Vacation rentals in Wapello

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Top-rated vacation rentals in Wapello

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A historic brick building is showcased, featuring ornate arched windows and a decorative façade. The structure includes a ground-level entrance with signage, while bicycles and outdoor seating are visible nearby. Traffic signals and a crosswalk are evident in the foreground.
Apartment in Galesburg
4.92 out of 5 average rating, 607 reviews

Downtown apt. 8

I bedroom apartment in historic downtown building. 2 blocks from Knox College; 3 blocks from Amtrak Station. Several good restaurants and bars nearby; downtown Y a block away. 12' ceilings, hardwood floors, full kitchen and bathroom, coin laundry down the hall. Heat from radiators. Window AC units in summer. TV in bedroom. (For some reason, the listing says 4 beds; that is incorrect.) The apt. is on the 2nd floor: 26 steps. (No elevator.) Parking in lot across the street. Host lives nearby.

Guest favorite
Two Adirondack chairs face a glowing fire pit, surrounded by a grassy area. A swing set stands nearby, and the tranquil water reflects the colors of the sunset. Smoke gently rises into the evening sky, creating a relaxed atmosphere.
Cabin in Moline
4.93 out of 5 average rating, 236 reviews

Riverfront Firepit, Kayaks, Huge Deck

Firepit ready for relaxing nights by the river. Kayaks included for warm days Wake up to sweeping Rock River views, sip coffee on the wrap-around deck, paddle out in the kayaks, and end your evening by the firepit as the sky glows at sunset. This eclectic riverfront bungalow blends vibrant décor with cozy comfort and seamless indoor-outdoor living. Perfect for girls’ weekends, fishing trips, romantic escapes, or peaceful fall getaways — just steps from the water and minutes to shops and dining

Guest favorite
A wooden deck overlooks Lake Odessa, with several blue chairs arranged for seating. The calm water reflects the cloudy sky, and green vegetation borders the shore, creating a peaceful lakeside environment.
Cabin in Wapello
4.88 out of 5 average rating, 25 reviews

Waterfront Cabin on Lake Odessa

Take it easy at this unique and tranquil getaway on Lake Odessa in Wapello, Iowa. Enjoy beautiful views and access to fishing, boating, and other natural attractions. This quaint cabin offers plenty of space to relax and enjoy the peace and quiet. Cabin offers two bedrooms with 3 beds and 1 sleeper sofa in the living room. Enjoy two full bathrooms, a half bath and a full kitchen. Cabin is within walking distance of water access, boat ramp, fishing areas and a cute local seasonal restaurant.

Top guest favorite
Cottage in Carthage
4.96 out of 5 average rating, 467 reviews

Private Lakefront Romantic Cottage w/Swimspa&sauna

This cozy cottage is for couples looking to escape from it all and regenerate on many levels. You'll have your very own steam shower ....check out the company description.... . "Featuring 10 acupuncture jets, sunken tub and a high efficiency steam engine, the 608P steam bath is designed to greatly increase your spa experience. Indulge yourself in a state of complete relaxation". You'll also enjoy the comfy bed, fully stocked kitchen, private deck and access to a Swimspa and sauna 100 ft away.

Guest favorite
Home in New Boston
4.81 out of 5 average rating, 16 reviews

Liberty Street Inn kiak use included during stay

Great area for fishing, floating, kiaking or boating! Take a break and unwind at our peaceful Inn. Have a fun and or romantic getaway!Relax on the front or side porch. Grill your favorite food on a charcoal or gas grill. Spend an evening in the backyard around the fire pit. Just steps away to a public boat ramp leading to the large bay that connects to the Mississippi River, where you can launch your boat or kayak. Enjoy use of our 3 kayaks and paddle boat! Have fun with Family and Friends!

Top guest favorite
The log home features a front porch with several chairs, inviting relaxation while enjoying the surrounding nature. A wooden balcony extends from the upper level, complemented by decorative planters filled with flowers, enhancing the welcoming exterior.
Home in Letts
4.95 out of 5 average rating, 44 reviews

Shade Tree Farms in Letts, Iowa

Forget your worries in this spacious log home on 30 acres. Perfect for relaxing and renewing. Short drive to Muscatine with many historic sites, shops, unique restaurants. Near Grandview, Wapello, Letts, Columbus Junction with small town features and 35 miles from Iowa City. Mowed walking path around field. Exercise equipment. 2 car garage, 1 motorcycle garage. New pond. Privacy tucked into the field but just off the main highway. Sit and relax on massive front porch and watch the wildlife.

