The Jonca Creek House

Located on the Jonca Creek in the center of Ste. Genevieve County and only one mile from Hawn State Park, the Jonca Creek House offers a beautiful sanctuary filled with all the comforts of home. The home is wheelchair accessible and handicap friendly. While staying you will have access to the double car garage.

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Top guest favorite

Guesthouse in Farmington

5 out of 5 average rating, 64 reviews

The Dove's Nest established July 2023

TrilbyRating, 5 stars1 week ago

What a wonder charming stay! Kevin and Melissa’s communication was outstanding, from booking to the moment we departed. Their recommendations for all activities was amazing . All the well thought out touches for home was an added bonus. Loved every minute of this stay!!

Superhost

A cozy bedroom features light gray walls and a spacious bed covered with a white quilt. A sliding glass door provides access to the serene backyard, while a black shelf holds decorative items. A closet and laundry basket are visible, maximizing functionality.

Townhouse in Barnhart

4.84 out of 5 average rating, 74 reviews

Cozy town house - fenced backyard - Barnhart

MayaRating, 5 stars1 week ago

It was a cute 3br place that was more than sufficient for our needs. The owners put a lot of thought into decor. We only stayed one night, but it was fine.

Guest favorite

The exterior of the tiny home is highlighted by a stone façade and a modern roof. A wooden deck features two classic Adirondack chairs, positioned against large glass doors that provide natural light and views of the surrounding grassy area.

Tiny home in Bloomsdale

4.92 out of 5 average rating, 155 reviews

Coeur de la Crème Suite at Baetje Farms

TaylorRating, 5 stars1 day ago

Had an amazing stay! The Airbnb was pristine and the property is quiet and peaceful. Had a great time feeding the goats and hiked nearby at Pickle Springs. Would definitely stay again!

Top guest favorite

Cottage in Farmington

4.97 out of 5 average rating, 58 reviews

Parsons Cottage

SamanthaRating, 5 stars1 week ago

We had an amazing stay at the cottage. It was beautiful and had everything we could need for our family of six. The games were a hit for our kids and we enjoyed waffles in the morning! Would definitely love to come back!

Guest favorite

A rustic dining area features a large wooden table surrounded by six high-backed chairs. Exposed wooden beams and log walls create a cozy ambiance. A chandelier with six bulbs hangs above the table, providing ample light. A rocking chair is positioned in the corner, enhancing the inviting space.

Cabin in Festus

4.98 out of 5 average rating, 65 reviews

Relaxing Log Cabin Getaway on 20 Acres

TaylorRating, 5 stars1 month ago

We thoroughly enjoyed our stay. We celebrated our Mother’s Day here over the weekend. My mom, her husband, my husband, our daughter, Ava, and our small dog Jax. The kitchen had everything you could need. All of the bedrooms, bathrooms, and rec room were spotless. The surroundings of the house are simply beautiful. It is a short drive to the Little town of Kimswick, where they usually have many festivals, and Grant Farm, which we both enjoyed. it was a wonderful first Mother’s Day. we can’t thank Leslie enough for providing such a wonderful place to stay! The walking trails, play ground and fire pit are also a huge plus.

Top guest favorite

The exterior of the historic rock home features a welcoming entryway framed by vibrant flower beds. Colorful blooms, including roses and other flowering plants, accent the stone facade and a circular decorative piece adds visual interest near the path leading to the front door.

Home in Festus

5 out of 5 average rating, 49 reviews

Stonehaven Ranch LLC

ErinRating, 5 stars3 weeks ago

Our stay was nothing short of amazing! The bed sheets were super soft, and the host had every thing you could possibly think of. The kitchen was extremely stocked, and there were plenty of toiletries to choose from. We loved watching the chickens in the yard through the window, and the host's dog was super sweet. We will be telling all of our friends and family about this hidden gem, and we can't wait to come back!

Guest favorite

A bathroom is featured, containing a walk-in shower with a glass door, a toilet positioned beside it, and a wooden vanity with a sink. Natural light filters through a window, illuminating light-colored wall coverings and a tiled floor.

Home in Potosi

4.95 out of 5 average rating, 41 reviews

Hi-Meadow - R&R

ChaCasyRating, 5 stars1 week ago

A extremely beautiful place! The drive was a little bumpy due to the 40 minutes of back roads but I was definitely recommend this stay for anyone looking in the potosi area! Our original airbnb cancelled 12 hours before check in and we found this place and it was a place out of a dream definitely a lot better than the original booking we had!

Top guest favorite

A modern treehouse structure features large windows, allowing for ample natural light. A spiral staircase connects the elevated deck to the ground, where a gravel path is visible. The outdoor seating area is furnished with black chairs, creating a relaxed environment surrounded by greenery.

Treehouse in Perryville

4.99 out of 5 average rating, 83 reviews

TreeRise at BaseCamp - Hot tub + Outdoor Shower

ColleenRating, 5 stars1 month ago

I have absolutely nothing but great things to say about this place & Kaci & Waylon as hosts. We were meant to check in during severe weather and they were super communicative throughout the process. They watched the radar, made sure the storms had passed, and let us know when we could enter the treehouse safely. I could not have been more grateful for the communication, they even offered a late check out due to delays in checking in because of the weather. Which they definitely didn’t have to do. The place was beautiful and we absolutely loved everything about it. We were only there one night and while it was perfect, we are already planning a longer trip!! It’s so peaceful and they really do have everything you need there for a relaxing and disconnected stay.

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Vacation rentals in De Soto

Top-rated vacation rentals in De Soto

Vacation rentals for every style

Popular amenities for De Soto vacation rentals

Other great vacation rentals in De Soto

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