Places to stay near Museum of Life and Science

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Top-rated vacation rentals near Museum of Life and Science

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Guest favorite
A modern kitchen features vibrant turquoise cabinetry paired with neutral countertops. Stainless steel appliances, including a refrigerator and stove, are present. A small table with two bar stools occupies one corner, while a window allows natural light to fill the space.
Guesthouse in Durham

Modern Cottage With a Vintage Twist Near Downtown

Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. Our cottage is a cozy, lived-in retreat with rustic charm. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown! Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street

4.96 out of 5 average rating, 401 reviews
Top guest favorite
The exterior view of the studio guest house is presented, showcasing a soft blue facade and a warm wooden door. Sunlight filters through nearby trees, casting playful shadows on the wall. A wooden fence outlines the property, enhancing the sense of privacy.
Guesthouse in Durham

Little House Old North Durham

Welcome to our little house in Old North Durham. The 380 square foot studio guest house (open concept) sits behind our Bungalow in a centrally located historic neighborhood.; a 15-20 minute walk to Durham's vibrant Central Park District and a little further to downtown. Close by restaurants, music, movies and shows. Sleeps 2 comfortably on queen bed, and 2 additional on convertible couch from IKEA. Living area joins kitchen and is open to bedroom (see photos). Vaulted ceilings create openness.

4.97 out of 5 average rating, 192 reviews
Guest favorite
A charming single-story home is set on a lush green lawn, featuring a classic front porch with white railings and blue shutters. A brick chimney adds character, while the pathway leads to the entrance, surrounded by neatly trimmed hedges.
Home in Durham

Cottage with Yard, Mins to Duke

Relax in our sunny 2-bedroom cottage on a lovely corner lot! Perfect for families or remote workers, this home comfortably fits 4-6 guests. Enjoy a private, fenced backyard with a deck, grill, and firepit. Inside, find a dedicated workspace, cozy fireplace, and smart TV. Located in a walkable, family-friendly neighborhood just blocks from Northgate Park. Features include reliable WiFi, a full kitchen, and amenities for children. Your perfect home away from home awaits!

4.88 out of 5 average rating, 168 reviews
Guest favorite
A cozy kitchenette is located on the left, featuring a mini fridge and a microwave. A comfortable blue sofa sits against the wall, complementing the light-colored walls. Natural light enters through a nearby window, illuminating the space and a small collection of wall-mounted photos.
Apartment in Durham

Apartment in leafy Colonial Village, Durham

I turned my house into a duplex, by turning a very 70s addition into a private, cozy, and charming space. There's a kitchenette, a dining area, and a sitting area, a bedroom, and a bathroom. The location would be ideal for someone who needs quick access to Duke Regional Hospital (4 minutes away) or downtown (6 minutes), or someone who wants to keep up a running habit (the greenway is nearby). A taqueria, a grocery store, and a coffee shop are within walking distance.

4.83 out of 5 average rating, 162 reviews
Top guest favorite
A tiny house is depicted, featuring a bright blue exterior and a welcoming wooden deck. Surrounding trees provide shade, and a stone walkway leads to the entrance. The setting is lush with greenery, enhancing the serene atmosphere of the backyard escape.
Tiny home in Durham

Five & Dime Tiny House

Experience the charm of tiny living in this pet-friendly studio located in my serene yet urban backyard. It offers a peaceful escape while remaining convenient to the attractions & amenities that Durham has to offer. -only a mile east of downtown -1.5 miles to DPAC and Carolina Theatre -ten minutes to both Duke Hospital and Duke Regional -less than 20 minutes to RDU airport Let your dog run around the fully fenced yard while you sit on the deck and sip your coffee!

4.97 out of 5 average rating, 348 reviews
Guest favorite
A comfortable seating area features a blue sectional sofa paired with a modern white coffee table. An accent chair complements the space, while framed art hangs on the walls. Natural light streams through large windows with simple blinds, enhancing the inviting atmosphere.
Bungalow in Durham

Cheerful 50s Cottage Near Duke

This charming 1950s two-bedroom 800-square-foot cottage is located just north of Duke’s East Campus in Durham’s Walltown neighborhood. The home sleeps up to four adults with two queen beds, offers keyless entry, and includes high-speed internet. Inside, you’ll find a bright, renovated space with a modern kitchen, colorful artwork, and a bathroom with a small soaking tub. Outside, a short set of steps leads to a large, fenced backyard shaded by mature oak trees.

