
Guesthouse vacation rentals in Gainesville
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Gainesville
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Gainesville guesthouse rentals
Family-friendly guest house rentals

King room at Pareners Branch Creek Guesthouse
This place was a perfect getaway for us. The pool area is amazing and so relaxing. My family enjoyed the pickleball and basketball. The beds were so comfortable and the room was very clean. Jane greeted us and was very friendly and accommodating. We would love to visit again.

Studio loft/ kitchenette/porch/bath
Absolutely loved Dianne’s barn loft space! The property is beautiful and peaceful and the loft has a lot of character, a welcome change from the typically cookie cutter AirBnB decor. Dianne was very kind and accommodating of us parking our car with trailer at her place in the midst of cross country moving road trip.

Renovated Private Studio - Walking Distance to UF
Came down for my son to attend Florida days. This place is absolutely perfect. The bathroom is amazing. This place has everything you need. Perfect little studio. Exactly as described and even better in person. This will be my go-to place when I visit my son!

Gator Getaway
A great, cozy place to stay. Its the closest place you will find right next to the Easton Archery Center.
Guest house rentals with a patio

Papy's Place - Horse Farm Retreat
We had the best experience! We arrived after dark the first day and was immediately greeted by the sweet dog Athena who met us at the gate and showed us back to the house. After settling in we went outside and were greeted by a pony and a large horse. Super magical setting! Dawn was really responsive and the house was clean and beautiful. We would book over and over again!

Hilltop Retreat
This place is amazing! Situated on a working farm with donkeys, cows, horses, goats, and a handsome pig named Junior! Amazing place to stay with children or enjoy the quiet peaceful sounds of nature on 20 acres. The home was very clean and cozy. Bed was soft and comfortable. Plenty of utensils and flatware to cook for yourself. 10/10 would stay any day! Christina was so kind enough to allow our family to walk the farm and feed/pet all the animals. I almost forgot about their beautiful farm pup, Molli! Thanks for an unforgettable stay! We hope to return.

The house of smiles.
Great stay! Angela is very responsive and fixed and issue with the tv/internet. Thanks Angela!

Horning’s Guest House -room for 14
Stayed here for a day trip and this place was so nice!! The owners were so communicative and hospitable, even bringing us eggs, milk, and other condiments, The snow cone machine was so good, and we loved the variety of syrups for coffee! Everyone had a great time and there were more than enough spaces for people to sleep on. Will definitely have to book again😆

Walk to UF! Historic King Bed Loft w/ Private Deck
We were comfortable in the space. Very convenient location to our points of interest. Would definitely book again.

Our Nest Cute House!
Luis is by far the best host I’ve encountered on Airbnb—kind, helpful, and incredibly responsive. The place was clean, cozy, and quiet, all at a great price. What more could you ask for? Highly recommended!!

"Nest" in the Guest House up in the Trees near UF
We loved our stay in this beautifully appointed home. The kitchen was stocked with everything we needed to prepare a meal, and there were even snacks and drinks upon our arrival. Deborah goes above and beyond to make sure her guests feel welcome and well accommodated. We are so glad we found this very special place and will definitely return when visiting Gainesville again.

Blue Springs Suite on 5 beautiful acres
This place was really beautiful down to the last detail. You can tell they customized this whole building and all of the decorations were absolutely gorgeous. We really enjoyed our stay and will be back next time. We are in high Springs.
Guest house rentals with a washer and dryer

Downtown Studio - 1/2 Mile from UF Campus
Nice small guest house to stay in, right next to UF. Perfect for our needs.

Mother in Law suite/Apartment @ Staycation
Another fantastic quick stay at this Airbnb in downtown High Springs! The location is unbeatable—just a short walk to great restaurants, shops, and coffee spots, and only a quick drive to the beautiful natural springs. The home was clean, comfortable, and had everything I needed for a relaxing stay. Whether you're here for outdoor adventures or just to enjoy the charming town, this is the perfect place to stay. I’ll definitely be back!

Cedar Guesthouse
It was a perfect location for visiting my children at the University of Florida. I had a great stay, I felt at home. The only thing was that there was no soap or shampoo, but fortunately I had brought my own. I would definitely stay there again.

Palm N' Pillow • Guesthouse by UF, HCA-FL & Shands
Great stay!! Super cute and cozy.

Garden Cottage Sanctuary
By far, the best place I have stayed in Gainesville. The home was lovely and very safe for someone traveling by themselves. Laura was a fantastic host by offering local suggestions and even had a welcome bottle of wine and snacks waiting on me. I will plan my work trips around availability as this is now the only place I want to stay.

Tudor Farm Serenity Cottage
Cheri's place was perfect for our weekend getaway in Ocala. Check-In & Out was a breeze. The cottage was new, clean, and comfortable. We enjoyed the fire pit at night while our two beagles enjoyed exploring the large fenced in yard. Affordable stay all while being 5 minutes away from the World Equestrian Center. Would book Cheri's place again! Thank you!

Lovely Studio Apt, Walk to UF
Beautiful and quiet neighborhood, close to everything but feels away from everything. The suite is so comfortable and just what we need. Will stay again and again.

Amazing farm cottage !
The property is very nice and on a quiet country road where you can escape the sounds of city life and enjoy the quiet and see the stars in the night sky. It is very dog friendly with plenty of room for them to run around while being surrounded by horses in fields. Don and Keara are great hosts and are very responsive and friendly when you run into them on the horse farm taking care of the horses. This is definitely a must-stay place if you’re looking to get away from the fast-pace of city life!
Quick stats about guesthouse rentals in Gainesville
Total rentals
30 properties
Nightly prices starting at
ﺩ.ﺇ110 before taxes and fees
Total number of reviews
4.2K reviews
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Wifi availability
30 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
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- Ginnie Springs
- Rainbow Springs State Park
- Manatee Springs State Park
- Gilchrist Blue Springs State Park
- Paynes Prairie Preserve State Park
- Ichetucknee Springs State Park
- Eagle Landing Golf Club
- Ocala National Golf Club
- Florida Museum of Natural History
- Citrus Springs Golf & Country Club
- Ocala Golf Club
- Ravine Gardens State Park
- Depot Park
- Fanning Springs State Park
- The Preserve Golf Club
- Ironwood Golf Course