Family-friendly vacation rentals in San Marco

Home in Southeast Jacksonville

A modern living space features a neutral color palette with a comfortable couch and a round wooden coffee table. A flat-screen TV is mounted on the wall, displaying a serene landscape. The open kitchen is visible in the background, showcasing stainless steel appliances.

4.93 out of 5 average rating, 121 reviews

Renovated home in Jacksonville near San Marco

Cozy, Convenient and Clean! Modern, 3 bedroom/2 bath home Near San Marco! Close to great shopping and restaurants, conveniently located a short distance from downtown, but just far enough away, great place to stay for downtown events. We provide Shampoo, conditioner, body wash, coffee, blow dryer, make up wipes, all the little things to make you feel right at home. Stream your favorite shows from every bedroom in the house. Washer and dryer included as well. 2.5 miles from Brooks Rehab Hospital

Tiny home in Southeast Jacksonville

The inviting sleeping area features a queen bed with a soft duvet and decorative pillows. A spacious work desk is situated nearby, complemented by a light fixture. Two vibrant wall art pieces enhance the room's ambiance, while soft blue walls and natural light contribute to the overall brightness.

4.89 out of 5 average rating, 127 reviews

San Marco Orange Blossom Cottage

Welcome to Orange Blossom Cottage! Beautifully appointed with all of the modern amenities that you might need. Full size stainless appliances, modern kitchen, high speed internet, Roku smart tv, cozy living room. Comfy queen bed, plenty of storage and a dedicated work space. Light and bright with a front porch and a private back patio. Enjoy a glass of wine or coffee, read a book and listen to the birds sing. Perfect for a weekend getaway or a longer stay if you prefer. Conveniently located!

A spacious living area features a leather sectional sofa adjacent to a round coffee table, complemented by two armchairs. Large windows provide natural light, and a dining table with seating for six is visible in the background, with an open kitchen area behind it.

4.99 out of 5 average rating, 224 reviews

Serene Cottage in Walkable, Historic San Marco

This beautifully renovated cottage is a 5-min walk to local Hospitals and Clinics. San Marco Square is within walking distance w/ a theater, shops, & the best restaurants in town. The Southbank Riverwalk is blocks away & lovely for a sunset stroll. The elevated people mover is close by & handy for concert and stadium events. This home is perfect for professionals & health care visitors. Wonderful neighborhoods of Avondale & Riverside are just across the river. Centrally located for easy access.

4.88 out of 5 average rating, 145 reviews

A charming brick building features a welcoming green door and neatly arranged front steps. Flanking the entrance are two blue chairs and well-maintained landscaping, including bushy greenery and flowering plants along the pathway leading to the building.

Apartment in San Marco

San Marco Suite (2nd Floor) - a Hip Historic Space

Comfy for corporate travelers, short visits, extended stays & family friendly. Located within blocks to restaurants, shops, downtown Jacksonville, the sports and entertainment districts, and minutes to hospitals! This is a comfy, clean, and stylish second floor (2nd floor) apartment with 2 bedrooms plus 1 full bathroom to comfortably accommodate 6 guests when utilizing the sleeper sofa. Close proximity to Jax Water Taxi. Please view our other listings at this address by opening my profile.

Superhost

The living area features a dark leather sofa facing a wall-mounted television. A decorative coffee table sits atop a colorful rug, with a plant and art piece adding visual interest. Two accent chairs provide additional seating, while natural light enters through the nearby window.

Apartment in San Marco

4.82 out of 5 average rating, 286 reviews

Comfy, Cozy San Marco Gem

Everyone is raving about our San Marco apartment! We've been offering it since late July, 2019 and have been so pleased with the response. It has been wonderful to host great guests from so many different places. Located on a nice street near the St. Johns River, you'll find the unit puts you close to sports, entertainment, restaurants and medical facilities. Each bedroom sleeps 2 people. There is enough room in either the living room or foyer to put an air mattress. Come stay with us!

4.97 out of 5 average rating, 188 reviews

Beautiful Retreat in the heart of San Marco

This charming, historic, all brick brightly lit home has been completely renovated with high end finishes and beautiful hardwood floors throughout. The open gourmet kitchen is fully equipped with stainless appliances and plenty of amenities. Master bedroom has en-suite bath with adjoining laundry room. Relax in the screened-in porch. Amazing location within walking distance to St. John's river, restaurants & shops in San Marco square, and major hospitals. Everbank Stadium is 2 miles away.

