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Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The sitting area features a modern gray sofa adorned with decorative pillows and is complemented by a wooden coffee table. Artwork hangs on the walls, and large glass doors provide ample natural light and views of a private balcony and the surrounding greenery.
Apartment in Puerto Ayora
4.91 out of 5 average rating, 201 reviews

Planet House Apt2 Sunny 1 BR flat. Great location

This is a beautiful legally registered property, with great views and wonderful fresh ocean breeze. Our apartment is located two blocks away from Charles Darwin Avenue. Guests can enjoy a leisurely walk to main attractions like the Charles Darwin Research Station and beach, great restaurants, cafés, shops, dive shops, tour operators and more. Great option for guests seeking flexibility, comfort and good value. The bedroom has AC, however the living area only benefits from a nice sea breeze.

Top guest favorite
A spacious terrace features large windows providing abundant natural light and views of the surroundings. A colorful hammock is suspended between wooden posts, inviting relaxation. The tiled floor complements the wooden walls, creating a comfortable space suited for leisure and enjoyment.
Apartment in Puerto Ayora
4.97 out of 5 average rating, 75 reviews

Dominga Terrace/in front of main Pichincha Bank

Ubicado en la terraza de uno de los edificios más altos de la isla, encontrarás una maravillosa vista todo el día. Muy fácil de localizar, en av. principal Baltra. Rodeado de restaurantes, tiendas y cajero automático Banco Pichincha cruzando la calle. A 4 cuadras de Terminal Terrestre y 3 cuadras de Mercado Municipal y parada de bus a zonas rurales. Privacidad en tu propia terraza abierta equipada con elementos para ejercitar, comedor y cocina con utensilios. Perfecto para reuniones.

Top guest favorite
A bright common area features two comfortable sofas with decorative cushions and a wooden coffee table at the center. A TV is placed on an easel, and vibrant wall art adds character to the space. The open layout is enhanced by wooden beams and pendant lighting.
Apartment in Puerto Ayora
4.96 out of 5 average rating, 183 reviews

Updated apartment close to centre of town

Our private, bright, spacious apartment is centrally located in Puerto Ayora close to Darwin Avenue. Restaurants, shops, Darwin Station and the main passenger pier are just a few minutes walk away. The apartment is equipped with wifi, large kitchen with fridge, induction stovetop and microwave, and a large common area. It is good for couples, families or small groups. There are two bedrooms with A/C and sofa beds so a family group can easily be accommodated. Patio available upstairs.

Top guest favorite
An airy open space showcases a wooden dining area with three stools and a brightly lit kitchen in the background. Two woven light fixtures hang from above, while a large potted plant adds a touch of greenery to the warm-toned interior.
Home in Puerto Ayora
5 out of 5 average rating, 40 reviews

Villa Náutica

Welcome to your cozy home in the Galápagos Islands! Escape to my enchanting villa loft, where my Swiss and Galápagos roots intertwine, experience the perfect harmony of vibrant island life and cozy Swiss vibes. With bright, airy interiors and unique nautical touches, my space invites you to unwind in style. Located just an 10 min stroll from the Charles Darwin Ave. I’m here to ensure your stay is magical. Come & discover the beauty of the Galápagos—your unforgettable journey awaits!

Guest favorite
A welcoming living area features sleek furniture and a natural wood floor that reflects light. Two modern chairs are positioned around a minimalistic coffee table on a round woven rug. Large double doors open to a balcony, offering scenic views of the surroundings.
Apartment in Puerto Ayora
4.84 out of 5 average rating, 166 reviews

Oceanview Suite: Casa Nido

Welcome to our one-of-a-kind, bird’s nest-inspired suite in Puerto Ayora, Galapagos. Enjoy: ๏ Ocean views from your private balcony ๏ Cozy hanging bed for ultimate relaxation ๏ Artistic tree staircase ๏ Fully-equipped kitchen ๏ High-speed Wi-Fi (120 Mbps) and workspace ๏ Ventilated living space The bathroom is located just below the suite, offering added privacy. Stroll to nearby cafes, bakeries, and restaurants. Let us help you discover the best of the islands!

