House vacation rentals in Pickens County

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Top-rated house rentals in Pickens County

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Guest favorite

An open living space features a large wooden bar countertop with three metal stools. A cozy seating area is arranged around a stone fireplace, complemented by a television mounted on the wall. Light streams in from the adjacent room, highlighting the rustic charm.

Home in Greenville

4.88 out of 5 average rating, 122 reviews

15 Fisher's Paradise on Lake Saluda w Boat Ramp

Stay at Saluda Lake Landing in this unique lakefront property getaway that has a house, cafe, boat ramp, and dock. Perfect for fishing, kayaking, paddle boarding and more. Once home, relax and cook the days catch indoors and out. This property is partially public as we do get other customers for the cafe, dock, and boat ramp. Please be aware that our employees will be around the property during normal working hours. If you are planning to bring your furry friend with you please reach out as we

Top guest favorite

A charming two-story home is showcased with a brick exterior and welcoming front porch. Lush green shrubbery and flower beds surround the entryway, while a flag hangs from the porch, adding a touch of Americana. Tall trees provide a natural backdrop, enhancing the peaceful setting.

Home in Seneca

4.99 out of 5 average rating, 193 reviews

Lakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤

Lake lovers and college football fans...you will LOVE this house! Lots of privacy, huge kitchen, dock, fire pit, gas grill, kayaks, and more! Beautiful Lake Hartwell home… where 1000 miles of shore awaits you! Our home is located just minutes away from Clemson, Seneca, Anderson, and more! Just 25 steps to your private dock, and 7 miles/ 10 mins from Death Valley (Memorial Stadium!) 4 bedrooms, and 3 full bathrooms. You must be at least 25 to rent. NO pets allowed, sorry! No fireworks.

Top guest favorite

A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.

Home in Seneca

4.95 out of 5 average rating, 173 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Superhost

A two-story home is surrounded by lush greenery, featuring a covered balcony on the upper level. The stone and wood exterior is complemented by a garage and a paved driveway. Comfortable outdoor chairs are positioned near the entrance, inviting relaxation.

Home in Six Mile

4.85 out of 5 average rating, 230 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Top guest favorite

A wooden deck features bright blue adirondack chairs, positioned for leisure by the water. Lush green trees frame the scene, creating a serene backdrop, with views of the lake visible just beyond the railing.

Home in Six Mile

5 out of 5 average rating, 10 reviews

Lake Keowee SC Lakehouse Escape

Bring the whole family to this Great Lake Keowee home near Clemson SC. Enjoy lake fun in lots of beautiful comfortable space.4-bedroom, 4.5 bath vacation rental house in Six Mile, SC! Directly on Lake Keowee enjoy newly decorated very clean/organized spacious property. Easy walk to lake will enjoy 1 boat parking spot, 2 jet ski lifts, kayak, paddle boat, lake floats. Enjoy lots of outside space: top deck lounge chairs, pick nick tables on the deck, large outdoor seating porch & sunroom.

Top guest favorite

A spacious dining area features a large wooden table surrounded by six chairs. Sunlight filters through the window blinds, illuminating the warm hardwood floors. A modern light fixture hangs above the table, and a staircase is visible in the background, leading to the upper level.

Home in Central

5 out of 5 average rating, 34 reviews

Modern Clemson Cottage +Lakes + Trails

Our charming 3-bedroom, 3-bathroom stone cottage is 5 minutes from downtown Clemson and has a level 2 charging station. This beautifully remodeled home blends historic charm with modern, luxurious interiors. We have brand-new, cozy mattresses, high-quality linens, and plush pillows. Ample boat parking. 13 mins to a boat landing on Lake Keowee and 3 mins to Lake Hartwell. We are 2 mins from Isaqueena biking and hiking trails. Bedrooms: 1 King, 1 Queen, 2 Twin beds & an air mattress.

Top guest favorite

A single-story home is showcased, featuring a smooth driveway that leads to a covered front porch. Brightly colored chairs are placed on the porch, surrounded by landscaped shrubs. Tall trees provide a lush backdrop, creating a serene and inviting setting.

