Guesthouse vacation rentals in Lexington County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Lexington County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Lexington County guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Columbia
4.9 out of 5 average rating, 86 reviewsCozy Camper in St. Andrews, Irmo, Harbison Blvd.
Oct 20 – 27
Guesthouse in Columbia
4.08 out of 5 average rating, 39 reviewsCoziest Studio Cabin near USC, 5 pts & Hospitals
Jul 23 – 30
Guesthouse in Columbia
5.0 out of 5 average rating, 371 reviewsCozy studio apartment, convenient location
Dec 18 – 25
Guesthouse in West Columbia
4.94 out of 5 average rating, 600 reviewsCarriage House: Studio Bed & Bath - Pool & Hot Tub
Jan 21 – 28
Guesthouse in Lexington
4.94 out of 5 average rating, 247 reviewsCome Pause and Relax!
May 15 – 22
Guest house rentals with a patio
Guesthouse in West Columbia
5.0 out of 5 average rating, 10 reviewsAviation A-Frame Airbnb
Jun 17 – 24
Guesthouse in Columbia
5.0 out of 5 average rating, 66 reviewsRestful Refuge
Oct 16 – 23
Guesthouse in Lexington County
4.96 out of 5 average rating, 24 reviewsMom's Place
Aug 19 – 26
Guesthouse in Columbia
4.95 out of 5 average rating, 80 reviewsQuaint Haven: Your Cozy Retreat
Jul 22 – 29
Guesthouse in Columbia
4.94 out of 5 average rating, 18 reviewsThe Wren | 1BR 2BA Guesthouse
Jan 23 – 30
Guesthouse in Batesburg-Leesville
5.0 out of 5 average rating, 5 reviewsBeautiful Lake Front 1 bedroom Guest House
Mar 23 – 30
Guesthouse in Lexington
5.0 out of 5 average rating, 49 reviewsA Pondside Oasis close to Lake Murray and Columbia
Jul 18 – 25
Guesthouse in Chapin
4.95 out of 5 average rating, 22 reviewsNEW Lakefront guesthouse with private dock.
Oct 9 – 16
Guest house rentals with a washer and dryer
Guesthouse in Lexington
5.0 out of 5 average rating, 5 reviewsGarage Apartment
Jan 5 – 12
Guesthouse in West Columbia
4.95 out of 5 average rating, 44 reviewsSpringdale Getaway
Apr 12 – 19
Guesthouse in Gilbert
4.89 out of 5 average rating, 92 reviewsShull Island Retreat
Oct 15 – 22
Guesthouse in Columbia
4.98 out of 5 average rating, 85 reviewsBrand New Studio Guest House with Full Kitchen.
Feb 8 – 15
Guesthouse in Columbia
4.89 out of 5 average rating, 65 reviewsFaber's Rest LLC
Dec 26 – Jan 2
Guesthouse in Columbia
4.94 out of 5 average rating, 31 reviewsCasa Abelia - Downtown Columbia
Apr 8 – 15
Guesthouse in Columbia
5.0 out of 5 average rating, 13 reviewsTrendy 1 Bed/1 Bath in quiet upscale neighborhood
Jul 5 – 12
Guesthouse in Columbia
4.97 out of 5 average rating, 36 reviewsGraymont Place | Cottage near USC, Downtown, Vista
Nov 23 – 30
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