Guesthouse vacation rentals in Santa Clarita

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Santa Clarita

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A tranquil evening scene by the pool features illuminated water in shades of blue. A jacuzzi is situated nearby, while string lights create a warm ambiance overhead. Comfortable seating is arranged around the pool area, surrounded by lush greenery, providing a welcoming outdoor space.

Guesthouse in Newhall

4.98 out of 5 average rating, 494 reviews

Cozy Guesthouse with Private Pool + Heated Jacuzzi

✅ Prime Location: 12 min to Magic Mountain, 30 min to Universal Studios, 45 min to the beach. Close to dining and shopping. *Private guesthouse with its own entrance, fully fenced for your peace and privacy. *Relax with a private pool (not heated), a large heated spa, and a Blackstone griddle for outdoor cooking. *Master bedroom + open loft (as a second bedroom), kitchenette (no oven), living room, WiFi, washer/dryer. *Dedicated parking. Max 8 guests (contact us for exceptions). No parties.

Guest favorite

A private wooden deck extends from the studio, bordered by a natural landscape filled with trees. Sunlight filters through the leaves, creating a serene setting. Large windows reveal views of the surroundings, enhancing the sense of tranquility and connection to nature.

Guesthouse in Topanga

4.91 out of 5 average rating, 262 reviews

Topanga Mountain Studio Retreat

Privacy is paradise, and this studio with its own entrance, tucked away among the treetops at the end of a little known Topanga country road, provides the sanctuary you seek. Designed by one of Topanga's most beloved architects, Cary Gepner, this modern Spanish abode has breathtaking views. The tranquil studio is well appointed with modern amenities including a brand new kitchen, luxurious bathroom, and private deck. Get away from it all while still being a 15 min drive to the beach or valley.

Top guest favorite

A private outdoor area is depicted, featuring a charming koi pond surrounded by smooth stones. A small wooden bridge crosses the pond, while a green bench offers a tranquil spot to sit. A red door leads into the interior space, framed by a wooden fence.

Guesthouse in Sylmar

4.93 out of 5 average rating, 128 reviews

Private Cozy Mountain View with Koi Pond Zen

Welcome to your PRIVATE AND COZY MOUNTAIN VIEW KOI POND ZEN EXPERIENCE. A beautiful new 1 bedroom 1 bath with private keypad self-entrance, comfortable queen bed, full bathroom, sofa bed, dinning table, full size refrigerator, coffee maker, silverware, disposable plates/utensils, 4K Smart TV with access to apps and complimentary guest Wi-fi. Close to shops, restaurants, mission college and major freeways. Short drive to amusement parks & beaches. Sorry no pets, if pets are found - $200 charge.

Top guest favorite

A large private pool is surrounded by lush tropical plants and a spacious deck area. A shaded cabana offers a comfortable retreat nearby, with light filtering through the draped curtains, creating a refreshing outdoor environment.

Guesthouse in Reseda

4.99 out of 5 average rating, 715 reviews

Plant Lover's Paradise: Jacuzzi/Pool, 420 Welcome

Unwind in our studio guesthouse, tucked away in a peaceful backyard retreat with a large private pool, cabana, massage chair, and hot tub. Immerse yourself in paradise, surrounded by tropical fruit trees, an organic garden, and an aquaponics system. Outdoor bliss awaits for 420 enthusiasts (outdoors only). Mention '420 friendly' while booking to receive a gift of our homegrown, pesticide-free cannabis. Max 2 guests, no exceptions. Kindly review our description and house rules before booking.

Guest favorite

The exterior of a house is depicted, featuring a welcoming entrance marked by a large arched doorway. Surrounding landscaping includes vibrant pink roses and manicured grass. A shaded patio area with an umbrella and chairs is visible, along with tall cypress trees framing the scene.

Guesthouse in Canyon Country

4.87 out of 5 average rating, 209 reviews

HILLSIDE GETAWAY next to Magic Mountain

Great reviews beautiful quiet neighborhood on top of hill with an amazing view of the surrounding mountains w/private entrance 15min drive to six flags magic mountain bike paths an nature trails shopping and malls less than 5 min drive everything newly built all guests have given me 5star accommodations easily sleeps 4 people fold out couch in living room queen size bed in bedroom room 16 ft high cathedral ceiling private balcony /tables&chairs purfect to unwind 30 min from universal studios

Top guest favorite

A cozy sleeping area features a spacious bed adorned with various pillows and a textured blanket. On either side of the bed, minimalist nightstands with lamps provide lighting. Three abstract artworks are displayed above the headboard, enhancing the serene ambiance.

Guesthouse in Simi Valley

4.92 out of 5 average rating, 160 reviews

Serene Studio | Modern Touches & Natural Light

Modern studio centrally located to everything the Simi Valley area has to offer. Just a few minutes from the freeway, shopping and restaurants. This recently renovated, private studio is fully equipped for your stay. A combination of modern and natural tones gives this studio a warm feeling of style and comfort. Just right for couples or solo travelers looking for a snug place to rest. Please note the studio is attached to the main home and a train passes nearby. Possible noise may be heard.

