
House vacation rentals in St. Charles County
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Top-rated house rentals in St. Charles County
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for St. Charles County house rentals
House rentals with a pool

Private indoor pool & sauna

'Hidden Paradise' on 5 Acres w/ Hot Tub & Deck!

Clark Brick House w/ Pool | Historic St. Charles

Blair's Pool House - Creve Couer Hot Tub Game Room

"The Villa" at Villa Augusta in MO wine country

Group & Family Getaway

Roomy Oasis with hot tub on the Hill!

Pool/Speakeasy/Spaceship/Beach/pool/Costumes.
Weekly house rentals

The Wild Rose Cottage in Historic Old St Charles

Separate Entry Basement Apartment 1BR, 1BA

Luxurious couples retreat just steps from Historic

12 Sleep, 2 King Bed @ safe Neighborhood

Welcome home! Private and tranquil bungalow

Fenced St. Charles Charmer

The Frenchtown Inn | 2BR Charmer

Spacious Historic Townhouse - Character for All
Private house rentals

Charming Home in Cozy Frenchtown

Cozy Midcentury Style

Spacious Centrally Located Ranch" Newly Renovated"

Norma's House 1

*NEW* La Maison Douceur in Historic St Charles

St. Charles Victorian Gem | Steps to Main Street

#7- The Hub Le Velo Inn 1 bd 1 ba perfect getaway

Oma’s Haus - Walk to Main Street!
Destinations to explore
- Rentals with lake access St. Charles County
- Kid-friendly rentals St. Charles County
- Pet-friendly rentals St. Charles County
- Rentals with a fireplace St. Charles County
- Rentals with a patio St. Charles County
- Condo rentals St. Charles County
- Boutique hotel rentals St. Charles County
- Rentals with a hot tub St. Charles County
- Rentals with a washer and dryer St. Charles County
- Hotel rentals St. Charles County
- Rentals with an EV charger St. Charles County
- Apartment rentals St. Charles County
- Rentals with a kayak St. Charles County
- Rentals with a fire pit St. Charles County
- Rentals with an accessible height toilet St. Charles County
- Fitness-friendly rentals St. Charles County
- Smoking-friendly rentals St. Charles County
- Rentals with breakfast St. Charles County
- Waterfront rentals St. Charles County
- Bed and breakfasts St. Charles County
- Rentals with outdoor seating St. Charles County
- Loft rentals St. Charles County
- Rentals with pools St. Charles County
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- Busch Stadium
- Six Flags St. Louis
- Saint Louis Zoo
- Central West End
- Enterprise Center
- Gateway Arch National Park
- Missouri Botanical Garden
- St. Louis Aquarium at Union Station
- City Museum
- Cuivre River State Park
- Saint Louis Science Center
- Meramec State Park
- Pere Marquette State Park
- Castlewood State Park
- The Winery at Aerie's Resort
- Cathedral Basilica of Saint Louis
- Grafton Winery the Vineyards
- St. Louis Country Club
- Missouri History Museum
- Hidden Valley Ski Resort
- Raging Rivers WaterPark
- Norwood Hills Country Club
- Adventure Valley Zipline Tours and Paintball Park
- Boone Valley Golf Club