Guesthouse vacation rentals in Port St. Lucie

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Top-rated guesthouse rentals in Port St. Lucie

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A rustic guest apartment is set alongside a spacious outdoor area. A large tree provides shade, with a swing hanging from its branch. A wooden deck extends from the apartment, offering a porch with seating and a clear view of the surrounding greenery.

Guesthouse in Vero Beach

4.9 out of 5 average rating, 356 reviews

Charming, Barn Apartment on Farm, with Animals

Our charming and rustic guest apartment is built into half of our 8 stable horse barn on our 5 acre farm. If you are looking for a unique place to stay in Vero Beach, our guest suite is perfect. Built in 2015, it has one queen bedroom, a sleeping loft, a living area, kitchenette, a bathroom, and plenty of outdoor area to enjoy the farm, such as our fish pond, small chicken range, miniature silky fainting goats and horse Mr T. We are in the country, but close the beaches and Dodgertown.

Top guest favorite

A bright, airy guest house interior features a white tufted sofa adorned with decorative pillows. A surfboard labeled 'BEACH' hangs on the wall, while a cozy area rug complements the wooden flooring. Two twin beds are visible in the background, promoting a relaxed and welcoming environment.

Guesthouse in Hobe Sound

5 out of 5 average rating, 13 reviews

To The Sea in 143

Looking for a beach break? Located 1.43 miles from the Atlantic Ocean. Brand new, immaculate little guest house over our garage. About a 30 minute drive from Palm Beach International Airport. Many delicious restaurants nearby. There ARE stairs to get to apartment, so keep this in mind, before booking. There is One King bed, and two twin beds. The guest house is small, but has everything you need. The host lives on the property, so if you need anything, you can text them, and they will assist.

Top guest favorite

An outdoor shared patio area is shown, featuring a wooden table surrounded by four wicker chairs. String lights create a warm ambiance above, and a hammock hangs nearby. The space is adorned with potted plants and a decorative star-shaped light fixture.

Guesthouse in Stuart

4.95 out of 5 average rating, 148 reviews

Comfy and Cozy

Comfy for one and Cozy for two - efficiency apartment. 10 min. drive to public beaches and 20 min. leisurely walk to downtown Stuart -full of inviting shops, restaurants, and music. Laundry facilities available for guests who are here at least a week. One of House Beautiful Magazine's Top Ten charming USA towns: #10 - Stuart, Florida The "sailfish capital of the world" is best for those who love the perfect climate during the winter but want a less touristy destination to soak up some sun.

Top guest favorite

An outdoor fire pit area features two blue chairs arranged around a central chiminea. The space is enclosed by a wooden fence and includes lush greenery, with clear blue skies overhead. The ground is paved with circular stones, providing a cozy spot for gatherings.

Guesthouse in Port St. Lucie

5 out of 5 average rating, 10 reviews

Beautiful Guesthouse in Port St-Lucie, Florida

Welcome to our Sunshine Haven Guesthouse located in Port St-lucie. Our cozy 1 bedroom retreat is a perfect relaxing getaway. Our guest house offers a comfortable and private space near The Savanah and Jensen Beach. The bright, airy interior features modern amenities, a little kitchenette and a plush queen size bed. Step outside to enjoy the garden, fire place or breakfast under the umbrella. Short distance from the Jensen Beach Mall, Walmart, Publix and restaurants. Come and stay with us!

Guest favorite

A fenced saltwater pool is framed by a screened enclosure, featuring a decorative statue at the center of the pool deck. Lush greenery and flowering plants are visible in the background, contributing to a serene outdoor environment.

Guesthouse in Port St. Lucie

4.87 out of 5 average rating, 79 reviews

Private guest house with heated pool.

This property is located in Southbend Lakes neighborhood in the beautiful Port St Lucie, Florida. This is one of the nicest neighborhoods in the area. Tropical themed guest house with 55 inch roku tv and queen size bed. Private bathroom and access to semi private Heated salt water pool. Owners and kids may use pool as well on occasion. Take time to enjoy the sound of nature all around you. The backyard overlooks the canal and has a variety of plants, flowers , and trees.

Top guest favorite

An aerial view captures the oceanfront estate's layout, with a spacious main house surrounded by lush greenery and palm trees. A sandy beach path is visible leading to the ocean, highlighting the property's serene coastal setting.

Guesthouse in Fort Pierce

4.97 out of 5 average rating, 193 reviews

Extraordinary location, private, beach path, cozy

Location, privacy, ocean. Due to health concerns, pool seen from aerial shots not available Nov-May because owners will be in residence in the main house. Welcome to Nova Beach Cottage, the guest house on the oceanfront estate of famous sculptor, Mihai Popa, a.k.a. “Nova”. Located on the south tip of North Hutchinson Island directly next to the Fort Pierce Inlet State Park. Garden and beach path a few steps from the cottage. Screened patio from bedroom.

Top guest favorite

Guesthouse in Fort Pierce

4.95 out of 5 average rating, 207 reviews

Blue Water Efficiency on South Hutchinson Island

Welcome to our cozy efficiency on South Hutchinson Island, Florida! Our one bedroom is perfect for singles or couples, with a queen Murphy bed and private ground-level entrance. an induction cooktop, convection oven, full-size refrigerator, Smart TV, and a full bathroom. Located in a friendly neighborhood, we're close to beaches, jetties, restaurants, and historic downtown. Come stay with us and enjoy all that the Treasure Coast has to offer!

Guest favorite

A quaint guest house is surrounded by lush greenery and mature trees, providing a natural setting. The charming exterior features large windows and a welcoming entrance, inviting visitors to explore the one-acre property. A grassy area leads up to the home, enhancing the tranquil environment.

