Vacation rentals in Mira Mesa

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Top-rated vacation rentals in Mira Mesa

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Mira Mesa
5 out of 5 average rating, 24 reviews

2 Masters, Newly Renovated New Furnishings 4BR 3BA

The perfect blend of comfort and convenience for groups, families, and business travelers. Features 2 private masters, 2 guest bedrooms, and 3 full bathrooms. Open-concept layout connects 2 living rooms, dining area, and a fully equipped kitchen. Enjoy BBQ grill, Blackstone flat-top, outdoor dining, and a fire pit with relaxing seating. Professionally cleaned and stocked with home & travel essentials, this well designed space promises to exceed your expectations and have you feel right at home.

Top guest favorite
Guesthouse in La Mesa
4.97 out of 5 average rating, 116 reviews

East Watch- a private getaway

East Watch is a 740 sq ft, 1 bedroom private retreat that provides the comforts and amenities of home with the style of a high-end hotel. All 5 to 15 min from shopping, downtown, and the beach. It's a short walk from Mt. Helix Park which offers a 360* view, weekday yoga, and stunning sunrises and sunsets. We have EV high speed car charging, a full kitchen with all appliances, workspace with dedicated fast WIFI, a spa shower, and super comfortable beds and pillows. Stay and let us charm you!

Top guest favorite
Guesthouse in La Mesa
4.97 out of 5 average rating, 158 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

Welcome to your personal resort! This is your private Guest House with a salt & heated pool + hot tub. Located in a very quiet & safe neighborhood in beautiful San Diego. Drive 15 minutes to the beach, downtown, La Jolla, Zoo, stadiums, Sea World, Convention Center + more. Hike next door at Cowell Mountain or Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo, top quality finishes & furniture. Everything you need for memorable vacation! No smoking or vaping on the property.

Top guest favorite
A private yard is illuminated with string lights, highlighting the artificial grass area. A patio extends from the back of the suite, with a white fence enclosing the space. The contrasting dark sky adds depth to the peaceful outdoor setting.
Guesthouse in Mira Mesa
4.94 out of 5 average rating, 142 reviews

Explore San Diego from This Pet-Friendly Retreat

Welcome to our cozy Mira Mesa guesthouse in San Diego! This private 600 sq ft suite is perfect for families, friends, and pet-friendly stays. Enjoy a brand-new sofa bed (Sept 13, 2025) plus recent updates including a side bed, added storage, new wall décor, and curtains (Mar 22, 2026). The space also features a bright workspace with fast WiFi—ideal for remote work. Conveniently located near Freeway 15, you’re just 15–20 minutes from beaches, downtown, and top San Diego attractions.

Guest favorite
Guest suite in Mira Mesa
4.91 out of 5 average rating, 154 reviews

Stunning Private Entrance 2bd/1ba Suite

Located in the heart of San Diego, guests are a short drive or bus ride to all the local hotspots. Shopping and restaurants are within walking distance. The space itself is large, exquisitely decorated, has a dedicated driveway parking space and its own private entrance in the front of the house. Also available are the washer/dryer for laundry, beach equipment, electric bikes (with signed waiver), cribs/toys/etc. for children. Short drive to SeaWorld, Zoo, Safari Park and beaches.

Guest favorite
A wooden play structure featuring a slide and windows is placed on mulch in the backyard. A green sandbox sits nearby, under a shaded tree. The fenced area provides a safe and inviting space for outdoor play.
Home in Mira Mesa
4.94 out of 5 average rating, 357 reviews

Contemporary Family-Friendly Home in SD with EV&AC

Welcome to San Diego, the city of sun and fun. This newly-renovated, spacious home has 3 beds and 2 baths with central AC, and is conveniently located in the center of San Diego with easy access to freeways 5, 805 and 15. It's close to many attractions -Legoland, Sea World, San Diego Zoo, Balboa Park, and beautiful beaches. The neighborhood has a variety of restaurants, cafes, movie theater, shopping center, and grocery stores. Just a few minutes from Sorrento Valley and UCSD.

