Guesthouse vacation rentals in Amarillo

A spacious living area is highlighted by a plush leather sofa and a vibrant area rug with stripes. Natural light spills in through a window with blinds, while a wall-mounted television is positioned for viewing. A small table with a plant adds a touch of greenery.

4.98 out of 5 average rating, 965 reviews

Private & Relaxing Guest House off I-40 & I-27

This AirBnB is a detached private guest house in the historic neighborhood locally known as Wolflin. If you are just swinging through town for the night, our central location just off of Interstate 40 and Interstate 27 will get you in and out with ease. And if you’re planning on staying a little bit longer, you will feel right at home with amenities such as your own fully equipped kitchen and private laundry room. So take the opportunity to stay in this newly renovated guest house and enjoy!

A small patio area is seen beside the garage apartment, featuring two white metal chairs and a small table on a neatly maintained lawn. A large tree offers shade, and a fence is visible in the background, enhancing privacy.

4.95 out of 5 average rating, 136 reviews

Cubby Hole Garage Apartment

Tiny detached garage apartment, in a beautiful tree-lined neighborhood with brick streets. Separate entrance and parking in the alley. Small bedroom, kitchen, and bathroom (no door on Bathroom) with all the basic necessities supplied. 216 sq. ft. Centrally-located, just blocks from I-40, I-27, and Amarillo College. 2 miles to downtown. The neighborhood is the star of this location. Perfect for walks, runs and enjoying quiet spaces. 2 city parks are within 5 blocks. Local guests not accepted.

A spacious sleeping area is furnished with a large bed covered in a light gray blanket. Natural light enters through a window dressed with dark curtains. A dresser and a chair are visible, along with a lamp providing soft illumination.

4.95 out of 5 average rating, 108 reviews

Historic Route 66 Studio in a great location

No Pets / No Smoking. Hypoallergenic detergents used on all linens and towels. HEPA air purifier & Air-frier. Come get your kicks on Route 66. A nicely appointed private studio near Historic Route 66, the Amarillo Country Club and only 3-4 minutes from Hospitals. Great location for traveling healthcare workers. Modern touches for a comfortable stay. Enjoy a stylish experience at this centrally-located place, with outdoor spaces for your exclusive use allowing you to sit, cook and eat outside.

A contemporary living space features a dark leather futon adorned with textured pillows. A wall-mounted TV is positioned across from a small dining area with a round table and chairs. The room is light-filled, complemented by a rug with a modern pattern.

4.97 out of 5 average rating, 859 reviews

Studio Collin. Ideal DT property 4 work/play/relax

Perfect for the business traveler & sm fams! FULLY stocked w/anything u might need. Just bring your clothes! We have exterior sec cameras in frt of main house & driveway where u will park Qn sz PURPLE mattress. Futon avl 4 extra guests. Pack n Play avl upon REQUEST ($15 fee) Fridge, microwave, toaster, toaster oven, 2 burner elec cooktop, ice maker, coffee/tea bar. 2 Smart tvs. Workspace w/desk, chair, & PRINTER! Iron & board, hangers, luggage rack, extra blankets/pillows, box fan, yoga mat

A cozy studio apartment is displayed, featuring a colorful turquoise wall. A spacious bed covered in a patterned blanket is placed beside a sleek kitchenette with a refrigerator. A comfortable sofa is situated on a black and white rug, creating a welcoming living area.

4.93 out of 5 average rating, 194 reviews

New Beginnings

Cozy little studio apt with full kitchen, shower, wash/dryer. Motion lights. Yard for relaxing. Off street parking. Right off I-40 & I-27 in historic district. Close to downtown and centrally located to many hotspots. Walking distance to restaurants/clubs/baseball stadium. Short drive to historic RT 66, Palo Duro Canyon approx 30 mins away. Hospital/Airport 10 min drive. Close to parks. Great/safe/quiet walking neighborhood. Get refreshed at New Beginnings. Come for a day or stay awhile.

A round wooden table is centrally placed on a light-colored area, accompanied by a white chair. A decorative macramé wall hanging is displayed above the table. The seating area features a bright yellow cushion and two pillows with floral designs, enhancing the cozy environment.

4.92 out of 5 average rating, 432 reviews

Cadillac Ranch Casita

Welcome to the Cadillac Ranch Casita! Right off of I-40. This one bedroom apartment is nestled on the outskirts of Amarillo but less than a couple of miles from fine dining, convenient retail shops, hospitals, and entertainment. While staying here, you will experience the most beautiful sunsets imaginable from your private patio! Our little casita is equipped with all the essentials of home. Don’t forget to visit the historic Cadillac Ranch, located less than a mile from our front door!