Superhost

The main living space presents a spacious layout with a queen bed and a comfortable couch. A sleek coffee table sits in the center, and a Smart TV is positioned on a dresser. Natural light fills the room through large windows overlooking the outdoor area.

Guest suite in Southeast Jacksonville

4.89 out of 5 average rating, 198 reviews

Charming Studio in San Marco

Enjoy this charming studio located near everything you could want during your stay in Jacksonville. The space is located 5 minutes from San Marco Square, with many local shops and restaurants to enjoy. You will also be only 10 minutes from Downtown Jacksonville, 15 minutes from TIAA Bank Field, and 25 minutes from Jacksonville Beach. This studio is tucked away in one of Jacksonville’s quaint neighborhoods, and will make you feel just like a local! The area is extremely safe and quiet.

A backyard oasis features a light blue hot tub and a pool surrounded by lounge chairs. Two umbrellas provide shade over a dining table. Lush greenery and a charming wooden fence offer privacy, while a whimsical figure stands nearby, adding a playful element to the serene setting.

4.8 out of 5 average rating, 148 reviews

San Marco Home • Pool, Hot Tub, Grill

Welcome to your Jacksonville getaway! This stylish 3-bedroom, 2-bath home in the heart of San Marco is just 10 minutes from Jaguars Stadium and close to vibrant cafes, parks, and boutiques. Ideal for families, couples, groups, or long-term stays, this home combines comfort, charm, and resort-style amenities. Pool Heating: $100 per stay for short visits (≤4 nights). For longer stays or winter months: $50 setup + $12/night, or $200 flat. Please request at least 48 hours in advance.

Apartment in Southeast Jacksonville

The studio features a spacious bed with a light-colored blanket and decorative pillows. A cozy sofa sits in the corner, accompanied by a coffee table. Green plants are placed throughout, and ample natural light enters through a window, complemented by thoughtful décor on the walls.

4.99 out of 5 average rating, 204 reviews

The Cozy Basement in San Marco

Make yourself at home in this studio-style apartment located in a quiet neighborhood with a kitchenette and full bathroom that features modern updates. Centrally located, less than 5 minutes from historic downtown San Marco with trendy restaurants and shopping, just minutes away from all the shops and nightlife in the village square. Less than 15 minutes to Riverside and downtown Jacksonville including multiple hospitals. Also only 30 minutes from the airport and beaches.

Home in Southeast Jacksonville

4.96 out of 5 average rating, 139 reviews

Luxury Designer San Marco Oasis-Sleeps 6

Welcome home to your home away from home! 2 bedrooms/ Sleeps 6, 9 min. to the Stadium, 5 min. to Baptist/Wolfson Children's/MD Anderson hospital, 8 min to Memorial Hospital, 9 min to St. Vincent's hospital, 3 min to San Marco Square, 24 min to Jax Beaches. This designer home with spacious high ceilings is stocked with all details including a Ninja blender, Air fryer and Insta pot. Enjoying relaxing in the Gazebo in the peaceful backyard and grilling out.

A spacious studio features a queen-size bed adorned with light blue bedding, paired with a comfortable fold-out couch in a matching tone. Natural light filters through large windows, illuminating the tiled flooring and stylish coffee table centered on a soft area rug.

4.98 out of 5 average rating, 153 reviews

The Riverside Studio | San Marco

Private standalone studio in San Marco with your own entrance, gated courtyard, and dedicated parking. Walk to the river, San Marco Square, restaurants, and shops. Full kitchen, in-unit laundry, fast Wi-Fi, and a 55-inch smart TV. Just 3 minutes from Baptist Hospital and MD Anderson. 5 minutes to EverBank Stadium. A real home base whether you're in town for work, treatment, a Jags game, or just exploring Jacksonville.

A modern kitchen is equipped with white cabinetry and marble countertops, featuring a spacious island with seating. Multiple pendant lights hang above, illuminating the area. Stainless steel appliances, including a gas stove and a double sink, are visible alongside wooden utensils and knife blocks.