
Hotel vacation rentals in South San Francisco
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Top-rated hotel rentals in South San Francisco
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for South San Francisco hotel rentals
Family-friendly hotel rentals

Club Wyndham Canterbury One-Bedroom Suite
Nice Hotel, everything was clean and comfortable. Unfortunately there is no parking, it's near by and costs 40$ a day. But I think that's pretty common in this area.

Superior King Room with Ensuite Bathroom
What a lovely place to stay! To be honest, we stayed because of the reviews saying it was located in a noisy area full of nightlife! We wanted to be immersed in a vibrant neighborhood and we were not disappointed. So much good energy just steps away. From a giant park with artists and musicians by day to local restaurants and bars with live music by night. So much amazing food! So many wonderful bars. And it really wasn’t loud at night from inside our room. We slept peacefully. The Inn itself was a total delight. Super cute inside with many nice touches such as a wonderfully stocked 24 hr coffee bar and several seating options. We brought back food several times and just enjoyed the common space. The room was adorable, cozy and just perfect for our needs. You cannot beat this location. We walked everywhere within minutes. Close to cable car line so easy to get around if you don’t want to go everywhere on foot. I’d absolutely stay again!

Elegant Union Square hotel room
We were so pleased with our accommodations at Club Donatello. The beds were super comfortable with awesome sheets. It was very quiet, day and night, and the entire room - the entire hotel, actually - was immaculate. Although Covid restrictions meant no coffee was being served on the club level, it was unexpectedly lovely up there with a large wrap-around terrace. Meimei was extremely responsive and helpful. I have already recommended this airbnb to friends and definitely plan to be back.

Standard Quad Room w/Ensuite Bathroom
The best place I’m love it 😍

Studio Suite with Kitchen
Been booking this place for a couple of weeks now for some work in Sunnyvale and it’s great for staying for up to a week because of it’s kitchen. Space is also huge!

Contemporary & Cozy Room - City Center
Clean and high quality rooms. very attentive and pleasant staff

Hotel Pac Hgts 2 Bed Free Car ParkF
This inn was a pretty nice place to stay. Could do a little better on cleanliness but it was still good. Location is great and there was parking so it was a plus.

SF Bay Views Waterfront 2 Bdr Apt-Fishermans Wharf
Jayna’s penthouse is simply lovely!! The place is beautifully decorated, with spectacular views of the bay (including Alcatraz island). Is walking distance from all main attractions. This was the first time for me and my family visiting San Francisco, and Jayna’s place contributed to make it unforgettable!!!
Hotel rentals with a pool

Guild & Pepper bath amenities & courtyard views
Nice place to stay for the value. Easily walkable to SF SOMA and Market Street areas. The front desk is super helpful and friendly. Absolutely recommended if you're looking for a good value place to stay in SF. Note: they do charge a $20/night fee on top of the Airbnb booking and will require a $200 deposit hold on your credit card when you check in. The deposit is refunded when you check out if there are no issues.

Newly Renovated Room No Cleaning Fee Pleasanton!
Enjoyed my stay at Four Points! Front desk was extremely helpful. The outside pool/garden area was well kept and nice to be able to walk out to from the first floor rooms. Will definitely stay here again.

Best Place to Unwind! 2 Spacious Units, Pool
Thank you everything was perfect, we will definitely be going back if in the area.

Cozy - East popular Destination - Free Breakfast
I really enjoyed my stay at Redwood. I am grateful to have made the booking even though it was last minute. It was nice for a little getaway. I loved how clean the place was and wish I could’ve taken more advantage of the amenities such as access to the gym and pool. I would def book again :)

Classic Double at Hotel Valencia Santana Row
Great place and service!

King bedroom in Silicon Valley hotel
Thank you! Great location being so close to the airport!

Feel the Spacious Studio: Free Breakfast
The value for the price was excellent All common spaces were very clean and modern. The breakfast was fresh and good with a wide variety of offerings. Scrambled eggs, bacon, sausage and potatoes. Fresh fruit and much more. We couldn't have asked for a better breakfast. We really appreciated the good coffee. It was better than other places we have stayed. This is a great place to stay.
Hotel rentals with a patio

Broadmoor 2 Room Suite 436
We loved staying at The Broadmoor. It was like going back in time. Beautiful old but well maintained building. Very friendly staff (front desk and restaurant). The suite was spacious. Large bedrooms separated by a small living/kitchenette space. Note that there are no walls separating the bedroom areas from the living area. The advertised "mini" kitchen really is just that (no plates, utensils or dish soap to clean the glasses/mugs that were provided). Great included breakfast with lots of choice and nice welcome treats in the unit.

Rock Roulade Cocoon
Perfect stay! So easy and great central area - even brought my dog and so accommodating – just perfect and exactly what I needed. Thank you so much for sharing your home! Kindly, Kalli

Broadmoor King Studio 247
We had a great stay here. The hotel and the staff both were great and friendly. Herbert at the reception is a very loving and cheerful person. He made us feel like at home. Sunil from the kitchen team hosted us so well. He took care of our diet restrictions. We would definitely love to stay here again.

Broadmoor Large Studio 245
From the minute, I walked in to check in I knew I had found my home away from home in San Francisco. The atmosphere was joyful and friendly, the staff was so helpful and the lovely senior citizens were charming. They have an included breakfast that is cooked to order and simply delicious. I had to extend my stay due to some weather at my destination, and they were responsive and took care of me immediately. The bed was super comfortable. The linens were soft and clean. And the icing on the cake was the lovely outdoor patio where I could relax after a day of sightseeing. There was even a delicious bottle of red wine in my room when I checked in. My daughter lives just around the corner so I will be visiting San Francisco often and feel comfortable safe and well taken care of at the Broadmoor. I miss you guys already!

5-Bedroom Flat, Central, Close to Castro & Mission
Sri’s place was the perfect spot for a big family visiting SF! The house is spacious rooms are spread out - allowing you to feel like you have a space to retreat to along with several shared spaces where you can be together. Walkable to Duboce Park, public transit and great bars and restaurants. My family thoroughly enjoyed their stay here - we highly recommend this spot!

Broadmoor Studio 347
Great location. Easily walkable to any main attractions. Great host and very responsive/understanding.

San Francisco Suites Studio II on Nob Hill
Had everything we needed for a quick stay and was within walking distance of a lot of attractions !
Quick stats about hotel rentals in South San Francisco
Total rentals
50 properties
Nightly prices starting at
ﺩ.ﺇ588 before taxes and fees
Total number of reviews
230 reviews
Family-friendly rentals
20 properties are a good fit for families
Pet-friendly rentals
40 properties allow pets
Rentals with a pool
10 properties have a pool
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- Golden Gate Park
- Stanford University
- Twin Peaks
- Oracle Park
- Washington Square
- Davenport Beach
- Bolinas Beach
- Brazil Beach
- Montara State Beach
- Pescadero State Beach
- Rodeo Beach
- Rockaway Beach
- Bonny Doon Beach
- China Beach, San Francisco
- Black Sands Beach
- Drakes Beach
- Joaquin Miller Park
- Children’S Fairyland
- Limantour Beach
- San Gregorio State Beach
- Muir Woods National Monument
- Mission Dolores Park
- Golden Gate Bridge
- Waddell Beach