
House vacation rentals in Picayune
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Top-rated house rentals in Picayune
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Picayune house rentals
House rentals with a pool

Heated Pool, Hot Tub, Boat/Fish Dock, No pet fees!
Our family group of 14 had a great time here. The house was large enough to accommodate all of us without feeling crowded, there was so much for everyone to do. The kids were busy all the time with paddling in the water behind the house, basketball, ping pong, soaking in the hot tub, roasting marshmallows. The house was so well stocked with everything we might need and much more. This is a great place to stay with kids of all ages!!!

Spencer’s Way Beach House A with heated pool
Great place. Comfortable, cute and clean. Walked to the beach/restaurants every night. Great pool area. Everything we needed and more!!

Chartres Landing | 10 Guests | Private Pool
We loved our stay in New Orleans and Alleshia was an excellent host. The house is charming with a great large kitchen to hang out in and nicely sized bedrooms. The extra touches of spare toothbrushes and welcome snacks made us feel right at home. We were able to walk to St Roche market and grabbed groceries at a nearby spot that had all we needed. Alleshia was a kind and flexible host, and very responsive. We would definitely recommend!

A True NOLA Experience-Near French.Q.-Salt Pool
I had the bachelorette weekend of my dreams in NOLA at The Dragonfly Inn. The house is perfect and Lore is such an amazing host. I can’t wait to come back!

Historic Spacious 3BR Home w/Heated POOL
We had great time, felt safe, used the pool every day, minutes to down town, slept like logs, thank you for sharing your home.

Luxurious Modern Mid City Marvel - Pool and Garage
We absolutely loved our stay here! The house is gorgeous, spacious and modern. Very thoughtfully designed and the perfect place to kick back and relax after a long day walking and exploring the city. Super comfortable beds, amazing showers, quiet surroundings. I would suggest renting a car as there is not too much in the immediate walking area, however the trolley was very close by and uber/lyft is super efficient throughout the city. Everything felt like a quick 10-15 minute drive away. Thomas was quick to respond to any questions and went above and beyond to help out. 10/10 would stay here again!

Cheerful 1-bdrm. studio w/pool
Barry and Christopher were awesome hosts! We really felt at home and loved to come back and relax after adventuring in the city.

Porch House W/SwimSpa/Pool &3Big Screens To Enjoy
If you have a group of 4 or less visiting NOLA, you MUST stay at Doody and Brady’s place! A perfect, cute neighborhood with plenty of walkable places (restaurants, coffee, trolley) and a short 10 minute Uber/trolley ride to French Quarter. Everything was exactly as advertised including the relaxing, perfect pool! Doody is the sweetest, best host! Highly recommend!
Weekly house rentals

Spacious, central 4br 2ba 6 beds heated toilets
The airbnb was easy accessible, easy to find. Clean and very spacious. Everything was pretty straightforward as to what the description said. Everywhere I wanted to go was nearby like the French quarter/ Bourbon street, Cvs, grocery store. I highly recommended!

Bywater 4-Bedroom, 2 stories, 2 bathrooms!
Awesome host , had some bad weather but Ian was super proactive in helping. The stay was very interesting. Would book with Ian again 10/10

Secluded Beach House with Amazing Views 5 Bedrooms
It was great for a family gathering. Beautiful location. Great porch, swing, bikes, and games. Two kitchens and refrigerators. Stocked by someone who values cooking, food, and entertainment. Responsive host. Great value.

Maison de Colette, Luxury Home with Outdoor Patio
This was a perfect stay for our group. A quick walk to the historic trolleys that take you right to the French Quarter. You can pretty much throw a rock in any direction and hit a place with good food. Overall, this spot was good for the group and met all expectations.

Oasis Steps to Beach, Pet-Friendly, Walk Downtown
location, Location, LOCATION! This place is walkable to the beach, many restaurants and lots of cute local shops. Loved the accessibility of it all. Also, super pet friendly, a fenced in yard that was perfect for my dogs. Cute sitting area out back by the fire pit and every item you would. need in the kitchen. Best shower ever in any Airbnb I've ever stayed at. Will certainly stay here again.

The White Owl – St. Anthony in the Marigny Triangle
I love it when I check into an AirBB and realize that the unit is better than the listing! Christopher’s place is super comfy, well stocked, and in the perfect location - just outside the quarter in the Marigny. Lovely welcome gift of champagne and snacks, love the design / aestheic, super easy entry, and plenty of street parking if you need it. Highly recommend!!!

