
Guesthouse vacation rentals in Lee County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Lee County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Palm Paradise | Quiet area | Fenced yard, Fire Pit
Book our family friendly, tropical themed guest house with high vaulted ceilings in SE Cape Coral today! Just a 10 min drive to Sun Splash waterpark, the Eco Preserve, downtown Ft Myers, and only a few mins to shops and restaurants. Less than 30 min to Ft. Myers beach & Sanibel Island. A fire pit, lush palm lined fenced yard, & outdoor umbrella patio table creates an amazing experience! INCLUDED FOR FREE ✔️ WiFi ✔️ Propane ✔️ Coffee and Tea ✔️ All kitchenette utensils ✔️ Beach Towels and more!

Waterfront Hideaway
This picturesque Airbnb is a hidden gem nestled along a canal, one minute boat ride to the Caloosahatchee River. The living room, bathed in natural light is perfect for taking in the scenic views. The spacious bedroom has a king-size bed, ensuring a night of blissful rest. The full kitchen is equipped with all modern appliances. Close to Sanibel & Fort Myers Beach. Bring your boat & dock it on the seawall, ready to set sail whenever your heart desires. Book now - your coastal paradise awaits!

Perfect Place for your Vacations
This Guesthouse has everything you need for your vacation, it is central located, in a peaceful and safe neighborhood and have a very well distributed space. Its located few minutes from the Caloosahatche River and the beautiful beaches of the Gulf of Mexico, it includes bicycles, kayaks, umbrella, beach chairs, fishing rods and other items that will enhance your vacation. It is also very close to highly recommended restaurants, famous shops (walmart,Publix, McDonald) and other essential places.

Hezekiah's 2 Story Guesthouse with Pool
Hezekiahs Guesthouse a perfect getaway in sunny SWFL! You will be staying in the guest house with a private entrance. This property has a living room and kitchenette downstairs and a spacious bedroom with master bathroom upstairs. This Airbnb is attached to our home. You will have access to the pool and our outside grill area. Complimentary coffee, water, soda and more.. Lots of nearby restaurants and shopping. Minutes away to Fort myers or Bonita beach, FGCU and RSW Airport and Hertz Arena.

Cozy haven
Enjoy a stylish experience at this centrally-located place (close to beach) This brand new space has one bedroom with a king bed, closet and dresser, blow up queen bed mattress and pull out single couch along with additional seating. It has a tub/shower combo in the bathroom along with a washer and dryer. The fully equipped kitchen has anything you need. Has Patio/deck. Guesthouse is completely private but entrance is through the detached garage. You will have your own code to access all doors

Get Away to the Mango Cottage
Nestled on the outskirts of Historic downtown Fort Myers abides the Mango Cottage overlooking the Caloosahatchee River. The sunsets are amazing. You will enjoy the luxurious linens on the King sized bed to the relaxing patio it will delight the senses. You will be able to enjoy the 60" flat screen Smart TV! . The cottage is complete with Keurig coffee maker, toaster, microwave/convection oven and grill outside. We are minutes from restaurants and night life. This is a NON-SMOKING property.

Saltwater Pool • Canal Front • Kayaks Provided
In S Fort Myers. Relax by the saltwater pool, then launch kayaks or a two-person canoe from the pet-friendly fenced backyard to explore mangrove-lined canals. Drive 13 miles to Sanibel Island, 6 miles to Fort Myers Beach. Walk to Lakes Park/Wednesday Farmers Market or Castle Golf (mini golf). Bike trails nearby. Close to Publix, shops & restaurants. Private 1st-floor guest suite with private entry, 1 bed, 1 bath & full kitchen. Owners live upstairs. Convertible sofa for extra sleeping space.

Sleep over the water- Boathouse with Private Dock
This 1920s boathouse offers a once-in-a-lifetime stay directly over Whiskey Creek, where the gentle sound of water beneath your feet lulls you to sleep. With a private entrance, dock and waterfront views, this isn't just a room--it is an unforgettable Florida experience. This boathouse has been ungraded with all modern conveniences and is centrally located close to downtown, restaurants and shopping. Sip your morning coffee on the dock as herons and bald eagles glide across the creek.

Adorable Estero Cottage - Heated Pool/Spa - Sauna
Come and relax in this calm, stylish space located on one acre property full of pines and fruit trees, with access to the House Heated Pool with Jacuzzi and the sauna. Modern design will make you feel comfortable. Close to Bonita, Ft.Myers, Lovers key and Sanibel beaches & fishing piers. Cottage is 12 miles away (19 km) from RSW airport, about 20 min of driving. We are happy to meet our guests, but also respect your privacy. Your comfort is our priority.

Seahorse Studio
Take it easy at this unique and tranquil getaway with a massive botanical garden (photos show plants from our half acre garden), water views, and pool access! We are 20-35 minutes from the ocean and even less from the beautiful river and connecting canals. Kayak the gorgeous canals and right iut to the Caloosahatchee river! See manatees, dolphins, gators and a plethora of birds and other wildlife! Please do not tresspass on neighboring properties.

