Guesthouse vacation rentals in Santa Ana

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Santa Ana guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Rowland Heights
4.93 out of 5 average rating, 231 reviews

The Villa - Clean, Serene, Quiet & Amazing Views!

TiaRating, 5 stars3 weeks ago
We are a very private family and this stay was perfect! I work a very busy corporate job so when we take vacation I always appreciate the opportunity to have a peaceful place to stay! I cannot thank you enough for the hospitality. I will definitely save this as a place to visit again!
Top guest favorite
Guesthouse in Upland
4.99 out of 5 average rating, 236 reviews

Claremont College Close - Private Upstairs Cottage

SusanRating, 5 stars1 week ago
As nomadic travelers who stay in Airbnb rentals pretty much full time, we can honestly say that Cheryl & Tim’s brilliant, adorable attic conversion is the most welcoming, cozy,well maintained unit we have ever had the pleasure to call home. These hosts could teach a master class in making guests feel comfortable. The other reviews accurately describe all the tangible amenities, so I’ll just add that we truly appreciate the space these hosts created & can highly recommend to any person/ couple staying in the Upland/Claremont area. We already booked a return stay.
Top guest favorite
Guesthouse in Silver Lake
4.9 out of 5 average rating, 310 reviews

Private Silverlake Guesthouse

EmilyRating, 5 stars3 weeks ago
Janet was very responsive and allowed us to stay for just 1 night with an early check in. The place was prepped and cleaned by the time we arrived early and she gave clear instructions on how to access the space. She was friendly when we greeted one another in person and it was a very peaceful quiet place to stay in a great area of town. The onsite parking was a plus!
Guest favorite
Guesthouse in Westminster
4.73 out of 5 average rating, 501 reviews

Cozy guest home in O.C with 2 rooms

JoelRating, 5 stars2 weeks ago
The place was just at home comfortable and homey
Superhost
Guesthouse in Whittier
4.85 out of 5 average rating, 304 reviews

2-Bedroom 1-Bathroom Guesthouse

BenjaminRating, 5 stars10 months ago
Every thing was good and perfect. We enjoyed and sure we came back again because we had best time there.
Guest favorite
Guesthouse in Belmont Heights
4.96 out of 5 average rating, 427 reviews

Walk to Sandy Beaches from a Blissful Home

TinaRating, 5 stars1 week ago
An absolutely beautiful home in a fantastic location. We stayed a week with our family of four at Kate's AirBnB. It was walkable to a lagoon beach, a playground, and restaurants. Parking was very easy. There were always plenty of spots on the street for grandpa and grandma to park. Additionally, Kate's home had a garage which made it easy to load/unload the kiddos. On top of that, Kate made it really easy to check-in and out. It was probably the most seamless transition into/out of a house we've had on the app!
Guest favorite
Guesthouse in Pasadena
4.9 out of 5 average rating, 522 reviews

Vintage Modern Guesthouse

TakeshiRating, 5 stars1 month ago
Bryant and Margaret were the great host. Always very responsive and helpful. The place was exactly the same as posted - spacious for one (in my case), quiet environment, clean, had everything I needed. Would love to come back again one day! Thank you for having me stay!
Superhost
Guesthouse in Silver Lake
4.89 out of 5 average rating, 113 reviews

BACKHOUSE BIRDIE: Silverlake foothills home

KristalRating, 5 stars1 month ago
This place is beautiful and cozy. I loved all the details, there was nice clean products to use in the bathroom and for the laundry. The beds were absolutely heaven to sleep in and it was nice to find some condiments offered in the fridge, all the little things that making it feel really welcoming and homey.

Guest house rentals with a patio

Guest favorite
Guesthouse in Pasadena
4.92 out of 5 average rating, 128 reviews

Luxury Cottage Near Old Town, Rosebowl, and More

BrendaRating, 5 stars1 week ago
Great location behind a lovely Craftsman home in Pasadena. A stand alone cottage overlooking A beautiful landscaped yard. Brett is a great host. Friendly and responsive. Cottage is all new within the last few years. Very clean well supplied. One of the nicest we have stayed in. I would definitely book again.
Top guest favorite
Guesthouse in Whittier
4.99 out of 5 average rating, 192 reviews

Cozy city hideaway for families.

OzmhelRating, 5 stars4 days ago
Very nice! Clean and quiet, comfortable beds. The area is very nice and safe. Would stay again.
Guest favorite
Guesthouse in South Gate
4.94 out of 5 average rating, 162 reviews

Guest house unit B

OscarRating, 5 stars3 days ago
I’ve stayed here multiple times now and always have a great experience. The place is super clean, fully stocked with everything you need, and just feels perfect every time. It’s easy to get into, very private, and nice and quite perfect for relaxing. The kitchen is spacious and well equipped, I got to enjoy the upgraded TVs during this stay, which was a nice bonus. This time I also had the chance to meet Maricela, she’s an amazing host and even cooked me a delicious homemade meal. I definitely recommend this spot. It’s run by someone who truly cares, and it has everything you need to enjoy your stay.
Guest favorite
Guesthouse in Long Beach
4.92 out of 5 average rating, 145 reviews

