
Guesthouse vacation rentals in Lexington County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Lexington County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Doc & Amy's Downstairs R&B Studio
Fishermen! Enjoy a safe secure location with plenty of parking! This studio has a very classy yet groovy feel, the main colors are Red & Black. Originally this was going to be a room for our pool table. So it gives off that feel with the tile on the walls, the sporty bathroom (with a urinal), the lighting in the room, and a very nice sound system. We are excited to share this awesome space with you. If you are traveling with other persons there is another similarly well equipped space upstairs
ValueLocationAccuracy

Detached Garage Studio in Beautiful Neighborhood!
Enjoy our beautiful neighborhood in Irmo, SC close to I-26 at our wonderful small studio (~280 sq ft) over our garage! Best for a 1-2 night trip as this is a smaller studio. The space has a mini kitchen area with microwave, stove top, mini-oven/air fryer, Keurig, and more. All space is in one studio area with a bathroom. 4 occupancy based off of a twin trundle bed with twin that rolls out underneath… and then a queen air mattress. Best for 2 adult + 2 children, 4 adults would be crowded.
ValueFamilyKitchen

Guesthome
Relax with the whole family in this peaceful country retreat on a private, wooded half-acre in Lexington, SC. This fully equipped home offers comfort, privacy, and convenience just 15 miles from Downtown Columbia, 12 miles from Lake Murray, and about an hour from Augusta, GA. Shopping, dining, and quick access to I-20 are minutes away. Ideal for families, professionals, or corporate guests, with a safe, quiet setting. Owners live on the property with 24-hour assistance available if needed.
ValueFamilyAccess

Lake front Lake Murray in the Heart of Lexington
Walk out onto Lake Murray in the heart of Lexington! From sunrise to sunset this home is perfect for that relaxing get away; a private beach is steps from your door, a dock to fish from, boat ramp to launch your lake toys, quite cove with beautiful wild life! As the owners we live in the upstairs of the home (completely securely separated) and are available if you need anything! We enjoy sharing this beautiful home with others! Please note the beach, dock and lake are shared spaces.
FamilyValueIndoor spaces

Cozy 1-Bedroom Guesthouse Walking Distance to USC
Keep it simple at this peaceful and centrally-located place, with lovely garden views. 1 bedroom/1 bath apartment with a twin sized day bed in the living room. Full kitchen. Walking distance to USC and Five Points. Close to Williams Brice Stadium (1.5 miles); Fort Jackson (5 miles); Soda City Market, Main Street, the Capital building, and the Koger Center (1 mile plus). Parking in driveway or on the street using our guest parking pass. City of Columbia License No. BL002050-08-2023
ValueFamilyComfort

Restful Refuge
Restful Refuge is a renovated one-bedroom studio apartment that includes a full kitchen and full bath downstairs to our home. For your stay with us you will have a private entrance. We are located just minutes from Downtown Columbia but secluded in a small community on a pond. Our desire is to provide a place to help you unwind & rejuvenate during your time in Columbia. Whether you are in town for business or pleasure, we would love to share our Restful Refuge with you.
LocationFamilyComfort

Modern Cottage in Peaceful and Central Location
Nestled on a secluded property, overlooking beautiful land, our peaceful guest house is perfect for a relaxing stay away from home. Ideally located off I-20, this private cottage is less than 10 miles from downtown Columbia, Riverbanks Zoo & the airport and it is just minutes from Lake Murray, restaurants, coffee & shopping. We have sought to make your stay relaxing, quiet & secure. Enjoy this cottage all to yourself with a private entrance and off-street parking.
LocationFamilyComfort

High Honey
A well-appointed space walking distance from the Governor's Complex, Lace House & Gardens, and newly revitalized Finley Park. Near downtown and easy access to major highways. A fully equipped kitchen and two restaurants just steps away make dining easy—no matter your style. Bright and whimsical, the space offers all the comforts of home with the convenience of a central location. Stay through Sunday and check out Monday to unlock extra availability at a discount.
LocationValueCondition

Lizzi & Scott’sTiny Guest House secluded USC-Vista
Welcome to our tiny guest cottage hidden in the heart of the city. It's within blocks of restaurants, coffee shops, an art movie house, and a lovely river walk. The Lace House/Governor’s Mansion, business district, MiLB & UofSC are a short walk or bike ride away. At the rear of our home, it’s private, secure & quiet. A partition & movable screen separate the bathroom area. There’s a smart tv, small fridge, microwave, coffeemaker & work-table.24 hr self check-in.
LocationValueShared spaces

