Some info has been automatically translated. Show original language

Vacation rentals in Santa Fe District

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Fe District

Guests agree: these stays are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Apartment in Santa Fe
New place to stay

LaQhia Casa Loros 4

Your Panamanian adventure begins nestled in the greenery of a lush rainforest near SantaFe National Park. Your private apartment secluded from the world offers warm air & the scent of greenery&orchids Sounds of the jungle/tropical birds call daily LaQhia Eco Retreat has Cayucos Bar/Restaurant Also a mind body yoga shala offers other services *fees apply Deeper into the rainforest discover cascading hidden waterfalls. Soak in the beauty&relax with nature *Refe to house manual for more amenities

Home in Santa Fe
New place to stay

Entire house in Santa Fe, Santiago – Nature

Welcome to our home in La Culaca, Santa Fe. Perfect for families, groups of friends, or couples looking to disconnect and enjoy nature 🏡 Entire house perfect for families or groups: 🛏 3 bedrooms | 5 beds | 🛁 1 full bathroom with towels 🍳 Equipped indoor kitchen + outdoor kitchen for barbecues Spacious 🛋 living room and dining room 🚗 Secure patio for 3 cars 🌊 Close to crystal clear rivers and trails ✨ Enjoy nature, tranquility and relaxation in a safe environment

The entrance of the cabin is framed by a well-maintained garden featuring various plants. A stone pathway leads to the front door, flanked by trees and lush greenery, creating a serene and natural ambiance. The cabin's roof is adorned with bright tiles, complementing the exterior.
Cabin in Santa Fe
4.71 out of 5 average rating, 7 reviews

Cabins San Agustin Santa Fe Veraguas

2 Cabins, the first $130.00 this has its own private patio and a beautiful view. The other costs $95.00 Surrounded by nature, you can relax, pleasant weather, you do not need a/c, to share with your family or friends, enjoy away from the noise of the city. Internet Wifi in the common ranch. 2 bedrooms , 1 PRIVATE BATHROOM, dining room, PRIVATE KITCHEN with stove, refrigerator, basic kitchen utensils. Only 2. 5km from downtown Santa Fe. PRICES MAY VARY BY SEASONS

A modern cabin with a unique architectural design is showcased, featuring an orange and stone exterior. A covered porch area provides shelter and views of the surrounding greenery. A gray vehicle is parked in front, illustrating easy access to this welcoming space.
Cabin in Santa Fe
4.71 out of 5 average rating, 14 reviews

Rincon de Cielo Cabin

Enjoy nature and a stylish experience at this home located in downtown Santa Fe and close to Rios, Cascadas and Mountains. The property has beautiful views of the mountains and a small lake. The property can accommodate more than two guests prior to coordination and for an additional price per person. The cottage is stylish and has a room with A/C , laundry, cosine and living room/dining room. The use of the kitchen and laundry room is an additional cost of $10.00

A modern cabin is set within a serene forest of towering pine trees. The structure features a light-colored exterior with a red metal roof and a combination of stone and textured walls. Natural light filters through the windows, enhancing the peaceful atmosphere.
Cabin in Calobre
4.57 out of 5 average rating, 14 reviews

La Pinea Lodge

Enjoy a pleasant and cozy stay in the Cabin among the Pinos. Ideal for those looking for tranquility, comfort and a pleasant stay with family and friends. Located at the entrance of the La Yeguada Natural Park, on a large plot of land near natural attractions such as Lake el Flor, Cascada la Furunera and 3 km from the Lagoon. it has basic amenities; in addition to shower with hot water, good Tigo mobile phone signal, ample parking space.

A spacious white house is set against a backdrop of lush greenery. The building features large windows and is surrounded by various trees. A gently sloping grassy area leads up to the house, providing an open and serene environment.
Vacation home in Santa Fe
4.52 out of 5 average rating, 25 reviews

A charming place to enjoy with family or friends

Enjoy a spacious house exclusively for you, your family or group of friends. A place where you will have complete privacy and total tranquility and where you will not have to share the facilities with other guests. Hostal Vernaza is a safe and quiet house, with access to everything (supermarket, pharmacy, health center,church,restaurants, crafts market, rivers, trails, waterfalls, mountain, beach and so on).

Guest favorite
A tranquil garden scene is depicted, featuring a winding pathway of smooth stones and pebbles. Surrounding areas are adorned with various flowering plants and a small pond, enhancing the peaceful ambiance. Lush greenery is visible in the background, contributing to the serene atmosphere.
Farm stay in Santa Fe
4.9 out of 5 average rating, 297 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Superhost
Cottage in Santa Fe
5 out of 5 average rating, 4 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

A spacious outdoor pool area is illuminated at night, featuring a rectangular pool surrounded by lounge chairs with red cushions. Lush palm trees are positioned around the space, complemented by soft lighting that enhances the tranquil ambiance.
Apartment in PA

THE MOST LUXURIOUS TOWER IN PANAMA TRUMP TOWER

Stay in the most luxurious tower in fully furnished Panama, 4 pools, the best gym, supermarkets, and shopping malls on foot . It has all the advantages of the JM Marriott hotel. more than 5 restaurants in the same tower. netflix , amazon prime, high speed internet. cleaning available . full air conditioning, electric dishwasher, washer dryer , safe .

A rural house with a terracotta roof is situated among lush greenery, framed by mountains. A vehicle is parked in front, with a natural landscape extending around the property. Whispering trees and distant hills offer a serene background.
Cottage in Santa Fe
4.91 out of 5 average rating, 11 reviews

Country house, La Mismísima

La Sismísima is a magical place to disconnect and live a unique experience surrounded by nature. A spacious place that invites you to meditate, read, have a nice coffee with a delicious and special climate for photography lovers. It is a cottage with the comforts to make you feel at home, with the tranquility and peace that nature gives you.

Guest favorite
Cabin in Calobre
4.82 out of 5 average rating, 22 reviews

La Yeguada - Forest Point Cabin

It takes the whole family to this fantastic place with many areas to have fun, fully equipped cottage with spacious kitchen, living room with access to TV, hammocks, refrigerator, stove, hot water and everything you need to have a good time away from the noise and live with nature.

A cozy sleeping area features a spacious bed, surrounded by natural wooden walls made from woven materials. A wooden dresser holds neatly arranged towels, with soft lighting creating a serene ambiance. A textured area rug complements the wooden floor.
Cabin in Santa Fe
4.81 out of 5 average rating, 52 reviews

Cabin with river view

Take it easy at this unique and tranquil getaway. Enjoy the unique experience of nature in your bedroom and living room : -) Comfortable cabin. (glamping). Access to the river. Panoramic view. Very quiet, very zen. Massages and osteopathy upon request.

Popular amenities for Santa Fe District vacation rentals