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Vacation rentals in Chepo

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Chepo

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Tiny home in Islas Maqui
5.0 out of 5 average rating, 11 reviews

Overwater Paradise Cabin| AnsuBirya | San Blas |

🌴 Stay in a traditional waterfront hut in the heart of the paradise-like San Blas archipelago. Surrounded by a turquoise lagoon, white beaches, and palm trees, it offers a unique getaway away from the crowds and mass tourism. Spend your days snorkeling, swimming, and exploring uninhabited islands with our kayak, which is provided with the cottage, and spend your evenings admiring the spectacular Caribbean sunsets. Indulge in seafood from our top chef, Ibin. The offer includes 3 meals a day in the restaurant.

Guest favorite
Home in Distrito de Monterico
5.0 out of 5 average rating, 12 reviews

Cozy and Safe Atmosphere Near the Airport

An ideal house to enjoy a comfortable and peaceful stay with independent access. It has 2 spacious bedrooms (1 with a queen-size bed and air conditioning, the other with 2 single beds and a fan), 1 full bathroom, a living room with comfortable furniture, a dining room, an equipped kitchen, a laundry room, free parking, a terrace, Wi-Fi, and a 50" TV. Located on a traffic-free street with easy access to main avenues, shopping malls, and transportation, and just minutes from the international airport.

Guest favorite
Apartment in Panama City
4.93 out of 5 average rating, 160 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favorite
A serene river flows beside the property, surrounded by lush greenery and rocky formations. Trees and tropical plants frame the scene, while small cascades create a gentle noise, enhancing the tranquil atmosphere of the natural landscape.
Cottage in Panama City
4.92 out of 5 average rating, 121 reviews

Round House River Dreams Cerro Azul

Get away from it all and relax in an idyllic tropical rustic retreat set beside a beautiful river with small cascades in the mountains of Cerro Azul. This spacious 2-story, one bedroom home is ideal for couples, small families or groups, with ample space to sleep 6 to 7 people. The property lies within Charges National Park with all its tropical flora and fauna, blue butterflies, hummingbirds, waterfalls and walking trails at your doorstep. Come experience this unique vacation home destination.

Top guest favorite
Place to stay in Panama City
5.0 out of 5 average rating, 20 reviews

Casa Condal - Your Luxury Retreat in Cerro Azul

Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

Superhost
Cabin in Panama City
5.0 out of 5 average rating, 5 reviews

Club House facing the lake with dock, jacuzzi and BBQ

Wake up by the lake in Cerro Azul, where nature and design come together in perfect harmony. This modern house offers 4 bedrooms with private bathrooms and 2 guest bathrooms, making it ideal for special celebrations, intimate weddings, or unforgettable gatherings with family and friends. Its open-plan, industrial-style kitchen is complemented by spacious areas and a terrace that blends into the landscape. The master suite, featuring a Jacuzzi, invites you to unwind and reconnect with yourself.

Top guest favorite
Boat in San Blas Islands
5.0 out of 5 average rating, 8 reviews

Private Catamaran live on board

Welcome aboard catamaran Yoyo, your floating home in the San Blas Islands. Your stay includes breakfast and snacks, with an optional meals and drinks package for USD 80 per person per day. For stays of 5 or more days, meals and drinks are included. Spend your days swimming, snorkeling, fishing, exploring hidden beaches, or relaxing on deck, and your nights unwinding under the stars. Experience the perfect blend of adventure, freedom, and laid-back island living with all the comfort you need.

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.97 out of 5 average rating, 87 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favorite
An outdoor space features a heated pool surrounded by light-colored tiles. A covered patio includes modern seating arrangements and a table, suitable for dining. Lush greenery is visible beyond the walls, with a glimpse of the sky above, providing a bright and open feel to the area.
Home in Vacamonte
5.0 out of 5 average rating, 43 reviews

The Hidden Gem

Here you will find your home away from home in this hidden gem. Furnished with all of the creature comforts, you will have plenty to do from relaxing on the patio while listening to music, to taking a dip in the heated pool, to relaxing on the comfy couch and watching Netflix. The house is situated on a beautiful gated beach property where you can find various activities from kayaking to the local water park. You can find the relaxation you were searching for here in this hidden gem.

Superhost
A tranquil dipping pool is framed by lush greenery, featuring white loungers and a large umbrella for shade. The pool area exudes a serene vibe with vibrant bougainvillea in the background, enhancing the inviting outdoor space.
Home in Taboga Island
4.94 out of 5 average rating, 221 reviews

Casa Rosie - Dream Home on Tabogá Island

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Guest favorite
Cabin in Panama City
4.93 out of 5 average rating, 91 reviews

The Crystal House: Luxury Modern Wood Cabin

Create unforgettable memories at this unique and family-friendly place. Stay in a cabin in the middle of Chagres National Park, 50 minutes from the city. You can be in contact with nature while having all the comforts of a luxury accommodation. With one of the best views of the city, you can enjoy a good barbecue, a nap in the hammock, or a meeting around the fireplace. Relax and connect with the beautiful green of Panama. We'll be waiting for you!

Top guest favorite
A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.
Home in Distrito Arraijan
4.98 out of 5 average rating, 233 reviews

Tropical Haven with Pickleball/Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Popular amenities for Chepo vacation rentals