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Vacation rentals in Santa Clara, Panama City

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Top-rated vacation rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Apartment in Panamá
4.93 out of 5 average rating, 104 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favorite
A bright studio layout showcases a spacious bed with crisp linens and two framed artworks on the wall above. A comfortable sofa with decorative pillows complements the modern decor, while natural light filters through the sheer curtains, creating a soft and serene atmosphere.
Condo in Costa del Este
4.92 out of 5 average rating, 13 reviews

Furnished Oceanview Executive Studio in Panama

Discover elevated living in Costa del Este with this modern studio at Arcadia Condo Suites—where comfort meets convenience. Designed to cater to business travelers, families, or couples, this spacious and contemporary home offers the perfect balance of comfort and sophistication for both work and leisure. - Bright and spacious 70 m² studio - Partial views of the Pacific Ocean and surrounding cityscape - Fully equipped, modern kitchen - Pet-friendly accommodations - 24/7 concierge service

Guest favorite
Loft in Panama
4.94 out of 5 average rating, 53 reviews

Modern apartment 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Superhost
Apartment in Panamá
4.85 out of 5 average rating, 33 reviews

confort- Apt+WiFi6,1000M+AC+Laundry+TV+

✔️ SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! Apartamento en Panamá, Panamá 📍Excelente ubicación 🏡 Espacio limpio, cómodo y seguro. 💬 Estoy disponible para ayudarte durante toda tu estancia. 🔑 ¡Reserva hoy y siéntete como en casa en Panamá! 👨‍👧‍👧 Ideal para todo tipo de turista El apartamento ofrece: 🌐 Wifi 📺 TV 🍳 Cocina 💻Zona de trabajo 🌬️Aire acondicionado 🚗Estacionamiento 🌸Lavadora 🧖‍♂️🧖‍♀️ducha con agua caliente

Superhost
An inviting living area is featured, showcasing a modern grey sofa accented with decorative pillows. A round glass dining table is surrounded by chairs, and artistic wall frames complement the space. Natural light is filtered through elegantly layered window shades.
Apartment in Panamá
4.93 out of 5 average rating, 136 reviews

Luxury apartment in downtown Panama, banking area

We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Guest favorite
A modern dining area features a white table set for four, surrounded by stylish chairs. Large windows allow natural light to fill the space, revealing views of the city skyline. A sleek kitchen is visible in the background, showcasing a gas stove and granite countertops.
Apartment in Panamá
4.94 out of 5 average rating, 115 reviews

k*| Delightful 1 BR w/King Bed in Calle 50

Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 138 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favorite
A modern living room is depicted, featuring a wall-mounted television above a black media console. Two light-colored armchairs are positioned beside a round coffee table, which is adorned with decorative items. A large window allows natural light and offers views of the surrounding area.
Apartment in Costa del Este
5 out of 5 average rating, 8 reviews

1bd/2Bthrm East Coast-Panama

What are you waiting for to get to know and enjoy Panama? Stay in our modern, furnished and quiet apartment in Costa del Este, where you can enjoy a spectacular view, fast Wi-Fi, a fully equipped kitchen, access to the pool on the top floor overlooking the city and an incredible sunset, gym and more. Surrounded by cafes, parks and everything you need to have the best experience in the city.

Top guest favorite
A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.
Apartment in Costa del Este
5 out of 5 average rating, 25 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Guest favorite
A cozy living area is illustrated with a modern television positioned on a wooden console. A dining table with a simple setting is visible, accompanied by dark-colored chairs. Light-colored tiles cover the floor, and a clock is mounted on the wall, providing a functional accent.
Apartment in Panamá
5 out of 5 average rating, 16 reviews

Cozy, downtown and accessible

Enjoy the simplicity of this cozy and centrally located accommodation. Fully equipped and close to everything (transportation, supermarket, parks, restaurants). Rest at ease and in peace, after a day full of activity in the wonderful city of Panama. It has TV, Internet, air conditioning, 1 luxury bathroom, hot water, top-notch white goods with internal laundry and parking.

Guest favorite
Guesthouse in Panama City
4.89 out of 5 average rating, 244 reviews

Boho Studio - Private Terrace 9 km from airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

Guest favorite
A small outdoor seating area is shown, featuring a blue two-seater sofa positioned against a green wall. Lush plants are visible nearby, and a covered terrace area offers shade. The flooring consists of tiled squares, creating a clean and inviting space.
Guest suite in Panamá
4.78 out of 5 average rating, 76 reviews

Nice and cozy studio apartment

Annex with private bathroom, kitchen and separate entrance, house in a very quiet residential development a few meters from the main road, close to supermarkets and shopping center. We have 1 dog and 1 turtle, the property has everything you need to have a pleasant stay, transportation service is offered if required.

Popular amenities for Santa Clara, Panama City vacation rentals

  1. Airbnb
  2. Panama
  3. San Miguelito
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