Hotels in South San Francisco

Find and book unique hotels on Airbnb

Top-rated hotels in South San Francisco

Guests agree: these hotels are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Hotel room in Oyster Point
4.81 out of 5 average rating, 181 reviews

Explore the City by the Bay! Pets are Welcome Here

Discover a plethora of attractions near the hotel's ideal location, next to San Francisco International Airport. Explore the vibrant city of San Francisco, where iconic sites like the Golden Gate Bridge, Fisherman's Wharf, and Alcatraz Island await. Visit the nearby Oracle Park for a memorable baseball game, or wander through the lush gardens of Golden Gate Park. Dive into the scientific wonders at the California Academy of Sciences, or indulge in world-class shopping and dining at Union Square.

Superhost
Hotel room in Downtown / Union Square
4.9 out of 5 average rating, 30 reviews

Prime Location Union Square. Close to all

Private HOTEL room w/private bathroom, timeshare hotel property at THE DONATELLO in UNION SQUARE (sleeps 4) in the heart of San Francisco You are not obligated to attend a timeshare presentation. The front desk will require the following in order to get the room key: 1. Refundable security deposit $250 - credit card preferred Bank issued debit cards may be accepted. Sorry Chime, Netspend, Visa Gift etc are not accepted at this time for the deposit 2. Valid photo Government ID - must be 18+

Guest favorite
Hotel room in Yerba Buena
4.98 out of 5 average rating, 80 reviews

Sophisticated Stay | Cable Cars Tours. Gym

Located on Market Street, Hyatt Regency San Francisco Downtown SOMA is a sophisticated destination hotel close to the city’s most innovatively stimulating sights. Attractions are just nearby: ✔Picturesque picnics at Golden Gate Park ✔Contemporary and modern paintings, photographs, sculptures and designs from the 20th century, all housed at SF MOMA ✔Postcard-worthy shots, at Golden Gate Bridge ✔Beaux-Arts wonder, the Palace of Fine Arts ✔Best views of San Francisco at Twin Peaks

Superhost
The exterior view of The Marker showcases its Beaux-Arts architecture with elegant detailing. Multiple stories feature large windows, illuminated at dusk, creating a welcoming ambiance. The building is framed by trees and streetlights, set against a softly lit sky.
Hotel room in Tenderloin
4.9 out of 5 average rating, 291 reviews

Union Square Steps Away | On-Site Dining + Gym

Steps from San Francisco’s vibrant Union Square, The Marker blends over a century of hospitality with modern elegance. This boutique Beaux-Arts hotel offers curated amenities like PATH water bottles, FloWater stations, and a 24-hour state-of-the-art fitness center. Dine at Tratto, serving rustic Italian dishes and craft cocktails. With concierge service, curbside valet parking, and California Green Lodging certification, The Marker pairs timeless charm with contemporary comfort.

Superhost
Hotel room in Hayes Valley
5 out of 5 average rating, 3 reviews

Getaway by SF City Hall & Opera House - 50% Off

Discover the best of San Francisco from Club Wyndham Inn at the Opera, an elegant, budget-savvy gem nestled in the Civic Center. With City Hall, Opera House, Symphony Hall, and United Nations Plaza practically at your doorstep, every day becomes a cultural adventure. Savor world-class dining and chic favorites nearby. Transit takes you to iconic landmarks like the Golden Gate Bridge, Golden Gate Park, Alcatraz, and more. Enjoy all this at half the price of comparable hotels.

Superhost
A spacious guest room features a king-sized bed with fresh white linens, complemented by bedside tables with lamps. A comfortable armchair sits in the corner, and a large window with blinds offers natural light. The entrance is framed by a wooden door with decorative panels.
Hotel room in Millbrae
4.86 out of 5 average rating, 104 reviews

Hotel Room | Free Breakfast. Bay Area.

If you plan to explore the Bay Area, The Millwood Inn & Suites is a great jumping-off point. This quaint hotel is located in Millbrae, California, only minutes from Bay Area attractions such as the Golden Gate Bridge. It is also only a six-minute drive from San Francisco International Airport, perfect for those flying in! Be welcomed into a world of comfort and convenience after a long day of exploring California's best. ✔ Free breakfast ✔ Free parking ✔ Fitness center

Superhost
Hotel room in North Los Altos
4.69 out of 5 average rating, 116 reviews

Near Stanford Univ + Breakfast. Kitchen. Pool.

