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Guesthouse vacation rentals in Midtown - Downtown, Columbia

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Top-rated guesthouse rentals in Midtown - Downtown, Columbia

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guesthouse in Shandon

4.93 out of 5 average rating, 100 reviews

Bubba’s Tranquil Treehouse

Next door to Bubba’s Bungalow & within walking distance of Columbia's 5 Points,the Divine Corridor,Anytime Fitness & USC,this vintage charmer sits in Our oldest historical & prestigious neighborhood.Crisp, soothing colors,an abundance of natural light, 2 porches (classic French Quarter Balcony in front & cozy Charleston Carriage House deck covered in Confederate Jessamine in back)complete the dream.If your travels include Columbia, congratulations:You’ve just discovered it’s most unique getaway!

Top guest favorite

A charming yellow house is set within a landscaped yard, featuring a welcoming porch with ceiling fans and string lights. Lush green plants surround the pathway, which leads to the entrance. The backyard is enclosed by a wooden fence, providing a sense of privacy.

Guesthouse in Columbia

5 out of 5 average rating, 126 reviews

Amazing Studio Guesthouse in COLA suburb.

Just 10 mins off of route 77, Fort Jackson & Downtown COLA only 20-30 min drive. Studio’s located in a beautiful family-friendly, suburban Lake community in Columbia SC with grocery stores & gas stations within minutes. Enjoy a night in equipped with movie screen & projector, then finish the night by melting your worries away into an incredibly soothing king size memory foam bed. Let our all-in-one washer/dryer do the work for you and wake up to a finished cycle and sounds of SC’s native birds.

A charming cottage is framed by a lush garden, showcasing vibrant greenery and blooming flowers. A brick pathway leads to a welcoming front porch adorned with railings and decorative accents. Tall trees provide shade while sunlight filters through the surrounding foliage.

Guesthouse in Columbia

4.89 out of 5 average rating, 902 reviews

Tiny Guest House secluded USC-Vista-Capitol-Dwntwn

Welcome to our tiny guest cottage hidden in the heart of the city. It's within blocks of restaurants, coffee shops, an art movie house, and a lovely river walk. The Lace House/Governor’s Mansion, business district & UofSC are a short walk or bike ride away. At the rear of our home, it’s private, secure & quiet. A partition & movable screen separate the bathroom area. There’s a smart tv, small fridge, microwave, coffeemaker & work-table.24 hr self check-in.HOUSEHOLD VACCINATED STRO-000579-03-2024

A custom barn door, crafted from reclaimed wood, separates the bathroom from the living area. The bathroom features a glass-enclosed shower, and a small area reveals a breakfast bar with two stools, brightened by natural light from a nearby window.

Guesthouse in Columbia

4.9 out of 5 average rating, 198 reviews

Vintage Rosewood Carriage House

Our cozy guest house has been completely remodeled and is ready for action! Lots of natural light, custom woodwork, and salvaged items make this space extra unique. The main floor has a kitchenette, living area with a pull out couch, and full bathroom. Head up to the loft to relax in the queen bed. Our place is in the heart of Rosewood where you can walk or bike easily to the grocery store, several parks and bars/restaurants. Downtown Columbia and USC's campus are both less than 3 miles away.

An outdoor patio area features colorful Adirondack chairs and a BBQ grill under a wooden ceiling with string lights. The view overlooks a peaceful waterfront surrounded by trees, with boats visible on the lake.

Guesthouse in Lexington

4.97 out of 5 average rating, 158 reviews

Lake front Lake Murray in the Heart of Lexington

Walk out onto Lake Murray in the heart of Lexington! From sunrise to sunset this home is perfect for that relaxing get away; a private beach is steps from your door, a dock to fish from, boat ramp to launch your lake toys, quite cove with beautiful wild life! As the owners we live in the upstairs of the home (completely securely separated) and are available if you need anything! We enjoy sharing this beautiful home with others! Please note the beach, dock and lake are shared spaces.

