Vacation rentals in Midlands of South Carolina

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Top-rated vacation rentals in Midlands of South Carolina

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A cottage resides beside a serene pond, surrounded by lush trees. Its inviting exterior features large windows reflecting on the water's surface. A wooden deck extends over the pond, providing access to nearby fishing and kayaking equipment, creating a peaceful natural setting.
Cottage in Lexington
5.0 out of 5 average rating, 179 reviews

Relax and unplug at this private oasis!

Our beautiful cottage for adults only is set on a private spring fed pond with all amenities to unwind from the day-to-day hustle. A porch with rocking chairs, brick fire pit and outdoor lighting in the courtyard make this your destination for relaxation. Take a walk in the 20 acres of wooded trails, fish, kayak, paddleboat, read a book, write, listen to music or just take a nap. This property lets you unplug from the world, relax, and connect with nature without giving up modern conveniences.

Superhost
Cabin in St. Matthews
4.77 out of 5 average rating, 197 reviews

A relaxing cabin on private pond. Old Bells Secret

Escape to our secluded cabin on 90 acres in St. Matthews, SC! This early 2000s style cabin features 2 cozy bedrooms, 1 bathroom, and a lovely porch. The large pond is perfect for swimming, fishing, or playing. It’s an endless adventure. The house can sleep up to 6 with the pull out couch. Accessible via a private road, it's perfect for weekend getaways with the family or housing for workers. Experience relaxation and adventure in nature at this wonderful cabin. Book now for a memorable stay!

Top guest favorite
The exterior of the Farmhouse is showcased, featuring a spacious covered porch with comfortable seating and a welcoming entrance. Large windows allow natural light to fill the interior, and the surrounding landscape offers a glimpse of the tranquil rural setting.
Tiny home in Elgin
5.0 out of 5 average rating, 192 reviews

The Farmhouse @ Goat Daddy's

Nestled on 66 acres with a gorgeous pond/farm view, you will find Goat Daddy's Farm and Animal Sanctuary. Our luxurious tiny house has everything you need to make your farm stay comfortable and relaxing. Guests will have access to the farm during specific hours, as well as over 2.5 miles of paths and two ponds to explore. With your feet in the sand, by a fire, in the hot tub, on the trails, or getting some goat/animal therapy, The Farmhouse and Sanctuary has something to offer for all.

Guest favorite
An outdoor game area features a pool table, with a set of colorful balls arranged on the surface. The scene includes a grassy lawn leading to the water, where a sunset illuminates the landscape. Two red chairs and a picnic-style setup are visible nearby.
Home in Prosperity
4.9 out of 5 average rating, 103 reviews

Sunset Cove-Beautiful Lake views

Your home away from home on Lake Murray! Spacious, modern clean, home with 3 levels of living -3 spacious decks, screen porch, and sunroom all with massive lake views! Plenty to do at Sunset Cove relaxing with family and friends and toys galore! "Wow just wow, best Airbnb ever..Sarah, June 2026. "..clean, beautiful view and so many fun games..Lisa, Oct 2025."Perfect setting for a quiet getaway. The house was amazing, clean, and had all the amenities we were looking for.."Jay, Sept 2025

Top guest favorite
A fire pit is surrounded by four Adirondack chairs, set upon a stone patio. The flames glow against the backdrop of a calm lake at sunset, with soft pink and orange hues reflecting on the water's surface and a tree-lined shore in the distance.
Home in Lake Murray
4.95 out of 5 average rating, 210 reviews

10 Mile View on Lake Murray w/ Dock and Ramp

Enjoy our Waterfront getaway on Lake Murray. It includes a private boat ramp, private dock, and over 600 sq ft deck across the entire lake front of the home. The front yard is large and perfect for cornhole, frisbee, and other activities. This cove is known for excellent kayaking, fishing, boating, and watersports. We have included 2 Kayaks and we work directly with a pontoon rental company if you would like a boat delivered. The .4 acre lot has plenty of parking for all guests.

Top guest favorite
A modern kitchen with sleek white cabinetry and granite countertops is highlighted. Four black bar stools are positioned at an island, and stainless steel appliances, including a stove and refrigerator, are visible. Natural light enters through multiple windows, creating a bright and functional space.
Home in West Columbia
4.99 out of 5 average rating, 149 reviews

Golden Reflections Getaway

Welcome to the Golden Reflection Getaway—a spacious, stylish retreat perfect for families and groups. Enjoy this 2,600+ sq. ft. spacious family area with three luxury themed bedrooms upstairs and extra sleeping options with a full bathroom on the main level. Tucked away in a peaceful neighborhood, just 7 minutes from the vibrant heart of Downtown Columbia and 18 minutes from Fort Jackson. Relax, recharge, and make lasting memories in this thoughtfully designed and comfortable home.