Guest favorite
An open living space features a comfortable sofa facing a mounted television. A stone accent wall complements the modern design. In the background, a fully equipped kitchen and dining area are visible, with natural light streaming through large windows.
Home in Mira Mesa
4.83 out of 5 average rating, 263 reviews

Modern Kitchen Zen Backyard Putting Green with AC

Our beautiful home is located in the heart of San Diego. From the living room front door you'll see through to the kitchen, family room, and straight into the wide backyard with a putting green. Set up perfectly for family gatherings. Kitchen comes fully equipped. - Thermador stove, down vent hood, microwave, oven, and wide island Backyard perfect for a gathering: Safe and clean for the kids to run around. Has putting green, fire pit, and multiple lounge areas.

Top guest favorite
Guesthouse in Mira Mesa
4.93 out of 5 average rating, 89 reviews

Gated Detached Large House Convenient/Quiet

The spacious detached casita/guest house comes with private entrance and a backyard. It has a large bedroom, walk-in closet, full bathroom, living dinning, and kitchen. The kitchen has new sink, stove/oven, refrigerators, essential cookware, utensils, and tableware. The house has a queen size bed that can sleep two adults, a sofa sleeper bed and a queen size air mattress for additional guests. Guest may use the new LG washer/dryer combo unit.

Guest favorite
Home in Mira Mesa
5 out of 5 average rating, 8 reviews

Luxury 4BR, 6 beds Smart Home in San Diego

Modern, fully upgraded 4BR/2BA home in central Mira Mesa. Prime location close to UCSD, La Jolla beaches, shopping, restaurants, and major freeways. Enjoy a stylish new kitchen, beautiful décor, spacious living room with a 75" TV, and a brand-new back patio plus a lovely front yard. Washer and dryer provided for your convenience. Perfect for families, groups, and business travelers looking for a comfortable, convenient home base in San Diego.

Top guest favorite
A single-story ranch home is set amidst a landscaped front yard featuring vibrant green grass and white gravel accents. A large tree provides shade by the entrance, while a well-maintained driveway leads to a garage. Clear skies add to the welcoming exterior ambiance.
Home in Mira Mesa
4.98 out of 5 average rating, 96 reviews

Charming Family 3BR w/ Game Room

Experience San Diego living in this welcoming 3-bed, 2-bath Mira Mesa home. Perfect for families with a fun game room for entertainment and a spacious backyard featuring covered patio seating and grill for outdoor dining. Minutes from scenic hiking trails, family-friendly parks, and beautiful beaches. Easy access to diverse local restaurants. Your ideal Southern California base with space for both lively gatherings and relaxing downtime.

Guest favorite
A spacious living room features a high, beamed ceiling and large windows allowing natural light. Comfortable seating includes a blue sofa and two armchairs, arranged around a central coffee table. A stone fireplace and decorative plants add to the inviting ambiance.
Home in Mira Mesa
4.94 out of 5 average rating, 124 reviews

Open Concept modern ranch w/ bounce house included

Come and relax at our California ranch style family friendly home which is a 1 story (no stairs) 3 bedroom 2 bath home in Sunny San Diego.. This open concept home has two living rooms and a backyard patio to grill and lots of grass for the kiddos to run around in. This house is centrally located in San Diego and a quick drive to the beach, the San Diego Zoo, local hospitals, Petco Park for padres, Legoland, and downtown San Diego.

Top guest favorite
Guest suite in Mira Mesa
4.9 out of 5 average rating, 218 reviews

STUDIO 56

Entire Private Studio Suite. The entire suite is brand new and updated with 1 queen bed, 1 double bed, and 1 full bath. Quiet midtown of Mira Mesa central drive in San Diego. Studio fully equipped with 2 beds, a leather sofa, working desk, kitchenette meant for light food warm, full size refrigerator, single sink meant for light cup and dish wash All shops, restaurants, a cinema within minus drive about 2 miles away.

Popular amenities for Mira Mesa vacation rentals

Quick stats about vacation rentals in Mira Mesa

  • Total vacation rentals

    Explore 290 vacation rentals in Mira Mesa

  • Nightly prices starting at

    Mira Mesa vacation rentals start at ﺩ.ﺇ 73 per night before taxes and fees

  • Verified guest reviews

    Over 12,420 verified reviews to help you choose

  • Family-friendly vacation rentals

    120 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 60 rentals that welcome pets

  • Vacation rentals with a pool

    70 properties feature pools

  • Rentals with dedicated workspaces

    190 properties have a dedicated workspace

  • Wi-Fi availability

    290 of Mira Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mira Mesa rentals

  • 4.8 Average rating

    Mira Mesa stays are highly rated by guests—averaging 4.8 out of 5!

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