Hotel vacation rentals in Missouri

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Top-rated hotel rentals in Missouri

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Top guest favorite

A cozy king bedroom showcases a plush bed adorned with colorful pillows. Overhead, large decorative lanterns provide soft lighting. A blue armchair resides in one corner, complemented by a textured area rug. Natural light enters through a large window and double doors leading to a balcony.

Hotel room in Ironton

5 out of 5 average rating, 23 reviews

The King Suite at Pickle & Perk

Located on Main Street in the heart of The Valley. Tucked above our locally loved coffee bar, a cozy king suite perfect for solo travelers or couples looking for a quaint, bed-and-breakfast style escape. Featuring a plush king bedroom, a full private bathroom with a stand-up shower, and a kitchenette equipped for light bites and midnight snacks. A private entrance opens directly into our caged courtyard, giving you a quiet, off-the-street entrance and a peaceful nook to enjoy your morning brew.

Guest favorite

A studio hotel room is presented with a spacious King size bed, a flat-screen TV mounted on the wall, and a kitchenette equipped with modern appliances. A small dining area with a table and chairs is included. Light-colored walls enhance the bright, inviting atmosphere.

Hotel room in Washington

4.95 out of 5 average rating, 129 reviews

River Sirens Hotel Deluxe Suite

11 Room Boutique Hotel in beautiful Downtown Washington. Each room has: Private Entrance Guest Access - Key Pad, Free Parking, King Size bed, TV, Wifi, Hair Dryer, Individual A/C & Heat. Guests can enjoy a shower room featuring a changing area with separate vanity and water closet spaces. Every room as a very large balcony with river views. Each room is also equipped with a full kitchen featuring large refrigerators w/ ice dispensers, induction stove top, microwave, toaster, and coffee station.

Guest favorite

Private room in Gerald

4.9 out of 5 average rating, 178 reviews

Enjoy your stay at the Rock Island Whistle Stop.

You will enjoy this cozy get away. The retro kitchen and new upscale bath blends into down home comfort. Records playing and Roku streaming offer a bit of the old and new in a quaint studio apartment. Awesome sunrises and starry nights, crackling fire on the patio, in two acres of woods, creates a step back into nature. Just one block off US Hwy 50, by the Rock Island Trail State Park, it is the perfect B & B. For guests staying Saturday and Sunday, breakfast is included at our Gerald Cafe.

Top guest favorite

The room features a queen size bed adorned with a decorative red and gold coverlet. Two windows are dressed with plush maroon curtains. A dresser with a mirror and a TV are positioned against one wall, while a faux fireplace adds warmth to the inviting space.

Hotel room in Osceola

4.92 out of 5 average rating, 106 reviews

Historic Commercial Hotel(1868),Sally Rand Suite

The Historic Commercial Hotel (Est.1868) on the Downtown square in beautiful Osceola,Missouri. Old world feel with modernized accommodations. The Historic Commercial Hotel has numerous themed rooms which are designed and named after past historical guests. This specific room is "The Sally Rand Suite". Named after past historical guest Sally Rand ( 1904 – 1979) who was an American burlesque dancer and Silver Screen star, most noted for her ostrich feather fan dance and balloon bubble dance.

Guest favorite

The spacious common area features an open kitchen with a dark granite countertop, blending modern functionality with historic charm. Two large stained glass windows cast colorful light throughout the room, while a grand staircase leads to an upper level, showcasing the building's architectural elegance.

Hotel room in St. Louis

4.98 out of 5 average rating, 44 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Discover refined elegance in The Riverfront Suite, where Gothic grandeur meets contemporary comfort. This distinctive retreat showcases original stained glass windows and exotic wood finishes . A plush queen bed and ambient electric fireplace create an intimate atmosphere, while the luxurious en-suite bathroom features heated floors, designer tile work, and a 2-person soaking tub. Take in panoramic city views from the shared rooftop hot tub. Perfect for couples seeking a romantic escape.

Top guest favorite

A charming motor court unit is showcased, featuring rustic stone walls and vibrant green front doors. Two red chairs and a small table are positioned on the porch, complemented by a plant nearby. The structure is outlined against a clear sky.

