
Vacation rentals in Shawnee
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Top-rated vacation rentals in Shawnee
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The Weber Farm - Enjoy a beautiful 100 acre farm!
Enjoy a 125+ year old country home with large yard and beautiful shade trees located on a 100-acre farm in the rolling hills of SE Missouri. The house is very clean and spacious with 4 large bedrooms, comfortable beds, beautiful hardwood floors and a large living room. We have hand-made quilts and antique furniture throughout. The kitchen is fully furnished. Relax on our 40’ front porch with swing, by the fire pit or in a hammock. A perfect place for you to recharge from stress & busy schedules!
4.99 out of 5 average rating, 140 reviews
JGB’s Farm and Getaway
We are in the country next to a blacktop road.This is a very laidback place , there are farm animals across the road at our farm. This was my moms farm house and I just want people to enjoy it as much as she did. We are close to Kincaid Lake, the local winerie, the World Shooting Complex, and hiking trails (Piney Creek Revenue). Come and enjoy a day fishing or just sitting on the back deck enjoying the peaceful surroundings. Later build a fire and sit back and relax. Come and enjoy the country.
4.93 out of 5 average rating, 143 reviews
Homestead Cottage
Enjoy tiny farmhouse life in this adorable 375 sq. foot cottage. Loaded with everything you need this little cottage is nestled privately behind some trees on our 11 acre farm. You will soon forget how close you are to town with the beautiful view from your windows and the pasture fence just steps out the back door. Whether you’re here for the wineries, amazing hiking, an SIU event (3 miles) or to visit with family, the Homestead Cottage will provide a comfortable retreat from any adventure.
5.0 out of 5 average rating, 306 reviews
Wine Trail Days & Golden Farm Views
What makes The Loft truly unique is its location. At the start of the S.I. Wine Trail, the cabin is just minutes to Cedar Lake, 15 minutes from nationally award winning BBQ, delicious ice cream, shopping, and fun of all sorts! On a 70 acre organic farm, the cabin is tucked into a breathtaking valley next to the Shawnee National Forest and has a gourmet kitchen and is filled with antiques, games & play space, original eclectic artwork, plus toddler gear so you can travel light! You’ll love it!
4.96 out of 5 average rating, 247 reviews
The Dome At Blueberry Hill
Escape to The Dome at Blueberry Hill, where comfort meets nature for a truly unforgettable glamping experience. Set on two private acres along the scenic Shawnee Hills Wine Trail and minutes from the charming village of Cobden- you’ll enjoy peaceful seclusion with easy access to local charm. The fully insulated dome offers cozy, climate-controlled comfort year-round. Sip wine under the stars or unwind in style indoors. Make lasting memories at The Dome- your luxury glamping retreat awaits.
5.0 out of 5 average rating, 229 reviews
Twisted Sassafras Treehouse
A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!
5.0 out of 5 average rating, 216 reviews
Private Treehouse Retreat | Hot tub
The TreeLoft is the first of two treehouses at BaseCamp—designed for cozy seclusion, romance, and rest. Nestled in a private forest just 1 hour from St. Louis, it blends upscale comfort with immersive nature, while still being 20–35 minutes from hiking, wineries, and dining. ✨Our NEW treehouse, The TreeRise, offers an even more elevated, spacious experience at BaseCamp. Perfect for romantic getaways, anniversaries, personal retreats, and intentional escapes to unplug and reconnect.
5.0 out of 5 average rating, 721 reviews
Under the Stars - Farmhouse
Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint
4.94 out of 5 average rating, 287 reviews
Cobden Retreat in the Woods
Eva’s Roost Retreat Cabin is located at Center For Lost Arts near Cobden, Illinois. Uniquely crafted rustic, zen-style cottage, designed to be close to the earth & nature. Extensive, curtainless windows facing the forest & pond allow for private views: sunrise, moonrise, forest & wildlife. Yoga mat, guitar & some art supplies. Personal outdoor space with firepit & comfy adirondack chairs. Entrance to wandering trails right outside your back door. Perfect place to retreat and renew.
4.95 out of 5 average rating, 344 reviews
Downtown Guesthouse- Romantic Getaway
The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.
4.94 out of 5 average rating, 615 reviews
Rural Comfort in Fruitland
Enjoy a peaceful, private, country setting on the back patio with country views and a large yard space, while also having easy access to I-55, Cape Girardeau, and Jackson & multiple restaurants within a few mile radius. This home offers two fully furnished living spaces, two bedrooms, 1.5 bath and a fully equipped kitchen. There is a full laundry room/mud room with full size washer and dryer and use of the garage is negotiable.
4.91 out of 5 average rating, 45 reviews
Fall in Shawnee | 20 Acres | Wine & Bourbon
Alto Cabin is a 20-acre retreat in the Shawnee Forest, just minutes from the Wine Trail. With 3 bedrooms, 3 full baths, a stocked kitchen, arcade games, and a loft with workspace, it’s perfect for couples, families, or friends. Relax in the hot tub, gather at the firepit, or explore nearby trails and vineyards. Whether you’re seeking romance, adventure, or a cozy escape, Alto Cabin has it all.
4.96 out of 5 average rating, 109 reviewsPopular amenities for Shawnee vacation rentals
Other great vacation rentals in Shawnee

The Cabin at Timber Creek
4.95 out of 5 average rating, 88 reviews
Historic House in the heart of Altenburg
4.88 out of 5 average rating, 41 reviews
Gorgeous 1856 Log Cabin, Completely Renovated
4.82 out of 5 average rating, 56 reviews
The Wooded Walnut House
5.0 out of 5 average rating, 84 reviews
The Plum Door
5.0 out of 5 average rating, 8 reviews
Gem in Heart of Altenburg
4.87 out of 5 average rating, 23 reviews
Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!
4.86 out of 5 average rating, 57 reviews
Enchanted Mermaid A-Frame | Creek | Pet Friendly
4.98 out of 5 average rating, 53 reviewsDestinations to explore
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