Vacation rentals in Mesa County

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Top-rated vacation rentals in Mesa County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A private hot tub is illuminated with soft blue light, positioned under a shelter. A cozy seating area features comfortable chairs adjacent to a fire pit, with warm flames flickering. Twinkling string lights provide a welcoming ambiance against the night sky.
Home in Palisade
4.93 out of 5 average rating, 306 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Sandstone views, outdoor area with private hot tub, can be kept cool in hot weather just message your preference. Bedrooms with en-suite bathrooms and are situated on opposite sides of the home for privacy. 7-10 minute bike ride to downtown, 5-10 minute walk to three vineyards,. Orchard surrounds 900 sq ft bedrooms and the living room have smart TVs, the kitchen is well equipped. The fenced yard has shaded outdoor areas to BBQ and enjoy sunsets. Best for 4 guests comfortable roll away bed for 5.

Guest favorite
A welcoming entrance features wooden steps leading to a front door framed by greenery. The façade is complemented by natural stone accents and surrounded by lush grass and aspen trees, creating an inviting connection to the outdoors.
Home in Mesa
4.9 out of 5 average rating, 127 reviews

Powderhorn Grand Mesa Classy Family Cabin

Enjoy the outdoor recreation paradise of Powderhorn and the Grand Mesa from your spacious, cozy home. Winter brings downhill and cross-country skiing, snowshoeing, ice fishing and beautiful snowy vistas. Summer allows hiking and all things outdoors sounded by million acres of public lands. The 800 square mile top of the Grand Mesa hosts 300 lakes for fishing as well as paddle boarding and other small watercraft. Hiking trails galore and Powerhorn mountain supports summer mountain biking.

Top guest favorite
A covered porch is supported by wooden beams, featuring outdoor seating arranged on a textured rug. Large windows reflect the golden hour light, blending the indoor and outdoor spaces. Scenic views extend beyond the deck, highlighting the natural surroundings.
Guesthouse in Cedaredge
4.97 out of 5 average rating, 227 reviews

Yonder Mountain Retreat

A beautiful guesthouse on 5 acres a few miles north of the quaint town of Cedaredge. Multiple access points to the Grand Mesa, the ultimate outdoor playground for snowmobiling, hiking, motorcycling, ATVs, UTVs, fishing & hunting! Extra parking for motorcycles, ATVs, UTVs, or snowmobiles! YMR permits guests to bring one furbaby without pre-approval ($100 pet fee still applies). To bring more than one pet, pre-approval & addt’l. fees apply. One external security camera by the kitchen door.

Top guest favorite
A contemporary home is presented with a wooden exterior, surrounded by a gravel area. Large glass doors offer views into the interior space. Two outdoor chairs are positioned on the patio, with wildflowers and vegetation framing the scene.
Home in Loma
4.99 out of 5 average rating, 711 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Top guest favorite
The cabin's exterior features a wooden porch with a railing, providing a peaceful place to sit and enjoy the surroundings. A gas grill is located nearby, and steps lead down to a gravel path, inviting exploration of the natural landscape.
Cabin in Paonia
4.94 out of 5 average rating, 194 reviews

Cozy Yucca Cabin

Please note! We are in the mountains and a 4WD vehicle is highly recommended for winter travel. Welcome to beautiful Paonia and your cozy and peaceful cabin getaway. Just 3.5 miles from the town of Paonia means you're oh-so-close yet so far away from it all. Stillness, beauty, and relaxation. If you're looking for a cozy little reconnect with nature and a disconnect from the rat-race, you've found it. The Yucca Cabin is a perfect Paonia home base for exploring the North Fork Valley.

Top guest favorite
The exterior of a rustic barn-style structure is presented, featuring warm brown siding and a prominent Colorado flag. The building includes a balcony above the entrance, flanked by double garage doors. A gravel area is visible in the foreground, with a scenic backdrop of hills.
Farm stay in Delta County
4.96 out of 5 average rating, 139 reviews

Loft Apartment on Horse Ranch

Tongue Creek Ranch offers everything from beautiful views of the famous Grand Mesa and Adobe Buttes to the peaceful sounds of creeks flowing around the property. Our petting zoo has 5 of the sweetest Nigerian Dwarf Goats, chickens, and the star of the show, BoMama our miniature donkey. Make a bonfire or visit a number of wineries, fishing holes, mountain hikes, snowboarding and skiing, boating, 4x4 trails, skydiving, scenic mountain towns, historical museums, national parks and more.

