
Guesthouse vacation rentals in Santa Ana
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Top-rated guesthouse rentals in Santa Ana
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santa Ana guesthouse rentals
Family-friendly guest house rentals

Orange Slice - Near Disneyland, Chapman Univ.
Tony and Shelly's "Orange Slice" was excellent. The space was the perfect size. Accommodations were comfortable and the outside space was beautiful and relaxing. Tony and Shelly were very responsive when we had questions and very generous hosts. I would recommend this space to others. We had a great experience!

Charming 2 br condo nr. beach
Absolutely loved our stay in this beautiful Corona del Mar home! The location was perfect—just a short walk to the beach, shops and restaurants. The space was spotless, stylish, and thoughtfully stocked with everything we needed. The host was responsive, kind, and made check-in a breeze. We felt like locals and didn’t want to leave. Highly recommend—this is a gem!

Disney Guesthouse Sleeps 7 near the Beaches in O.C
They have great communication with me and didn’t take long to respond.

Entire Guest Pool House
Place was an amazing stay. The area was nice and quiet. Entrance to the place was very easy and the place has a pool and outdoor patio with a fire pit which was amazing! Beds and sheets were very comfortable and soft with an AC available. The room has a complimentary coffee station which was amazing!!! The place was clean and aesthetic! Highly suggest this place!

Cozy Guesthouse in Historic Village
Thoroughly enjoyed our time at Jacob’s space. It was three blocks from downtown and very easy to move around the area. They were wonderful host house was ex extraordinarily comfortable and had everything we needed for our stay. The space was cozy without feeling crap. We have plenty of room to unpack and plenty of room to move around. We had breakfast either in the dining area or out on the front patio every morning.

Fully Loaded Newport Beach Studio
Peaceful comfortable place. We loved it. Ryan is very nice. The place is cleaned.

Cozy Place - Unit11
The house was easy to find, have clear instructions to check in and check out, the owner communicated everything with detail, I felt like a really comfy place with any essential you need on your stay

Two-room Cottage/Kitchen/Tennis Ct/Pool 独立俩房/厨房/泳池
First time in california and felt right at home. There’s so much to do around the area and we visited LA frequently throughout our stay. Sarah was super sweet and friendly, she let us drop off our luggage earlier than our check in time and gave us a mini tour of the beautiful guesthouse along with its amenities. We felt super comfortable and right at home. 10/10 would highly recommend.
Guest house rentals with a patio

Adorable Back House w/Secluded Garden & Yard
This place is absolutely stunning, with one of the most beautiful front and back gardens I’ve ever seen. The backyard was a peaceful spot to relax, and the pool added quite a bit of luxury. I didn’t meet Geoff, but Daren was incredibly warm and welcoming—easily one of the best hosts I’ve had, striking the perfect balance between friendliness and giving space. Has the basic kitchen essentials, hot plate in a drawer, kettle, toaster oven, microwave, wine fridge; it’s PLENTY for a short stay. The guest house feels closely connected to the main home, and the vibe was nothing but positive! I’d stay here again in a heartbeat—10/10 experience

Private Spanish Guesthouse w/ Pool & Views
We had a wonderful stay at Pablo's house, which was not only beautiful but also felt like home. The house was immaculately clean, with a comfortable bed and bathroom, and its cozy atmosphere made it perfect for a couple. The neighborhood was very safe, with no parking issues, and the hosts were extremely friendly and responsive. We're grateful they shared their lovely home with us.

Guest house unit B
This is a great place and Maricela is a gold-star host and person. Highly recommend. Will stay again.

Adorable 1 bedroom house with pool and patio
Lovely place! Looks better in person and has a real homey feel to it, which makes you instantly comfortable. It also smelled really good upon entry which I appreciated. I would definitely recommend.

Modern Hillside Escape surrounded by Nature
I stayed at Dana’s place in Monrovia, CA for a couple of days and had a great experience. The space was super clean, peaceful, and relaxing—just what I needed. Dana was incredibly supportive; when I was confused during check-in, she showed up right away to help. The location is perfect for me since I come to the area for work once a month, it's close to the business and also near great hiking trails and restaurants. Most importantly, the neighborhood feels very safe. Highly recommend!

Runaway Inn Minutes from Claremont/Pomona Colleges
Loved staying at Tammy’s place! This was a perfect airbnb we wished we could move in! Tammy provided so much. All of the cooking items and many spices. Bathroom came with all toiletries. The ac and electric fire was sooo nice and romantic!! We absolutely hated that we had to leave. The star jasmine outside was EVERYTHING!

Guest house has private Entrance
Had a great stay. It was everything advertised, very clean, Albert was all ways very helpful. Would love to stay again.

Private Guest Quarters with Patio & Bathroom
I had a great stay and highly recommend this Airbnb if you are a solo traveler. It was very clean, updated, and well stocked. I felt safe and the hosts were very nice. I will definitely book again when I am in town to visit my daughter!
Guest house rentals with a washer and dryer

Guest Suite in Santa Ana
We loved our stay! Very quiet and chill neighborhood, very conveniently located for exploring everything in the area. We had a couple extra requests and I appreciate the immediate and helpful responses. We'll gladly stay here again!

Villa del Sol in La Verne, CA Private Home
Fantastic stay, well worth the price. The pool house feels like it's right out of the 30's or 40's. The pool itself was right out of the same time period with lavender lining one side and table and chairs on the other. The place was spotless and wonderful to stay in. I loved every minute of it. Kim did a fantastic job decorating the space. She was responsive and friendly. Just what I needed.

1919 Spanish Casita | 12 min. to Anaheim
I had a great stay at Jana's place with my 5 year old toddler. We had minor issue with wrong keypad during checkin. But Jana was responsive and we figured it out. The house is small, quite, clean and cozy. Kitchen had good amenities for light meal preps. The outdoor garden is beautiful. Jana was sweet to add a small step stool for my daughter and also gave us some toys for her to play with. My daughter was excited and noticed the small details.

Disneyland Neighbor Studio
Super nice place, much better than a hotel. Happy I found her place and will try to stay here again if available on my next trip!

Private Entrance/Bathroom Free Parking King Bed
Great place. Quiet, felt very safe. Host was very accommodating and pleasant. I was extremely happy with my stay and the price. Would love to stay here again on my next visit out.

Cozy Lemon Tree Guest Studio with Garden
Such a lovely airbnb to stay in. Me and my friend enjoyed the lemon tree. As long as you followed the instructions, finding the place was easy. Very responsive if any issues were to occur during the stay.
Southbay Hideaway: Garden Oasis featuring hot tub!
Great hosts, awesome spot. Loved it

Welcom 3bedroom,2bath guesthouse Westminster OC
The stay was good came to Disney felt like home everything clean.
Quick stats about guesthouse rentals in Santa Ana
Total rentals
80 properties
Nightly prices starting at
ﺩ.ﺇ184 before taxes and fees
Total number of reviews
7K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
30 properties have a dedicated workspace
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- Venice Beach
- Santa Catalina Island
- Santa Monica Beach
- Disneyland Park
- Oceanside City Beach
- Universal Studios Hollywood
- Los Angeles Convention Center
- Santa Monica State Beach
- Crypto.com Arena
- Hollywood Walk of Fame
- San Clemente State Beach
- SoFi Stadium
- Oceanside Harbor
- San Onofre Beach
- Bolsa Chica State Beach
- University of California, Los Angeles
- Topanga Beach
- University of Southern California
- Huntington Beach, California
- Rose Bowl Stadium
- Huntington Beach International Surfing Museum
- Disney California Adventure Park
- Salt Creek Beach
- Trestles Beach