Vacation rentals in Louisa County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Louisa County

Guests agree: these stays are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1
Top guest favorite
A historic four-bedroom home is captured with tall trees framing the exterior, set against a clear blue sky. The architectural features include a prominent turret and multiple windows, reflecting the home's charm. A snow-dusted yard leads to a view of the nearby Mississippi River.
Home in Muscatine
4.96 out of 5 average rating, 155 reviews

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Guest favorite
Home in New Boston
4.84 out of 5 average rating, 19 reviews

Liberty Street Inn kiak use included during stay

Great area for fishing, floating, kiaking or boating! Take a break and unwind at our peaceful Inn. Have a fun and or romantic getaway!Relax on the front or side porch. Grill your favorite food on a charcoal or gas grill. Spend an evening in the backyard around the fire pit. Just steps away to a public boat ramp leading to the large bay that connects to the Mississippi River, where you can launch your boat or kayak. Enjoy use of our 3 kayaks and paddle boat! Have fun with Family and Friends!

Top guest favorite
The log home features a front porch with several chairs, inviting relaxation while enjoying the surrounding nature. A wooden balcony extends from the upper level, complemented by decorative planters filled with flowers, enhancing the welcoming exterior.
Home in Letts
4.96 out of 5 average rating, 50 reviews

Shade Tree Farms in Letts, Iowa

Forget your worries in this spacious log home on 30 acres. Perfect for relaxing and renewing. Short drive to Muscatine with many historic sites, shops, unique restaurants. Near Grandview, Wapello, Letts, Columbus Junction with small town features and 35 miles from Iowa City. Mowed walking path around field. Exercise equipment. 2 car garage, 1 motorcycle garage. New pond. Privacy tucked into the field but just off the main highway. Sit and relax on massive front porch and watch the wildlife.

Top guest favorite
Loft in Muscatine
5 out of 5 average rating, 18 reviews

Downtown;Walk to Shops, Restaurants, Entertainment

Located in the heart of Downtown - Enjoy great views of historic downtown Muscatine. - Steps away from restaurants, pubs, museums, and shopping. - Two blocks away from Mississippi Riverfront. - Enjoy a walk or bike ride along the trail system. - 2 bedrooms - one King and one Queen bed - WiFi, Smart TV and charging stations - Secure, safe location There are stairs to climb to reach the loft, and there is no elevator, but the spectacular views of Downtown are worth it when you get there!

Guest favorite
A spacious home is visible with a combination of brick and siding exterior, featuring multiple gables and a large covered porch. A manicured lawn extends toward a serene pond, enhancing the natural surroundings. Clear blue skies contribute to the relaxing outdoor atmosphere.
Home in Morning Sun
4.9 out of 5 average rating, 262 reviews

Buckman's Bed and Breakfast (5 Bedrooms+)

Enjoy the comfort and welcoming atmosphere of a home built to entertain family & friends. There are 5 guest bedrooms rooms: Room 1-King bed, sofa bed & recliner Room 2-Queen & sofa bed Room 3-Twin beds & convertible sofa Room 4-Queen & sofa bed Room 5-King & recliner Rooms 1,2 &5 have in suite bathrooms. Bathroom for room 4 is next door. Rooms 2 &3 share an inner door; ideal for parents with children. Breakfast is included. To book a room instead of the house, see separate listings.

A quaint cottage exterior is surrounded by tall trees, featuring a green porch with two light-colored chairs. Two windows are visible, framed by white trim, letting in natural light. The structure's siding is white and showcases a simple, welcoming design amidst a natural setting.
Cottage in New Boston
4.8 out of 5 average rating, 101 reviews

Cozy waterfront cottage

Amazing waterfront cottage on Stuergeon Bay. This is the perfect place for a weekend getaway or a longer stay. Spend time fishing, swimming, around the bonfire. Bring your own boat or jet ski lots of fun. The launch is about a mile down the road on the Mississippi. It's cozy and quiet, just a nice place to be. Sturgeon Bay is a backwater lake created by the Mississippi River. The water levels are controlled by the levels of the Mississippi. When low, there is more beach than water.