Guesthouse in Vero Beach

4.95 out of 5 average rating, 60 reviews

The Jolie House-Bright European Studio Guesthouse

A quaint guest house nestled on an acre property, with modern amenities and a relaxed inspired design. This private 600 sqft cottage has an airy open floor plan which includes a kitchenette, full bathroom, king sized canopy bed, and living room with sofa bed. The double french doors lead to outdoor seating under mature oaks and tropical vines. Located walking distance from downtown shops, parks, and minutes from local beaches.

Guest favorite

A landscaped garden features winding stone pathways bordered by vibrant plants and flowers. Lush greenery and decorative stones create a serene ambiance. A potted plant adds a touch of natural beauty to the area, promoting a peaceful outdoor experience.

Guesthouse in St. Lucie West

4.91 out of 5 average rating, 353 reviews

Port St Lucie - Peaceful home away from home.

Defined as a dwelling attached to my private home with its own private entrance, containing all the essentials of a home. Lovely, safe, quiet, family neighborhood, decorated with blackout drapes. Host only 1 person or 1 couple max at a time. Freshly renovated with private patio, independent with full kitchen. Mini fridge, coffee maker, microwave, Iron, hair dryer available. 42” LCD tv/premium channels, WiFi, streaming.

Guest favorite

A compact kitchenette features a sleek black countertop, white cabinetry, and essential appliances including a microwave and coffee maker. Ample storage is provided with open shelves displaying items, while a sink and stovetop are positioned for convenient meal preparation.

Guesthouse in Hobe Sound

4.8 out of 5 average rating, 157 reviews

Sandee's Cottage

Cute little cottage in a quiet small beach town neighborhood. One and a half miles to beautiful Hobe Sound Beach, an easy walk or bike ride.! Plenty of little shops and grocery stores within a mile of the cottage. If you like fishing bring your poles, lots of good spot Animals under 40lbs. are welcome; we do have a nice fenced in yard.! No cats! Highly allergic!!! A 25.00 fee 1 time will be charged for all pets

Guest favorite

An elegant outdoor space features a tiled pool surrounded by lush greenery. A beautiful outdoor staircase leads to the upper level, with a screened enclosure providing a comfortable transition between the pool area and the surrounding nature.

Guesthouse in Hutchinson Island

4.9 out of 5 average rating, 184 reviews

Private Detached Guesthouse Oasis

Hutchinson Island locale a two minute walk to private beach/Indian River Lagoon/fishing dock. Preserve, and, park surroundings, great hiking trails, and, awesome fishing spots. Guest house, with bedroom, living room, and bathroom, includes an alcove with small fridge, Keurig, toaster oven, and microwave. -Never a cleaning fee. -No pre check-out chores. -This is a private property listing.

Top guest favorite

A private outdoor area is laid out with a stone pathway leading to a circular patio featuring a glass-top table and four green chairs. Lush greenery and trees surround the space, contributing to a serene outdoor setting.

Guesthouse in Vero Beach

4.95 out of 5 average rating, 139 reviews

Private 1 Bedroom Hideaway

Keep it simple at this peaceful and centrally-located in-law suite. 2 private outdoor areas that are not shared with the homeowner. Separate entrance means you can enjoy your privacy. Compact full kitchen to prepare meals while you enjoy your stay. Living area has a loveseat, bedroom has a queen size bed. 1.5 miles to downtown Vero and just 11 minutes to the beach

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What guests are saying

New Waterfront Hideaway Studio!

4.95 out of 5 average rating, 22 reviews3 days ago

We thoroughly enjoyed our stay! The hideaway was delightful and the outdoor space was very relaxing! I enjoyed my morning coffee overlooking the canal. What a great start to each day! Renata couldn’t have been a more gracious host! She made us feel so welcome.

Guesthouse in Palm City

What guests are saying

Modern 2-bedroom house with pool

4.83 out of 5 average rating, 12 reviews3 weeks ago

Diego was a fantastic host!! I booked for 3 people including myself and there was plenty of space. a private and enclosed pool was at our disposal. He was very responsive and helped me with a few things I had a hard time figuring out. I would absolutely 110% recommend staying here. You won’t regret it!

Guesthouse in Port St. Lucie

What guests are saying

Private Guest Suite 6 miles to the beach

4.9 out of 5 average rating, 30 reviews2 weeks ago

Mercede's rental was extremely well stocked for a smaller space, we weren't lacking for any supplies for cooking, eating and keeping food. The space was also well apportioned and didn't feel small at all. The comfy bed and a nice spacious shower were plusses for a smaller unit! We'd definitely rent again next time we are in the Vero area!

Guesthouse in Vero Beach

What guests are saying

Roonie's river cottage

4.95 out of 5 average rating, 20 reviews3 weeks ago

My wife and I spent the entire month of March in 'Rooney's Cottage'. Our hosts, Christi and George were very helpful and friendly. The waterfront location is close to downtown Stuart parks, shops, and restaurants. A convenience store with a nice selection of wine and beer is just a block away. Easy drive to nearby Hutchinson Island beaches. The cottage has a comfortable couch and a comfortable bed. WiFi works well. The kitchen is well stocked with various pots pans and appliances. Washer/dryer on site. They also have beach gear and bicycles.

Guesthouse in Stuart

What guests are saying

Tropical Retreat - Private, Cozy, No Train Horns

5 out of 5 average rating, 91 reviews1 week ago

This is our third time at this beautiful place that we call Home-away-from-home. We love everything about it. Peaceful all around, great to cook and eat on the terrasse. Gary and Katherine are very friendly hosts. This year we discovered a great local fresh fish market just 10 minutes away, on Route 1 near Publix.

Guesthouse in Stuart

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