Stay minutes from Stanford University, Google, and downtown Palo Alto at Residence Inn Palo Alto Los Altos. Enjoy spacious suites with full kitchens, separate living areas, and free Wi-Fi. Start your day with a complimentary hot breakfast, unwind by the outdoor pool, or keep up with workouts in the fitness center. Steps from shopping, dining, and tech hubs, this pet-friendly hotel offers the perfect blend of convenience, comfort, and Northern California charm.

Guest favorite
A cozy room is presented with a spacious bed topped with smooth white linens. Soft natural light enters through a large window covered by a beige roller shade. A small table next to the bed is complemented by a decorative flower arrangement.
Hotel room in Downtown / Union Square
5 out of 5 average rating, 25 reviews

Fun Escape | Happy Hour. Game Room. Location.

Axiom Hotel, a 4-star establishment in San Francisco's city center, is an ideal accommodation for those looking for a fun hotel to stay in during their trip to SF. It features a fitness center and a game room. Guests can also venture out to see prime attractions nearby, like Moscone Center and the Ferry Building. ✔ Fitness center ✔ Robot-delivered room service ✔ Pet-friendly ✔ Arcade games ✔ Cafe on-site ✔ Breakfast, lunch, dinner, boba and a full bar

Guest favorite
A comfortable living area features a light-colored sofa with green accent pillows, accompanied by a modern armchair. A round coffee table sits in the center, complemented by a decorative piece. Natural light enters through two windows, framed by soft curtains, highlighting the warm tones of the walls.
Hotel room in Nob Hill
4.98 out of 5 average rating, 55 reviews

Nob Hill Inn 1 Bedroom Apartment

This 1-bedroom apartment with a living room in the heart of Nob Hill offers the perfect blend of comfort and convenience. What makes this space special is the combination of privacy and space, featuring a separate living area for relaxation and a well-appointed bedroom for restful nights. Located in the prestigious Nob Hill neighborhood, you’ll be steps away from top San Francisco attractions, iconic landmarks, and local dining gems.

Guest favorite
Hotel room in Moss Beach
5 out of 5 average rating, 6 reviews

Near Montara Mountain + Free Breakfast & Parking

Tucked beside a coastal bluff in Moss Beach, Seal Cove Inn offers boutique charm just 30 minutes from San Francisco. Surrounded by cypress trees and steps from Fitzgerald Marine Reserve, this peaceful escape includes daily breakfast, free bike rentals, Wi-Fi, and parking. Explore Half Moon Bay’s beaches, trails, and shops, then unwind with wine on your private patio or by the in-room fireplace.

Superhost
Hotel room in San Francisco
5 out of 5 average rating, 3 reviews

Donatello San Francisco Downtown Studio

This elegant resort is a quiet haven in San Francisco’s Union Square neighborhood. After spending your days touring the picturesque hills, parks, and waterfront by foot or famous cable car, step into a therapeutic hot tub or sauna before settling on the rooftop deck, cocktail in hand, to admire the city lights. Many great restaurants in the area including a highly rated on there in the resort.

Superhost
An outdoor pool area features a rectangular swimming pool surrounded by lounge chairs positioned on wooden decking. Palm trees provide shade, while several seating areas with tables and chairs are visible in the background, all set against a modern architectural backdrop.
Hotel room in Mountain View
4.9 out of 5 average rating, 926 reviews

King Bed at Shashi Hotel in Mountain View

Experience our King room type at Shashi Hotel Mountain View, an Urban Resort. Conveniently, located in the heart of the Silicon Valley - walking distance to Shoreline Amphitheatre. Taste incredible cocktails and delicious bites at our Emerald Hour Bar designed by our Michelin-rated Chef. Enjoy complimentary amenities including our outdoor pool, fitness center, sauna and steam rooms.

Popular amenities for South San Francisco hotels

Quick stats about hotels in South San Francisco

  • Total vacation rentals

    Explore 70 vacation rentals in South San Francisco

  • Nightly prices starting at

    South San Francisco vacation rentals start at ﺩ.ﺇ331 per night before taxes and fees

  • Verified guest reviews

    Over 480 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 50 rentals that welcome pets

  • Vacation rentals with a pool

    30 properties feature pools

  • Rentals with dedicated workspaces

    60 properties have a dedicated workspace

  • Wi-Fi availability

    70 of South San Francisco vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across South San Francisco rentals

Destinations to explore