Superhost
A modern kitchen features a long wooden dining table accompanied by stylish pendant lights. A sleek refrigerator stands against a wall, while shelves display kitchen essentials. Light wooden flooring enhances the spacious feel, and a doorway leads to an adjoining area.
Home in Grandview
4.52 out of 5 average rating, 23 reviews

R7 Reclaimed Downtown

Girlfriends Getaway! This place is perfect for group trips, retreats, and meetings. Furnished in R7's unique blend of modern + reclaimed style you will find yourself staying in a magazine worthy setting to enjoy your time away. 3 spacious bedrooms. 2 brand new luxury bathrooms. Private patio. Sleeps up to 10. Close to beautiful outdoor parks, kayaking and boating opportunities. Ask about a private shopping experience at R7 barn or day use of the event room next door to the condo.

Top guest favorite
A view of the open-concept space highlights a kitchen area with a green countertop and a stove. The living area features light brown and tan upholstery on the seating, complemented by green carpet. A ceiling fan is visible along with warm lighting throughout the space.
Loft in Muscatine
4.94 out of 5 average rating, 247 reviews

The Emerald Loft Apartment

Stay in a Historic District Downtown loft! River views. Nearby park, playground, bike trails, boat ramps & marina. Shopping, live music, & restaurants. Private entry with 1,000 sqr ft of space, open concept, full kitchen, TV, laundry, private bath, literally right in middle of everything. Check in at Creations by Oz "Jewelry, Wine, & Unique Finds". Enjoy a glass of wine upon check-in. Come hungry. Photo comments provide dining options within steps of the Emerald Room.

Guest favorite
The inviting living area features a vaulted wooden ceiling, with a comfortable seating arrangement on dark leather sofas. A coffee table sits atop a cozy area rug in front of a brick fireplace, while large windows provide natural light and views of the outdoors.
Home in New Boston
4.88 out of 5 average rating, 58 reviews

Cute Cottage on the Bay

This charming cottage perfectly combines comfort and nature with direct access to Boston Bay at the bottom of a winding set of stairs. Soak in the amazing views from the new deck. The house has everything you need for your rustic getaway. There is also a convenience store/gas station in town and 2 bars/restaurants. Bring your boat or jet ski to the launch just down the road on the Mississippi at one of the public launches at the riverfront park and campground.

Superhost
An historical brick building features three stories and incorporates large windows on the ground floor. A fire escape ladder extends from the upper level, alongside a balcony adorned with decorative railings. The facade presents a classic architectural style, complemented by detailed signage above the entrance.
Apartment in Columbus Junction
4.76 out of 5 average rating, 34 reviews

Columbus 2 bedroom unit with great Downtown views!

Your family will be close to everything when you stay at this centrally-located place. Take a quick stroll to downtown Columbus Junction which is know for having some of the best Mexican food in Southeast Iowa! Take a 5 minute walk after to the famous swinging bridge or enjoy some of the local bars which are walking distance. Owners live next door and are available for any questions or concerns throughout your stay!

Guest favorite
The exterior of the studio is shown, featuring a simple design with a combination of brown siding and cream accents. Two wooden steps lead to separate entrances, with white-framed windows offering natural light. Surrounding trees indicate a serene, natural environment.
Cabin in New Boston
5 out of 5 average rating, 8 reviews

Campground Living

Take it easy at this unique and tranquil getaway. We are next do the campground in a quiet little river town. Enjoy boating, fishing, hunting and relaxing with no worries. Make yourself at home in this simple studio with a kitchen.

Superhost
The exterior porch features a welcoming seating area with a wicker chair, alongside decorative bunting and flower pots. An American flag flutters above, while a ramp provides accessibility. The surrounding greenery and well-maintained landscaping enhance the outdoor space.
Vacation home in Letts
4.8 out of 5 average rating, 10 reviews

2-Bedroom vacation home with deck and fire pit

Master bedroom with king size bed, 2nd bedroom has twin bed with trundle bed. Full kitchen with seating at bar, plus a dining room table as well, washer and dryer. Short walk to see the river.

Popular amenities for Louisa County vacation rentals

Destinations to explore