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Apartment vacation rentals in Santa Fe

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Santa Fe

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in Miguel Hidalgo
4.84 out of 5 average rating, 125 reviews

Curated Apt w/Balcony | Prime District+Rooftop

Wake up in Polanco and enjoy one of Mexico City’s most sophisticated neighborhoods, steps from renowned restaurants, museums, and high-end boutiques. This apartment features contemporary design, a private balcony, and a curated atmosphere to unwind after exploring the city. The building offers a jacuzzi terrace, fully equipped gym, and a lounge with a pool table. Steps from Masaryk Avenue, Antara, and the Soumaya Museum. Ideal for urban getaways, couples, or flexible stays in a prime location.

Top guest favorite
Apartment in Polanco
4.97 out of 5 average rating, 335 reviews

Luxury Polanco Stay | Best Location+Daily Service!

IN THE HEART OF POLANQUITO—steps from PARQUE LINCOLN & one block from Presidente Masaryk—this spacious 3BR retreat blends boutique-hotel comfort with local charm. Wake to tree-lined views; stroll to cafés, restaurants & museums incl. Anthropology Museum; return to relax in style. Enjoy rare perks: weekday housekeeping (Mon–Fri—beds made, dishes done), concierge connections, welcome basket, smart-lock entry, fast Wi-Fi & family amenities (crib & high chair on request). Laundry service available.

Top guest favorite
A modern dining area features a glass table with six chairs, accompanied by decorative vases and greenery. A comfortable living space is visible, highlighted by large windows offering city views and showcasing a lounge area with a sectional sofa and a wall-mounted TV.
Apartment in Cuajimalpa
4.96 out of 5 average rating, 107 reviews

Depa AvSantaFe yParqueLaMexicana

Disfruta de una gran experiencia sobre Av. Santa Fe, pegado al Parque la Mexicana y con acceso directo al parque (a un costado). El edificio está arriba del supermercado City Market, y cuenta con grandes amenidades. Disfruta del gimnasio muy bien equipado, billar, sala de juegos, terraza, sala de cine, ludoteca, rooftop con vistas panorámicas de toda la ciudad, etc. El depa está en piso 15, cuenta con 1 cajón de estacionamiento, cafetera super automática, aire acondicionado y calefacción.

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.88 out of 5 average rating, 128 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Top guest favorite
A spacious living area features a gray sofa and a minimalist chair on a textured rug. A coffee table sits in the center, surrounded by natural light from large, framed windows. A modern staircase leads to the upper level, complemented by a pendant light overhead.
Apartment in Roma Norte
4.9 out of 5 average rating, 338 reviews

Award-winning Loft in Roma´s Heart 24/7 Security

Design department. NEW and with an unbeatable location in Colonia Roma; Walk to the best restaurants, Galleries, and cafes but stay in a quiet area. Rosetta and Orinoco are just a stone's throw away, as are OMR Gallery and Luis Cabrera Park. There is simply no better location. Are you arriving early or leaving late? Don't worry, our doorman will store your bags at no cost. The apartment is impeccable and has all the services. The building has won several prestigious design prizes.

Superhost
Apartment in Polanco
4.89 out of 5 average rating, 465 reviews

Kukun Homero Polanco

You’re about to discover your next stay! We’re thrilled to welcome you to our apartments. This building is not only in a prime location, but it also tells a story that celebrates contemporary Mexican art and culture. From handcrafted Talavera pieces made in Puebla to iconic quotes by renowned Mexican creatives like Octavio Paz and Alejandro González Iñárritu, every corner is designed to inspire you. Plus, you’ll get to enjoy one of the best views in the city.

Top guest favorite
A spacious living area is filled with natural light from large windows overlooking greenery. A comfortable sectional sofa and a minimalist wooden coffee table are positioned on a textured rug. Shelves with potted plants and decorative items provide a touch of nature and warmth.
Apartment in Roma Norte
4.98 out of 5 average rating, 142 reviews

Blue Rock Condesa

Blue Rock Condesa is a beautiful two-bedroom apartment in a housing complex built by a renowned Mexican architect, in the heart of Condesa. Its wide space with beautiful windows to the trees gives a feeling of volatility to the space. Fully equipped to generate a most welcoming stay. The apartment is located in the most beautiful area of the Condesa neighborhood. Staying at Blue Rock Condesa will make your experience in Mexico unique

Guest favorite
Apartment in Miguel Hidalgo
4.87 out of 5 average rating, 115 reviews

Premium Loft: A/C, KingSz Bed, Gym, Roof & Co-Work

Enjoy a premium experience in this central apartment with unique views, located in the heart of Mexico City and a few steps from Polanco. ✔ Air conditioning ✔ King Size Bed ✔ Rooftop ✔ Washer-dryer ✔ Business center ✔ Gym ✔ Children's playroom ✔ Designer furniture You will be located in the favorite colony by locals and travelers for its cultural offer and strategic location to move to all the most iconic sites in the city.

Top guest favorite
A spacious rooftop terrace features a Jacuzzi surrounded by lush greenery and modern outdoor furniture. A large glass enclosure offers panoramic views, while stylish pendant lights enhance the ambiance. A shaded area is created by a large umbrella, providing comfort for relaxation or social gatherings.
Apartment in Condesa
4.99 out of 5 average rating, 102 reviews

Epic Penthouse | Private Rooftop | Condesa

Welcome to our stunning penthouse (PH) in the heart of La Condesa, Mexico City's most vibrant and safe neighborhood. Recently remodeled, this luxurious property is just a stone's throw away from Parque España, surrounded by an array of museums, famed restaurants, chic cafes, art galleries, and lush parks, making it the perfect spot for travelers seeking a blend of cultural immersion and urban convenience.

Guest favorite
A modern living space features a black leather sofa facing a wall-mounted television. A glass table rests on a soft blue rug, with an elegant orchid arrangement placed centrally. Floor-to-ceiling windows allow natural light to illuminate the room, offering a view of the lively street outside.
Apartment in Polanco
4.95 out of 5 average rating, 154 reviews

Beautiful Apartment View Av Presidente Masaryk123

Enjoy Polanco and Mexico City in a modern apartment with an excellent location. Equipped with everything you need to feel at home. If you like history, culture, good food, enjoying the day and night, you'll be in the right place. In addition to the amenities included in the building: gym, jacuzzi, roof garden, parking. 24/7 security. Ideal for those who need something super central, clean, and safe,

Guest favorite
An outdoor terrace features a wooden dining table surrounded by benches, set among lush greenery. A decorative planter adds a touch of nature, while a clay fireplace is positioned to one side. Large glass doors lead into the spacious indoor living area.
Apartment in Condesa
4.94 out of 5 average rating, 335 reviews

Condesa rooftop private terrace apartment.

Unique rooftop apartment in the heart of Mexico City, in Condesa neighborhood. Close to 3 parks, & the vibrant restaurant area. The apartment is on a quiet street, at the top of a 3 storey building, It’s a walk-up. Full of light, and with great views on both sides of the property. The bedroom and the bathroom are tiny, but the kitchen and living room that extends into the terrace are very spacious.

Superhost
Apartment in Condesa
4.84 out of 5 average rating, 1,722 reviews

Chic & Equipped Apt | Rooftop+Gym+B/Center+Lounge

This stylish apartment in the heart Roma Norte and Condesa offers the perfect setup for digital nomads—ultra-fast Wi-Fi, a sleek workspace, and steps from the trendiest cafés, restaurants, and nightlife. Enjoy top-tier amenities: a business center, a full gym, a game room, and a rooftop with stunning views. Stay productive, stay inspired, and experience CDMX like a local.

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