We’re sorry, some parts of the Airbnb website don’t work properly without JavaScript enabled.

Airbnb your place

Little Italy, San Diego vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in Little Italy, San Diego

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

1 of 3 pages

Apartment in Downtown San Diego

4.83 out of 5 average rating, 398 reviews

Relaxing Studio Apt in Little Italy

Welcome to our Sunny & Relaxing Studio Apartment in the Heart of Little Italy, San Diego! This Beautifully Appointed Apartment is Perfect For Those Seeking a Tranquil Retreat in a Vibrant Neighborhood. The Studio is Open and Bright, With Large Windows That Let in Plenty of Natural Light. The Decor is Minimal & Tasteful, With Comfortable Furnishings & High-Quality Linens. The Living Area Features a Plush Sofa and Hammock Chair As Well As a Smart TV With Streaming Services For Your Entertainment.

Dec 25 – Jan 1

ﺩ.ﺇ578 per night

Apartment in Mission Hills

4.98 out of 5 average rating, 142 reviews

Clean, Private, Quiet, Centrally Located Apartment

This spacious 1BR/1BA is nestled in Mission Hills, one of San Diego's most historic neighborhoods. We provide comfortable accommodations within walking distance to many restaurants and pubs. We're only minutes away from Old Town, Little Italy, Gas Lamp, the airport and more. We have all the amenities to make you feel at home while you away from home. The neighborhood is quiet and safe. This property is detached with a private entrance. Includes parking. The laundry is shared with our neighbor.

Aug 18 – 25

ﺩ.ﺇ502 per night

Apartment in Downtown San Diego

4.9 out of 5 average rating, 256 reviews

PENTHOUSE + VIEW DECK Urban Design in Little Italy

Cozy memory foam King-size bed with two additional sleeper sofas! This penthouse suite is located in the heart of San Diego's highest rated neighborhood, Little Italy! Quick and secure access. Boasting over 36 retail establishments within a two block radius! Enjoy an area that is rich in exquisite cuisine, boutiques, patio cafés, exciting bars and local breweries. Area amenities nearby feature the famous San Diego Zoo, beautiful Balboa Park, Waterfront Park, the Convention Center and much more!

Dec 13 – 20

ﺩ.ﺇ1,277 per night

Apartment in Downtown San Diego

4.95 out of 5 average rating, 260 reviews

Trendy Studio, Natural Light - Heart of Downtown

Large studio with comfortable queen sized Murphy Bed, a love seat, private entrance and private bath. Located in Cortez Hill - walk to the nicest neighborhoods in downtown like Little Italy, Gaslamp, East Village, and the Embarcadero. There is no full kitchen, but there is a small refrigerator, small microwave, and a pot for heating water. This is an ideal space for solo travelers, couples, events at the Convention Center, Padres Games, great eateries, and the best of Downtown San Diego.

Oct 1 – 8

ﺩ.ﺇ487 per night

Guest suite in San Diego

4.98 out of 5 average rating, 734 reviews

MIKE'S PLACE - A PRIVATE COTTAGE

The cottage features full amenities that include: Tempurpedic™ queen-size bed. Wi-Fi . Cable HDTV, air conditioning, refrigerator, microwave, wet bar, coffee maker, toaster, and iron. Window seat for sitting, reading or lounging. Private entrance and patio connecting to a courtyard and Japanese garden. Spacious bathroom with 12 foot high tiled shower. French doors open to a private sitting area. If the days are booked in the cottage we might have an opening at, Mikes House and Garden.

Apr 13 – 20

ﺩ.ﺇ569 per night

Home in Bunker Hill - Park West

4.95 out of 5 average rating, 396 reviews

Admire Harbor Views from the Porch at a City Gem

Unwind in a cozy colorful casita in this light-filled 1920s Spanish bungalow with Mexican accents and a casual feel.Take a walk into Little Italy for dinner. What’s best, is how close you are to so much, all without needing a car. A very small single car garage is provided, think compact car. Street parking is free but challenging at times. The house is located directly below the incoming flight path. You are encouraged to read the reviews regarding this. Ideal for four or less persons.