Top guest favorite

A charming blue house is set among greenery, showcasing a traditional architecture style. Two vehicles are parked in front, and the entrance is framed by steps leading to a porch adorned with potted plants. The surrounding area features a landscaped yard with foliage.

Guesthouse in Downtown Columbia

4.96 out of 5 average rating, 112 reviews

Cozy 1-Bedroom Guesthouse Walking Distance to USC

Keep it simple at this peaceful and centrally-located place, with lovely garden views. 1 bedroom/1 bath apartment with a twin sized day bed in the living room. Full kitchen. Walking distance to USC and Five Points. Close to Williams Brice Stadium (1.5 miles); Fort Jackson (5 miles); Soda City Market, Main Street, the Capital building, and the Koger Center (1 mile plus). Parking in driveway or on the street using our guest parking pass. City of Columbia License No. BL002050-08-2023

The exterior of the apartment features a set of stairs leading to the entrance, illuminated by a wall-mounted light. The house is painted in light colors, with a welcoming entrance marked by a door and a small area of landscaping nearby.

Guesthouse in Columbia

4.94 out of 5 average rating, 214 reviews

Private w/kitchen - quiet walkable neighborhood.

Beautiful, private Lake Carolina apartment w/full kitchen. ~30 minutes (easy drive) from USC. Conveniently located close to Blythewood, Ft. Jackson & Columbia. Ideal for stays close to family when you want your own space. Space is quiet & in a walkable neighborhood with tree-lined streets & wide sidewalks. Walk to the town center for coffee, wine or dinner. Fenced, shaded yard with benches. We are onsite, across the yard, and eager to help you make the most of your visit.

Top guest favorite

A bright kitchen area features stainless steel appliances, including an oven and refrigerator. A small round table with two chairs is positioned near two large windows, allowing natural light to flow in. The modern cabinets and countertop provide ample space for cooking.

Guesthouse in Lexington

5 out of 5 average rating, 247 reviews

Modern Cottage in Peaceful and Central Location

Nestled on a secluded property, overlooking beautiful land, our peaceful guest house is perfect for a relaxing stay away from home. Ideally located off I-20, this private cottage is less than 10 miles from downtown Columbia, Riverbanks Zoo & the airport and it is just minutes from Lake Murray, restaurants, coffee & shopping. We have sought to make your stay relaxing, quiet & secure. Enjoy this cottage all to yourself with a private entrance and off-street parking.

Guesthouse in Lexington

4.94 out of 5 average rating, 262 reviews

Come Pause and Relax!

Looking to relax and unwind in a little home away from home? Our newly renovated guest house is the ideal place for total comfort. Nestled behind our home awaits your quiet “cottage in the trees.” Here you’ll find a full kitchen for cooking and a spacious living area for relaxing. Heavenly sleep awaits you in this oh-so-cozy bed with bamboo sheets. A stylish bath gives you what you need to refresh. Soak up fresh air in a backyard oasis. Destination relaxation!

The guesthouse sits elevated, featuring a welcoming deck with stairs leading down to a gravel area. Two bright red Adirondack chairs surround a fire pit, and string lights are draped overhead, enhancing the tranquil outdoor environment surrounded by trees.

Guesthouse in Shandon

4.87 out of 5 average rating, 411 reviews

Cozy retreat near Williams Brice/Ft. Jackson/UofSC

Follow us @southshandonstreet! – 900 sq. ft. charming guesthouse in the heart of historic Columbia. – Fully furnished with modern/boho decor. – 2-3 miles from Ft. Jackson; 2 miles from UofSC; walking distance from Williams-Brice Stadium – Walking distance to the famous Rosewood Dairy Bar where you can go for quick fried snack or soft serve ice cream. Restaurants, grocery store, and bars also located within walking distance.

A spacious living area features a comfortable blue sofa and a stylish glass coffee table atop a textured area rug. A sleek television is mounted on the wall, while natural light enters through large windows adorned with light curtains. A dining table is situated in the background.