A cozy sleeping area features a spacious bed adorned with a star-patterned quilt in earthy tones. A large television and wooden dresser are positioned against the wall. Natural light filters through the window, complemented by simple decor, including a cowboy-themed wall hanging.

4.94 out of 5 average rating, 516 reviews

The Texas Suite at Wolflin (I-40 & I-27)

NO LOCAL BOOKINGS. Cozy back guest house with private entrance in Amarillo's historic Wolflin neighborhood. Cozy unit with big Texas pride. Ideal for solo travelers or couples. Guest Wi-fi and dedicated work space make for a productive stay. Complimentary snacks and drinks. (PLEASE: No smoking, no pets, no parties and only registered guests- READ ALL HOUSE RULES). Only 1 service animal in accordance with ADA mandates and Texas law (specifically HB 4164-Fraudulent Service Dog Law).

A cozy sleeping area features a spacious bed with light blue linens and decorative pillows. Natural wood beams adorn the ceiling, while a large door leads to the exterior. A flat-screen TV is mounted on the wall opposite, with a glimpse of a kitchenette visible in the background.

4.86 out of 5 average rating, 109 reviews

Discover Your Cozy Amarillo Hideaway - Near RT. 66

Welcome to your cozy escape in Amarillo! Our charming central flat offers comfort and style for up to two guests. Located minutes from Route 66 and vibrant dining, it's the perfect retreat. Enjoy your private patio and experience our top-rated hospitality, earning us a 4.95-star rating. Guests love our home's comfort and reliability. Whether you're here to relax or explore, book now for a memorable stay in the heart of Amarillo! - 4 blocks off I-40 - near RT. 66 - DISCOUNTS!!

Superhost

A modern kitchen features dark cabinetry and open shelving displaying plants and dishware. Stainless steel appliances, including a coffee maker and oven, complement the stylish design. A wooden dining table is set for meals, enhancing the functional and inviting atmosphere.

4.96 out of 5 average rating, 578 reviews

Camp Hideaway

Completely renovated spring of 2019!! We are located in a quiet neighborhood right off Highway 27 just 20 minutes from the beautiful Palo Duro Canyon and Downtown (home of the brand new SodPoodles baseball stadium)! Whether you are just passing through or on vacation, you will be sure to feel at home in this adorable hideaway with all the amenities you need including a private patio with firepit and hammock, fully stocked kitchen, coffee/tea bar, smart tv, wifi and washer dryer!

4.95 out of 5 average rating, 298 reviews

The exterior of a cozy one-bedroom guest house is shown, featuring a light-colored facade and a welcoming porch. A decorative sign is displayed beside the door. Two chairs are positioned on the porch, and landscaped greenery adds a touch of nature.

Guesthouse in Canyon

Charming Canyon

Charming Canyon is Registered though the City of Canyon! It’s a Cozy, 700 square foot, one bedroom house with an en-suite bathroom minutes from downtown Canyon’s restaurants and shopping. Five minutes from WTAMU and Panhandle Plains Museum. Twenty minutes from Palo Duro Canyon with activities that include biking, hiking, and zip-lining! The second bed, a small Rollaway bed, is available to be set up upon request and is best for small children. Full Laundry room for guest to use!

A cozy corner features a round wooden table surrounded by two blue velvet chairs. The spacious bed showcases a decorative headboard and is adorned with patterned pillows. A decorative mirror and warm lighting add subtle elegance to the room.

4.99 out of 5 average rating, 317 reviews

Nifty Nest Oasis / Impeccable Studio + Garden

An incredible and intimate space with vaulted ceilings, a curated garden, and hand-painted floors. Not a single detail has been overlooked in the creation of this beautiful guest studio apartment. Enjoy evenings on the patio, surrounded by the warm glow of bistro lighting or whip up a delightful breakfast in the fully stocked kitchen for a comforting, slow morning. This home is the perfect place for deep relaxation, thoughtful meditation, or just a simple escape from busy life.

Superhost

The exterior of the studio features a charming green façade with wooden accents. An orange door welcomes visitors, while a small patio area with a round table and two chairs is set under a covered entrance. Surrounding greenery is present, enhancing the inviting appearance.