Aug 30 – Sep 6

ﺩ.ﺇ809 per night

Apartment in Downtown San Diego

4.88 out of 5 average rating, 864 reviews

At Mine | Central Suite in the Gaslamp Quarter

This unit is a meticulously renovated historical hotel suite, designed by the renowned Italian firm Pininfarina, located in Downtown San Diego. Nestled in the vibrant Gaslamp Quarter, you'll find yourself in the midst of nightlife with an array of restaurants and bars in close proximity. The suite provides private and spacious accommodations catering to both vacationers and business travelers. Its features include a comfortable king-sized bed, a smart TV, central AC, and a mini-fridge

Sep 4 – 11

ﺩ.ﺇ533 per night

Apartment in Downtown San Diego

4.97 out of 5 average rating, 272 reviews

The Urban Hut Retreat (Heart of Downtown SD!)

A cozy urban retreat truly in the heart of Downtown San Diego awaits you! The excitement of East Village and the sophistication of downtown San Diego Gaslamp right out the door! Walk to Petco Park Stadium, the convention center, & the best SD attractions & restaurants in minutes! When you're not out exploring, relax with some classic records on the vintage record player or relax on the large spacious balcony! Create memories that will last forever, here, in the heart of it all!

Aug 25 – 30

ﺩ.ﺇ635 per night

Apartment in San Diego

4.98 out of 5 average rating, 175 reviews

Eco | Filtered Air | Modern | North Park | deck |

2nd-story apartment in the heart of one of the hippest neighborhoods of San Diego - North Park. We're in a quiet area and still walking distance to Balboa Park as well as coffee, breweries, restaurants, etc. Welcome to @CasaMiranDiego ⭐Queen memory-foam Nectar mattress ⭐Filtered Air ⭐Blackout curtains (bdrm) ⭐AC/Heat ⭐Fiber internet ⭐Solar panels ⭐Smart TV ⭐97 walkscore ⭐Edible garden ⭐Private deck ⭐Washer/Dryer ⭐Easy free street parking ⭐We welcome people from all backgrounds

May 10 – 17

ﺩ.ﺇ548 per night

Guesthouse in Mission Hills

4.91 out of 5 average rating, 415 reviews

Mission Hills Charming suite, walkable to all.

Heart of Mission Hills, upscale area, this private guest suite, separate from the house, is perched above the pool (separate building from main house), own entrance; sure to provide privacy. We are minutes from airport, walking distance to coffee & restaurants and central to all of SD. Please note this property is wiped down after each visit with Clorox as well as all linens washed. We also don’t rent back to back giving time for thorough cleaning.

Oct 23 – 30

ﺩ.ﺇ374 per night

Guesthouse in North Park

4.97 out of 5 average rating, 183 reviews

Fresh, hip and cozy private North Park guest house

Enjoy peaceful sunny San Diego days listening to the palm trees sway in this private backyard garden retreat set behind a 1925 California craftsman. The guest house is tucked away in a quiet quintessential Southern California neighborhood while only being a short and easy walk to amazing restaurants, world class breweries and cozy coffee shops. Balboa Park, the San Diego Zoo, beaches and downtown are all a few minutes drive away.

Feb 16 – 23

ﺩ.ﺇ474 per night

Cottage in San Diego

4.82 out of 5 average rating, 150 reviews

Stylish, cozy studio in the heart of Little Italy

La Cantuccio - "the nook" - is Villa Little Italy's cozy studio. Set in an original 1930's bungalow, this two room studio, this has a main room with a Murphy bed and stylish living area as well charming kitchen. Every effort has been made to make this small space both functional and exquisitely comfortable ... the perfect hideaway to launch your exploration of Little Italy, San Diego, and parts beyond!