Guesthouse in Columbia

4.9 out of 5 average rating, 152 reviews

Brand New Studio Guest House with Full Kitchen.

Enjoy a stylish experience at this centrally-located house. Within a one mile radius of downtown Columbia, University of South Carolina, Benedict College stadium, Prism Health Richland Hospital, Prism Health Baptist Hospital and MUSC medical center. Fort Jackson is less than 10 minutes away! Certified service animals only are welcomed with a fee. There is also a fee for guest under the age of 25.

A clean bathroom featuring a washbasin with modern fixtures, surrounded by sleek tile work. A mirror above the sink reflects a compact space, complemented by a small plant. A gray cabinet with neatly folded towels adds functionality to the room.

Guesthouse in Columbia

4.87 out of 5 average rating, 191 reviews

Quaint Haven: Your Cozy Retreat

Welcome to Quaint Haven, your ultimate cozy retreat! Our charming Airbnb offers a tranquil and intimate getaway nestled in a picturesque setting. Immerse yourself in the warmth and comfort of our thoughtfully designed space, featuring a minimalist yet stylish interior. A cozy living area, and a compact kitchenette, our Quaint Haven provides everything you need for a relaxing stay.

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Popular amenities for Midtown - Downtown, Columbia guesthouse rentals

Free parking on premises

Air conditioning

Family-friendly guest house rentals

The exterior of a 2012 Jayco Swift travel camper is shown, featuring a well-maintained facade with sliding entry steps. A swing set with a padded seat is positioned nearby, surrounded by landscaped gravel and a grassy area, adding to the inviting outdoor space.

Guesthouse in Columbia

4.87 out of 5 average rating, 91 reviews

Cozy Camper in St. Andrews, Irmo, Harbison Blvd.

Top guest favorite

The salt-water pool features clear turquoise water, surrounded by lush greenery and tall trees. A small waterfall adds visual interest, while a spacious deck offers room for relaxation. The tranquil setting is ideal for enjoying nature and spacious outdoor activities.

Guesthouse in West Columbia

4.95 out of 5 average rating, 671 reviews

Carriage House: Studio Bed & Bath - Pool & Hot Tub

An open living space is shown, featuring a round wooden dining table surrounded by four light-colored chairs. A cozy sofa is situated near a large window, while a beige area rug provides warmth underfoot. Natural light fills the room, enhancing its inviting feel.

Guesthouse in Lexington

4.94 out of 5 average rating, 262 reviews

Come Pause and Relax!

Top guest favorite

A well-maintained front yard features manicured grass, landscaped bushes, and trees providing shade. A parked vehicle is visible in the driveway, with the entrance of the home framed by greenery and a welcoming porch in the background.

Guesthouse in Columbia

5 out of 5 average rating, 424 reviews

Cozy studio apartment, convenient location

Guest house rentals with a patio

A cozy outdoor seating area features a woven chair with a soft cushion, positioned beside stylish lamps and lush greenery. The double doors lead to a well-lit interior space, creating a welcoming ambiance as warm light spills onto the porch.

Guesthouse in Columbia

5 out of 5 average rating, 16 reviews

Lake Coach Cottage/ Amazing stay/Columbia,SC

A large screened window frames a view of the tranquil Cary Lake, surrounded by lush greenery and trees. Soft morning light filters through the screen, highlighting the peaceful setting and reflecting on the calm water.

Guesthouse in Columbia

4.85 out of 5 average rating, 113 reviews

Cary Lake Guesthouse - Slice of Heaven

A spacious sleeping area features a large bed with decorative pillows and a light quilt. A small desk and chair are positioned to one side. Natural light filters through dark curtains, while a small couch and decorative rug complete the inviting ambiance.

Guesthouse in West Columbia

4.91 out of 5 average rating, 22 reviews

Aviation A-Frame Airbnb

A cozy sleeping area features a spacious bed with white linens. A geometric wall art piece and a warm light bulb lamp sit on a shelf beside the bed. A large wooden mirror reflects the room's neutral tones, offering a sense of openness.