Cary Lake Guesthouse - Slice of Heaven
Awake refreshed and ready for a day exploring in the City of Columbia! This guest house overlooking the private Cary Lake is centrally located in the neighborhood of Arcadia Lakes. You will be within 10 minutes of downtown, USC, and Fort Jackson. You’ll be close to everything in the capital, but far enough to enjoy a relaxing trip. Cook in your own kitchen, clean up in the remodeled bathroom, and sink into the soft bed after seeing the city.
FamilyLocationLayout

Private Loft Studio close to Ft. Jackson and USC
Located in a quiet residential neighborhood in Columbia, SC, this private studio feels tucked away yet is just minutes from everything. Only 10–15 minutes to downtown and the University of South Carolina, 5 minutes to Ft. Jackson, and close to Trenholm Plaza for great restaurants, coffee, and shopping. Perfect for Ft. Jackson visits, boot camp or college graduations, football weekends, business travel, or a relaxing getaway.
LocationFamilyGetting around

Writer's haven in private guesthouse.
Cozy guesthouse makes an ideal writer's retreat! Located in an attractive, quiet neighborhood close to dining and shopping. On-street parking on non-busy side street. Hosts will work with you on creating fun rewards for writing goals. Space has a microwave, refrigerator, coffee maker, and electric kettle, and hosts will provide coffee, tea, wine, bottled water, and snacks, as well as continental breakfast.
LocationFamilyGetting around
Popular amenities for Lexington County guesthouse rentals
Family-friendly guest house rentals

Cozy Hideaway
ValueFamilyLong stay

Vintage Rosewood Carriage House
ValueFamilyDecor

Cozy studio apartment, convenient location
LocationFamilyAccuracy

Casita - COLA & Hot Tub
ValueLocationIndoor spaces

Private space
QuietHospitalityCheck-in

Garden 1BR Cottage off Devine St in Historic Home
LocationOutdoor spacesQuiet

Shared Guest House room #1 - 15 Min to Downtown
QuietCleanliness

Shared Guest House room #2 - 15 Min to Downtown
Quiet
Guest house rentals with a patio

Garden Hideaway
FamilyLocationParking

The Wren's Nest | 1BR 2BA Guesthouse
LocationFamilyAmenities

Beautiful Lake Front 1 bedroom Guest House
LocationFamilyOutdoor spaces

Private Garden Cottage | 5 Mins to USC & Vista
LocationFamilyAmenities

Aviation A-Frame Airbnb
LocationLaundryBathroom

Lakefront guesthouse with private dock.
FamilyLocationView

Pickleball, Gym, Pond | 10 Mins to Lake Murray
FamilyConditionSleep quality

Come stay in our cozy cottage
Sleep qualityComfortCondition
Guest house rentals with a washer and dryer

Guesthouse- Ft. Jackson/USC/Williams-Brice Stadium
ValueLocationHospitality

Cozy Congaree Studio
LocationComfortKitchen

Springdale Getaway
ValueLocationCondition

Capers Guesthouse |Private 1BR Retreat
QuietComfortAccuracy

Bubba’s Tranquil Treehouse STR-000211-2025
FamilyLocationTV

2 Bed Garage Apt Private Entr. (Ft Jackson)
ValueFamilyCondition

Light & Airy Modern Suite | Close To Everything
LocationHospitalityCheck-in

Earlewood Craftsman - Guest House LONG TERM STAY
LocationFamilyAmenities
Destinations to explore
- Hotel rooms Lexington County
- Loft rentals Lexington County
- Rentals with breakfast Lexington County
- Townhouse rentals Lexington County
- Rentals with a kayak Lexington County
- Rentals with lake access Lexington County
- Family-friendly rentals Lexington County
- House rentals Lexington County
- Condo rentals Lexington County
- Private suite rentals Lexington County
- Rentals with pools Lexington County
- RV rentals Lexington County
- Rentals with a hot tub Lexington County
- Apartment rentals Lexington County
- Pet-friendly rentals Lexington County
- Guesthouse rentals South Carolina
- Guesthouse rentals United States
- University of South Carolina
- Congaree National Park
- Riverbanks Zoo and Garden
- Williams Brice Stadium
- South Carolina State House
- South Carolina State Museum
- West Columbia Riverwalk Park and Amphitheater
- Columbia Museum of Art
- Colonial Life Arena
- Saluda Shoals Park
- Sesquicentennial State Park
- Columbia Metropolitan Convention Center
- Dreher Island State Park
- Edventure
- Riverfront Park
- Soda City Market
- Koger Center for the Arts
- Lake Murray Dam North Recreational Area
- Segra Park
- Frankie's Fun Park