Top guest favorite
A screened porch features a round table surrounded by four chairs, all with green cushions. Natural light streams through the screens, showcasing views of a tranquil lake framed by colorful autumn foliage.
Guesthouse in Berwick
4.98 out of 5 average rating, 256 reviews

Private Guest Lake House On 37 Acres In Country

Private guest lake house, located next to main house, on private lake in the country. 2 bedroom, 1 full bath, full kitchen, washer and dryer and large attached screen porch. Private 37 acres of woods and prairie. Fishing and walking trails. Great window views of lake, woods, prairies and river valley. Please note, this guest house is located 1 mile down a county maintained gravel road. 25 minutes from Galesburg, IL, 20 minutes from Monmouth, IL and 35 minutes from Macomb, IL.

Top guest favorite
A modern cabin is set on a landscaped lot with a gravel path leading to the entrance. The structure features a mix of dark siding and wood accents, surrounded by open fields and distant tree lines, offering a serene rural setting.
Cabin in Princeton
4.96 out of 5 average rating, 164 reviews

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Guest favorite
A spacious home is visible with a combination of brick and siding exterior, featuring multiple gables and a large covered porch. A manicured lawn extends toward a serene pond, enhancing the natural surroundings. Clear blue skies contribute to the relaxing outdoor atmosphere.
Home in Morning Sun
4.9 out of 5 average rating, 258 reviews

Buckman's Bed and Breakfast (5 Bedrooms+)

Enjoy the comfort and welcoming atmosphere of a home built to entertain family & friends. There are 5 guest bedrooms rooms: Room 1-King bed, sofa bed & recliner Room 2-Queen & sofa bed Room 3-Twin beds & convertible sofa Room 4-Queen & sofa bed Room 5-King & recliner Rooms 1,2 &5 have in suite bathrooms. Bathroom for room 4 is next door. Rooms 2 &3 share an inner door; ideal for parents with children. Breakfast is included. To book a room instead of the house, see separate listings.

Guest favorite
A charming two-story house features a welcoming front porch with steps leading up to the entrance. The property is surrounded by a well-maintained lawn, with trees providing shade and a white picket fence outlining the yard. A driveway is visible to the side.
Home in Burlington
4.88 out of 5 average rating, 157 reviews

Cheerful Bungalow with original woodwork

This home features original woodwork, charm and character- great open front porch and back porch, living room, dining room and eat in kitchen, 3 upper level bedrooms. Full basement with laundry plus shower and stool. There is a desk for when you need a quick catch on your laptop or ipad. Relax on the porch or in the original metal kitchen with glass panels and enamel farmer sink. 1 large bedroom with queen bed and two small bedrooms with double bed Basic cable and WIFI included

Superhost
The inviting living area features a vaulted wooden ceiling, with a comfortable seating arrangement on dark leather sofas. A coffee table sits atop a cozy area rug in front of a brick fireplace, while large windows provide natural light and views of the outdoors.
Home in New Boston
4.87 out of 5 average rating, 54 reviews

Cute Cottage on the Bay

This charming cottage perfectly combines comfort and nature with direct access to Boston Bay at the bottom of a winding set of stairs. Soak in the amazing views from the new deck. The house has everything you need for your rustic getaway. There is also a convenience store/gas station in town and 2 bars/restaurants. Bring your boat or jet ski to the launch just down the road on the Mississippi at one of the public launches at the riverfront park and campground.

Top guest favorite
A black mailbox stands on a white post displaying the address '306 N. 2nd St.' The mailbox is wet from recent rain, with a grassy area surrounding it and a road visible in the background. Trees line the street, contributing to a quiet, residential setting.
Home in Oquawka
4.98 out of 5 average rating, 126 reviews

The Little House

The Little House started as a cabin in the early 1900’s. A refreshed cozy getaway in a great little river town. Restaurants, bars and river access are walkable or close drive. Plenty of room to park boat etc.

Popular amenities for Wapello vacation rentals

  1. Airbnb
  2. United States
  3. Iowa
  4. Louisa County
  5. Wapello