Hotel vacation rentals in Lee County

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Top-rated hotel rentals in Lee County

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An aerial view captures the coastline of Estero Island, showcasing a blend of sandy beaches and gentle waterways. The calm waters meet the shore, revealing lush greenery along the banks, with distant views of the horizon and coastal landscape under a clear blue sky.

Hotel room in Fort Myers Beach

4.87 out of 5 average rating, 46 reviews

Comforts of Home. 2 bedrooms 2 baths, pool View.

Tropical Sands Resort is a 39-unit Resort on Estero Island. The resort offers 2-bedroom, 2-bath, 1350 square foot condominiums. Amenities on property include heated outdoor pool, 8 seat spa, work out room, bicycles (complimentary), video cassette payers, radio/CD players/3 TV’s, washer/Dryer in unit, onsite activities and much much more. Tropical Sands Resort offers both weekly rents and ownership. Guests checking in must meet the minimum age requirement of 23. The rates are comparable to hotel rates but our visitors get much more for their money! Tropical Sands Resort is located near many tourist attractions including the beach, great restaurants, the Thomas Edison Home and spring training for major league baseball. Please do not hesitate to ask for those “little extras” we might be able to provide you to make your stay with us the most enjoyable you have every experienced.

A panoramic view captures the serene shoreline of Ft. Myers Beach, with soft white sand meeting gently lapping waves. The setting sun casts a warm glow over the Gulf of Mexico, while nearby buildings and distant beachgoers create a relaxed coastal atmosphere.

Hotel room in Fort Myers Beach

5 out of 5 average rating, 3 reviews

Resort Relaxation Unit #2 is Ready for You!

In Ft. Myers Beach - your pool beach view 7th floor suite awaits your arrival for an entire week of relaxation & fun. Enjoy Diamondhead Resort Amenities, The Cabanas Bar & Grille is open. Relax by the pool or take strolls along the beach. Take a short walk down the Blvd. to the nearby Food trucks while Ft. Myers Beach is making improvements. A full service kitchen is in the unit & there's a Publix's for groceries or stop to pick up groceries before you take the bridge over to get to the resort.

A waterfront view showcases a vibrant two-story building surrounded by greenery. Bright blue lounge chairs are positioned along the deck, with kayaks and paddle boards resting nearby. The expansive outdoor space, framed by tropical plants, invites relaxation and outdoor activities.

Hotel room in Bonita Springs

4.83 out of 5 average rating, 799 reviews

Latitude 26 Boutique Resort (Deluxe King Studio)

Latitude 26 Waterfront Boutique Resort. Perched on a bay just down from Barefoot Beach. This beach decor studio comes with fireplace, streaming TV, beach rock shower, king bed, kitchenette with fridge,sink,microwave,coffeemaker,hot plate, cutlery,dishes. We are located right on the water with a dock. We have a plunge pool, complimentary bicycles, kayaks, and paddle boards available for you to explore! Come stay in style, less than a mile to Barefoot Beach. Complimentary continental breakfast.

Guest favorite

A heated pool is surrounded by lush tropical landscaping, featuring several lounge chairs and umbrellas. Additionally, a shaded tiki hut and barbecue grill are visible nearby, creating a relaxed outdoor space.

Hotel room in Bonita Springs

4.71 out of 5 average rating, 122 reviews

Bonita Beach Inn & Suites King ADA Accessible 106

Each room comes fully sanitized prior to your arrival. There will be a door code sent through chat, allowing for a 24 hour check-in. The Bonita Beach Inn & Suites is located in Bonita Springs just 1.2 miles from Bonita Beach while also providing guests easy access to restaurants, nature parks, shopping and entertainment. The Bonita Beach Inn & Suites offers guests a unique mix of hotel suites and 1 bedroom courtyard villas. The Bonita Beach Inn & Suites provides guests with a heated pool.

A spacious covered patio features a dining table surrounded by blue chairs, offering a view of the landscaped garden. Light-colored walls and flooring create a bright atmosphere, while large windows allow natural light to fill the area. A ceiling fan adds comfort to the space.