Adorable 1 bedroom house with pool and patio

DonnishaRating, 5 stars1 month ago
Lovely place! Looks better in person and has a real homey feel to it, which makes you instantly comfortable. It also smelled really good upon entry which I appreciated. I would definitely recommend.
Guest favorite
Guesthouse in Orange
4.88 out of 5 average rating, 215 reviews

Adorable little guest house with beautiful garden

RyanRating, 5 stars6 days ago
Easy, clean, easy instructions, exactly as advertised. Answered any questions we had quickly and without issue. Zero complaints. Great place!
Top guest favorite
Guesthouse in Monrovia
4.98 out of 5 average rating, 174 reviews

Modern Hillside Escape surrounded by Nature

DariusRating, 5 stars3 weeks ago
I loved this place. I have been traveling a lot to California for business and usually staying in Hotels. This place is such a better alternative to a hotel room. It's quiet, clean and very comfortable. The neighborhood is really nice, and it definitely seems like a safe place to take a walk. I highly recommend this place, you won't be disappointed.
Top guest favorite
Guesthouse in Upland
4.96 out of 5 average rating, 216 reviews

Champagne Retreat in Upland

KathleenRating, 5 stars5 days ago
We found Kim’s place to be everything we wanted and needed! It was beautifully appointed, private, and had a lovely little front yard with table and chairs. Our little dog felt right at home and the beds were very comfortable! Kim was incredibly prompt in responding to my questions and always very helpful! I highly recommend this spot and hope to stay there again in the future sometime!! Thank you again for a lovely stay!
Top guest favorite
Guesthouse in Atwater Village
4.98 out of 5 average rating, 121 reviews

Atwater Guest Suite with Garden

CricketRating, 5 stars2 weeks ago
We enjoyed our stay at Camille’s place! It was clean and comfortable. The location was great, with several cute restaurants and shops within walking distance. We also really enjoyed the garden area. Would be happy to stay there again!

Guest house rentals with a washer and dryer

Superhost
Guesthouse in La Puente
4.83 out of 5 average rating, 158 reviews

Relaxing and Comfortable Home 2Bed, 1 Bath

JackyRating, 5 stars3 months ago
Very nice and clean place. I like that the mattresses are more firm and doesn't sink you in like most hotel ones. Checkin and parking was easy and straightforward.
Superhost
Guesthouse in Huntington Beach
4.8 out of 5 average rating, 249 reviews

Guest House in Huntington Beach (400 sq ft)

EdwardRating, 5 stars6 days ago
Great experience and area. The host was helpful and quick to fix anything that came up. Overall amazing!!
Guest favorite
Guesthouse in Fullerton
4.87 out of 5 average rating, 381 reviews

Lovely garden cottage close to Disney.

LorraineRating, 5 stars1 week ago
We had a vey nice 3 day stay at Alan’s rental unit. The location and neighborhood was outstanding, nice area to run, hike on trails, go to Hillcrest park all without having to get in your car. The unit has a large separate bedroom, with a very comfortable bed!!! The living room also had a smaller table for dining or to use for computer. The kitchen was small studio type kitchenette, with full size refrigerator. Would be tough to cook a large meal, but was fine for our breakfast needs and reheating take out food. Lots of good restaurants are located very close. I recommend this nice quiet location and neighborhood Airbnb.
Top guest favorite
Guesthouse in Glendora
4.95 out of 5 average rating, 268 reviews

Petite Style Studio

RalphRating, 5 stars3 days ago
Very nice place. Very clean. All amenities you would need.
Top guest favorite
Guesthouse in Sierra Madre
5 out of 5 average rating, 104 reviews

Studio Back House w/ Kitchenette and Washer/Dryer

DebRating, 5 stars1 month ago
Jeff and Teresa’s studio was the perfect home base for my visit. I used to live in the area and wanted someplace close and familiar. The price was the same or less than a hotel with the benefit of privacy and peaceful quiet. Everything was clean and comfortable and Jeff and Teresa were very responsive hosts. Definitely recommend and will stay again when I’m in the area.
Top guest favorite
Guesthouse in Rowland Heights
4.96 out of 5 average rating, 160 reviews

Newly renovated studio with balcony and kitchen

JaneRating, 5 stars4 weeks ago
Sandy’s place was nice and quiet. She was quick to response to any questions I had. I enjoyed my stay there a lot. Would definitely recommend staying here :)
Superhost
Guesthouse in Santa Ana
4.88 out of 5 average rating, 195 reviews

Gorgeous family friendly 2 bdrm - 12 min to Disney

MosesRating, 5 stars3 weeks ago
Great place to stay. Very close to Disney. Marcela was a great host!
Guest favorite
Guesthouse in Anaheim
4.93 out of 5 average rating, 167 reviews

Charming Studio Guesthouse, Ideal for OC Getaways

LukeRating, 5 stars1 month ago
This was probably my favorite place I’ve stayed with my wife in and around Anaheim.

Quick stats about guesthouse rentals in Santa Ana

  • Total rentals

    80 properties

  • Nightly prices starting at

    ﺩ.ﺇ184 before taxes and fees

  • Total number of reviews

    7K reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

Destinations to explore