Dec 22 – 29

ﺩ.ﺇ640 per night

Vacation rentals for every style

Get the amount of space that is right for you

Apartments

Convenient locations with everyday essentials

Houses

A space thats all yours, with room for everyone

Hotels

Stylish accommodations and amenities

Popular amenities for Little Italy, San Diego vacation rentals

Laptop-friendly workspace

Air conditioning

Stay near Little Italy, San Diego's top sights

Waterfront Park114 locals recommend

Maritime Museum of San Diego124 locals recommend

Little Italy Mercato Farmers' Market247 locals recommend

Filippi's Pizza Grotto Little Italy59 locals recommend

The Crack Shack - Little Italy145 locals recommend

Ironside Fish & Oyster207 locals recommend

Other great vacation rentals in Little Italy, San Diego

Loft in Downtown San Diego

4.96 out of 5 average rating, 343 reviews

Room U at The Dutra Inn - Little Italy

Aug 17 – 24

ﺩ.ﺇ919 per night

Home in San Diego

4.89 out of 5 average rating, 607 reviews

#1 LOCATION - Rare Luxury Home in Downtown

Dec 28 – Jan 4

ﺩ.ﺇ1,662 per night

Guesthouse in Point Loma Peninsula

4.98 out of 5 average rating, 125 reviews

Private Studio Cottage with Outdoor Patio

Dec 19 – 26

ﺩ.ﺇ632 per night

Guesthouse in Mission Hills

5.0 out of 5 average rating, 108 reviews

Santorini-Inspired Cottage #1 w/ Hot Tub + Views

Jan 10 – 17

ﺩ.ﺇ1,201 per night

Guesthouse in North Park

4.99 out of 5 average rating, 251 reviews

Detached Private Studio Apartment with View

Dec 5 – 12

ﺩ.ﺇ534 per night

Apartment in Downtown San Diego

4.91 out of 5 average rating, 142 reviews

Spacious + Sunny 3bd in the Heart of Little Italy!

Oct 1 – 8

ﺩ.ﺇ1,197 per night

Apartment in Downtown San Diego

4.94 out of 5 average rating, 174 reviews

Little Italy by the sea-roomy 2bd 2bath

Aug 22 – 29

ﺩ.ﺇ1,640 per night

Guest suite in San Diego

4.98 out of 5 average rating, 520 reviews

Serene, Updated Cottage in Quiet Neighborhood

Sep 5 – 12

ﺩ.ﺇ561 per night

Other great vacation rentals in Little Italy, San Diego

Apartment in Bunker Hill - Park West

4.86 out of 5 average rating, 56 reviews

Modern Bankers Hill Studio on Maple Canyon

Sep 26 – Oct 3

ﺩ.ﺇ493 per night

Condo in Downtown San Diego

4.96 out of 5 average rating, 28 reviews

Modern Studio in Little Italy

Oct 19 – 26

ﺩ.ﺇ679 per night

Loft in San Diego

4.9 out of 5 average rating, 29 reviews

Waterfront Little Italy Loft

Sep 7 – 14

ﺩ.ﺇ1,057 per night

Home in Downtown San Diego

4.91 out of 5 average rating, 32 reviews

Stylish Studio walking distance to Little Italy

Jan 6 – 13

ﺩ.ﺇ480 per night

Loft in Downtown San Diego

4.91 out of 5 average rating, 11 reviews

Contemporary Loft with Harbor & City Views

Jan 14 – 21

ﺩ.ﺇ1,086 per night

Guest suite in Coronado

5.0 out of 5 average rating, 40 reviews

Sunny Relaxing Studio in Beautiful Coronado

Oct 22 – 29

ﺩ.ﺇ535 per night

Townhouse in Downtown San Diego

4.82 out of 5 average rating, 94 reviews

Contemporary, Fully Renovated Loft in Little Italy

Aug 20 – 27

ﺩ.ﺇ1,111 per night

Condo in Downtown San Diego

4.86 out of 5 average rating, 37 reviews

Little Italy Loft Free Parking/Excellent Location

Jun 8 – 15

ﺩ.ﺇ1,041 per night

Quick stats about vacation rentals in Little Italy, San Diego

Total rentals
390 properties
Rentals with dedicated workspaces
210 properties have a dedicated workspace
Rentals with a pool
70 properties have a pool
Pet-friendly rentals
130 properties allow pets
Family-friendly rentals
150 properties are a good fit for families
Total number of reviews
26K reviews

Destinations to explore