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Vacation rentals in Santa Clara, Panama City

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Top-rated vacation rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 248 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Guest favorite
Apartment in Panamá
4.93 out of 5 average rating, 134 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favorite
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Apartment in Panamá
4.87 out of 5 average rating, 393 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.98 out of 5 average rating, 80 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favorite
A modern living area features a brown sofa and two accent chairs positioned around glass-topped tables. A geometric area rug adds visual interest to the space. A staircase leads to the upper level, while large tiles reflect natural light entering through the nearby windows.
Loft in Panamá
4.95 out of 5 average rating, 20 reviews

Entire Apartment #7, 20 minutes from the airport

Comfortable and cozy loft on Avenida la Pulida! Equipped for executives and couples, this loft apartment features a bedroom with a queen bed, a full bathroom, a fully equipped kitchen, a living/dining room, a Smart TV, air conditioning, a water heater, a laundry area, and a walk-in closet. Just an 8-minute walk from the Cincuentenario Metro Station and with easy access to any point in the city. Located in a quiet and discreet central building. Enjoy a perfect stay! Parking available.

Top guest favorite
Apartment in Panamá
5 out of 5 average rating, 19 reviews

Luxury Balcony Stays + Pool Casco Viejo

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Guest favorite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in Panamá
4.92 out of 5 average rating, 117 reviews

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Guest favorite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.92 out of 5 average rating, 161 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 149 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Superhost
A spacious balcony offers a panoramic view of Panama City's skyline, with a backdrop of dramatic clouds and sunlight illuminating the scene. A modern swing chair sits alongside a potted plant, inviting relaxation among the urban landscape.
Apartment in Panamá
4.8 out of 5 average rating, 41 reviews

Luxury Suite 18th View Coco del Mar Panama

Immerse yourself in the elegance and comfort of this beautiful apartment located in the heart of Panama. With stunning views of the ocean and the city, it is designed to provide you with a unique experience. Equipped with top-notch amenities such as a pool, gym and social areas, this space guarantees a stay full of tranquility, luxury in this haven of tranquility and exclusivity. Your home away from home!

Guest favorite
Home in Panamá
4.94 out of 5 average rating, 408 reviews

Private Studio 10 Min from the Airport!

Apartamento Entero 10 MINUTES FROM the Airport! The apartment is fully furnished, including appliances and kitchenware, toiletries, a living/dining room, a work table, and more. Only a few minutes' walk to the SAN ANTONIO METRO Station and METROMALL. We offer tours to San Blas - Tours to Monkey Island and the Panama Canal to help you make the most of your trip. Our home is Your home in Panama 🇵🇦

Top guest favorite
Apartment in Costa del Este
5 out of 5 average rating, 32 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Popular amenities for Santa Clara, Panama City vacation rentals

  1. Airbnb
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  3. San Miguelito
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