Vacation rentals in Mayo Lake

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Top-rated vacation rentals in Mayo Lake

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern cabin is set among trees, featuring a dark exterior with string lights accentuating the entrance. A gravel patio surrounds a fire pit with a stone border, and a picnic table is positioned nearby, creating a welcoming outdoor space for gatherings.
Cabin in Roxboro
4.95 out of 5 average rating, 20 reviews

Mayo Lake Cabin Fun Peaceful Retreat With Firepits

Moonlight Cabin is a modern waterfront home on Mayo Lake. The lake house and nature provides a secluded and peaceful stay while being minutes from shopping, winery, and dining options. This family friendly cabin is both fun and relaxing. Enjoy quiet mornings overlooking the water with a coffee, swim & play in water, spend evenings by the fire pits, and take in the serenity of nature. Indoors, relax with board games, movies, reading, and fast WiFi. Perfect for couples, families, or work escapes.

Top guest favorite
A fire pit area with several Adirondack chairs surrounds a central space. String lights illuminate the area, creating a cozy evening ambiance. The two-story home is visible in the background, featuring large windows and a spacious deck. Lush trees surround the setting.
Home in Roxboro
4.98 out of 5 average rating, 93 reviews

Private Lakefront Paradise - Paddleboards & Kayaks

*Dogs only allowed with approval from owner. Scroll down to read more.* Beautiful 3 bedroom, 3 bath home on Mayo Lake in Roxboro, NC. Incredible views of the lake. You rarely see anyone on our secluded cove. You can swim, fish, paddleboard, kayak or tie up your boat. House is only 5 minutes from the marina and comes with paddleboards and kayaks and has a fire pit. Large, open kitchen, family room/ entertainment room, ping pong table, and jetted tub. Close to hiking, fine dining, and VIR.

Top guest favorite
A wooden dock extends over the calm water, featuring a blue water slide attached to a covered platform. A set of white patio chairs is arranged on the dock, providing a space for relaxation by the lake.
Cabin in Roxboro
4.88 out of 5 average rating, 191 reviews

Water Front Lake House!

Waterfront home on MAYO LAKE. 2 Bd, 1.5 bath fully furnished . Wi-fi, Smart TVs, Alexa, frig, stove washer/dryer, microwave. Queen-size bed, sleeper sofa and bunk bed. Wrap around porch w/ rocking chairs, swing and 2 picnic tables. Large yard for playing, just feet away from the water, and fire pit. Firewood not provided. Lots of fishing, single kayak, 2 person kayak, canoe and 2 paddle boats available. PERFECT FOR ANY SEASON LONG OR SHORT STAY. Located on Mayo Lake in Roxboro, NC

Superhost
A calm lake reflects a clear blue sky with scattered clouds. Lush greenery borders the water, creating a serene atmosphere. Lily pads are visible near the shore, adding to the natural beauty of the landscape.
Home in Roxboro
4.73 out of 5 average rating, 15 reviews

Lake House Hide Away

Experience a peaceful lakeside escape with this beautifully maintained and amenity-rich home steps from tranquil Mayo Lake. Whether you're visiting for fishing, hunting or simply to relax in nature, this Airbnb delivers! This 2 bedroom ,1 bath has a King size bed in one room & a queen in the other . The Kitchen is fully stocked & includes a waffle maker & coffee bar !Whether you want to roast s’mores at the fire pit , take a ride on the kayaks or just relax this is the place for you

Top guest favorite
The tiny house features a modern design with vertical wood siding and large windows that invite natural light. A spacious deck is visible on one side with seating, and a fire pit area is provided for outdoor gatherings. Surrounding the home are mature trees.
Tiny home in Hillsborough
4.96 out of 5 average rating, 194 reviews

Peaceful tiny house retreat on 30 acre farm

This new tiny house is nestled amongst mature hardwood trees on a 30 acre working family farm in Hillsborough. Quiet your mind and restore your body in the luxurious hot tub or warm up by the cozy fire-pit. Under 10 miles to Hillsborough or Durham, and their many restaurants, breweries and shops. Enjoy the privacy of two secluded wooded acres, surrounded by the sights and sounds of our farm, where we are growing fruits, veggies and mushrooms & caring for our animals and pastures.

Guest favorite
The interior space features a warm wooden ceiling and a large Smart TV mounted on the wall. A glass sliding door offers views of the lush greenery outside and the lake beyond, leading to a deck with outdoor seating.
Home in Leasburg
4.93 out of 5 average rating, 170 reviews

Mountain cabin feel on Hyco Lake.

Unwind at this hidden jewel tucked in the woods on Hyco Lake. Forget tiny houses, this “Skinny House” boasts two bedrooms, two baths, a spacious open floor plan, cedar ceilings, fully equipped kitchen, gas grill, solo stove, laundry room. Indoor and outdoor living that is large enough for six adults. Floating dock invites you to spend your days on the lake - swimming, fishing, boating, or just soaking in the views. Canoe, Kayaks, Paddle-boards & life vests provided!