Top guest favorite

A cozy studio interior showcases a queen bed adorned with decorative pillows and a soft throw. A futon is positioned nearby, with a small table between them. Natural light fills the space, highlighting the calming color palette and inviting decor, along with a glimpse of the kitchen area.

Guesthouse in Sylmar

4.99 out of 5 average rating, 226 reviews

Tranquil Studio w/ private patio

A beautiful and well maintained Tranquil Studio/ With a Private Patio. Entire Studio to yourselves. 2 guests. 1 queen bed..1 queen/futon couch, with lovely bed linens and plush towels. 1 tub/shower.Futon made up on request at the time of booking. Full kitchen with everything you’d need to make delicious meals. 55” TV/ DVDs Washer/dryer...please bring your own laundry soap and dryer sheets. The gorgeous private patio has plenty of space to relax and enjoy your meals, or just hang out.

Top guest favorite

An open studio guest house features a plush queen bed framed by bedside lamps and a ceiling fan. A cozy sofa and recliner are situated beside a small retro refrigerator and a coffee station. A neutral area rug enhances the warmth of the wood flooring.

Guesthouse in Canyon Country

5 out of 5 average rating, 133 reviews

Hideaway Heaven $120 per night + 25.00 cleaning

Where movie magic happens nestled in the heart of Santa Clarita is a charming studio guest house thoughtfully designed with all the comforts of your own home including a soak in tub to enjoy and relax after a long day. Location is key, and this beautiful guest home is minutes from the 14 freeway,hiking trails , dining, Six Flags Magic Mountain, and film locations. This attached suite is newly renovated with all new furnishings, a private and separate entrance with a designated parking spot.

Top guest favorite

A cozy guest room is equipped with a spacious bed covered in a textured blanket. A sleek work desk and chair are visible, along with a television displaying a beach scene. Large glass doors lead to an outdoor patio area, and a potted plant adds a touch of greenery.

Guesthouse in Burbank

4.98 out of 5 average rating, 297 reviews

Private Guest Quarters with Patio & Bathroom

Enjoy a stylish experience at this centrally-located place in Burbank. Walking distance to Starbucks, minutes away from Disney Studios, Warner Bros. and Universal Studios. Conveniently located near the Hollywood Burbank Airport. Perfect for one-guest. Host lives on premises. Room has a private entrance with outdoor patio. There are two cameras located on the property, one on the Hosts front door, the second one attached to the Hosts home overlooking the backYard.

Top guest favorite

A green wooden exterior features a welcoming front door framed by two large windows. A small seating area includes a metal chair next to the entrance, and potted plants add a touch of greenery along the pathway leading up to the door.

Guesthouse in Lake Hughes

4.92 out of 5 average rating, 332 reviews

The Guesthouse at Hidden Acres

Beautiful, rustic, quiet country get-away. Just 90 minutes North of L.A. on the edge of Angeles National Forest. Perfect for an artist or writer's retreat. Private studio guesthouse on 17 acres. New mini split unit keeps the space comfortable year round. And the wood-burning stove is super cozy on cold nights. Includes fully stocked kitchen, sunken tub in bath, large writer's desk, and miles of hiking trails along the Pacific Crest Trail.

Guest favorite

A spacious bedroom includes a large bed with a light coverlet, complemented by natural light from two windows dressed with soft curtains. A small wooden table and a woven basket provide additional decor, while greenery adds a fresh touch to the inviting space.

Guesthouse in Simi Valley

4.96 out of 5 average rating, 101 reviews

Rustic Ranch Retreat: Guesthouse with Nature Views

Escape to the tranquility of our picturesque working ranch, where you can experience the rustic charm of farm life like never before. Welcome to our one-of-a-kind Airbnb. Ranch Getaway: Unplug and unwind in our cozy guesthouse, nestled amidst the rolling hills of our working ranch. Here, you'll find a true escape from the hustle and bustle of city life, while only being one mile from the freeway. Parties are not allowed at The Ranch.

Top guest favorite

A serene bedroom features a spacious bed adorned with lavender and white linens. Elegant bedside tables flank the bed, while floral decor adds a touch of softness. A piece of art depicting roses hangs on the wall, complementing the gentle purple tones.

Guesthouse in Canyon Country

4.9 out of 5 average rating, 117 reviews

Luxury Studio Lavender

Nestled in the heart of Santa Clarita Valley, this home is a charming guest house. The entrance is private and separate with a parking space. Tastefully decorated and furnished with new amenities, this place is perfect for your getaway. Hosts have created stylish accommodation, perfect for solo travelers, couples and even small families. Come and stay and let us please you with our hospitality, cleanliness and attention to detail.