
Guesthouse vacation rentals in Santa Ana
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Top-rated guesthouse rentals in Santa Ana
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for Santa Ana guesthouse rentals
Family-friendly guest house rentals

The Villa - Clean, Serene, Quiet & Amazing Views!
We are a very private family and this stay was perfect! I work a very busy corporate job so when we take vacation I always appreciate the opportunity to have a peaceful place to stay! I cannot thank you enough for the hospitality. I will definitely save this as a place to visit again!

Claremont College Close - Private Upstairs Cottage
As nomadic travelers who stay in Airbnb rentals pretty much full time, we can honestly say that Cheryl & Tim’s brilliant, adorable attic conversion is the most welcoming, cozy,well maintained unit we have ever had the pleasure to call home. These hosts could teach a master class in making guests feel comfortable. The other reviews accurately describe all the tangible amenities, so I’ll just add that we truly appreciate the space these hosts created & can highly recommend to any person/ couple staying in the Upland/Claremont area. We already booked a return stay.

Private Silverlake Guesthouse
Janet was very responsive and allowed us to stay for just 1 night with an early check in. The place was prepped and cleaned by the time we arrived early and she gave clear instructions on how to access the space. She was friendly when we greeted one another in person and it was a very peaceful quiet place to stay in a great area of town. The onsite parking was a plus!

Cozy guest home in O.C with 2 rooms
The place was just at home comfortable and homey

2-Bedroom 1-Bathroom Guesthouse
Every thing was good and perfect. We enjoyed and sure we came back again because we had best time there.

Walk to Sandy Beaches from a Blissful Home
An absolutely beautiful home in a fantastic location. We stayed a week with our family of four at Kate's AirBnB. It was walkable to a lagoon beach, a playground, and restaurants. Parking was very easy. There were always plenty of spots on the street for grandpa and grandma to park. Additionally, Kate's home had a garage which made it easy to load/unload the kiddos. On top of that, Kate made it really easy to check-in and out. It was probably the most seamless transition into/out of a house we've had on the app!

Vintage Modern Guesthouse
Bryant and Margaret were the great host. Always very responsive and helpful. The place was exactly the same as posted - spacious for one (in my case), quiet environment, clean, had everything I needed. Would love to come back again one day! Thank you for having me stay!

BACKHOUSE BIRDIE: Silverlake foothills home
This place is beautiful and cozy. I loved all the details, there was nice clean products to use in the bathroom and for the laundry. The beds were absolutely heaven to sleep in and it was nice to find some condiments offered in the fridge, all the little things that making it feel really welcoming and homey.
Guest house rentals with a patio

Luxury Cottage Near Old Town, Rosebowl, and More
Great location behind a lovely Craftsman home in Pasadena. A stand alone cottage overlooking A beautiful landscaped yard. Brett is a great host. Friendly and responsive. Cottage is all new within the last few years. Very clean well supplied. One of the nicest we have stayed in. I would definitely book again.

Cozy city hideaway for families.
Very nice! Clean and quiet, comfortable beds. The area is very nice and safe. Would stay again.

Guest house unit B
I’ve stayed here multiple times now and always have a great experience. The place is super clean, fully stocked with everything you need, and just feels perfect every time. It’s easy to get into, very private, and nice and quite perfect for relaxing. The kitchen is spacious and well equipped, I got to enjoy the upgraded TVs during this stay, which was a nice bonus. This time I also had the chance to meet Maricela, she’s an amazing host and even cooked me a delicious homemade meal. I definitely recommend this spot. It’s run by someone who truly cares, and it has everything you need to enjoy your stay.

Adorable 1 bedroom house with pool and patio
Lovely place! Looks better in person and has a real homey feel to it, which makes you instantly comfortable. It also smelled really good upon entry which I appreciated. I would definitely recommend.

Adorable little guest house with beautiful garden
Easy, clean, easy instructions, exactly as advertised. Answered any questions we had quickly and without issue. Zero complaints. Great place!

Modern Hillside Escape surrounded by Nature
I loved this place. I have been traveling a lot to California for business and usually staying in Hotels. This place is such a better alternative to a hotel room. It's quiet, clean and very comfortable. The neighborhood is really nice, and it definitely seems like a safe place to take a walk. I highly recommend this place, you won't be disappointed.

Champagne Retreat in Upland
We found Kim’s place to be everything we wanted and needed! It was beautifully appointed, private, and had a lovely little front yard with table and chairs. Our little dog felt right at home and the beds were very comfortable! Kim was incredibly prompt in responding to my questions and always very helpful! I highly recommend this spot and hope to stay there again in the future sometime!! Thank you again for a lovely stay!

Atwater Guest Suite with Garden
We enjoyed our stay at Camille’s place! It was clean and comfortable. The location was great, with several cute restaurants and shops within walking distance. We also really enjoyed the garden area. Would be happy to stay there again!
Guest house rentals with a washer and dryer

Relaxing and Comfortable Home 2Bed, 1 Bath
Very nice and clean place. I like that the mattresses are more firm and doesn't sink you in like most hotel ones. Checkin and parking was easy and straightforward.

Guest House in Huntington Beach (400 sq ft)
Great experience and area. The host was helpful and quick to fix anything that came up. Overall amazing!!

Lovely garden cottage close to Disney.
We had a vey nice 3 day stay at Alan’s rental unit. The location and neighborhood was outstanding, nice area to run, hike on trails, go to Hillcrest park all without having to get in your car. The unit has a large separate bedroom, with a very comfortable bed!!! The living room also had a smaller table for dining or to use for computer. The kitchen was small studio type kitchenette, with full size refrigerator. Would be tough to cook a large meal, but was fine for our breakfast needs and reheating take out food. Lots of good restaurants are located very close. I recommend this nice quiet location and neighborhood Airbnb.

Petite Style Studio
Very nice place. Very clean. All amenities you would need.

Studio Back House w/ Kitchenette and Washer/Dryer
Jeff and Teresa’s studio was the perfect home base for my visit. I used to live in the area and wanted someplace close and familiar. The price was the same or less than a hotel with the benefit of privacy and peaceful quiet. Everything was clean and comfortable and Jeff and Teresa were very responsive hosts. Definitely recommend and will stay again when I’m in the area.

Newly renovated studio with balcony and kitchen
Sandy’s place was nice and quiet. She was quick to response to any questions I had. I enjoyed my stay there a lot. Would definitely recommend staying here :)

Gorgeous family friendly 2 bdrm - 12 min to Disney
Great place to stay. Very close to Disney. Marcela was a great host!

Charming Studio Guesthouse, Ideal for OC Getaways
This was probably my favorite place I’ve stayed with my wife in and around Anaheim.
Quick stats about guesthouse rentals in Santa Ana
Total rentals
80 properties
Nightly prices starting at
ﺩ.ﺇ184 before taxes and fees
Total number of reviews
7K reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
30 properties have a dedicated workspace
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- Disneyland Park
- Los Angeles Convention Center
- Universal Studios Hollywood
- Crypto.com Arena
- SoFi Stadium
- Long Beach Convention and Entertainment Center
- Disney California Adventure Park
- Rose Bowl Stadium
- University of California, Los Angeles
- Huntington Beach International Surfing Museum
- Surf Beach
- Palisades Park
- University of Southern California
- Knott’S Berry Farm
- Angel Stadium of Anaheim
- Redondo Beach Breakwall
- Mountain High
- Long Beach City Beach
- Chino Hills State Park
- Hollywood Forever Cemetery
- Pechanga Resort Casino
- Hollywood Walk of Fame
- The Huntington Library
- Avenue H Beach Lifeguard Tower