Vacation rentals in Irene

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Top-rated vacation rentals in Irene

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Top guest favorite
A modern riverside retreat is surrounded by landscaping featuring natural stones and wooden pathways. The exterior showcases large windows and a sleek design, while a spacious patio extends out, encouraging outdoor enjoyment and relaxation in the peaceful setting.
Home in Larchwood
5 out of 5 average rating, 84 reviews

A River House Near Sioux Falls

Get out of the city, to this riverside retreat. Enjoy the oversized patio/firepit watching the sunset, listening to the Big Sioux River right below your feet. Relax inside by the fireplace of this recent luxury remodel, 3 king bedrooms, 3 bathrooms,on 1 level is rare to find, gorgeous kitchen and oversized island to host those closest to you. Nestle in upstairs the loft and enjoy the views of this river valley. Never to far from all amenities the big city has to offer, but perfect to unplug

Top guest favorite
The entrance features a light blue door adorned with a decorative wreath. A nearby window allows natural light, while a small potted plant and flowers brighten the entrance. Two black chairs are positioned on the steps, enhancing the welcoming appearance.
Cottage in Viborg
4.95 out of 5 average rating, 106 reviews

Parkview Cottage ~ Charming Tiny Home ~ Queen Bed!

Step into the comfort of this charming Parkview Cottage nestled in the very heart of Viborg, SD. It promises a relaxing retreat allowing you to walk to the booming Main St., with excellent Danish restaurants, shops, and attractions. Once you are done sightseeing, retreat to the lovely 1915 renovated home whose cozy design will satisfy your every need. ✔ Comfy Queen Bed + Sleeper Sofa ✔ Open Studio Living ✔ Full Kitchen ✔ Patio ✔ Smart TV ✔ High-Speed Wi-Fi ✔ Free Parking See

Top guest favorite
The split-level home is set against a backdrop of greenery, featuring a stone chimney and an American flag. An attached garage is visible alongside the well-maintained gravel driveway. Nearby, a large barn adds to the rural landscape, creating a calm and serene environment.
Home in Wakonda
4.98 out of 5 average rating, 215 reviews

Quiet split level farm home w/ garage parking

Welcome to the Gregoire Farm. Our home is a recently remodeled split level located on our family farm. It has 3 bedrooms and two baths as well a sofa bed. Park your car in our two car garage. Great place for a larger group to have plenty of room. A little ways off the beaten path but worth a little extra drive. 15 min drive to Vermillion, 20 min drive to Yankton and 35 minutes to Sioux Falls. If you are looking for a quiet place to yourself please consider us. Non-smoking, pet free home.

Top guest favorite
Cabin in Yankton
4.98 out of 5 average rating, 48 reviews

Secluded Ridgeway Hideout | Cozy, Porch, Fireplace

The Hideout on Ridgeway, a peaceful escape tucked away in nature yet close to everything you came for. 5 minutes to Gavin’s Boat Ramp on Lewis & Clark Lake, this spacious retreat is perfect for lake days, family gatherings and weekends with friends. Sip your coffee on the screened-in porch, cozy up by the fireplace, or settle in for movie night on the 75” TV in the loft. The home is fully stocked—linens, coffee, and cooking essentials are all provided—so you can arrive, unpack, and relax.

Top guest favorite
A lower level entertainment room features a gray sofa adorned with a red blanket and a decorative pillow showcasing the initials 'USD.' A ping pong table and a foosball table are visible, with a university flag displayed on the wall.
Home in Vermillion
4.99 out of 5 average rating, 124 reviews

Townhouse in Vermillion close to USD

Relax with all your family & friends as you enjoy the wonderful town of Vermillion during your stay in this comfortable and spacious duplex. Conveniently located close to USD's campus, restaurants, and shopping. Walk down and enjoy a USD event. Or take the family to the park. Closely located to Prentis Park where you can cool off at pool, play on the playground or basketball courts and enjoy the beautiful picnicking areas. This home is sure to accommodate for a fun stay during your visit.

Top guest favorite
Cabin in Yankton
5 out of 5 average rating, 13 reviews

The Eden, Yankton SD Lakeside Lewis & Clark Lake

Take it easy at this unique & tranquil quaint getaway in the peaceful neighborhood of the House of Mary Shrine & right across from the popular Lewis & Clark Lake Rec area. Featuring a peek-a-boo view of the lake, amble wildlife viewing, this one-bedroom small cabin is perfect for a quick romantic get a way; or stay longer to enjoy the great amenities and area. An out door firepit and grill await outdoors while inside enjoy the small quiet home with the lux of modern day features. Book it!