Top guest favorite
A wooden pergola with a dining table and chairs is situated in a garden area, framed by lush greenery. A yellow building and a red barn with a green roof are visible in the background, set against a colorful sunrise sky.
Home in Palisade
4.97 out of 5 average rating, 296 reviews

Galloway Ranch Palisade Colorado

Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Top guest favorite
A spacious living area features a comfortable sofa and a coffee table, with a view of the open kitchen and dining space. Large windows provide ample natural light, and a ceiling fan helps circulate air. Decorative accents include a vibrant area rug and potted plants.
Farm stay in Fruita
4.98 out of 5 average rating, 323 reviews

Karie’s Hideaway Fruita

Escape to this modern guesthouse just north of Fruita, offering the perfect blend of convenience and seclusion. Located only 10 minutes from downtown Fruita and 20 minutes from Grand Junction, this standalone retreat ensures privacy, safety, and plenty of parking for vehicles, RVs, and trailers. Enjoy fast and reliable Starlink Wi-Fi, unwind on the covered front porch, or challenge yourself to a game of horseshoes—all while soaking in breathtaking mountain views in every direction.

Top guest favorite
Farm stay in Grand Junction
4.99 out of 5 average rating, 101 reviews

Mount Garfield Views and Plenty of Space

Charming ranch home on a small six acre farm 5 miles east of downtown Grand Junction. It has beautiful views of Mount Garfield and the Grand Mesa. The house is 6 miles from Palisade and a short drive to the Orchards of Orchard Mesa. Skiing at Powderhorn Mountain Resort is a short 40 minute drive. Fruita, with world class mountain biking, is a 40 minute drive. The home is 1/4 mile off of Business Loop 70 with easy access to Interstate 70. A small farm within city limits.

Top guest favorite
A view of the yurt from across the river, framed by vibrant greenery. The yurt features a distinct round shape with a white exterior and a black roof. A sturdy wooden railing lines the riverbank, enhancing the natural surroundings and creating a serene atmosphere.
Yurt in Hotchkiss
4.98 out of 5 average rating, 117 reviews

River Walk Yurt/sumptuous, hot tub, fast internet

Our Yurt is a perfect winter sojourn. Between the Rockies and the desert, only 2 miles from Paonia, is a luxury yurt placed on a large wrap-around redwood deck. Hovering above the North Fork of the Gunnison River, your private sanctuary is far removed from neighbors and intrusions. Amenities include a full kitchen (minus oven), queen bed, shower, hot tub, fireplace, piano, sitting area, and dining table. "In seed time learn, in harvest teach, in winter enjoy." W. Blake

Guest favorite
A modern house is set against a clear night sky filled with stars. The exterior features large glass doors, providing a seamless view of the surroundings. A spacious patio area is visible, bordered by natural landscaping, creating a sense of tranquility and connection to nature.
Home in Palisade
4.97 out of 5 average rating, 175 reviews

Rapid Creek Retreat

High above the town of Palisade, nestled in the foothills of the Grand Mesa, is the Rapid Creek Retreat. Surrounded by untouched public land you will experience the true gift and grit of Colorado. Enjoy views of the big sky from sunrise to sunset and beyond for magical star gazing. We planned for this home to be ours, every detail of this home was built with intent and love. The feeling here is truly special. For those ‘rough around the edges. Sincerely, The Busch’s

Top guest favorite
A two-story house is seen from the outdoor area, featuring a patio with several chairs and tables. A gravel driveway leads to lush vineyards in the background, framed by distant mountains under a clear blue sky.
Home in Palisade
4.99 out of 5 average rating, 150 reviews

Love Orchard

You will enjoy breathtaking endless views of orchards, vineyards and the Bookcliff mountains and amazing sunsets from the bright, open great room and balcony. You may think you are in the clouds! The peace and quiet you will feel in this lovely new home will surely refresh you. Located on the fruit and wine byway, there are 6 wineries within 3 miles yet you are only 2.5 miles from downtown Palisade and its plentiful offerings. This home is calling your name!

Popular amenities for Mesa County vacation rentals