Guest favorite
A spacious rooftop terrace features a checkered tile pattern, with seating areas and a large umbrella for shade. Panoramic ocean views are provided, showcasing multiple boats in the water and the coastal landscape, creating a serene outdoor space for relaxation.
Townhouse in Puerto Ayora
4.92 out of 5 average rating, 130 reviews

Casa Marina, Galapagos

Casa Marina Galapagos is a unique contemporary, 1.400 square feet, 3 floor townhouse located in the heart of Santa Cruz Island in Galapagos. This family friendly home is suitable for everyone even for your corporation events. We offers spacious rooms with a modern kitchen, large dining table, and comfortable seating in the living area. The roof top terraces with ocean view & highland are astonishing. We welcome you to engage your hearts for an experience of a lifetime.

Top guest favorite
Cabin in Santa Cruz
4.96 out of 5 average rating, 203 reviews

Casa Vikingo • A Unique, Secluded Highland Cabin

Casa Vikingo blends Scandinavian-inspired design with tropical modernism: airy, climate-responsive spaces that embrace nature, panoramic ocean views, and wildlife encounters just steps from your door. Set in the highlands on the sunny east side of Santa Cruz, this off-grid cabin borders the national park and sits on 2.5 acres of private land. Ideal for adventurous couples, honeymooners, and nature lovers seeking privacy. Taxi pickup can be arranged; no car required.

Top guest favorite
The dining area features a modern table accompanied by four black mesh chairs. Dark roller blinds cover the windows, providing privacy and control over light. A potted plant adds a touch of greenery, while a black door leads to the rest of the space.
Apartment in Puerto Ayora
4.97 out of 5 average rating, 75 reviews

Cozy apartment right in the center

Enjoy a stylish experience at this centrally-located place to enjoy unforgettable moments in paradise. The 120 square meter house offers two bedrooms; the first with a double bed and full bathroom. The second with two full beds. Fully-equipped kitchen. In the living room, you'll find a guest bathroom, furniture set, and dining room. In addition to a small patio with a laundry and clothes drying area.

Guest favorite
A charming exterior of a private accommodation is presented, featuring a rustic wooden door framed by lush greenery and colorful flowering plants. The natural stone pathway leads to the entrance, enhancing the inviting atmosphere of the serene outdoor space.
Home in Puerto Ayora
4.88 out of 5 average rating, 137 reviews

El Galapagueño House

Come! Enjoy the simplicity of this magical, quiet, centrally-located, and private place with your partner, family, or friends! An ideal place to rest after visiting the most extraordinary tourist sites of the Galapagos Islands!!! 🏡🐢🏞️🏝️☀️🐚 We look forward to seeing you! 15 minutes' walk to the pier 100 meters from the entrance to Tortuga Bay Beach 20 meters from the tennis court

Top guest favorite
An open-concept living area features a comfortable blue couch facing a wooden coffee table. Large windows allow natural light to fill the space. A modern kitchen is visible, showcasing wooden cabinetry and a dining table for four. Access to the outdoor area is provided through sliding glass doors.
Home in Puerto Ayora
4.88 out of 5 average rating, 130 reviews

Casa Tortuga - Spacious, Bright, and Private Home

Casa Tortuga is a fully licensed Airbnb offering a peaceful, private getaway in the Galapagos. This bright, spacious two-bedroom + 1.5 bathroom home is tucked inside a walled garden oasis with its own entrance, large terrace, and modern kitchen — perfect for couples, families, or friends. Please note this is a fully legal airbnb, operating with a license from the Ministry of Tourism

Guest favorite
Vacation home in Puerto Ayora
4.92 out of 5 average rating, 72 reviews

Family Suite with Jacuzzi (free) Photos 2026.

ペYOUR NEW HOME AT AN UNBEATABLE PRICE Enjoy our apartment/suite with your family or friends in a quiet place with modern and cozy comfort with everything included. Fully furnished!! Fully customized for you. Access to a park in front of your stay (soccer, basketball, and children's games) Just a 3-4 minute drive to famous beaches, Charles Darwin Station, and the pier.

Top guest favorite
A well-lit living area features large windows offering panoramic views of the bay. A comfortable sofa and armchairs are arranged around a minimalist wooden coffee table. A wall-mounted television is positioned above a sleek sideboard, enhancing the space's modern feel.
Apartment in Puerto Ayora
5 out of 5 average rating, 51 reviews

Modern Suite with the Best Sea View

Discover the most luxurious suite with panoramic bay views that surpass any other property in the area Baysight is a new proposal through a Suite in a 4-story building, plus terrace, located on Charles Darwin Avenue, just a step away from restaurants, shops, banks, market, cafes, tour operators and more sites of interest.

Popular amenities for Santa Cruz vacation rentals

Destinations to explore

  1. Airbnb
  2. Ecuador
  3. Galápagos
  4. Santa Cruz