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Vacation rentals in Mira Mesa

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mira Mesa

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A bright living area features a cozy sofa paired with a stylish coffee table, surrounded by large windows that allow natural light. A round mirror hangs above the seating, while indoor plants add a touch of greenery, creating a serene atmosphere.
Guesthouse in Poway
4.95 out of 5 average rating, 144 reviews

Charming Guest House in Poway - Kid friendly

Welcome to our cozy and private 1 bed/1 bath guest house, nestled in the heart of Poway. Our space offers a queen-sized bed, spacious bathroom with a walk-in shower, a living area and kitchen with large windows providing great natural lights. The kitchenette is well-equipped for you to channel your inner chef and comes with a fully stocked coffee/tea station. Stay connected with high-speed Wi-Fi and unwind with Smart TV entertainment. Enjoy the luxury of a private entrance for added privacy.

Top guest favorite
The exterior of a stone studio is seen at dusk, featuring an arched entrance framed by natural stone walls. Steps lead to a small patio area, with expansive views of the surrounding landscape, including distant city lights and the twilight sky.
Cave in Lake San Marcos
5 out of 5 average rating, 103 reviews

Casa Grotto, Romantic Stone Cottage w/ Ocean Views

Perched 800ft above sea level with panoramic ocean views from La Jolla to Catalina Island, Casa Grotto is a unique stone studio carved into the ocean view hillside of Lake San Marcos . Built in the 80's using stone from the mountain, the space was updated in 2025 with modern touches—featuring a rock shower, full kitchen, AC, and gym. Just 20 minutes from the beach, it’s a dreamy escape for surfers, hikers, and couples looking for a romantic getaway. No pets—our two friendly boxers live on-site

Top guest favorite
The poolside area features a well-maintained saltwater pool reflecting the colors of the sunset. Comfortable seating arrangements, including lounge chairs and a cozy fire pit, are visible. Large umbrellas provide shade, and lush greenery adds to the serene ambiance.
Guesthouse in La Mesa
4.97 out of 5 average rating, 158 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

Welcome to your personal resort! This is your private Guest House with a salt & heated pool + hot tub. Located in a very quiet & safe neighborhood in beautiful San Diego. Drive 15 minutes to the beach, downtown, La Jolla, Zoo, stadiums, Sea World, Convention Center + more. Hike next door at Cowell Mountain or Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo, top quality finishes & furniture. Everything you need for memorable vacation! No smoking or vaping on the property.

Guest favorite
A bright kitchen area features vaulted ceilings and large windows offering views of the surrounding greenery. The space includes modern appliances, a mini island with bar stools, and light-colored cabinetry, creating an open and airy atmosphere.
Guest suite in Santa Fe
4.93 out of 5 average rating, 178 reviews

Private Apartment - Secluded 2 Acre Estate/Orchard

Enjoy our serene and beautiful loft apartment in south Rancho Santa Fe. Quiet and completely private retreat on garden like 2 acre farm estate with orchard. Kid friendly and just minutes from the beach, fair grounds, restaurants, golf, horse riding, hiking, and shopping. This spacious 900 sq ft. getaway includes wifi, 2 smart ROKU TVs, full kitchenette, dining table, King bed, additional two twin XL beds. 7 miles from the beach, 2.5 miles from Trader Joe's and multiple restaurants.

Top guest favorite
A private yard is illuminated with string lights, highlighting the artificial grass area. A patio extends from the back of the suite, with a white fence enclosing the space. The contrasting dark sky adds depth to the peaceful outdoor setting.
Guesthouse in Mira Mesa
4.94 out of 5 average rating, 142 reviews

Perfect Home Base for Family Adventures

Welcome to our cozy Mira Mesa guesthouse in San Diego! This private 600 sq ft suite is perfect for families, friends, and pet-friendly stays. Enjoy a brand-new sofa bed (Sept 13, 2025) plus recent updates including a side bed, added storage, new wall décor, and curtains (Mar 22, 2026). The space also features a bright workspace with fast WiFi—ideal for remote work. Conveniently located near Freeway 15, you’re just 15–20 minutes from beaches, downtown, and top San Diego attractions.

Guest favorite
A spacious room is furnished with a plush brown sectional sofa adorned with red accent pillows and an ottoman. A large bed with neutral bedding is positioned nearby, and framed artwork adds subtle elegance to the wall, complemented by soft ceiling lights that enhance the inviting space.
Guest suite in Mira Mesa
4.91 out of 5 average rating, 154 reviews

Stunning Private Entrance 2bd/1ba Suite

Located in the heart of San Diego, guests are a short drive or bus ride to all the local hotspots. Shopping and restaurants are within walking distance. The space itself is large, exquisitely decorated, has a dedicated driveway parking space and its own private entrance in the front of the house. Also available are the washer/dryer for laundry, beach equipment, electric bikes (with signed waiver), cribs/toys/etc. for children. Short drive to SeaWorld, Zoo, Safari Park and beaches.