Bright, Private Studio Retreat in Cape Coral, FL
Welcome to your home away from home. This studio rental is detached from the main house, giving you absolute privacy and a quiet space to relax. The kitchenette is fully equipped with all the essentials to cook real meals. Step outside and you'll find a small private patio that's all yours, perfect for morning coffee or just getting some fresh air. You've also got your own parking spot in the driveway, so no need to stress about street parking.

Charming Carriage House in Historic Neighbourhood
This lovely carriage house backs onto the famous Edison Ford Estates making it a truly unique location- you really don’t have far to go to explore its beautiful gardens! Hit the Downtowns restaurants, bars and shops nestled within Art Deco architecture in stunning pastel colours for a real ‘Old Florida’ experience! DT is a 20 minute walk away or take advantage of the free trolley service from Nov-May 1. SWF airport 17 miles.
Popular amenities for Lee County guesthouse rentals
Family-friendly guest house rentals

Private Casita in Lehigh Acres • Parking

Downtown Ft Myers |The Bamboo Nest | Pet Friendly

Caloosahatchee Cottage - Waterfront, 5 min to D/T

“Luxury Efficiency in San Carlos

Sun Spotters Pet Friendly

Cozy Suite Near Historic River District & Beaches!

Private Bungalow Ft Myers Home Near Beaches/FGCU

Island Oasis
Guest house rentals with a patio

1/1 Relaxing Retreat in Sunny Bonita Springs

Beachside Living – Walk to the Water!

Serene Studio Steps from the Water

Cozy Guest Suite with Private Entrance

Luxury on the Lake

Cozy Private Studio •Great location

Cozy tiny home

Adorable & spacious efficiency w/ full kitchen
Guest house rentals with a washer and dryer

Private guest house—minutes to the best beaches!

Downtown Fort Myers Florida - Home Away From Home

Julie’s Rivers Edge Retreat North Ft Myers

Barefoot Bungalow – Cozy 2 BR Beach Retreat

Modern Independent Tiny House

Florida Cottage with Pool, off McGregor Blvd.

The Flamingo Guesthouse on CANAL

Arden's Garden
Destinations to explore
- Smoking-friendly rentals Lee County
- Rentals with outdoor seating Lee County
- Rentals with beach access Lee County
- Vacation home rentals Lee County
- Luxury rentals Lee County
- Rentals with an accessible height toilet Lee County
- Rentals with a fireplace Lee County
- Rentals with a home theater Lee County
- Farmstay rentals Lee County
- Condo rentals Lee County
- Boutique hotels Lee County
- Resort rentals Lee County
- Beachfront rentals Lee County
- Ski-in/ski-out rentals Lee County
- Rentals with a kayak Lee County
- RV rentals Lee County
- Rentals with a sauna Lee County
- Hotel rooms Lee County
- Rentals with a washer and dryer Lee County
- Waterfront rentals Lee County
- Rentals with a hot tub Lee County
- Fitness-friendly rentals Lee County
- Villa rentals Lee County
- Rentals with lake access Lee County
- Rentals with a fire pit Lee County
- Rentals with breakfast Lee County
- Rentals with a patio Lee County
- House rentals Lee County
- Pet-friendly rentals Lee County
- Tiny house rentals Lee County
- Family-friendly rentals Lee County
- Private suite rentals Lee County
- Serviced apartment rentals Lee County
- Rentals with an EV charger Lee County
- Apartment rentals Lee County
- Cottage rentals Lee County
- Townhouse rentals Lee County
- Rentals with pools Lee County
- Guesthouse rentals Florida
- Guesthouse rentals United States
- Naples Beach
- Captiva Island
- Caspersen Beach
- Manasota Key Beach
- Englewood Beach
- Lovers Key Beach
- Myakka River State Park
- Florida Gulf Coast University
- Stump Pass Beach State Park
- Blind Pass Beach
- North Jetty Beach
- Bowman's Beach
- Barefoot beach Bonita Springs,FL
- Bonita National Golf & Country Club
- Jetblue Park
- Boca Grande Pass
- The Naples Pier
- South Jetty Beach
- Clam Pass Park
- Edison & Ford Winter Estates
- Yacht Club Public Beach
- Bunche Beach
- Ave Maria University
- Delnor-Wiggins Pass State Park
- Things to do Lee County
- Nature and outdoors Lee County
- Things to do Florida
- Wellness Florida
- Art and culture Florida
- Tours Florida
- Entertainment Florida
- Sightseeing Florida
- Food and drink Florida
- Sports activities Florida
- Nature and outdoors Florida
- Things to do United States
- Tours United States
- Food and drink United States
- Sightseeing United States
- Entertainment United States
- Sports activities United States
- Art and culture United States
- Wellness United States
- Nature and outdoors United States





