Vacation rentals in East Prairie

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Top-rated vacation rentals in East Prairie

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Guest favorite

The rustic treehouse is positioned near the water's edge, reflecting beautifully in the calm lake. Surrounded by trees, the structure features a wraparound deck on stilts, offering a serene view of the private lake at sunrise.

Cabin in Vienna

4.83 out of 5 average rating, 301 reviews

Samson's Whitetail Mountain Lakeside Cabin

The rustic lakeside treehouse has two bedroom loft upstairs, one lower bedroom, amazing views of our private lake and an assortment of animals (deer, axis, fallow, elk, and rams) that roam freely on the gated property. Enjoy kayaking, fishing,or lounge around the lake. Plan a trip to Garden of the Gods, Jackson Falls, Tunnel Hill Trail or Shawnee National Forest finishing the evening roasting hotdogs around the fire. *No parties or events allowed during your stay. DOOR CODE SENT PRIOR TO ARRIVAL

Top guest favorite

The cabin's welcoming entrance features a wooden porch supported by sturdy beams. Two rocking chairs sit on the porch, surrounded by greenery and stone accents. A red door and a large window enhance the cabin's rustic charm, while the natural setting invites relaxation.

Cabin in Cobden

4.99 out of 5 average rating, 126 reviews

Pop’s Country Cabin

Pop’s Country Cabin is a small remote cabin that sits 1/2mile off the road above a 5 acre lake on 77 acres of private land. The view from the front porch is amazing! You can sit, unwind, and watch the wildlife with a distant view of Bald Knob Cross. The cabin sits in the heart of Shawnee National Forrest and the Southern IL wine trail. You can enjoy the fire pit while watching the stars, with no distractions from neighbors, traffic, or lights. You can enjoy catch & release fishing from the bank

Top guest favorite

The exterior of a charming house is displayed, featuring a red and white color scheme. A covered porch with a swinging bench is visible, along with a flag pole supporting an American flag. Two windows allow natural light to enter the home.

Bungalow in Karnak

4.98 out of 5 average rating, 114 reviews

Trails End Tunnel Hill Bike Trail Overnight Stay

Located at the end of the 58 mile Tunnel Hill Bike Trail. Fully furnished with full size kitchen, bathroom with shower, bedroom and pool table. No need to pack, all the basic essentials are provided including, but not limited to, bottled water, paper plates, utensils, towels, soap, shampoo, toothpaste, coffee, juice, milk, bread, etc. If it's not there, the Dollar General Store is located 5 blocks away. Full size bed, room for 2 additional people, inflatable mattress available upon request.

Guest favorite

A cozy outdoor gathering area is illuminated by string lights at dusk. Several turquoise Adirondack chairs are arranged around a fire pit, inviting relaxation and conversation. A wooden structure stands nearby, enhancing the space's welcoming ambiance.

Home in Union City

4.93 out of 5 average rating, 137 reviews

Rosie's Retreat new w outdoor kitchen & fire pit!

Completely refurbished and modernized, Rosie's Retreat has 2 bedrooms each with a queen bed, large closet, and fireplace. There is additional sleeping space for 2 on the queen sectional/sofa bed and 1-2 more on the futon in the dressing room! Rosie's has 1 full bathroom, but an additional spacious dressing room with lots of mirrors and more. Rosie's has a full kitchen with everything you need for cooking. There is a grill, large fire pit, and plenty of comfy Adirondack chairs for hanging out!

Guest favorite

A modern kitchen with stainless steel appliances is presented. White cabinets provide ample storage, complemented by a neutral-toned countertop. Natural light brightens the space through a window, while a comfortable sofa with patterned cushions sits nearby, creating an inviting atmosphere.

Tiny home in Bloomfield

4.94 out of 5 average rating, 104 reviews

1-bedroom tiny home located in historic Bloomfield

Kick back and relax in this calm and stylish space located minutes from the Missouri Veterans Cemetery and The Stars and Stripes Muesum and Library. 1bdrm/1bath comfortably sleeps 2 and is furnished with everything you need. Inside you will find all new appliances, bedding, and linens. Circle drive with parking. No smoking or pets allowed. Local restaurants include Las Brasis and Elderland. Or try out locally owned businesses just 6.5 miles drive to Dexter such as Hickory Log and Dexter BBQ!

Superhost

A spacious dining area is seen with a glass table surrounded by light blue chairs. A stylish chandelier hangs overhead, illuminating the space. Decor includes a large area rug and decorative elements, while bicycles are parked nearby, hinting at an outdoor adventure option.

Apartment in Cape Girardeau

4.85 out of 5 average rating, 622 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Top guest favorite

The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 151 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Top guest favorite

A cozy living area features a stone fireplace complemented by a wooden mantel. Comfortable seating includes two armchairs and a spacious sofa. A television is situated on a dark wood cabinet, with natural light filtering through the partially opened blinds.

Cabin in Martin

4.99 out of 5 average rating, 130 reviews

Gated Country Retreat with Lakeview

This rustic lakeside home boasts 4 sleeping rooms, 3 bathrooms, and an upstairs bonus room. An ideal base to explore Martin, just 3.5 miles from city limits of Martin. To relax, try the surround jets in the master shower! Note: We only own the house and part of backyard. We do not own the lake, the land around the lake, or the shop behind the house. Fishing and recreation are not allowed on the lake at this time. High speed fiber internet is coming in 2026. Current WiFi is slow

Guest favorite

A modern farmhouse is depicted at sunset, featuring a welcoming entrance with a covered porch. A stone pathway leads to the front door, bordered by a grassy lawn that extends to fields and trees in the background.

Barn in Cape Girardeau

4.94 out of 5 average rating, 212 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Superhost

The exterior of a newly renovated home is showcased, featuring a brown brick façade, a welcoming front porch with seating, and decorative flower pots. A well-kept lawn leads to a gravel driveway that provides access to the entrance.

Home in Sikeston

4.94 out of 5 average rating, 17 reviews

Newly Renovated 3 Bedroom 2 Bath Home - Sleeps 9

Looking for a spacious and welcoming Airbnb in Sikeston? 🏡✨ This gorgeous, newly renovated 3 bedroom, 2 bathroom home is the ideal destination for unforgettable memories with your loved ones. The house sleeps up to 9 guests comfortably, making it perfect for families and groups. Conveniently located in a fantastic residential area, you're just moments away from local attractions, shopping, and dining spots.

Top guest favorite

A cozy bedroom features a dark brown accent wall, providing a warm backdrop for a spacious wooden bed dressed in crisp white linens. A small seating area with a round table and chairs is positioned nearby, with soft lighting from a stylish chandelier above.

Home in Clinton

4.99 out of 5 average rating, 179 reviews

The Peery House at Springhill Farms

The Peery House is our family home-place, built circa 1900, transformed into a quaint Airbnb. It is located on our farm, Springhill Family Farms in Western KY and is a great place for someone looking to get away from the busyness of life, looking for rest and relaxation or just looking for a unique, little farmhouse while passing through the area.

Guest favorite

The exterior entrance features a covered porch with white railings and brick accents. A welcoming front door is framed by large windows, while a well-maintained lawn extends alongside the porch. The porch provides easy access to the home in a peaceful neighborhood.

Home in Dexter

4.92 out of 5 average rating, 108 reviews

Home Away from Home

If you're gonna stay in a small town, you might as well make yourself at home! That is just what this airbnb offers. A complete house in a quiet neighborhood in southeast Missouri, located across the road from Dexter's main park and right off the main road. Make this homey two bedroom house yours for a short while.