Top guest favorite
A tranquil lakeside scene features a circular stone fire pit surrounded by black Adirondack chairs. The vibrant sunset reflects on the calm water, with lush green trees framing the view, creating a serene outdoor space for relaxation.
Home in Camden
4.95 out of 5 average rating, 119 reviews

Big Water Sunset at Lake it Easy

Escape to Beautiful Lake Wateree for a relaxing weekend away with friends or family. This updated house features 2 bedrooms & 2 bathrooms. Enjoy the cozy vibes of a tastefully decorated space, perfect for unwinding after a day on the lake. Step outside to a serene screened in porch, a fire pit, and stunning big water sunsets that will take your breath away. Whether you're into fishing, kayaking, or simply relaxing by the water, this lakefront house has something for everyone!

Top guest favorite
A spacious living area features a warm wooden door, large windows allowing natural light, and a cozy seating nook with cushions. A flat-screen TV is mounted on the wall above a fireplace, while light-colored wood accents enhance the ambiance.
Treehouse in West Columbia
4.99 out of 5 average rating, 710 reviews

Luxury Treehouse in the heart of Columbia

Mid-Century Modern Treehouse with no stairs to climb but walk across a bridge thru beautiful professionally landscaped gardens onto a spacious deck with a hot tub. The view is over a bubbling creek set back into the woods. The barbecue grill and fire pit area complete with a twinkling chandelier and string lights. Relax inside and curl up and watch a movie in front of the fireplace! You have parking next to a walkway located between the treehouse and gardens next to our home.

Top guest favorite
An open-concept living space showcases a modern kitchen with white cabinetry and a large island featuring granite countertops. Elegant archways lead to the dining area with a wooden table. Ample natural light fills the room, highlighting the hardwood floors and contemporary chandelier.
Home in Columbia
4.99 out of 5 average rating, 472 reviews

Elmwood Retreat for Remote Work & Family Fun

Come and enjoy your stay at Elmwood Retreat, a beautifully renovated 4 BR home in historic Elmwood Park. Built in 1905 and updated with modern comfort, it's perfect for remote work, family trips or extended stays. Enjoy high-seed Wi-Fi, a dedicated workspace, and a peaceful neighborhood. Steps from Main Street and the Vista and close to Riverwalks, museums, parks and Colonial Life Arena, this home offers charm, safety and convenience, for every guest to feel home.

Top guest favorite
A charming cottage features a sloped roof and rustic brick exterior, surrounded by lush greenery. Natural light filters through the trees, enhancing the serene setting. A hammock and seating area are visible in the background, inviting relaxation in the natural surroundings.
Cottage in Gaston
4.96 out of 5 average rating, 751 reviews

Congaree Vines - Woodland Cottage by a Vineyard!

-Enjoy a Quiet Country Stay! This charming European style cottage is set by a Hobby Vineyard! Enjoy complimentary port wine from our vineyard, a fire pit and hammock under the stars! -Congaree Vines also has the Barn Bungalow. Pets are welcome for a fee. If service dog, bring paperwork. -We are near Congaree National Park (33 min), Columbia, USC, Ft. Jackson, Airport I-26 & Hwy 77. -15% off Guided Kayak in CNP w/Carolina Outdoor Adventures.

Guest favorite
A historic log cabin is nestled among tall trees, with lush greenery surrounding it. The cabin's porch overlooks a serene lake, reflecting the natural beauty of the landscape. Sunlight filters through the leaves, creating a tranquil outdoor space by the water.
Cabin in Prosperity
4.91 out of 5 average rating, 195 reviews

Historic Log cabin on private fishing lake

Magnificent historic Log Cabin located on the shores of a private 10 acre lake surrounded by over hundreds of acres of forested isolation. One mile into the woods and away from the stress, hustle and bustle of everyday life. Access to 100 acre parcel for walking trails, fishing, canoeing, swimming, campfire and wildlife. Great opportunity to unplug from the stress and engage with family and friends! A great spot for an artist retreat!

Guest favorite
An outdoor fire pit surrounded by several blue adirondack chairs is set on a gentle slope near the lake. Tall trees provide shade as soft sunlight filters through the leaves, casting a warm glow over the peaceful scene.
Home in Lake Murray
4.91 out of 5 average rating, 119 reviews

Lazy Creek Cove Cottage w EV Plug!

Welcome to Lazy Creek Cove Cottage - your luxurious lakefront retreat! This charming Airbnb offers a serene getaway with a hot tub, private dock, paddle boards, kayaks,a fire pit, and a NEMA 14-50 outlet for EV charging or Camper. Enjoy a cozy living space, well-equipped kitchen, comfortable bedrooms, and reliable internet access. Immerse yourself in nature's beauty, explore the nearby attractions in Chapin.

Popular amenities for Midlands of South Carolina vacation rentals