Canal DOWN |Streetcar Line MidCity| Add More Space
We had fun, everything was well described! There was nothing wrong, the location was quiet and peaceful. We did get a complaint about our noise level before 10 but we managed to meet everybody’s expectations! I would book this place again! Issac was also very helpful!

A Welcoming Place
This place feels like home or a grandparents house of love. it was perfect
Private house rentals

Big Easy GEM LARGE & Spacious New Orleans Home
Our family had an amazing stay! The home is beautiful and located in a quiet residential neighborhood. There were five of us with ample space for everyone. One of the bedrooms had an en suite bathroom, and the two other bedrooms shared a bathroom. The bedrooms were spacious, with plenty of space to unpack. There were televisions in every bedroom. The decor is New Orleans-themed, making the house feel like home. Right outside the front door is the Lafitte Greenway with a beautiful walking and bike trail. The Canal St. streetcar is only a walkable few blocks away and you can ride it all of the way to the French Quarter. I had a little difficulty connecting to wifi (I think the problem was more on my end) and the host was very responsive (literally within minutes) to get me connected to the right network which was robust enough and very reliable for streaming a lecture I had to attend during my stay. I cannot recommend it enough! I would definitely book again!

Farmhouse Charm w/cabin, firepit, & hot tub
We enjoyed ourcstay and plan on going back. Quiet, relaxing place. Fatm vibes. Not far from local attractions. They were quick to respond to b any questions i had. Spacious . All the amenities that you need. It was exactly what i needed after the hectic holidays.

Modern Marigny Pad Near Frenchmen!
Great large house just walking distance of everything you want in the French Quarter. Far enough away to be nice and quite, but close enough to get around without Ubers if you like. Marigny was also very responsive and gave helpful information. Would stay here again.

Live like a local! - Private Guest Suite
Great home she was very nice communicated and made shore I was okay very good directions will stay here again my next visit if I can

Victorian Cottage with a Modern Touch! ~ 4BR/2BA
Our stay at the property was great! Beautiful house and area. If we come again to Mississippi I would love to stay here again. Also, Wendy the house gave me to good decorations ideas for my house. Thanks for helping us with a great getaway!

GAme ROom, Sleep 12, Huge Back Yard, Beach (C)
We loved our stay. Kim was exceptionally quick to respond to texts and requests. The place was immaculate- no dirt to be found. My kids loved the pool table and ping pong table. The location was safe and close to the beach as well as to the Ship Island Harbor.

3BR Home near Caesars Superdome & Bourbon St
The house was exactly as described. It was in a quiet neighborhood in Mid City with a mix of other Airbnbs and neighbors. About 15 min from the Quarter, there was a trolley stop close by. There were some good local eateries around the neighborhood as well. We had a minor issue that required repair and Gabriella had a person out to fix the issue that same evening. We felt comfortable leaving our car parked in the gated driveway with both an automatic gate and pedestrian gate access.

Biloxi Beach View Getaway
This was such a wonderful home and place to stay! We had both of our mothers travel in with us for the Christmas holiday and we couldn’t have asked for a better stay. The location is perfect - so close to the beach, shopping and the casinos. The house was so clean and had everything we needed and a great backyard for our dogs. Would definitely recommend and would look to stay here again the next time we’re in Biloxi.
Quick stats about house rentals in Picayune
Total rentals
20 properties
Nightly prices starting at
ﺩ.ﺇ110 before taxes and fees
Total number of reviews
260 reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
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- St. Louis Cemetery No. 1
- Biloxi Beach
- Tulane University
- Smoothie King Center
- Get Wet
- The National WWII Museum
- Mardi Gras World
- Saenger Theatre
- Fontainebleau State Park
- Mississippi Aquarium
- Buccaneer State Park
- Fallen Oak Golf
- English Turn Golf & Country Club
- Gulf Island National Seashore
- Steamboat Natchez
- Money Hill Golf & Country Club
- Milićević Family Vineyards
- Grand Bear Golf Club
- The Beach
- Louis Armstrong Park
- Preservation Hall
- Amatos Winery
- Ogden Museum of Southern Art
- New Orleans Jazz Museum