Guesthouse in Columbia

4.72 out of 5 average rating, 60 reviews

Retro Home

Guesthouse in Columbia

4.69 out of 5 average rating, 62 reviews

The Wren's Nest | 1BR 2BA Guesthouse

A cozy sleeping area is presented with a queen-sized bed dressed in floral linens. Nearby, an armchair with a cushion bearing the phrase 'welcome home' provides a nook for relaxation. Windowed doors lead to the outside, framed by dark curtains and complemented by wall art.

Guesthouse in Chapin

4.75 out of 5 average rating, 8 reviews

Clover Cottage: Charming Private Cabin

An open-concept kitchen is highlighted by a concrete countertop and herringbone tile backsplash. Three green stools provide seating at the breakfast bar. Modern appliances, including a stainless steel refrigerator and gas cooktop, are visible in the stylishly arranged space.

Guesthouse in Columbia

4.96 out of 5 average rating, 54 reviews

The Carriage House @Downtown!

Top guest favorite

The studio apartment features a cozy sleeping area with a spacious bed framed by warm-colored bedding. A leather sofa and a blue accent chair are arranged in the living space, complemented by side tables and soft lighting creating a calm ambiance.

Guesthouse in Columbia

5 out of 5 average rating, 119 reviews

Restful Refuge

Guest house rentals with a washer and dryer

A well-maintained backyard features neatly trimmed grass and stone pathways leading to the garage apartment. Decorative string lights are visible above, providing soft illumination. Surrounding greenery includes shrubs and trees, creating a peaceful outdoor environment.

Guesthouse in Columbia

4.95 out of 5 average rating, 39 reviews

Casa Abelia - Downtown Columbia

Top guest favorite

A fenced pool area is highlighted, featuring two lounge chairs with bright floral patterns. A large red umbrella provides shade, and surrounding greenery creates a natural backdrop. The pool is visible, offering a refreshing blue hue, while a small table and chairs complete the space.

Guesthouse in Blythewood

5 out of 5 average rating, 52 reviews

Avila Manor

A spacious patio features a large, leafy tropical plant alongside a well-groomed garden bed. A golden retriever rests nearby on the textured stone surface, contributing to the serene outdoor atmosphere. The area is surrounded by greenery, providing a sense of tranquility.

Guesthouse in Shandon

4.88 out of 5 average rating, 154 reviews

Bubba’s Bungalow

Guesthouse in Columbia

4.89 out of 5 average rating, 75 reviews

Faber's Rest LLC

A modern kitchen area features white cabinetry and a gray countertop, including a stainless steel sink and a sleek black refrigerator. An induction cooktop is visible beside the sink, and light-colored flooring enhances the spacious feel. An entrance door and storage drawer are seen in the background.

Guesthouse in Lexington

5 out of 5 average rating, 15 reviews

Garage Apartment

A bright kitchen features yellow walls, enhancing the lively atmosphere. An island with a wooden countertop is positioned in the center, surrounded by modern appliances, including a microwave and oven. Natural light is filtered through a window with white blinds, illuminating the space.

Guesthouse in Columbia

4.89 out of 5 average rating, 95 reviews

Amazing private guesthouse in North East Columbia

The exterior entrance features a grey door with a metal door handle. A warm light fixture is mounted beside the door. A welcome mat lies on a wooden porch, and a small table is positioned nearby. A sign indicates the guesthouse number.

Guesthouse in Elgin

4.84 out of 5 average rating, 93 reviews

Guesthouse ( Northeast Columbia, South Carolina)

Quick stats about guesthouse rentals in Midtown - Downtown, Columbia

Total rentals
20 properties
Nightly prices starting at
ﺩ.ﺇ184 before taxes and fees
Total number of reviews
4.2K reviews
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Wifi availability
20 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool

Destinations to explore