Home in Seneca

4.97 out of 5 average rating, 143 reviews

Lake Hartwell house w/ dock 2 miles from Clemson.

This is a simple, comfortable, recently renovated home for Clemson fans and lake vacationers. Decor is vintage/antique. It is 3 1/2 miles to stadium entrance. We have a deep water cove with fire ring, decks, dock, and stairs to gangway, parking for 6 cars, woods and lake on 3 sides, a variety of restaurants nearby. Clemson Marina is next cove over. Clemson golf course across the lake. We are PET FRIENDLY with a max of 2 dogs. There is a $75 pet fee. Read the house rules concerning pets.

Top guest favorite

A spacious waterfront house is nestled among trees, showcasing a large, manicured yard with diverse foliage. A circular driveway leads to the home, framed by a covered porch and a deck, providing ample outdoor space for relaxation and gathering.

Home in Central

5 out of 5 average rating, 38 reviews

Clemson Game Day Lake House

Waterfront house with private dock 2.8 miles from downtown Clemson and Death Valley. Perfect game weekend rental! This spacious home has 4 bedrooms and 3 full bathrooms. It has two open living areas with 75” smart TVs and an open kitchen and dining area. The outdoor space has a covered porch, a grill, and a large, flat yard perfect for yard games. There is a deck for outdoor dining and seating. This home is set up for the perfect Clemson weekend getaway! Room for 3 boats at the dock.

Top guest favorite

A two-story house is set against a backdrop of lush trees, with a wooden dock leading to the entrance. The home features a blend of light-colored siding and dark windows. A porch with seating is visible, surrounded by manicured landscaping.

Home in Clemson

4.98 out of 5 average rating, 46 reviews

Clemson Lake House

Best deal in town! This house is located .5 miles from campus right on the lake. The lake is right out the back door, with 2 story dock overlooking lake. The Famous Esso Club is right down the street . The house has open floor plan with a kitchen, living room, and dining room overlooking the water. There are two bedrooms and two bathrooms upstairs. Downstairs is a second kitchen, living space, two bedrooms, and two bathrooms. Football ticket and parking packages available.

Top guest favorite

A charming home is presented in a serene neighborhood setting, featuring a well-maintained lawn and flowering shrubs. The exterior showcases a light-colored façade with a welcoming front porch and a spacious driveway leading to a two-car garage.

Home in Seneca

4.99 out of 5 average rating, 205 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

Top guest favorite

An aerial view showcases a serene landscape featuring a four-acre pond surrounded by lush greenery and autumn foliage. A winding driveway leads to a guest house nestled within the wooded area. Rolling hills provide a backdrop, enhancing the natural beauty of the property.

Home in Pickens

4.97 out of 5 average rating, 147 reviews

Our Slice of Heaven w/Views of Table Rock-Pickens

Our slice of heaven is located in the foothills of the Blue Ridge Mountains only 8 mins from Table Rock State Park. Our guest house is sitting on 55 wooded acres with our 4-acre pond and amazing awe-inspiring panoramic views of Pinnacle and Table Rock Mountain. Wrap yourself in the serenity of nature, with nothing more to wake you in the morning than the pleasant sounds of songbirds beckoning you to delight in the new day.

Guest favorite

A welcoming cabin is nestled among tall trees, softly illuminated by string lights against the evening sky. A pathway leads toward the water, inviting relaxation with the gentle ambiance of nature surrounding the space.

Home in Easley

4.91 out of 5 average rating, 186 reviews

Spectacular Lakefront Retreat on the Saluda

Stunning views, quiet, still waters, wildlife in its natural habitat. This and more is what you'll find at Lakepoint on the Saluda. Better yet, this property is located on the water with 460' of lakefront and is just minutes from downtown Greenville, Furman, and Paris Mountain. Within 35 minutes you can be in Clemson. Includes kayaks, a canoe, hot tub (SEASONAL), work out room, and some of the best fishing in the upstate!