Hotel room in Sanibel

5 out of 5 average rating, 3 reviews

Driftwood Inn Cottages

Enjoy your vacation at this 4-cottage boutique inn, perfect for a quick secluded tropical getaway with its close proximity to all of the restaurants, shopping, and bike trails of Sanibel Island. All 4 units feature open living and dining areas, convenient and full kitchens, private lanais, two bedrooms, and two bathrooms. A 5-minute walk takes you to the private beach access at the end of Donax St and spills out to the sparkling, shell-filled waters of Sanibel. Relax, Unwind, Drift Away

Superhost

A light-filled living area features a comfortable white couch adorned with decorative pillows. A soft rug lies beneath a modern coffee table. Large sliding glass doors open to a balcony, providing scenic views and natural light. A reading nook is created with a cozy chair.

Hotel room in Bonita Springs

4.69 out of 5 average rating, 36 reviews

Penthouse studio with gulf views

Nestled directly across the street from the famous Doc's Beach Bar and mere steps from Bonita Beach Access #1, this penthouse studio promises an unforgettable stay with mesmerizing views of the Gulf of Mexico. Experience convenience paired with serenity in a location that places you within walking distance of local favorites like Coconut Jack's and The Fish House. Downtown Naples is just a 25-minute drive away, while Fort Myers Beach is a quick 20-minute journey.

Top guest favorite

A modern bathroom is presented, featuring a spacious double vanity with two sinks positioned beneath decorative mirrors. A walk-in shower with glass doors is visible, alongside light marble tile. An open closet area is seen in the background, offering additional storage options.

Private room in Fort Myers

4.97 out of 5 average rating, 93 reviews

A perfect place to be on vacations

It is a beautiful one bedroom apartment with a private bathroom, walking closet, 40” TV, Microwave, medium refrigerator and more utensils needed. Near to fort myers beach (35 minutes)and bonita Beach( 25 minutes) , sanibel and captiba islands . It has a private driveway and furniture patio for you to enjoy. There is a queen bed with confortable mattress. There is a sofa bed that acomódate 2 more people.

Resort in Fort Myers Beach

4.75 out of 5 average rating, 4 reviews

Beachfront Lani Kai Island Resort - Standard King

For nearly four decades, the Lani Kai Island Resort has welcomed guests from all over the world. The Conidaris Family has developed the Lani Kai Island Resort on Fort Myers Beach into the amazing and iconic property it is today. From the beginning, the hotel was the passion project of Bob & Grace Conidaris who wanted to create a fun, energetic place for both guests and the community.

Superhost

A modern bathroom sink area features a smooth countertop and a sleek faucet. Personal toiletries are neatly arranged beside the sink. Natural light is filtered through the window covered by white blinds, illuminating the space.

Hotel room in Boca Grande

4.5 out of 5 average rating, 12 reviews

Spotted Seatrout, One Bedroom King Suite

The Palmetto Inn is a historic seven-suite inn at the heart of Boca Grande, Florida. Originally built in 1900 as a private residence, it was converted to an inn 13 years later. The Inn is located on a quiet street, just one block away from beaches, downtown shopping, and the historic Gasparilla Inn!

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What guests are saying

Latitude 26 Boutique Resort (Studio with Deck)

4.8 out of 5 average rating, 61 reviews8 months ago

Latitude 26 at Bonita Springs was such a cozy place for our weekend getaway. We took advantage of the free bicycles and kayaks and the breakfast was plentiful. Checking in was super easy and the place was comfortable. I called ahead of time and requested room 10 which was perfect for us. Coming back soon, this time with the whole family! Restaurant next door was an added plus!

Hotel room in Bonita Springs

What guests are saying

Pinfish, Queen Studio Room

4.42 out of 5 average rating, 19 reviews9 months ago

We’ve stayed in The Palmetto Inn various times throughout the years, and as usual, this visit didn’t disappoint. It was a kids free trip and my husband and I were booked in the Pinfish Room. The pinfish is perfect for couples. We’ve stayed in every room they offered (with kids and without) and for a couples-only trip I think Pinfish is my fav. We were able to check in early, we were greeted enthusiastically and with kindness, and the Palmetto Inn was clean, especially our room! We adore Boca Grande and one of the great things is to experience it in different places. You can’t go wrong with The Palmetto Inn.

Hotel room in Boca Grande