Top guest favorite
A two-story house is set against a blue sky with fluffy clouds. The front porch features a spacious deck with wooden railings. Lush green grass surrounds the property, with small bushes lining the perimeter. Steps lead up to the entrance, enhancing accessibility.
Home in Blanch
4.99 out of 5 average rating, 110 reviews

Backwoods Family Getaway! 3 Bedroom house!

Originally an amish family house back in year 1995, that was remodeled and renovated to give that modern look. We are located 6 miles away from the local town nearby groceries, restaurants and fast food. You will not miss our house, as we are the last house by the end of the road, we have a half a mile gravel driveway from the stop sign, just come through the stop sign and you will see the property. This is 11 acres property near the woods, with different wildlife sightings.

Guest favorite
A spacious porch area is highlighted by three blue rocking chairs, each adding a pop of color against the natural wood decking. A decorative cushion with a paisley pattern sits on one chair, complementing the inviting outdoor space near large windows adorned with soft curtains.
Home in South Boston
4.95 out of 5 average rating, 101 reviews

Papa's Place at Foy's Farm

Relax with the family, friends, or solo... Welcome to Papa's Place! Our completely renovated 1959 two bedroom one bath home in South Boston VA where rustic meets modern. We invite you to enjoy the large front yard, let the butterflies greet you, watch the deer graze, cherish sunsets from the front porch or late nights by the firepit. Only 26 miles from VIR and 30 from the NEW CEASARS VIRGINIA CASINO!! Come visit Papa's Place... where you will ALWAYS be at home!

Guest favorite
Home in Roxboro
4.9 out of 5 average rating, 144 reviews

Lakefront Oasis-HotTub | GameRoom | Kayaks | Dock

At Pointe Mayo Lake, discover a serene, rustic retreat by Mayo Lake. Enjoy amenities like kayaks & canoes, private dock, fishing rods, a grill, a hot tub, a game room, and a fire pit. Perfect for avid vacationers, couples, families, groups of professionals, and even your furry friends! We are Pet and Family Friendly! Love what you see but not ready to book? Click the ❤️ "Save" button on the top right to easily find us again and secure your getaway when you're ready!

Superhost
A serene lakeside view captures the early morning mist hovering over the calm water. Soft hues of orange and yellow reflect on the surface, while the silhouette of trees outlines the horizon. A wooden dock extends into the scene, inviting peaceful moments by the water.
Home in Prospect Hill
4.84 out of 5 average rating, 178 reviews

Lakefront Hygge: Dock|Marine Hammock|Screen Porch

Discover a peaceful haven on the water in Prospect Hill! This stylish Scandinavian Modern house boasts a private dock on a quiet reservoir, offering a serene escape. Enjoy the natural beauty and tranquility, while still being a short drive to Hillsborough, Chapel Hill, Durham, Raleigh, Greensboro, Charlotte and Danville. With a cozy, inviting interior, and abundant places to enjoy the outdoors, this waterfront property is the perfect place to "press pause".

Top guest favorite
A serene lake is observed from a wooden dock, with calm waters reflecting surrounding greenery and a clear sky. The shoreline is lined with trees, creating a tranquil atmosphere. Ripples gently disturb the water's surface, highlighting the lake's peaceful environment.
Home in Roxboro
4.98 out of 5 average rating, 109 reviews

Long’s Lakehouse

Relax with the whole family at this peaceful waterfront property. It is a 2 bedroom, 2 bathroom house with one king bed, one queen bed, and a pull out sofa! The kitchen is fully stocked with a coffee pot, utensils, pizza pan, crock pot, skillet, pots , pans, baking sheets, toaster, oven and microwave! Bedrooms and living room have smart tvs. WiFi available! Enjoy the kayaks, lots of fishing, grilling, and fire pit! There is something for here for everyone!

Guest favorite
The log cabin is surrounded by lush greenery, with vibrant azaleas in full bloom occupying the foreground. A welcoming porch features bench seating, and large windows provide natural light. The sloped roof with gables adds architectural interest, set against a backdrop of trees.
Cabin in Roxboro
4.94 out of 5 average rating, 135 reviews

Majestic Lakefront Log Cabin in the NC High Plains

Cozy Log Cabin located on Lake Mayo just above Roxboro, North Carolina on Whispering Wolf Ranch. Easy access to a functional floating dock. Great for fishing, swimming, meditating, or to just enjoy nature. Paddle boards and Kayaks can be rented at nearby Mayo Lake Park. Can be used for a private romantic getaway or family retreat. Less than 5 miles from the events held at Lake Mayo Park. PARTIES OR EVENTS ARE NOT ALLOWED!

Popular amenities for Mayo Lake vacation rentals