Top guest favorite
Home in Emery
4.96 out of 5 average rating, 78 reviews

Pleasant Street Guesthouse.

Take it easy at this unique and tranquil getaway. Nestled in a quiet neighborhood in a small town not far from interstate 90 this home features all the amenities of larger home in a cozy package. Gas and groceries not far away. Enjoy the safety of a small town in the Midwest. Kitchen, Living room, loft, 2 bedrooms, pullout bed in couch, pack and play, washer and dryer. Smart TV in loft separate from living room. Kitchen, bathroom, living room, bedroom, laundry are all on ground level.

Top guest favorite
A fully equipped kitchen is highlighted by wooden cabinetry and modern appliances. A spacious central island with seating is complemented by hanging light fixtures. A large black refrigerator and stove are visible, along with a microwave and dishwasher, providing a welcoming space for meal preparation.
Home in Canton
4.99 out of 5 average rating, 84 reviews

The Lincoln House, steps to Downtown Canton

Beautiful home with brand new finishes located steps from downtown Canton. One block away from Main Street. Walking distance to restaurants, bars, parks and church. Great for a large families and large groups. Quiet location with nice backyard for the kids and friends to enjoy. Short drive to nearby wedding venues, receptions and several churches. Nearby shuttle services available. We are a short 7 minute drive to Calico Skies Winery, Inwood, IA, 25 miles to Sioux Falls, SD. Enjoy!

Top guest favorite
Guest suite in Sioux Falls
4.98 out of 5 average rating, 257 reviews

Luxury Suite • Private Yard • Hot Tub • King Bed

Welcome to The Chic Suite — a fully private, luxury guest suite designed for rest, convenience, and quiet comfort. Featuring a plush king bed, rainfall tile shower, secluded fenced yard, and your own hot tub, this space is perfect for business travelers, quick overnight stays, and couples looking for a peaceful retreat in northwest Sioux Falls. Tucked behind the main home garage with its own entrance, walkway, and outdoor space — you’ll have complete privacy during your stay.

Guest favorite
The treehouse is elevated on a sturdy platform, surrounded by snow-covered landscape and trees. The structure features a wraparound deck with a metal railing and a sloped roof, allowing for unobstructed views of the environment. Morning light casts a soft glow over the scene.
Treehouse in Valley Springs
4.91 out of 5 average rating, 413 reviews

Lookout Loft Treehouse

Welcome to the Lookout Loft Treehouse! Find a retreat in this peaceful hilltop oasis just a short 20 min drive out of Sioux Falls, SD. Sleep in the clouds on your dreamy pillow top mattress, wake up to stunning 360 degree views overlooking the surrounding countryside. Enjoy a cup of coffee on the wraparound deck, a propane fire on the mid-level deck and a dip in the hot tub at ground-level. Space includes a kitchenette, bathroom, and sleeping quarters, with AC and heat.

Top guest favorite
Barn in Hartington
4.97 out of 5 average rating, 33 reviews

Cozy Red Barn Cabin with Silo, Scenic Views

Enjoy a peaceful retreat in this cozy red barn with a silo, Featuring two upstairs bedrooms, a half bathroom on the main floor, and a full bathroom upstairs.Relax on the screened-in porch, warm up by the fire pit, and explore nearby trails and Willow Pond.Inside, you’ll find plenty of charming antique touches paired with modern amenities, creating a unique and welcoming space.Perfect for a quiet getaway with comfort and scenic views!

Guest favorite
A charming treehouse is elevated among cottonwood trees, featuring wooden balconies and illuminated with warm string lights. The evening sky displays vibrant hues, enhancing the cozy ambiance. A sign is visible in the foreground, indicating property guidelines.
Treehouse in South Sioux City
4.9 out of 5 average rating, 796 reviews

Kottage Knechtion Treehouse | Breakfast Included

Welcome to your enchanting treehouse retreat, Kottage Knechtion, located in South Sioux City, Nebraska. This unique 18-foot-high treehouse, nestled between two majestic cottonwood trees, offers a cozy escape for up to 2 guests. With 1 bedroom, 1 bed, and a half-bath, this adult-only getaway is crafted from reclaimed materials and designed to provide a serene and unforgettable experience. ⭑CONTACT US FOR SEASONAL DISCOUNTS⭑

Popular amenities for Irene vacation rentals

  1. Airbnb
  2. United States
  3. South Dakota
  4. Yankton County
  5. Irene