Hotel room in Springfield

4.94 out of 5 average rating, 230 reviews

“Camp Rockwood”at Rockwood Motor Court on Route 66

Rockwood Motor Court, on historic Route 66, was built in 1929. Each room is themed and furnished to the era of Route 66. Camp Rockwood pays homage to the important history of motor courts along the road. It is decorated with historic photos of Rockwood and other courts and motels. Newly renovated in 2019, you’ll enjoy clean and comfortable room amenities while experiencing authentic motor court lodging. Need more space? We have larger rooms or can package multiple rooms for your group.

Top guest favorite

A serene bedroom is featured with a king size bed adorned with cozy bedding, flanked by bedside tables with lamps. Hanging lights provide a warm glow. A small seating area includes a table and chairs, and a macramé hanging chair is present in the corner.

Hotel room in Perryville

4.95 out of 5 average rating, 21 reviews

Historic Hotel & Day Spa

Located in downtown Perryville in the Historic Hotel Perry, this is a truly unique stay! Guests enjoy a private bedroom with king size bed in our quiet, tranquil full service day spa. Also included during guests stay is unlimited use of our VIP spa amenities!! The spa is located in downtown Perryville, within walking distance of boutiques, coffee shops, restaurants, a grocery store and nightlife. Please see guest access for details regarding amenities, restroom, & bedroom privacy.

Guest favorite

A bright bedroom is adorned with a light blue wall, creating a serene atmosphere. The spacious bed is covered with a decorative blanket, flanked by crisp white linens. A bedside table and a dresser provide practical storage, while a large window allows natural light to fill the room.

Hotel room in St. Louis

4.87 out of 5 average rating, 735 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

Guest favorite

The spacious studio features high ceilings and large industrial steel-frame windows, allowing natural light to fill the room. A modern sofa and armchairs are arranged around a wooden coffee table. A dining area with seating is visible, complementing the minimalist design.

Hotel room in St. Louis

4.91 out of 5 average rating, 127 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings + bright 7’ industrial steel-frame windows, a spacious open layout, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, an Edison-illuminated community courtyard, and a fully-equipped kitchen with black stainless appliances and quartz countertops. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Guest favorite

The room features exposed brick walls and a wooden ceiling, enhancing the rustic charm. A spacious bed sits beside a cozy seating area with an orange armchair and a guitar. Natural light floods in through multiple large windows, with decorative elements like a cowhide rug and artwork adding character.

Hotel room in Hannibal

4.96 out of 5 average rating, 137 reviews

The Woodsman Suite

A third floor suite, facing the river with the train tracks only a couple blocks away. It took 2 months to do the ceiling. Carefully polished and placed the old lath in a specific design, the ceiling is a work of art. Eighty percent of the material used in this room is from re purposed lumber, either from this building or from a childhood barn built in the late 1800's. It will take you a while to notice every detail down to the toilet paper holder which is from an old barn post.

Superhost

A spacious room features exposed brick walls and large windows allowing natural light to fill the space. A cozy queen bed is positioned nearby, with a hanging chair and an accent table visible. Lush greenery adds vibrancy, complemented by a colorful area rug beneath.

Hotel room in Kansas City

4.88 out of 5 average rating, 107 reviews

Studio 2 @ Hotel No Vacancy®

Bright and minimal, Studio Two is as functional as it is fanciful. Neutral tones are supported with healthy doses of sunshine, creating a soft cozy environment throughout the day. A queen sized canopy bed offers the perfect escape for daydreaming and zzz-ing. There's 8 unique Studios to choose from, all with private bedrooms and restrooms. They have shared hallway access with optional use of common area courtyard + lounge.

Top guest favorite

The Governor's Suite features a four-poster bed elegantly framed against blue floral wallpaper. A light-colored blanket is neatly arranged atop the bed. A decorative mirror and a wooden side table complement the room, while a fireplace adds a cozy touch.

Hotel room in Ste. Genevieve

4.97 out of 5 average rating, 38 reviews

Dr. Hertich’s House - The Governor's Suite

Enjoy easy access to popular shops and restaurants from this charming place to stay. Step back in time and discover the enchanting history of the Dr. Hertich House with a cozy stay at The Hertich House Heritage Hotel in Ste. Genevieve, MO. The Governor's Suite welcomes guests with a blend of old-world charm and modern comforts, such as a private jacuzzi tub and romantic fireplace.