Vacation rentals with a patio in Cape Girardeau County

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guesthouse w/ pool, outdoor fireplace, game room

Bring the whole family to this great place with lots of room for fun and located in a quiet country subdivision with beautiful sunsets and Missouri wildlife. Enjoy a fire and s’mores in the outdoor fireplace or sit by the propane fire feature in the high-top table. All S’more essentials are provided. Amenities are numerous, including full-sized washer and dryer for guest use. Game room has Pac-man arcade, ping pong, pool table and air hockey. No parties, no smoking, no pets allowed.

Downtown Penthouse w/ Amazing River View!

AMAZING RIVERVIEW Plus Close to Downtown Cape? Our Airbnb is the best place to be! Relax in our Roof Deck after going around downtown and ENJOY THE VIEW. Located in a safe and quiet neighborhood plus it is WALKING DISTANCE from everything! It features a roof deck with (by far) the best view in Cape, enough space for six to sleep (two queen beds and two couches), one off street parking spot and a building with secure entry. Plus we just live across the street if you need anything.

The Outlook - Private Balcony

Welcome to 115 N Water, Unit 103 in Cape Girardeau, MO! This delightful property not only offers a cozy retreat but also boasts a private balcony with stunning, unobstructed views of the Mighty Mississippi River. Perfectly situated close to downtown, it's just steps away from a vibrant nightlife scene, with numerous bars and restaurants for an unforgettable date night experience. Enjoy the best of both worlds – scenic beauty and lively entertainment – right at your doorstep!

Cottage Near Casino

Welcome to your cozy cottage with a delightful retro feel, conveniently located near the Casino, Downtown, and SEMO University. You'll be greeted by the inviting sight of a white fence that surrounds the property, adding a touch of quaint charm to home away from home. This home features 2 bedrooms, 1 full bathroom and the convenience of main floor laundry. This is the perfect haven for traveling nurses or professionals seeking a comfortable and stylish residence.

Mid-Town Historic Like New Gem

This spacious and unique historic home is completely renovated; like new inside and out. Nice covered deck, overlooking a large back yard. 2 minute drive to SEMO University and the Cape Catfish. Within walking distance to Mercy Hospital, Muy Bueno, The Pickleball Factory, as well as Pacific Rim Market and Walmart Neighborhood Market for groceries. Centrally located within a 5 minute drive of most of Cape Girardeau. Close to downtown dining and entertainment.