4.9 out of 5 average rating, 395 reviews
Top guest favorite
Home in Durham

Duke Forest Zen Treehouse - pool table, decks

Enjoy a unique japanese-inspired custom home just 2 miles from Duke. Ascend through the gated entrance up the winding driveway to your own Zen treehouse retreat perched on the edge of the forest. large custom kitchen with a gas range, striking stonework and fireplaces. Outside there is a built-in grill, dining area, and firepit. The downstairs rec room is perfect for families featuring a pool table, movie watching area, and huge enclosed exrerior porch

4.98 out of 5 average rating, 104 reviews
Guest favorite
A light-filled living area is showcased with large windows that offer views of greenery. A modern sofa adorned with colorful throw pillows is complemented by a round coffee table on a patterned area rug. The kitchen, featuring turquoise cabinetry, is visible in the background.
Guesthouse in Downtown Durham

Duplex filled with natural light

A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023

4.94 out of 5 average rating, 155 reviews
Guest favorite
A newly built two-story home features a blue exterior with white trim, showcasing a covered porch with rocking chairs. Well-maintained landscaping surrounds the entrance, providing an inviting approach. Nearby greenery and a tree enhance the tranquil setting.
Home in Durham

New Build |Trinity Park | 5 Min to Duke & Hospital

Spotless new-build in Trinity Park with 2 ensuite bedrooms, fast Wi-Fi, and TVs in every room. Guests love the thoughtful touches, plush bedding, and fully stocked kitchen. Driveway parking for 2 cars plus EV charger. Just a 5-minute drive to Duke University, Duke Hospital, Ninth Street dining, and downtown Durham. Quiet, safe neighborhood with washer/dryer, blackout curtains, and white noise machines for restful stays—your home away from home.

4.96 out of 5 average rating, 107 reviews
Top guest favorite
A bright bedroom suite features a full bed with a patterned throw and modern furnishings. A wall mural displays a cow design, while a flat-screen TV is mounted nearby. A bistro table and two chairs are positioned by the kitchenette, leading to the bathroom in the background.
Guest suite in Durham

The Mural Suite, An Artsy One Bedroom in Durham

A mural filled one bedroom suite with a full bath and kitchenette attached to our house with its own separate entrance. Located less than 5 minutes by car to downtown Durham with easy access for those who prefer to travel by bicycle or foot to the Ellerbee Creek trail. Centrally located to Duke University and Duke Medical. Perfect for longer stays for visiting professionals as well as shorter stays to enjoy all Durham has to offer.

4.96 out of 5 average rating, 268 reviews
Guest favorite
A decorative pillow featuring two blue birds and a red heart is placed on a spacious bed. A cozy, textured throw blanket in neutral tones is draped nearby, contributing to a comfortable and inviting sleeping area.
Apartment in Downtown Durham

Garden Oasis in the heart of downtown Durham

Beautifully renovated must stay if visiting Durham downtown. Within walking distance of many restaurants and city sites. Close to Duke Medical and Campus, and a stone's throw from many of the great restaurants and activities downtown has to offer. Pearl mill (122) offers a secret garden courtyard, an oasis of serenity amongst the action of the city. Huge pool to enjoy, March through October, weather permitting.

4.94 out of 5 average rating, 141 reviews
Top guest favorite
Guesthouse in Durham

Pet Friendly | Cozy Cottage in Bull City

In town for work? Fun? Catching a game? This lovely cottage is an 8 minute drive to Main Street, which means it’s convenient to the fun, but peaceful and quiet when you’re ready for the party to stop. Also less than 15 minutes to Duke Hospital, 20 minutes to Chapel Hill, and 30 minutes to Raleigh. We are also dog-friendly with a fenced in back yard!

4.97 out of 5 average rating, 176 reviews

Popular amenities for vacation rentals near Museum of Life and Science