Guest favorite
A wooden play structure featuring a slide and windows is placed on mulch in the backyard. A green sandbox sits nearby, under a shaded tree. The fenced area provides a safe and inviting space for outdoor play.
Home in Mira Mesa
4.94 out of 5 average rating, 359 reviews

Contemporary Family-Friendly Home in SD with EV&AC

Welcome to San Diego, the city of sun and fun. This newly-renovated, spacious home has 3 beds and 2 baths with central AC, and is conveniently located in the center of San Diego with easy access to freeways 5, 805 and 15. It's close to many attractions -Legoland, Sea World, San Diego Zoo, Balboa Park, and beautiful beaches. The neighborhood has a variety of restaurants, cafes, movie theater, shopping center, and grocery stores. Just a few minutes from Sorrento Valley and UCSD.

Guest favorite
An open living space features a comfortable sofa facing a mounted television. A stone accent wall complements the modern design. In the background, a fully equipped kitchen and dining area are visible, with natural light streaming through large windows.
Home in Mira Mesa
4.83 out of 5 average rating, 264 reviews

Modern Kitchen Zen Backyard Putting Green with AC

Our beautiful home is located in the heart of San Diego. From the living room front door you'll see through to the kitchen, family room, and straight into the wide backyard with a putting green. Set up perfectly for family gatherings. Kitchen comes fully equipped. - Thermador stove, down vent hood, microwave, oven, and wide island Backyard perfect for a gathering: Safe and clean for the kids to run around. Has putting green, fire pit, and multiple lounge areas.

Guest favorite
An open-concept living space is displayed, featuring a modern sofa, a round coffee table, and a dining area with black chairs. Natural light is provided through large windows, and a well-equipped kitchen with bar seating is visible in the background.
Home in Bay Ho
4.87 out of 5 average rating, 104 reviews

Luxury 2 bedroom home with BBQ

Beautiful 2-Bedroom in San Diego with a Gorgeous Backyard Welcome to your dream stay in sunny San Diego! This stylish and cozy 2-bedroom home offers the perfect blend of comfort, relaxation, and outdoor charm—featuring a gorgeous backyard ideal for lounging or dining under the stars. Parking Info: Driveway parking is available—please pull all the way up to the garage. There’s also plenty of free street parking nearby. -All bedrooms have black out curtains

Top guest favorite
Guest suite in San Diego
4.94 out of 5 average rating, 159 reviews

Artist micro-villa with kitchen, firepit & theater

Not only is your stay private and chic, but its location is unbeatable: >apx 10 mins to La Jolla beaches and Pacific Beach restaurants/bars > apx 10 mins to SD zoo, Hillcrest nightlife and North park > apx 15-20 mins to Del Mar and Solana beaches and Encinitas As you enter this cozy San Diego gem, you are welcomed by many hand built and artistic thing to make you feel like you are at home! From hand built coffee and dining table, to painted murals.

Guest favorite
A spacious living room features a high, beamed ceiling and large windows allowing natural light. Comfortable seating includes a blue sofa and two armchairs, arranged around a central coffee table. A stone fireplace and decorative plants add to the inviting ambiance.
Home in Mira Mesa
4.94 out of 5 average rating, 124 reviews

Open Concept modern ranch w/ bounce house included

Come and relax at our California ranch style family friendly home which is a 1 story (no stairs) 3 bedroom 2 bath home in Sunny San Diego.. This open concept home has two living rooms and a backyard patio to grill and lots of grass for the kiddos to run around in. This house is centrally located in San Diego and a quick drive to the beach, the San Diego Zoo, local hospitals, Petco Park for padres, Legoland, and downtown San Diego.

Guest favorite
Guest suite in Mira Mesa
4.9 out of 5 average rating, 218 reviews

STUDIO 56

Entire Private Studio Suite. The entire suite is brand new and updated with 1 queen bed, 1 double bed, and 1 full bath. Quiet midtown of Mira Mesa central drive in San Diego. Studio fully equipped with 2 beds, a leather sofa, working desk, kitchenette meant for light food warm, full size refrigerator, single sink meant for light cup and dish wash All shops, restaurants, a cinema within minus drive about 2 miles away.

Popular amenities for Mira Mesa vacation rentals

Quick stats about vacation rentals in Mira Mesa

  • Total vacation rentals

    Explore 290 vacation rentals in Mira Mesa

  • Nightly prices starting at

    Mira Mesa vacation rentals start at ﺩ.ﺇ 73 per night before taxes and fees

  • Verified guest reviews

    Over 12,420 verified reviews to help you choose

  • Family-friendly vacation rentals

    120 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 60 rentals that welcome pets

  • Vacation rentals with a pool

    70 properties feature pools

  • Rentals with dedicated workspaces

    190 properties have a dedicated workspace

  • Wi-Fi availability

    290 of Mira Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mira Mesa rentals

  • 4.8 Average rating

    Mira Mesa stays are highly rated by guests—averaging 4.8 out of 5!

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